LOCUS       NP_001388206             209 aa            linear   ROD 31-MAR-2024
DEFINITION  regulator of G-protein signaling 1 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001388206 XP_006250036
VERSION     NP_001388206.1
DBSOURCE    REFSEQ: accession NM_001401277.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 209)
  AUTHORS   Hu,X., Tang,J., Zeng,G., Hu,X., Bao,P., Wu,J., Liang,Y., Deng,W.
            and Tang,Y.
  TITLE     RGS1 silencing inhibits the inflammatory response and angiogenesis
            in rheumatoid arthritis rats through the inactivation of Toll-like
            receptor signaling pathway
  JOURNAL   J Cell Physiol 234 (11), 20432-20442 (2019)
   PUBMED   31012109
  REMARK    GeneRIF: functional suppression of RGS1 inhibits the inflammatory
            response and angiogenesis by inactivating the TLR signaling pathway
            in rats
REFERENCE   2  (residues 1 to 209)
  AUTHORS   Eliasson,P., Andersson,T., Hammerman,M. and Aspenberg,P.
  TITLE     Primary gene response to mechanical loading in healing rat Achilles
            tendons
  JOURNAL   J Appl Physiol (1985) 114 (11), 1519-1526 (2013)
   PUBMED   23519232
REFERENCE   3  (residues 1 to 209)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (residues 1 to 209)
  AUTHORS   Soundararajan,M., Willard,F.S., Kimple,A.J., Turnbull,A.P.,
            Ball,L.J., Schoch,G.A., Gileadi,C., Fedorov,O.Y., Dowler,E.F.,
            Higman,V.A., Hutsell,S.Q., Sundstrom,M., Doyle,D.A. and
            Siderovski,D.P.
  TITLE     Structural diversity in the RGS domain and its interaction with
            heterotrimeric G protein alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 105 (17), 6457-6462 (2008)
   PUBMED   18434541
REFERENCE   5  (residues 1 to 209)
  AUTHORS   Denecke,B., Meyerdierks,A. and Bottger,E.C.
  TITLE     RGS1 is expressed in monocytes and acts as a GTPase-activating
            protein for G-protein-coupled chemoattractant receptors
  JOURNAL   J Biol Chem 274 (38), 26860-26868 (1999)
   PUBMED   10480894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Feb 7, 2022 this sequence version replaced XP_006250036.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ234088.1, SRR22582416.390338.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..209
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     Protein         1..209
                     /product="regulator of G-protein signaling 1 isoform 1"
                     /calculated_mol_wt=23965
     Region          18..42
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97844.3)"
     Region          86..199
                     /region_name="RGS"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; cl02565"
                     /db_xref="CDD:470619"
     CDS             1..209
                     /gene="Rgs1"
                     /coded_by="NM_001401277.1:23..652"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:54289"
                     /db_xref="RGD:3561"
ORIGIN      
        1 mraaaismpr lnkmpgmffs aspkdskeps hsllddnkqk krpktfgmdm kaylrsmiph
       61 lesgmkssks kdilsaeevm qwsqslekll anqmgqnvfg kflksefsee niefwlaced
      121 ykktetdllh nkaehiykaf vhsdavkqin idfhtresta kkiktptptc fdeaqkviya
      181 lmekdsyprf lksniylnll ndlqantlk
//
