LOCUS       NM_019339               5457 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus regulator of G-protein signaling 12 (Rgs12),
            mRNA.
ACCESSION   NM_019339
VERSION     NM_019339.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5457)
  AUTHORS   Lan,T., Li,Y., Fan,C., Wang,L., Wang,W., Chen,S. and Yu,S.Y.
  TITLE     MicroRNA-204-5p reduction in rat hippocampus contributes to
            stress-induced pathology via targeting RGS12 signaling pathway
  JOURNAL   J Neuroinflammation 18 (1), 243 (2021)
   PUBMED   34674723
  REMARK    GeneRIF: MicroRNA-204-5p reduction in rat hippocampus contributes
            to stress-induced pathology via targeting RGS12 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5457)
  AUTHORS   Willard,M.D., Willard,F.S., Li,X., Cappell,S.D., Snider,W.D. and
            Siderovski,D.P.
  TITLE     Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth
            factor-mediated differentiation
  JOURNAL   EMBO J 26 (8), 2029-2040 (2007)
   PUBMED   17380122
  REMARK    GeneRIF: RGS12 may play a critical, and receptor-selective, role in
            coordinating Ras-dependent signals that are required for promoting
            and/or maintaining neuronal differentiation.
REFERENCE   3  (bases 1 to 5457)
  AUTHORS   Lopez-Aranda,M.F., Acevedo,M.J., Carballo,F.J., Gutierrez,A. and
            Khan,Z.U.
  TITLE     Localization of the GoLoco motif carrier regulator of G-protein
            signalling 12 and 14 proteins in monkey and rat brain
  JOURNAL   Eur J Neurosci 23 (11), 2971-2982 (2006)
   PUBMED   16819986
REFERENCE   4  (bases 1 to 5457)
  AUTHORS   Pi,M., Spurney,R.F., Tu,Q., Hinson,T. and Quarles,L.D.
  TITLE     Calcium-sensing receptor activation of rho involves filamin and
            rho-guanine nucleotide exchange factor
  JOURNAL   Endocrinology 143 (10), 3830-3838 (2002)
   PUBMED   12239094
REFERENCE   5  (bases 1 to 5457)
  AUTHORS   Kimple,R.J., De Vries,L., Tronchere,H., Behe,C.I., Morris,R.A.,
            Gist Farquhar,M. and Siderovski,D.P.
  TITLE     RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with
            guanine nucleotide dissociation inhibitor Activity
  JOURNAL   J Biol Chem 276 (31), 29275-29281 (2001)
   PUBMED   11387333
REFERENCE   6  (bases 1 to 5457)
  AUTHORS   Schiff,M.L., Siderovski,D.P., Jordan,J.D., Brothers,G., Snow,B., De
            Vries,L., Ortiz,D.F. and Diverse-Pierluissi,M.
  TITLE     Tyrosine-kinase-dependent recruitment of RGS12 to the N-type
            calcium channel
  JOURNAL   Nature 408 (6813), 723-727 (2000)
   PUBMED   11130074
REFERENCE   7  (bases 1 to 5457)
  AUTHORS   Snow,B.E., Hall,R.A., Krumins,A.M., Brothers,G.M., Bouchard,D.,
            Brothers,C.A., Chung,S., Mangion,J., Gilman,A.G., Lefkowitz,R.J.
            and Siderovski,D.P.
  TITLE     GTPase activating specificity of RGS12 and binding specificity of
            an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain
  JOURNAL   J Biol Chem 273 (28), 17749-17755 (1998)
   PUBMED   9651375
REFERENCE   8  (bases 1 to 5457)
  AUTHORS   Snow,B.E., Antonio,L., Suggs,S., Gutstein,H.B. and Siderovski,D.P.
