LOCUS       NM_017214               2917 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus regulator of G-protein signaling 4 (Rgs4), mRNA.
ACCESSION   NM_017214
VERSION     NM_017214.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Wang,Y., Hou,X., Wei,S., Yan,J., Chen,Z., Zhang,M., Zhang,Q.,
            Lu,Y., Zhang,Q., Zheng,T., Jia,J., Dong,B., Li,Y., Zhang,Y.,
            Liang,J. and Li,G.
  TITLE     The roles of ubiquitin-proteasome system and regulator of G protein
            signaling 4 in behavioral sensitization induced by a single
            morphine exposure
  JOURNAL   Brain Behav 13 (3), e2922 (2023)
   PUBMED   36793204
  REMARK    GeneRIF: The roles of ubiquitin-proteasome system and regulator of
            G protein signaling 4 in behavioral sensitization induced by a
            single morphine exposure.
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Li,L., Zheng,B., Zhang,F., Luo,X., Li,F., Xu,T., Zhao,H., Shi,G.,
            Guo,Y., Shi,J. and Sun,J.
  TITLE     LINC00370 modulates miR-222-3p-RGS4 axis to protect against
            osteoporosis progression
  JOURNAL   Arch Gerontol Geriatr 97, 104505 (2021)
   PUBMED   34450404
  REMARK    GeneRIF: LINC00370 modulates miR-222-3p-RGS4 axis to protect
            against osteoporosis progression.
REFERENCE   3  (bases 1 to 2917)
  AUTHORS   Ehses,J., Fernandez-Moya,S.M., Schroger,L. and Kiebler,M.A.
  TITLE     Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in
            neurons
  JOURNAL   RNA Biol 18 (7), 988-998 (2021)
   PUBMED   32779957
  REMARK    GeneRIF: Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC
            in neurons.
REFERENCE   4  (bases 1 to 2917)
  AUTHORS   Luessen,D.J., Sun,H., McGinnis,M.M., McCool,B.A. and Chen,R.
  TITLE     Chronic intermittent ethanol exposure selectively alters the
            expression of Galpha subunit isoforms and RGS subtypes in rat
            prefrontal cortex
  JOURNAL   Brain Res 1672, 106-112 (2017)
   PUBMED   28736108
REFERENCE   5  (bases 1 to 2917)
  AUTHORS   Namvar,S., Fathollahi,Y., Javan,M., Zeraati,M., Mohammad-Zadeh,M.,
            Shojaei,A. and Mirnajafi-Zadeh,J.
  TITLE     The antiepileptogenic effect of low-frequency stimulation on
            perforant path kindling involves changes in regulators of G-protein
            signaling in rat
  JOURNAL   J Neurol Sci 375, 450-459 (2017)
   PUBMED   28320185
REFERENCE   6  (bases 1 to 2917)
  AUTHORS   Srinivasa,S.P., Watson,N., Overton,M.C. and Blumer,K.J.
  TITLE     Mechanism of RGS4, a GTPase-activating protein for G protein alpha
            subunits
  JOURNAL   J Biol Chem 273 (3), 1529-1533 (1998)
   PUBMED   9430692
REFERENCE   7  (bases 1 to 2917)
  AUTHORS   Tu,Y., Wang,J. and Ross,E.M.
  TITLE     Inhibition of brain Gz GAP and other RGS proteins by palmitoylation
            of G protein alpha subunits
  JOURNAL   Science 278 (5340), 1132-1135 (1997)
   PUBMED   9353196
REFERENCE   8  (bases 1 to 2917)
  AUTHORS   Tesmer,J.J., Berman,D.M., Gilman,A.G. and Sprang,S.R.
  TITLE     Structure of RGS4 bound to AlF4--activated G(i alpha1):
            stabilization of the transition state for GTP hydrolysis
  JOURNAL   Cell 89 (2), 251-261 (1997)
   PUBMED   9108480
REFERENCE   9  (bases 1 to 2917)
  AUTHORS   Druey,K.M., Blumer,K.J., Kang,V.H. and Kehrl,J.H.
