LOCUS       NM_019340               3722 bp    mRNA    linear   ROD 03-FEB-2024
DEFINITION  Rattus norvegicus regulator of G-protein signaling 3 (Rgs3), mRNA.
ACCESSION   NM_019340
VERSION     NM_019340.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3722)
  AUTHORS   Yono,M., Yoshida,M., Yamamoto,Y., Imanishi,A., Fukagawa,A.,
            Latifpour,J. and Eto,M.
  TITLE     Identification of potential therapeutic targets in
            hypertension-associated bladder dysfunction
  JOURNAL   BJU Int 105 (6), 877-883 (2010)
   PUBMED   19689474
REFERENCE   2  (bases 1 to 3722)
  AUTHORS   Ikeda,M., Inoue,S., Muramatsu,M. and Minatogawa,Y.
  TITLE     Characterization and identification of a steroid receptor-binding
            protein, SRB-RGS
  JOURNAL   Biol Pharm Bull 30 (6), 1056-1064 (2007)
   PUBMED   17541154
  REMARK    GeneRIF: SRB-RGS was characterized and identified as a steroid
            receptor-binding protein.
REFERENCE   3  (bases 1 to 3722)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   4  (bases 1 to 3722)
  AUTHORS   Costigan,M., Samad,T.A., Allchorne,A., Lanoue,C., Tate,S. and
            Woolf,C.J.
  TITLE     High basal expression and injury-induced down regulation of two
            regulator of G-protein signaling transcripts, RGS3 and RGS4 in
            primary sensory neurons
  JOURNAL   Mol Cell Neurosci 24 (1), 106-116 (2003)
   PUBMED   14550772
  REMARK    GeneRIF: RGS3 is expressed at high levels in C-fiber primary
            sensory neurons in the adult rat dorsal root ganglion (DRG) and
            sciatic nerve transection results in a downregulation of this
            transcript.
REFERENCE   5  (bases 1 to 3722)
  AUTHORS   Wang,Q., Liu,M., Mullah,B., Siderovski,D.P. and Neubig,R.R.
  TITLE     Receptor-selective effects of endogenous RGS3 and RGS5 to regulate
            mitogen-activated protein kinase activation in rat vascular smooth
            muscle cells
  JOURNAL   J Biol Chem 277 (28), 24949-24958 (2002)
   PUBMED   12006602
  REMARK    GeneRIF: role in regulating mitogen-activated protein kinase
            activation in rat vascular smooth muscle cells
REFERENCE   6  (bases 1 to 3722)
  AUTHORS   Castro-Fernandez,C. and Conn,P.M.
  TITLE     Regulation of the gonadotropin-releasing hormone receptor (GnRHR)
            by RGS proteins: role of the GnRHR carboxyl-terminus
  JOURNAL   Mol Cell Endocrinol 191 (2), 149-156 (2002)
   PUBMED   12062898
  REMARK    GeneRIF: cell surface expression and regulation of GnRHR bearing a
            carboxyl-terminus is altered by RGS10, but not by RGS3, proteins
REFERENCE   7  (bases 1 to 3722)
  AUTHORS   Ikeda,M., Hirokawa,M., Satani,N., Kinoshita,T., Watanabe,Y.,
            Inoue,H., Tone,S., Ishikawa,T. and Minatogawa,Y.
  TITLE     Molecular cloning and characterization of a steroid
            receptor-binding regulator of G-protein signaling protein cDNA
  JOURNAL   Gene 273 (2), 207-214 (2001)
   PUBMED   11595167
REFERENCE   8  (bases 1 to 3722)
  AUTHORS   Linares,J.L., Wendling,C., Tomasetto,C. and Rio,M.C.
  TITLE     C2PA, a new protein expressed during mouse spermatogenesis
  JOURNAL   FEBS Lett 480 (2-3), 249-254 (2000)
   PUBMED   11034339
REFERENCE   9  (bases 1 to 3722)
  AUTHORS   Pedram,A., Razandi,M., Kehrl,J. and Levin,E.R.