  TITLE     Molecular cloning and expression analysis of rat Rgs12 and Rgs14
  JOURNAL   Biochem Biophys Res Commun 233 (3), 770-777 (1997)
   PUBMED   9168931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 15, 2021 this sequence version replaced NM_019339.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: U92280.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000014.1  80034706-80034859   c
            155-2137            JAXUCZ010000014.1  80017243-80019225   c
            2138-2254           JAXUCZ010000014.1  80002966-80003082   c
            2255-2276           JAXUCZ010000014.1  79980009-79980030   c
            2277-2446           JAXUCZ010000014.1  79960836-79961005   c
            2447-2539           JAXUCZ010000014.1  79959933-79960025   c
            2540-2683           JAXUCZ010000014.1  79959170-79959313   c
            2684-2863           JAXUCZ010000014.1  79957267-79957446   c
            2864-3017           JAXUCZ010000014.1  79956860-79957013   c
            3018-3094           JAXUCZ010000014.1  79955713-79955789   c
            3095-3289           JAXUCZ010000014.1  79954077-79954271   c
            3290-3363           JAXUCZ010000014.1  79953748-79953821   c
            3364-3490           JAXUCZ010000014.1  79953156-79953282   c
            3491-3587           JAXUCZ010000014.1  79952432-79952528   c
            3588-3667           JAXUCZ010000014.1  79950908-79950987   c
            3668-3821           JAXUCZ010000014.1  79950384-79950537   c
            3822-5457           JAXUCZ010000014.1  79947479-79949114   c
FEATURES             Location/Qualifiers
     source          1..5457
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5457
                     /gene="Rgs12"
                     /note="regulator of G-protein signaling 12"
                     /db_xref="GeneID:54292"
                     /db_xref="RGD:3564"
     exon            1..154
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            155..2137
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..4420
                     /gene="Rgs12"
                     /function="GTPase activating protein for G-alpha subunits"
                     /note="regulator of G-protein signalling 12"
                     /codon_start=1
                     /product="regulator of G-protein signaling 12"
                     /protein_id="NP_062212.2"
                     /db_xref="GeneID:54292"
                     /db_xref="RGD:3564"
                     /translation="MYRAGEPGKRQSGPAPPRVRSVEVARGRAGYGFTLSGQAPCVLS
                     CVMRGSPADFVGLRAGDQILAINEINVKKASHEDVVKLIGKCSGVLRMVISEGSSHVE
                     PSSSDEEGGLCEGKGWLRPKLDSKALGINRAERVVEEVQSGGIFNMIFESPSLCASGS
                     EPLKLKQRSLSESAALRLDVGQDSLCTPHPSMLSKEEISKVINDDSVFTVGLDNHDDF
                     GLDASILNVAMVVGYLGSIELPSTSSNLEHDSLQAIRGCMRRLRAEQKIHSLVTMKVM
                     HDCVQLVTDRAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGCLAQEDEGALRT
                     SCHVFMVDPDLFHHKIHQGIARRFGFACTADPDTSGCLEFPASSLPVLQFISVLYRDM
                     GELIEGVRARAFLDGDADAHQNNSTSSNSDSGIGNFNQEEKSNRVLVVDLGGGSSRHG
                     QGSSPGWESVSGRGSQPWSAPWNGTFCHDSEAGSPLETSPNTDRFWDLTKHSGPVFHM
                     EVPPATLRSSIPPSKRGATGSSCGFNQRWLPVHVLQEWQCGHASDQESYTDSTDGWSS
                     VNCGTLPPPMSKIPADRYRVEGSFAQAPLSTQKRDWSRKAFGMQNLFGPHRNVRKTKE
                     DKKSSKLGRGVALAQTSQRTSARRSFGRSRRFSLTRSLDDLESATVSDGELTGADLKD
                     CISNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEE
                     NILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDILNAP
                     HPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVEGRTLPDSQQVPSSPASKHS
                     ISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRKGAFFSWSRSRSTGRSQKKKD
                     HGDHAHDALHANGGLCRRESQGSVSSAGSLDLSEACRTSALERDKAAKHCCVHLPDGT
                     SCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQDSSILATRDLRLE
                     KRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRLSGEKEPLDLG
                     APISSLDGQRVILEERDPSRGKVSTEKQKGAPVKQSSAVNSSPRNHSAMGEERTLGKS
