LOCUS       NM_001077589            2350 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus regulator of G-protein signaling 16 (Rgs16),
            mRNA.
ACCESSION   NM_001077589 XM_001071509 XM_341134
VERSION     NM_001077589.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Hendriks-Balk,M.C., Hajji,N., van Loenen,P.B., Michel,M.C.,
            Peters,S.L. and Alewijnse,A.E.
  TITLE     Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in
            vascular smooth muscle cells
  JOURNAL   Eur J Pharmacol 606 (1-3), 25-31 (2009)
   PUBMED   19374869
  REMARK    GeneRIF: S1P induces RGS2 and RGS16 mRNA expression but uses
            distinct S1P receptor subtypes and signalling pathways to regulate
            expression of these RGS proteins
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Hendriks-Balk,M.C., Tjon-Atsoi,M., Hajji,N., Alewijnse,A.E. and
            Peters,S.L.
  TITLE     LPS differentially affects vasoconstrictor responses: a potential
            role for RGS16?
  JOURNAL   J Physiol Biochem 65 (1), 71-83 (2009)
   PUBMED   19588733
  REMARK    GeneRIF: changes in RGS16 mRNA might contribute to the differential
            regulation of the contractile responses to vasoconstrictors upon
            lipopolysaccharide exposure
REFERENCE   3  (bases 1 to 2350)
  AUTHORS   Soundararajan,M., Willard,F.S., Kimple,A.J., Turnbull,A.P.,
            Ball,L.J., Schoch,G.A., Gileadi,C., Fedorov,O.Y., Dowler,E.F.,
            Higman,V.A., Hutsell,S.Q., Sundstrom,M., Doyle,D.A. and
            Siderovski,D.P.
  TITLE     Structural diversity in the RGS domain and its interaction with
            heterotrimeric G protein alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 105 (17), 6457-6462 (2008)
   PUBMED   18434541
REFERENCE   4  (bases 1 to 2350)
  AUTHORS   Kveberg,L., Ryan,J.C., Rolstad,B. and Inngjerdingen,M.
  TITLE     Expression of regulator of G protein signalling proteins in natural
            killer cells, and their modulation by Ly49A and Ly49D
  JOURNAL   Immunology 115 (3), 358-365 (2005)
   PUBMED   15946253
REFERENCE   5  (bases 1 to 2350)
  AUTHORS   Wang,X., Zeng,W., Soyombo,A.A., Tang,W., Ross,E.M., Barnes,A.P.,
            Milgram,S.L., Penninger,J.M., Allen,P.B., Greengard,P. and
            Muallem,S.
  TITLE     Spinophilin regulates Ca2+ signalling by binding the N-terminal
            domain of RGS2 and the third intracellular loop of
            G-protein-coupled receptors
  JOURNAL   Nat Cell Biol 7 (4), 405-411 (2005)
   PUBMED   15793568
REFERENCE   6  (bases 1 to 2350)
  AUTHORS   Hiol,A., Davey,P.C., Osterhout,J.L., Waheed,A.A., Fischer,E.R.,
            Chen,C.K., Milligan,G., Druey,K.M. and Jones,T.L.
  TITLE     Palmitoylation regulates regulators of G-protein signaling (RGS) 16
            function. I. Mutation of amino-terminal cysteine residues on RGS16
            prevents its targeting to lipid rafts and palmitoylation of an
            internal cysteine residue
  JOURNAL   J Biol Chem 278 (21), 19301-19308 (2003)
   PUBMED   12642593
  REMARK    GeneRIF: results suggest that the amino-terminal palmitoylation of
            regulator of G-protein signaling 16 protein(RGS16) promotes its
            lipid raft targeting that allows palmitoylation of a poorly
            accessible cysteine residue
REFERENCE   7  (bases 1 to 2350)
  AUTHORS   Chatterjee,T.K. and Fisher,R.A.
  TITLE     Cytoplasmic, nuclear, and golgi localization of RGS proteins.
