LOCUS       NM_019337                858 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus regulator of G-protein signaling 10 (Rgs10),
            mRNA.
ACCESSION   NM_019337 XM_001079315 XM_341936
VERSION     NM_019337.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Sun,H., Calipari,E.S., Beveridge,T.J., Jones,S.R. and Chen,R.
  TITLE     The brain gene expression profile of dopamine D2/D3 receptors and
            associated signaling proteins following amphetamine
            self-administration
  JOURNAL   Neuroscience 307, 253-261 (2015)
   PUBMED   26321241
REFERENCE   2  (bases 1 to 858)
  AUTHORS   Rivero,G., Gabilondo,A.M., Garcia-Fuster,M.J., La Harpe,R.,
            Garcia-Sevilla,J.A. and Meana,J.J.
  TITLE     Differential regulation of RGS proteins in the prefrontal cortex of
            short- and long-term human opiate abusers
  JOURNAL   Neuropharmacology 62 (2), 1044-1051 (2012)
   PUBMED   22056472
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Soundararajan,M., Willard,F.S., Kimple,A.J., Turnbull,A.P.,
            Ball,L.J., Schoch,G.A., Gileadi,C., Fedorov,O.Y., Dowler,E.F.,
            Higman,V.A., Hutsell,S.Q., Sundstrom,M., Doyle,D.A. and
            Siderovski,D.P.
  TITLE     Structural diversity in the RGS domain and its interaction with
            heterotrimeric G protein alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 105 (17), 6457-6462 (2008)
   PUBMED   18434541
REFERENCE   4  (bases 1 to 858)
  AUTHORS   Bender,K., Nasrollahzadeh,P., Timpert,M., Liu,B., Pott,L. and
            Kienitz,M.C.
  TITLE     A role for RGS10 in beta-adrenergic modulation of
            G-protein-activated K+ (GIRK) channel current in rat atrial
            myocytes
  JOURNAL   J Physiol 586 (8), 2049-2060 (2008)
   PUBMED   18276732
  REMARK    GeneRIF: Endogenous RGS10 has GTPase-activating protein (GAP)
            activity on the G-protein species that mediates activation of
            atrial GIRK channels.
REFERENCE   5  (bases 1 to 858)
  AUTHORS   Waugh,J.L., Lou,A.C., Eisch,A.J., Monteggia,L.M., Muly,E.C. and
            Gold,S.J.
  TITLE     Regional, cellular, and subcellular localization of RGS10 in rodent
            brain
  JOURNAL   J Comp Neurol 481 (3), 299-313 (2005)
   PUBMED   15593368
  REMARK    GeneRIF: RGS10 modulates pre- and postsynaptic G-protein signaling.
            Moreover, enrichment of RGS10 in transcriptionally active regions
            of the nucleus suggests an unforeseen role of RGS10 in modulating
            gene expression.
REFERENCE   6  (bases 1 to 858)
  AUTHORS   Castro-Fernandez,C. and Conn,P.M.
  TITLE     Regulation of the gonadotropin-releasing hormone receptor (GnRHR)
            by RGS proteins: role of the GnRHR carboxyl-terminus
  JOURNAL   Mol Cell Endocrinol 191 (2), 149-156 (2002)
   PUBMED   12062898
  REMARK    GeneRIF: cell surface expression and regulation of GnRHR bearing a
            carboxyl-terminus is altered by RGS10, but not by RGS3, proteins
REFERENCE   7  (bases 1 to 858)
  AUTHORS   Burgon,P.G., Lee,W.L., Nixon,A.B., Peralta,E.G. and Casey,P.J.
  TITLE     Phosphorylation and nuclear translocation of a regulator of G
            protein signaling (RGS10)
  JOURNAL   J Biol Chem 276 (35), 32828-32834 (2001)
   PUBMED   11443111
REFERENCE   8  (bases 1 to 858)
  AUTHORS   Chatterjee,T.K. and Fisher,R.A.