  TITLE     Inhibition of G-protein-mediated MAP kinase activation by a new
            mammalian gene family
  JOURNAL   Nature 379 (6567), 742-746 (1996)
   PUBMED   8602223
REFERENCE   10 (bases 1 to 2917)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017214.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF117211.1, SRR26643298.52153.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000013.1  84475733-84475884   c
            153-257             JAXUCZ010000013.1  84473391-84473495   c
            258-319             JAXUCZ010000013.1  84472899-84472960   c
            320-486             JAXUCZ010000013.1  84472440-84472606   c
            487-2917            JAXUCZ010000013.1  84469593-84472023   c
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2917
                     /gene="Rgs4"
                     /note="regulator of G-protein signaling 4"
                     /db_xref="GeneID:29480"
                     /db_xref="RGD:3567"
     exon            1..152
                     /gene="Rgs4"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..726
                     /gene="Rgs4"
                     /note="RGP4"
                     /codon_start=1
                     /product="regulator of G-protein signaling 4"
                     /protein_id="NP_058910.1"
                     /db_xref="GeneID:29480"
                     /db_xref="RGD:3567"
                     /translation="MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHSSSHSKKDK
                     VVTCQRVSQEEVKKWAESLENLINHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIK
                     SPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLM
                     EKDSYRRFLKSRFYLDLTNPSSCGAEKQKGAKSSADCTSLVPQCA"
     exon            153..257
                     /gene="Rgs4"
                     /inference="alignment:Splign:2.1.0"
     exon            258..319
                     /gene="Rgs4"
                     /inference="alignment:Splign:2.1.0"
     exon            320..486
                     /gene="Rgs4"
                     /inference="alignment:Splign:2.1.0"
     exon            487..2917
                     /gene="Rgs4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggattctgac agcttctttg cagagcagaa gcaactgtgc tcaaaataga aaccaccgtt
       61 gctcccgctg cctttctctc ctcgctccga atcccacagt taaacaagat gtgcaaagga
      121 ctcgctggtc tgccggcttc ctgcctgagg agcgcaaagg atatgaaaca tcggctggga
      181 tttctgctgc agaaatcaga ttcctgtgaa catagttctt cacacagcaa gaaggacaaa
      241 gtagtaactt gccagagggt gagccaagaa gaagtcaaga aatgggctga atcgctggaa
      301 aacctgatta accatgaatg tggactggca gctttcaaag ctttcctgaa gtcagaatac
      361 agtgaggaga acattgactt ctggatcagc tgtgaggagt acaagaaaat caaatcacct
      421 tctaaactaa gtcccaaggc caagaagatc tacaatgagt tcatctctgt gcaggcaaca
      481 aaagaggtga acctggattc ttgcaccaga gaggagacaa gccggaacat gttagagccc
      541 acgataacct gttttgatga agcccagaag aagattttca acctgatgga aaaggattca
      601 taccgtcgtt tcctcaagtc tcgattctat cttgacctga ccaatccttc cagctgcggg
      661 gcagagaagc agaaaggagc caagagttct gcagactgca cttccctagt ccctcagtgt
      721 gcctaattct cacacagagg cagagaaccg aaatgccaag actctatgct ctggaaaacc
      781 tgaggccaaa tattgatctg tattaagcat caatgctttc tccacattgt agcctagtat
      841 ccatgctgcc tgccgtgtgt gagtcacttc catgtaaaac tagacttagc tgtggtgtgg
      901 gggttttcat tggggtaaga cccaacttgt tttcaatttt cccaagtttc cttaaagggt
      961 gtcaggtgag caagtctcca aataatggcc ctgtaggtct ggattttcaa agatggttag
     1021 tagtccaccc cttccaacag tttgacctca agttagttgg tacacttcat gtgatgtcac
     1081 atgcacatgc aatgtcagcc agcagcactt cctacagact ttcaacgttt aggtgatatt
     1141 tgtgtatgtg tatgtatata ttaaatatat agaacatatg catatacatt ctgtatatat
     1201 tatatctatg tattcagtat gtgtgaatgt gcatgaatat atatatatat gcatatatat
     1261 atttgtatat gttcacacat gcacacacat ttcttcaaga aaagatggga aagatccttg
     1321 gtgctcaaat tggagtgtgt acacatgctt gcatgcatgt tctgacttct ggtccttcat
     1381 actgtgtctg aacagggcaa actaaattaa ctgccatgca ggctaagaaa ggaacactaa
     1441 cttgtaaaaa gtgagttccg tcaagccact gggtcttgat ggagcatagt cagggccttt
     1501 gtgtttaatc tcgtcaatgg cctccacatt gagcactgag ctatggggtg agtactccga
     1561 aaactctgct gtctgactga cacagagctg cctcgcaccg gtgattacta ctagcacttt
     1621 taagtcccta tgctgttggc catccctcct ttgcctgggt gctcagggca tgctgactag
     1681 cagctgggtt ggtctggaga tggatgtttg agaggaatga aggaatgcgg tccaggcctt
     1741 gttgcctagc cctacaaatg actactgctt aggtgagggc agaagacccc gaggttatct
     1801 taattctttc ctctcttgat aaggtgctct cctattccta cccccaaaga acgtcacctg
     1861 tcagatgagc ctctttactt ccccgtggtt ggttgctcac gttaggaacc atggccacct
     1921 gcaagtcatt ctaagctacc cgcttacatt tttcaaaagc atcaccaggg ggaaaggtta
     1981 tgctgtccca ggaggaagta agctcttatg agctgtaaac ccctttttgg ttttctgctt
     2041 tgaggtaaga gcttgttcat cccatcccaa acaccaaagt tagcagagac caacggaagg
     2101 agagaggaaa gaaaaaaaaa agaaagagaa gagaaaagag gaggacggga tatcagttgg
     2161 taggactact gtttggagct ttttaaggca cgtgaaatac ttgaaaattt ctcatttgtg
     2221 ttatttatgt tgttttgtac aatgttttta ttactgtatt gttttataaa tggaggtaca
     2281 ggatattacc cgaattatta atgaatgccc aagaagtaat tttcttctca ttcctctaaa
     2341 agtcctgcct ttgagagcgc acacagactc gtgcatactg caggcacagc tccagtttaa
     2401 attccatgca tgagcaccat tgtggctgca aagtgaagac actcatagtg tgaatccaag
     2461 tctcaccatt attgaagaag tcagttttct aacagtactg ttgtctctct tgacagtctt
     2521 gcgtataata tccccagagc tcccccatca gtggtcctaa ctcctttttg taatacacaa
     2581 gtccacagtc gtgtctgtat aactctccgg tcttgcccta atattatcat gactttgaga
     2641 ttgtacctgt actcccagac tgctgtctca caaataggtc tgggaaaagt cattctgaat
     2701 gagaagtaaa ttattttatg taatacatct tgagtgtgtc ttcagttgta tttgccatcg
     2761 ctctttggtc tggcgagcct gcctgctgct ggcccctgca aaggacgctc cttccagatg
     2821 catgtctgtt tctgccatgt gctttatagg cctcagcgct gatgcttcca atgaaacaca
     2881 tagatctgaa tgataacagg aaataaatgc ttcctac
//