  TITLE     Natriuretic peptides inhibit G protein activation. Mediation
            through cross-talk between cyclic GMP-dependent protein kinase and
            regulators of G protein-signaling proteins
  JOURNAL   J Biol Chem 275 (10), 7365-7372 (2000)
   PUBMED   10702309
REFERENCE   10 (bases 1 to 3722)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB055153.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_019340.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB055153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3722
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..3722
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /note="regulator of G-protein signaling 3"
                     /db_xref="GeneID:54293"
                     /db_xref="RGD:3566"
     exon            1..103
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2953
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /note="regulator of G-protein signalling 3"
                     /codon_start=1
                     /product="regulator of G-protein signaling 3"
                     /protein_id="NP_062213.1"
                     /db_xref="GeneID:54293"
                     /db_xref="RGD:3566"
                     /translation="MNRFNGLCKVCSERRYRQITIRRGKDGFGFTICCDSPVRVQAVD
                     SGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRVVPQIKPGP
                     DGGVLRRASCKSTHDLLSPPNKREKNCTHGAPTRPEQRHSCHLVCDSSDGLLLGGWER
                     YTEVGKRSGQHTLPALSRATTPTDPNYIILAPLNPGSQLLRPVYQEDAIPEEPGTTTK
                     GKSYTGLGKKSRLMKTVQTMKGHSNYQDCSALRPHIPHSSYGTYVTLAPKVLVFPVFV
                     QPLDLCNPARTLLLSEELLLYEGRNKTSQVTLFAYSDLLLFTKEEEPGRCDVLRNPLY
                     LQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAA
                     TPTERKMFETEADEKEMPLVEGKGPGAEERTPSKDPSPSQELPPGQELPPSKDPSPSQ
                     ELPPGQELPPSKDPSPSQELPPGQELPSSKNPSPSQELPAGQDLPPRKESFSGQEAAP
                     GPESPSSEDIATCQNPPQSPETSTSKDSPPGQGSSPTTEVPSCQGLPAGQESTSQDPL
                     LSQEPPAIPESSASDQNVLPSQESPPSQGSLSEKALAEQTISPGELPAATAGEPSASR
                     PNFVIPEVRLDSAYSQQDGAHGGSSGEDEDAEEGEEGEEGEEDEEDDTNDDNYGDRNE
                     AKRSSLIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEARGPCFASDTTLHCSDGEGT
                     TSTWAIPSPRTLKKELGRNGGSMHHLSLFFTGHRKMSGTDLADDVEASRKRKSKNIAK
                     DMKNKLAIFRRRNESPGAQPAGKADKTTKSFKPTSEEALKWSESLEKLLLHKYGLEVF
                     QAFLRTEFSEENLEFWLACEDFKKVKSQSKMAAKAKKIFAEFIAIQACKEVNLDSYTR
                     EHTKENLQSITRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL"
     exon            104..185
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            186..291
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            292..643
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            644..683
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            684..880
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            881..964
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1076
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1120
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1243
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..2374
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2436
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2538
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2600
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2767
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..3712
                     /gene="Rgs3"
                     /gene_synonym="SRB-RGS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagagctg ggctttcatg gggaggcagc tgaggcagga tctgcagcca tgaaccgctt
       61 caatgggctc tgcaaagtgt gctcagaacg ccgctacagg cagatcacca tccggagggg
      121 aaaagacggc tttggcttca ccatctgctg tgactctccg gtccgagtcc aggctgtgga
      181 ttctgggggc ccagcagaga gggcggggct gcagcagctg gacacagtac tacagctgaa
      241 tgagaggccc gtggaacact ggaaatgtgt ggagctggca cacgagatcc ggagctgtcc
      301 cagcgagatc atcctgctcg tgtggcgtgt ggtcccccag atcaagccag ggccagatgg
      361 cggagtcttg aggcgggcct cctgcaagtc cacacatgat ctcctgtcac cccctaacaa
