LOCUS       NM_021661               1317 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus regulator of G-protein signaling 19 (Rgs19),
            mRNA.
ACCESSION   NM_021661
VERSION     NM_021661.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1317)
  AUTHORS   Luessen,D.J., Sun,H., McGinnis,M.M., McCool,B.A. and Chen,R.
  TITLE     Chronic intermittent ethanol exposure selectively alters the
            expression of Galpha subunit isoforms and RGS subtypes in rat
            prefrontal cortex
  JOURNAL   Brain Res 1672, 106-112 (2017)
   PUBMED   28736108
REFERENCE   2  (bases 1 to 1317)
  AUTHORS   Serezani,C.H., Aronoff,D.M., Sitrin,R.G. and Peters-Golden,M.
  TITLE     FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that
            enhances rat lung macrophage antimicrobial functions
  JOURNAL   Blood 114 (15), 3316-3324 (2009)
   PUBMED   19657115
REFERENCE   3  (bases 1 to 1317)
  AUTHORS   Lou,X., McQuistan,T., Orlando,R.A. and Farquhar,M.G.
  TITLE     GAIP, GIPC and Galphai3 are concentrated in endocytic compartments
            of proximal tubule cells: putative role in regulating megalin's
            function
  JOURNAL   J Am Soc Nephrol 13 (4), 918-927 (2002)
   PUBMED   11912251
REFERENCE   4  (bases 1 to 1317)
  AUTHORS   Fischer,T., Elenko,E., Wan,L., Thomas,G. and Farquhar,M.G.
  TITLE     Membrane-associated GAIP is a phosphoprotein and can be
            phosphorylated by clathrin-coated vesicles
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4040-4045 (2000)
   PUBMED   10760275
REFERENCE   5  (bases 1 to 1317)
  AUTHORS   De Vries,L., Lou,X., Zhao,G., Zheng,B. and Farquhar,M.G.
  TITLE     GIPC, a PDZ domain containing protein, interacts specifically with
            the C terminus of RGS-GAIP
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12340-12345 (1998)
   PUBMED   9770488
REFERENCE   6  (bases 1 to 1317)
  AUTHORS   De Vries,L., Elenko,E., McCaffery,J.M., Fischer,T., Hubler,L.,
            McQuistan,T., Watson,N. and Farquhar,M.G.
  TITLE     RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G
            proteins, is located on clathrin-coated vesicles
  JOURNAL   Mol Biol Cell 9 (5), 1123-1134 (1998)
   PUBMED   9571244
REFERENCE   7  (bases 1 to 1317)
  AUTHORS   De Vries,L., Elenko,E., Hubler,L., Jones,T.L. and Farquhar,M.G.
  TITLE     GAIP is membrane-anchored by palmitoylation and interacts with the
            activated (GTP-bound) form of G alpha i subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (26), 15203-15208 (1996)
   PUBMED   8986788
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088141.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by NM_021661.3.
            
            On Jan 2, 2005 this sequence version replaced NM_021661.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088141.1, SRR8487227.21691.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1317
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..1317
                     /gene="Rgs19"
                     /gene_synonym="Camki; Gaip"
                     /note="regulator of G-protein signaling 19"
                     /db_xref="GeneID:59293"
                     /db_xref="RGD:629471"
     exon            1..216
                     /gene="Rgs19"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            217..322
                     /gene="Rgs19"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..943
                     /gene="Rgs19"
                     /gene_synonym="Camki; Gaip"
                     /note="calcium/calmodulin-dependent protein kinase I; G
                     alpha interacting protein; regulator of G-protein
                     signalling 19"
                     /codon_start=1
                     /product="regulator of G-protein signaling 19"
                     /protein_id="NP_067693.1"
                     /db_xref="GeneID:59293"
                     /db_xref="RGD:629471"
                     /translation="MPTPHEAEKQHTGPEEADRPPSMSSHDAAPSGPPSRNPCCLCWC
                     CCCSCSWNQERQRAWQVSRESKLQPLPSCEVCTPPSPEEVQSWAQSFDKLMHSPTGRS
                     VFRAFLRTEYSEENMLFWLACEELKTEADRHVVDEKARLIYEDYVSILSPKEVSLDSR
                     VREGINRKMQEPSPHTFDDAQLQIYTLMHRDSYPRFLTSPTYRSLLLQGAPQSSEA"
     exon            323..444
                     /gene="Rgs19"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            445..519
                     /gene="Rgs19"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            520..754
                     /gene="Rgs19"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1291
                     /gene="Rgs19"
                     /gene_synonym="Camki; Gaip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctagtcagt tggcctggcg agccttaggg gtgaatgccg catccccggc cccatcggag
       61 cggaactccg tgagcctttc tacctcgcga gtgcccggga gtgcgtcttg ctgtctgact
      121 taaatcctcg ctgctttaga gcacgcccct tcggcagcca gggtggggcc caaaccgaac
      181 ctggccctcc cgcccccatc tgcctttcgg tcgctgatct gccaggctcc tatgctgcac
      241 tgagagtcca gagctggcac cacagaatct gggcaacccc ctccactcac ccatgcccac
      301 cccacatgag gctgagaaac agcacacagg gccagaagag gcagacaggc ctccctcgat
      361 gtccagccat gatgcagccc cctcaggacc tcccagtcga aatccctgct gcttgtgctg
      421 gtgctgctgc tgtagctgtt cctggaacca agaacggcaa cgagcttggc aggtttcccg
      481 ggaaagcaag ctgcaacccc tccccagctg tgaagtctgc actccaccaa gccctgagga
      541 agtacagagc tgggcacagt cctttgacaa gttgatgcat agccccacgg gccgcagtgt
      601 attccgggca ttcctgcgca cagaatacag tgaggagaac atgctcttct ggctggcttg
      661 tgaggagttg aaaacagagg ctgaccgaca tgtggtggat gagaaggcgc gacttatcta
      721 tgaggactac gtgtccatcc tgtcccccaa ggaggtcagc ctggactccc gtgttcgaga
      781 aggcatcaat aggaagatgc aagaaccatc accacacaca ttcgacgacg cacagctgca
      841 gatctacacc ctcatgcacc gggactccta ccctcgcttc ctcacctccc ccacctaccg
      901 ctctctgtta ctccaggggg ccccacagtc ctctgaggcc taggtcattt gtcacacaga
      961 tgttctccca tgggcagcct aggggtggcc ctgctccact tggctgaaat agactgcaat
     1021 gccatgttct gctctgtcct agcctgctcc tactgggggt tctcctacat ggtgcctcag
     1081 accaccaccc tccagtcgtg tgcccaggag atgttctcat ggagaacatc ctgtatagca
     1141 acaagtttgt agcaggagaa cgttaattcc tcagaagcag atatagaacc tcagagtcag
     1201 actcaaatga agagcccatt tatattttat atattaactt taaagttgtc catactgtat
     1261 gttttatcaa aagaaaaaaa gagacctttc aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