                     NSIKIRGENGKSARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADD
                     QRGLLRKEDLVLPEFLRLPPGSSELALSSPPPVKGFSKRAVTSHGQEGAVQTEESYSD
                     SPATSPASAQSPCSAYSPGSAHSPGSAHSPGSAHSTPGPPGTAQPGEKPTKPSCISTV
                     QEGTTQAWRRLSPELEAGGIQTVEEEQVADLTLMGEGDISSPNSTLLPPPPLPQDTPG
                     PTRPGTSRF"
     exon            2138..2254
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2276
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2446
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2539
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2683
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2863
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..3017
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3094
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3289
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3363
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3490
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3587
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..3667
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3821
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..5457
                     /gene="Rgs12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccctacaa tgactgggtc ccgccccccc aggagtcgga gctccgctct taggggccgg
       61 accctgcccc tcccggagcc ccgcccccgg cccggcgacg gcggtgaccg ttgatgcttt
      121 cggcgggcgc ccggcgggag caagcggcgg cccgggtaac atttcaagac aaaaagccca
      181 gtagcatcgt gcattccttg agacatggag tctatggaat agtgggacat gcgaccagcc
      241 ttgacagtac accacgatgt acagggctgg ggagccaggg aagcggcagt ctggccctgc
      301 gccccctcgg gtgcggagtg tggaagtggc ccgaggcaga gctggctacg gcttcaccct
      361 gtcaggacag gcaccctgtg tgctcagctg cgtcatgagg ggcagccctg cagatttcgt
      421 gggcctccgg gctggggacc agatacttgc catcaacgaa atcaatgtga agaaagcctc
      481 acatgaagat gtggtgaaac tcatcgggaa atgctctgga gtgctgcgca tggtgatctc
      541 cgagggcagc agccatgtgg agccctcttc cagcgatgaa gaaggcggcc tgtgtgaggg
      601 gaaaggctgg ctgaggccga aacttgactc taaggctttg ggtataaaca gggcagagag
      661 ggttgtggaa gaggtgcagt ctggtgggat tttcaacatg atctttgaaa gcccaagtct
      721 ttgtgccagt ggctctgagc ccctgaaact gaagcagagg tccttgtcag agtcagctgc
      781 tttgcggctt gatgttggcc aggacagtct ctgtacacca catcccagca tgctttccaa
      841 ggaagagata tcaaaggtta tcaatgacga ttctgtgttc actgtagggc tggacaatca
      901 cgatgacttt ggactagatg caagtatttt aaatgttgcc atggttgtgg gctatttggg
      961 ctccatcgag ctcccttcca caagttccaa cctggagcat gacagtttac aggctattcg
     1021 tggctgcatg cgccgcctgc gggctgagca gaagatccac tcactagtga ccatgaaggt
     1081 catgcacgac tgtgtgcagc tggtcactga cagggctggt gtggtggcag agtaccctgc
     1141 cgagaagctg gcgttcagtg cagtgtgccc agacgacagg cggttcttcg ggctggtgac
     1201 catgcagacc aatgatgatg ggtgcttggc acaggaagat gaaggtgccc tgaggacatc
     1261 ctgccatgtc ttcatggtgg acccagactt atttcatcac aagatccacc aaggcatcgc
     1321 gagaagattt ggatttgcat gcacggcaga tccagacacg agtggctgtt tggaattccc
     1381 agcatcttcc ctccctgtgc ttcagttcat ctccgttctg taccgagaca tgggtgaact
     1441 gattgagggt gtgcgggccc gtgcctttct agatggggat gccgatgccc accagaataa
     1501 tagcaccagc agcaacagtg acagcggcat tggcaatttc aaccaggaag agaagagcaa
     1561 cagggtgctt gtagttgacc tgggtggggg ctcgagcagg catggccagg gcagtagtcc
     1621 ggggtgggag agtgtaagtg gaagaggctc acagccttgg agtgcaccct ggaatggaac
     1681 tttctgccac gactcagagg cgggctcccc actggaaacc agccccaaca ctgacaggtt
     1741 ctgggactta acaaagcatt cagggcctgt ttttcacatg gaggtccctc cagccacctt
     1801 gaggagttct ataccccctt ccaagagggg tgctacaggt tccagctgtg gtttcaacca
     1861 gaggtggctc cctgtccatg tgctacaaga gtggcagtgt ggacatgcca gtgaccagga
     1921 gtcttacaca gactctacgg acgggtggtc cagtgtgaac tgtggcacac tgccccctcc
     1981 catgagcaag attcctgcag accgataccg ggtggagggc agctttgctc aggccccact
     2041 gagtacccag aagagggact ggtctcggaa ggctttcgga atgcaaaacc tatttggacc
     2101 ccatcgaaat gttagaaaga ccaaagagga caaaaagagt tccaaattgg ggcggggagt
     2161 tgccctggcc cagacttctc agcgcacttc agctcgcaga tcctttggac gatctaggag