  TITLE     Cytoplasmic, nuclear, and golgi localization of RGS proteins.
            Evidence for N-terminal and RGS domain sequences as intracellular
            targeting motifs
  JOURNAL   J Biol Chem 275 (31), 24013-24021 (2000)
   PUBMED   10791963
REFERENCE   9  (bases 1 to 858)
  AUTHORS   Gold,S.J., Ni,Y.G., Dohlman,H.G. and Nestler,E.J.
  TITLE     Regulators of G-protein signaling (RGS) proteins: region-specific
            expression of nine subtypes in rat brain
  JOURNAL   J Neurosci 17 (20), 8024-8037 (1997)
   PUBMED   9315921
REFERENCE   10 (bases 1 to 858)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD372843.1 and AI453900.1.
            
            On or before Oct 28, 2007 this sequence version replaced
            XM_001079315.1, XM_341936.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD372843.1, AW252876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-659               CD372843.1         1-659
            660-858             AI453900.1         1-199               c
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..858
                     /gene="Rgs10"
                     /note="regulator of G-protein signaling 10"
                     /db_xref="GeneID:54290"
                     /db_xref="RGD:3562"
     exon            1..64
                     /gene="Rgs10"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..561
                     /gene="Rgs10"
                     /note="regulator of G-protein signalling 10"
                     /codon_start=1
                     /product="regulator of G-protein signaling 10"
                     /protein_id="NP_062210.1"
                     /db_xref="GeneID:54290"
                     /db_xref="RGD:3562"
                     /translation="MFTRAVSRLSRKRPPSDIHDGDGSSSSSHQSLKSTAKWASSLEN
                     LLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKTEDKKQMQEKAKKIYMTFLSNKA
                     SSQVNVEGQSRLTEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHRRTEE
                     EEEDPPDAQTAAKRASRIYNT"
     exon            65..183
                     /gene="Rgs10"
                     /inference="alignment:Splign:2.1.0"
     exon            184..270
                     /gene="Rgs10"
                     /inference="alignment:Splign:2.1.0"
     exon            271..414
                     /gene="Rgs10"
                     /inference="alignment:Splign:2.1.0"
     exon            415..843
                     /gene="Rgs10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggacgcccg cggcgatgtt cacccgcgcc gtgagccgac tgagcaggaa gcggccgccg
       61 tctgatatcc acgacggcga tgggagctca agcagcagcc accagagcct caagagcaca
      121 gccaagtggg cgtcctccct ggagaatctt ctggaagatc cagagggcgt gaagagattc
      181 agggaatttc tgaaaaagga attcagtgag gaaaacgtct tgttttggct agcgtgtgaa
      241 gatttcaaga aaacggagga caagaagcag atgcaggaaa aggccaagaa gatctacatg
      301 accttcctgt ccaataaggc ctcttcacaa gtcaatgtgg aggggcagtc tcggctcact
      361 gaaaagattc tggaagaacc acaccctctg atgttccaaa agctccagga ccagatcttc
      421 aatctcatga agtatgacag ctacagccgc ttcttgaagt ctgacttgtt tctgaagcac
      481 cggcggactg aggaagagga agaggatcct ccggacgctc aaactgcagc taagcgagct
      541 tccagaatct acaacacata agctgagccc ttcaccccca tggagcagag ggatggactc
      601 tcagactgtg tgcaggatgt cattgctttg ttgtgtttga ggactggagt gtgcaagacc
      661 ttccctcaga atatgtgtat tttattaact gtttgaccag taacttctgc atgatggcta
      721 atcctccatt aaaaacaaaa gtagctttaa agtttcagtt cacaaaacac atgagagtcc
      781 tccagcgctg gacactcaga gccttttaat cttgattaaa gttctcgtga agctacaggg
      841 gaaaaaaaaa aaaaaaaa
//