            Evidence for N-terminal and RGS domain sequences as intracellular
            targeting motifs
  JOURNAL   J Biol Chem 275 (31), 24013-24021 (2000)
   PUBMED   10791963
REFERENCE   8  (bases 1 to 2350)
  AUTHORS   Druey,K.M., Ugur,O., Caron,J.M., Chen,C.K., Backlund,P.S. and
            Jones,T.L.
  TITLE     Amino-terminal cysteine residues of RGS16 are required for
            palmitoylation and modulation of Gi- and Gq-mediated signaling
  JOURNAL   J Biol Chem 274 (26), 18836-18842 (1999)
   PUBMED   10373502
REFERENCE   9  (bases 1 to 2350)
  AUTHORS   Chen,C.K., Wieland,T. and Simon,M.I.
  TITLE     RGS-r, a retinal specific RGS protein, binds an intermediate
            conformation of transducin and enhances recycling
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12885-12889 (1996)
   PUBMED   8917514
REFERENCE   10 (bases 1 to 2350)
  AUTHORS   Galligani,L.
  TITLE     [Prevention of hepatitis B infection in the neonatal care section
            of the Biella Hospital during a 5-year period from 1986 to 1991.
            Results and conclusions]
  JOURNAL   Minerva Med 83 (12 Suppl 1), 37-40 (1992)
   PUBMED   1300469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Oct 19, 2022 this sequence version replaced NM_001077589.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.42448.1,
                                           SRR26643292.49504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000013.1  68438120-68438283
            165-275             JAXUCZ010000013.1  68438641-68438751
            276-337             JAXUCZ010000013.1  68439414-68439475
            338-504             JAXUCZ010000013.1  68439753-68439919
            505-2350            JAXUCZ010000013.1  68441467-68443312
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2350
                     /gene="Rgs16"
                     /gene_synonym="RGS-R"
                     /note="regulator of G-protein signaling 16"
                     /db_xref="GeneID:360857"
                     /db_xref="RGD:1589741"
     exon            1..164
                     /gene="Rgs16"
                     /gene_synonym="RGS-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..720
                     /gene="Rgs16"
                     /gene_synonym="RGS-R"
                     /note="retinally abundant regulator of G-protein
                     signaling; retinal-specific RGS"
                     /codon_start=1
                     /product="regulator of G-protein signaling 16"
                     /protein_id="NP_001071057.1"
                     /db_xref="GeneID:360857"
                     /db_xref="RGD:1589741"
                     /translation="MCRTLATFPNTCLERAKEFKTRLGIFLHKSELSSDTGGNGKFEW
                     ASKLSKERSFSEDVLGWRESFQSLLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKK
                     IRSATKLASRAHHIFDEYIRSEAPKEVNIDHETRELTKTNLQAATPSCFDVAQGKTRT
                     LMEKDSYPRFLKSPAYRDLAAQASATSASGSSPAEPSHT"
     exon            165..275
                     /gene="Rgs16"
                     /gene_synonym="RGS-R"
                     /inference="alignment:Splign:2.1.0"
     exon            276..337
                     /gene="Rgs16"
                     /gene_synonym="RGS-R"
                     /inference="alignment:Splign:2.1.0"