     2221 attcagcctc acgcgctccc ttgatgatct cgagtctgca actgtgtctg atggtgagtt
     2281 gacgggagct gacctgaagg actgcatcag caacaacagc ctgagcagca atgccagcct
     2341 ccccagtgtg cagagctgcc ggcgcctaag agagaggaga gttgcaagct gggcagtgtc
     2401 atttgagcgt ctgctgcagg atcctgtcgg cgtccgctac ttctccgatt ttctacggaa
     2461 ggaattcagt gaagagaaca ttttattctg gcaggcctgt gaatgtttca gtcatgtccc
     2521 tgcacatgac aaaaaagagc tctcttacag ggcccgggag attttcagta aattcctgtg
     2581 cagcaaagcc accactcctg tcaacattga cagccaggcc cagctggcag acgatattct
     2641 caatgcaccc caccccgaca tgttcaagga acagcagctc cagattttca acctgatgaa
     2701 gtttgacagc tatactcgat ttctgaaatc ccagctgtac caagaatgcg tcctggcaga
     2761 ggtggagggg cgtaccctcc cggactccca gcaggtcccc agcagcccag cttccaagca
     2821 cagcatcagc tctgaccact ccaatgtatc cacaccgaaa aagttaagtg gaaaatcaaa
     2881 atcaggacga tccctgaatg aagatgttgg ggaagaggat agtgagaaaa agcgcaaagg
     2941 ggcctttttc tcttggtcaa ggagcaggag cacggggcga tcccagaaga agaaggacca
     3001 tggtgatcat gcccatgatg cccttcatgc caatggagga ctctgccgtc gggagtccca
     3061 aggctctgtc tcttctgcgg ggagcctaga cctgtcagag gcctgtagga cctcagcact
     3121 cgagagagat aaggctgcca aacactgctg tgtccacctc ccagacggga catcctgtgt
     3181 ggttgctgtc aagtccgggt tttccatcaa agagatcctg tctggattgt gtgaacggca
     3241 tggcatcaat ggggctgctg tggacctctt cctggtgggc ggagacaagc ctctggtgct
     3301 gcatcaggac agcagcatcc tggccaccag ggacctacgg ttggaaaagc gtactttgtt
     3361 tcggctggat ctcgttccaa ttaaccggtc agtgggactc aaggccaagc ccaccaagcc
     3421 agtcacggaa gtgttgcggc ccgtggtggc caagtacggc ctggatctgg gtagcctgct
     3481 ggtgaggctg agtggggaga aggagcccct ggaccttggt gcccctatat caagtctgga
     3541 tggacagcgg gtcatcctag aggagaggga tccttctaga gggaaagtgt ccacagagaa
     3601 acagaaaggt gctcctgtca aacaaagctc agctgtgaac tccagcccca gaaaccactc
     3661 ggctatggga gaggagagaa cactaggcaa gtctaactct attaaaataa gaggagaaaa
     3721 tggaaaaagt gctagggatc cccggctttc aaagagagaa gaatctattg caaagattgg
     3781 gaaaaaaaaa tatcagaaaa ttaatttgga cgaagcagag gagttttttg agctcatttc
     3841 caaagctcag agcaacagag ccgatgacca gcgtgggctg ctaagaaagg aagacctggt
     3901 actgcctgag tttcttcgct tacctcctgg ttcctcagaa cttgccctgt ccagcccacc
     3961 cccagtcaag ggctttagca agagagcggt tacaagccat ggccaggagg gagcagttca
     4021 gacagaggag agctacagcg acagcccagc taccagccct gcctcagccc agagcccctg
     4081 ctcagcctac agccctggct ccgcccacag ccccggctct gcccacagcc ctggctccgc
     4141 ccacagcacc cctgggcctc ctgggaccgc ccaacctgga gagaagccta caaagccctc
     4201 ctgcatctcc acagttcaag agggcactac acaggcctgg aggaggctat caccagaact
     4261 ggaggctggg ggcatccaga ctgtggagga ggagcaggtg gctgacctga ccctgatggg
     4321 ggagggggac atcagcagcc ccaacagcac gctgctacca ccaccacccc ttccccaaga
     4381 cacaccagga cctacaagac caggtacctc caggttctga ctctacaccc ttgatctgtc
     4441 ctgctgactg cccatggcct gctccacctc atgttaataa agggaacact gagcaggcag
     4501 ccctgcttta cttctgtgct ttgacatgtc ctgagagaca gcctccttct ctcatattta
     4561 tggggcctcc tttgcctttt ctgaaaggaa agcaggtggc agccaaggct cagtgtccca
     4621 gggagagggt cactgaggct cagatagaca gaccacgttg agctggtcct gtgaaggtgc
     4681 catgggaatg gtgacccaca tccagtgact ccttgtgaag gcttgggtct ctgagtgtgg
     4741 atctcacctt taaaacctgc ttgctgccac tttagtgttt tagactcaag atggaaagag
     4801 aaaatagtat ttgttttgag caaatcagca agggtcccat gctgacaagg atcaggctgt
     4861 cagggtcagc ctctctctcc agccaggact tgctgactgc cctccatagg caagccttgc
     4921 acttgcacta ggcagtgttc accgactggc ctcaacagtg tccaggcatt tctcttagtg
     4981 gaagcatgaa gtccagtgtg tgtggatgcg agcagtgtga gcgagtggta gggatgctac
     5041 tctcgtccca cctaagacac tccctatccc acacgggtga cagggctccc gcgtgctcag
     5101 tgtcctcaca gtgacagtga tgagcctttc agtgcatgct gcctgttgtt cctgtctagg
     5161 ccttggctgt gatatgcagc aggcaatgtg ggtgctctgg gtcctgcttc ctgggcctgg
     5221 cggtgtcggg cctcatgcat gtttcatgta ctctcacaca ccatgggctg gacttcacag
     5281 ccccacccgt ggggatacac tcgatgagga ggcacaggca ccatgaagcg gccctgcgtg
     5341 catgcttggg cacctctgtc aggccacacc ctcctttctg ctcctttgta gctgcctgtt
     5401 tacagttcta tctgtgttct gactctgttc ttccaagaga aataaactct agagctc
//