      421 gagggagaag aactgtactc acggggctcc aacacgtccc gagcagcgcc acagctgcca
      481 cctggtgtgc gacagctctg atgggctact gctcggaggc tgggagcgct acactgaggt
      541 gggcaagcgc agcggccagc ataccctgcc tgcactgtcc cgggccacca cccctactga
      601 ccccaactac atcatcctgg ccccactgaa tcctggaagc cagttgctgc ggcctgtgta
      661 ccaggaggat gccatccctg aagaaccagg gactactact aaagggaaat cgtacactgg
      721 cctgggcaag aagtctcggt tgatgaagac agtgcagacc atgaagggcc acagcaacta
      781 ccaagattgc tcagccctga gaccacacat cccacattca agttacggca cctatgtcac
      841 cctggccccc aaagtcctgg tattccctgt ctttgtgcag cccctagatc tctgtaaccc
      901 tgcccggact ctcctgctgt cagaggagct gctgctctat gaggggagga acaagacttc
      961 ccaggtgaca ctgtttgcct actcggacct gctgctgttc actaaggagg aggaaccagg
     1021 ccgctgtgac gtcctgagaa accccctcta cctccagagt gtgaagctac aggagggttc
     1081 ttcagaagac ttgaaattct gtgtgctgta cctggcagag aaggcagagt gcttattcac
     1141 tttggaggct cactcgcagg agcagaagaa gagagtgtgc tggtgcctgt cggagaacat
     1201 cgccaagcag caacagctgg ctgcaacacc tacggagagg aagatgtttg agacagaggc
     1261 agatgagaag gagatgcccc tggtcgaggg gaaggggcca ggtgctgagg aacgcacacc
     1321 cagcaaagac ccctctccca gccaggagct gcctccagga caagaactcc cacccagcaa
     1381 agacccctct cccagccagg agctgcctcc aggacaagaa ctcccaccca gcaaagaccc
     1441 ctctcccagc caggagctgc ctccaggaca agaactccca tccagcaaaa acccctctcc
     1501 cagccaggag cttcctgcag gacaagacct cccacccagg aaggaatcct tttcaggcca
     1561 agaagcagct cctggcccag agtcaccatc cagtgaagac atagcaacct gccaaaaccc
     1621 ccctcaaagc ccagaaacct caacaagcaa ggactcccca ccaggccagg gatcctctcc
     1681 aaccacagaa gtcccatctt gccagggact tcctgctggt caagaatcta caagccagga
     1741 ccctctgctc agtcaagagc cccctgctat cccagaatcc tctgcctccg atcagaatgt
     1801 tctaccctct caggagtcac ctcccagcca gggctcccta tcagagaagg cccttgctga
     1861 gcagaccatc agccccgggg agctaccagc ggccactgca ggtgaacctt cagcctccag
     1921 acctaatttt gtgatccccg aggtccgcct ggatagtgcc tacagccagc aggatggagc
     1981 ccatggaggc agctctggtg aggatgagga tgcagaagag ggagaggagg gggaagaagg
     2041 ggaggaagat gaggaggacg acaccaacga cgacaactac ggggatcgta atgaggccaa
     2101 gcgcagcagc ctgattgaga ctggccaggg cgccgagggt ggcctctcgt tgcgtgtgca
     2161 gaactcgctg cggcgccgga cgcacagcga gggcagcctg ctgcaggagg cccgtgggcc
     2221 ctgctttgcc tctgacacca ccctacactg ctctgatggt gagggcacca catccacctg
     2281 ggccatccct tctccccgca ccctcaaaaa agaactgggt cgtaatggag gctccatgca
     2341 ccacctttcc ctgttcttca ctgggcacag gaagatgagt gggactgacc tcgcagatga
     2401 cgttgaagcc tcccggaaga gaaagagcaa aaacatagcc aaggatatga agaataagct
     2461 ggccatcttc aggcggcgga atgaatctcc tggggcccag ccagccggca aggcagacaa
     2521 gacaaccaag tccttcaagc ctacctccga ggaagccctc aagtggagcg agtccctgga
     2581 aaagctgctg cttcataaat atggcttaga agtgttccag gccttccttc gcacagagtt
     2641 cagtgaggag aacctggagt tttggctggc ttgtgaggat ttcaagaagg tcaaatcgca
     2701 gtccaagatg gcagccaaag ccaagaagat ctttgctgag ttcatcgcga tccaggcttg
     2761 caaggaggta aacctggact cgtacacacg agaacacact aaggagaacc tgcagagcat
     2821 cacccgaggc tgctttgacc tggcacaaaa acgtatcttc gggctcatgg aaaaggactc
     2881 ttaccctcgc ttcctccgct ctgacctcta cctggacctc attaaccaga agaagatgag
     2941 tcccccactc tagggaccac cagtatccag ctcagcgttc acaccaagcg gagcgggctc
     3001 cctgcccacc cgcctccctt ccctgtgacg gaggggacaa gtaagccccc agaggctgtg
     3061 tctccggaca gacagatgga catttgaatt cgaggcctgg gccgagagag acccaggcca
     3121 ctacaggaag taggaggacc agccgcatcg ggtccttaac gtcctggtac gaggggacca
     3181 agggccctgg caggtcaggg ccctggagga gccagatcgg gagctgtggc tccctgcttt
     3241 ggagataatg gagtctttac gctgaccaag ttcctttgag aactggctgg ggttgggaca
     3301 ggaggcccag gcctgggctc agggtccaac ctggggggct gttgggcctc acagctcaga
     3361 cctttcccca ttgagtttta tttatttaaa cagtagttgg atgcttggca catgaacggt
     3421 aataggagag ccctcaccct gtcagttttc ttaacttaca agtgcaatgt cttacccaag
     3481 gccttgtgaa ggccacctgg aggtgtgatc accgtcttac agtttcaggg catttgctgg
     3541 tcccaggaac cagtggcggc agctgggcct tctagactga catgaccttg gaggggatgc
     3601 tgcagaaatc tggcacccac cctgggtgcc caagagatct gggaaagcat agtgccctcc
     3661 ggccacacag aaacaagtgc tgggggcaaa taaaaggcct gtgttattct caaaaaaaaa
     3721 aa
//