     exon            338..504
                     /gene="Rgs16"
                     /gene_synonym="RGS-R"
                     /inference="alignment:Splign:2.1.0"
     exon            505..2350
                     /gene="Rgs16"
                     /gene_synonym="RGS-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtgctgct ctcccgaccc catcagcgca ggtcagaact tgctacagcc tcgcttttct
       61 ctcttcgccc tccggtccgt caccatcctc cccacgacgt gctgccctga gcccgcaacc
      121 atgtgccgca ccctggccac cttccctaac acctgcctgg aaagagccaa agagttcaag
      181 acacgcctgg ggatctttct tcataaatca gagctaagct cggatactgg gggtaacggc
      241 aaattcgagt gggccagtaa gcttagcaaa gagagaagtt tctcagaaga tgtattggga
      301 tggagagagt ctttccagtc actgctgaac agtaaaaatg gggtggccgc cttccacgcc
      361 ttcctaaaga cggagttcag tgaggagaac ctggagttct ggctggcctg cgaggagttc
      421 aagaagatcc gatcagccac caaactggcc tccagggccc accacatctt tgatgagtac
      481 attcgcagtg aagcccctaa agaggtaaac atagatcacg agacccgaga actgaccaag
      541 acaaacctac aggccgccac tcccagttgc ttcgacgtgg ctcaggggaa gacccgcaca
      601 ctgatggaga aagactctta cccacgcttc ctcaagtcac ctgcttaccg cgacctggct
      661 gcccaagcct cggccacctc tgcttctggc agcagcccag ctgagccttc acacacttga
      721 gcctccacag caaccaagaa ggaagagagg tggagtcacc catccctgaa gcagctgtcc
      781 tgtgtgggag gcaggccttg tgcagcaagt tcgagaggaa agtgaaggga tagacggaca
      841 gacgggcatc cccgcagctt gagtgtgaag aactccctct cctccagata ctgtggtggg
      901 cccggcgtag gagagactcc tcattgccag gacccgtggc tgagggctga catggaggct
      961 gtgtggggtg ctctggggaa gggtggtcct gcacttatgt tctttctccc aggcacactc
     1021 aaggaatgct ggggggttgg gaaccttgag tatgggagcc ggagagcgtc atggcagctg
     1081 tctacctgcc agacagttgg ctttgatccc gtcttgattt cctcagtcct ggacgtggcc
     1141 tagaaaaggc tatgtatgtg gaaccttcct cccctgcccc tgccttccca gggacaccca
     1201 gagactccta gctgaggcct cttaacattc ttaagctcat tctcacagtc tcacggaggt
     1261 cagcgagtca gtctgattct tgccccagat gagatttcta tacctcagaa actggcctgt
     1321 gagccccttt ccaggtcaac aatgaaccct gcaaaaagaa gccatttttg ctcacatgac
     1381 cctaggccgg gcgctctcgg tggctttctg taggtgggcc cctgacctca catttgcagc
     1441 ctgctctgct tgtgaacagg gctaactgag aagccttact gggccttgcg cctccttgga
     1501 tgaggtctaa ggagggaggt gggaggaagg aggcttcaag ccccgggacc agcattcatg
     1561 tccgacaact gagcaaagga gagaagtcat ggaaaaatcc atctgtaggg ggagcccaaa
     1621 agactagccg aagtcaaatc agttctcttt gtggatatga atatgggaaa aagatgcccc
     1681 ctacccctca cccccctggt ggaaggggag ccttgcacct ctttcctgtt gacatgagat
     1741 gcccaacgta gttaggggag aagtaggtca ggggtcaaga cagctctgga acagaagtta
     1801 gtgcagccaa gggagtattg cggatgtggg gggtgcctgg aaggatgggg ttggggggga
     1861 atcaatctgc ctatcacctc tgagtcttac cgaacaaaca ttccaagttg ggacttccag
     1921 caccagagac taagatggct gtggagatgt aggttgccag cattgttttc tctgcacttg
     1981 aggcttctcc gggagaaaat ccttttaagt atactatgtt gttctgttgt gctgattgtc
     2041 tcagctgctg ttgttgctgt tcttatttac tgtgatttgt ttgcccgtac tgaagaaact
     2101 caacgggagc tgctgcccga ccgcgcctcc tccctaccag actctacctc agcaagcctt
     2161 gcgaaccact gagggctgtc ggtgggtggg ggtgggggga ctccccactg tgttaatatt
     2221 tatttattgt taacaaaggg agctgggttc ctttatcagt ggtgtacgaa atccctgttt
     2281 ttctgtttga gcatgttata ttcttgtaaa aaaaatgaaa ataaaactca aaaaataatg
     2341 tcccatttcc
//
