LOCUS       NM_001401277            1263 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus regulator of G-protein signaling 1 (Rgs1),
            transcript variant 1, mRNA.
ACCESSION   NM_001401277 XM_006249974
VERSION     NM_001401277.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1263)
  AUTHORS   Hu,X., Tang,J., Zeng,G., Hu,X., Bao,P., Wu,J., Liang,Y., Deng,W.
            and Tang,Y.
  TITLE     RGS1 silencing inhibits the inflammatory response and angiogenesis
            in rheumatoid arthritis rats through the inactivation of Toll-like
            receptor signaling pathway
  JOURNAL   J Cell Physiol 234 (11), 20432-20442 (2019)
   PUBMED   31012109
  REMARK    GeneRIF: functional suppression of RGS1 inhibits the inflammatory
            response and angiogenesis by inactivating the TLR signaling pathway
            in rats
REFERENCE   2  (bases 1 to 1263)
  AUTHORS   Eliasson,P., Andersson,T., Hammerman,M. and Aspenberg,P.
  TITLE     Primary gene response to mechanical loading in healing rat Achilles
            tendons
  JOURNAL   J Appl Physiol (1985) 114 (11), 1519-1526 (2013)
   PUBMED   23519232
REFERENCE   3  (bases 1 to 1263)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 1263)
  AUTHORS   Soundararajan,M., Willard,F.S., Kimple,A.J., Turnbull,A.P.,
            Ball,L.J., Schoch,G.A., Gileadi,C., Fedorov,O.Y., Dowler,E.F.,
            Higman,V.A., Hutsell,S.Q., Sundstrom,M., Doyle,D.A. and
            Siderovski,D.P.
  TITLE     Structural diversity in the RGS domain and its interaction with
            heterotrimeric G protein alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 105 (17), 6457-6462 (2008)
   PUBMED   18434541
REFERENCE   5  (bases 1 to 1263)
  AUTHORS   Denecke,B., Meyerdierks,A. and Bottger,E.C.
  TITLE     RGS1 is expressed in monocytes and acts as a GTPase-activating
            protein for G-protein-coupled chemoattractant receptors
  JOURNAL   J Biol Chem 274 (38), 26860-26868 (1999)
   PUBMED   10480894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Feb 7, 2022 this sequence version replaced XM_006249974.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ234088.1, SRR22582416.390338.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000013.1  58573029-58573187   c
            160-240             JAXUCZ010000013.1  58572601-58572681   c
            241-302             JAXUCZ010000013.1  58572031-58572092   c
            303-466             JAXUCZ010000013.1  58570338-58570501   c
            467-1263            JAXUCZ010000013.1  58568844-58569640   c
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..1263
                     /gene="Rgs1"
                     /note="regulator of G-protein signaling 1"
                     /db_xref="GeneID:54289"
                     /db_xref="RGD:3561"
     exon            1..159
                     /gene="Rgs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..652
                     /gene="Rgs1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="regulator of G-protein signaling 1 isoform 1"
                     /protein_id="NP_001388206.1"
                     /db_xref="GeneID:54289"
                     /db_xref="RGD:3561"
                     /translation="MRAAAISMPRLNKMPGMFFSASPKDSKEPSHSLLDDNKQKKRPK
                     TFGMDMKAYLRSMIPHLESGMKSSKSKDILSAEEVMQWSQSLEKLLANQMGQNVFGKF
                     LKSEFSEENIEFWLACEDYKKTETDLLHNKAEHIYKAFVHSDAVKQINIDFHTRESTA
                     KKIKTPTPTCFDEAQKVIYALMEKDSYPRFLKSNIYLNLLNDLQANTLK"
     exon            160..240
                     /gene="Rgs1"
                     /inference="alignment:Splign:2.1.0"
     exon            241..302
                     /gene="Rgs1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..466
                     /gene="Rgs1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1263
                     /gene="Rgs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacttgt tgcgagagga ccatgagagc tgcagccatc tccatgccaa ggttgaacaa
       61 aatgccagga atgttcttct ctgctagccc aaaggattca aaagaaccaa gccattctct
      121 tctagatgac aacaagcaaa aaaagaggcc aaagactttt ggaatggaca tgaaagcata
      181 tctaagatct atgatccctc atctggaatc tgggatgaaa tcgtccaagt ccaaagacat
      241 actttcggct gaggaagtaa tgcagtggtc tcagtctctg gaaaaactcc ttgccaacca
      301 gatgggtcaa aatgtctttg ggaaattcct aaagtctgaa ttcagtgaag agaacattga
      361 attctggttg gcttgtgaag actataagaa aacagagact gatcttttgc ataacaaagc
      421 agagcatata tacaaagcat ttgtgcactc agatgctgtg aaacaaatca atattgactt
      481 tcatactcgg gaatcgacag ccaagaagat caaaacacca actcccacat gttttgatga
      541 agcacaaaaa gtcatatacg cacttatgga aaaggattct tatcccaggt tcctgaaatc
      601 aaatatttac ttaaatcttc taaatgacct tcaggcgaat accttaaagt gagtggttcc
      661 ttgctgacag gaattcaaag atagtatcaa ggacagaagg aacatgagac tgcctacagg
      721 atcagtctgg cctgcagagg agactcatca gtccggagaa gtgcagatga acggattcac
      781 acagaatgta tctcggtgga gacttgagga aacatcgcaa gaagaacagg gtgaggcaag
      841 tggaaggaga aactgtggta ctgtcatgaa atacagtggg actctattag acaaccctcc
      901 caactgggga ggtcagctga ctctggcaac acagaaactg tgaataattt gtatgagact
      961 gattactatg tgctataagc ttcaagaaca gcagacgtgt atgctacatg ctgttgtgta
     1021 caatgtgttg aactctgaca atctccttcc tgtacataat cagtccaaaa gtatatattg
     1081 caaataggag ttgctattat agacatgaag aactttttat ttgtttattt aattgtattt
     1141 ggcttggagt tgagaaagac aattatatat ttaacctatt ttttaatcta agaagttata
     1201 acacatctgt aaagtaaatt atcactgtgg caataataaa tgtgggcatt acattaaaat
     1261 aga
//
