LOCUS       NM_001107524            3485 bp    mRNA    linear   ROD 17-MAR-2024
DEFINITION  Rattus norvegicus repulsive guidance molecule BMP co-receptor a
            (Rgma), mRNA.
ACCESSION   NM_001107524 XM_001062354 XM_218791
VERSION     NM_001107524.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3485)
  AUTHORS   Katsu,M., Sekine-Tanaka,M., Tanaka,M., Horai,Y., Akatsuka,A.,
            Suga,M., Kiyohara,K., Fujita,T., Sasaki,A. and Yamashita,T.
  TITLE     Inhibition of repulsive guidance molecule-a ameliorates compromised
            blood-spinal cord barrier integrity associated with neuromyelitis
            optica in rats
  JOURNAL   J Neuroimmunol 388, 578297 (2024)
   PUBMED   38306928
  REMARK    GeneRIF: Inhibition of repulsive guidance molecule-a ameliorates
            compromised blood-spinal cord barrier integrity associated with
            neuromyelitis optica in rats.
REFERENCE   2  (bases 1 to 3485)
  AUTHORS   Feng,Y., Duan,C., Luo,Z., Xiao,W. and Tian,F.
  TITLE     Silencing miR-20a-5p inhibits axonal growth and neuronal branching
            and prevents epileptogenesis through RGMa-RhoA-mediated synaptic
            plasticity
  JOURNAL   J Cell Mol Med 24 (18), 10573-10588 (2020)
   PUBMED   32779334
  REMARK    GeneRIF: Silencing miR-20a-5p inhibits axonal growth and neuronal
            branching and prevents epileptogenesis through RGMa-RhoA-mediated
            synaptic plasticity.
REFERENCE   3  (bases 1 to 3485)
  AUTHORS   Zhang,R., Wu,Y., Xie,F., Zhong,Y., Wang,Y., Xu,M., Feng,J.,
            Charish,J., Monnier,P.P. and Qin,X.
  TITLE     RGMa mediates reactive astrogliosis and glial scar formation
            through TGFbeta1/Smad2/3 signaling after stroke
  JOURNAL   Cell Death Differ 25 (8), 1503-1516 (2018)
   PUBMED   29396549
  REMARK    GeneRIF: RGMa promotes reactive astrogliosis and glial scar
            formation by forming a complex with ALK5 and Smad2/3 to promote
            ALK5-Smad2/3 interaction to facilitate TGFbeta1/Smad2/3 signaling,
            thereby inhibiting neurological functional recovery.
REFERENCE   4  (bases 1 to 3485)
  AUTHORS   Wang,Y., Zhang,R., Xing,X., Guo,J., Xie,F., Zhang,G. and Qin,X.
  TITLE     Repulsive guidance molecule a suppresses angiogenesis after
            ischemia/reperfusion injury of middle cerebral artery occlusion in
            rats
  JOURNAL   Neurosci Lett 662, 318-323 (2018)
   PUBMED   29061393
  REMARK    GeneRIF: RGMa might suppress angiogenesis via VEGF, Ang2, Ang1 and
            BDNF after cerebral ischemia/reperfusion injury
REFERENCE   5  (bases 1 to 3485)
  AUTHORS   Chen,L., Gao,B., Fang,M., Li,J., Mi,X., Xu,X., Wang,W., Gu,J.,
            Tang,B., Zhang,Y., Wang,Z., Zhan,A., Chen,G. and Wang,X.
  TITLE     Lentiviral Vector-Induced Overexpression of RGMa in the Hippocampus
            Suppresses Seizures and Mossy Fiber Sprouting
  JOURNAL   Mol Neurobiol 54 (2), 1379-1391 (2017)
   PUBMED   26843113
  REMARK    GeneRIF: Overexpression of RGMa inhibited hyper-excitability of
            hippocampal neurons.
REFERENCE   6  (bases 1 to 3485)
  AUTHORS   Doya,H., Ito,T., Hata,K., Fujitani,M., Ohtori,S.,
            Saito-Watanabe,T., Moriya,H., Takahashi,K., Kubo,T. and
            Yamashita,T.
  TITLE     Induction of repulsive guidance molecule in neurons following
            sciatic nerve injury
  JOURNAL   J Chem Neuroanat 32 (1), 74-77 (2006)
   PUBMED   16863689
REFERENCE   7  (bases 1 to 3485)
  AUTHORS   Hata,K., Fujitani,M., Yasuda,Y., Doya,H., Saito,T., Yamagishi,S.,
            Mueller,B.K. and Yamashita,T.
  TITLE     RGMa inhibition promotes axonal growth and recovery after spinal
            cord injury
  JOURNAL   J Cell Biol 173 (1), 47-58 (2006)
   PUBMED   16585268
REFERENCE   8  (bases 1 to 3485)
  AUTHORS   Babitt,J.L., Zhang,Y., Samad,T.A., Xia,Y., Tang,J., Campagna,J.A.,
            Schneyer,A.L., Woolf,C.J. and Lin,H.Y.
  TITLE     Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone
            morphogenetic protein co-receptor
  JOURNAL   J Biol Chem 280 (33), 29820-29827 (2005)
   PUBMED   15975920
REFERENCE   9  (bases 1 to 3485)
  AUTHORS   Schwab,J.M., Conrad,S., Monnier,P.P., Julien,S., Mueller,B.K. and
            Schluesener,H.J.
  TITLE     Spinal cord injury-induced lesional expression of the repulsive
            guidance molecule (RGM)
  JOURNAL   Eur J Neurosci 21 (6), 1569-1576 (2005)
   PUBMED   15845084
  REMARK    GeneRIF: The expression of repulsive guidance molecule (RGM) is
            studied in the spinal cord of rats with spinal cord injury (SCI).
            After SCI, RGM+ cells accumulate in lesions and peri-lesional
            areas.
REFERENCE   10 (bases 1 to 3485)
  AUTHORS   Niederkofler,V., Salie,R., Sigrist,M. and Arber,S.
  TITLE     Repulsive guidance molecule (RGM) gene function is required for
            neural tube closure but not retinal topography in the mouse visual
            system
  JOURNAL   J Neurosci 24 (4), 808-818 (2004)
   PUBMED   14749425
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218791.4, XM_001062354.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..3485
                     /gene="Rgma"
                     /note="repulsive guidance molecule BMP co-receptor a"
                     /db_xref="GeneID:308739"
                     /db_xref="RGD:1311983"
     exon            1..366
                     /gene="Rgma"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1702
                     /gene="Rgma"
                     /note="repulsive guidance molecule A; RGM domain family,
                     member A; repulsive guidance molecule family member A"
                     /codon_start=1
                     /product="repulsive guidance molecule A precursor"
                     /protein_id="NP_001100994.1"
                     /db_xref="GeneID:308739"
                     /db_xref="RGD:1311983"
                     /translation="MQPPRERLVVTGRAGWMGMGRGAGRSALGLWPTLAFLLCSFPAA
                     ISPCKILKCNSEFWSATSSGSHAPASDDVPEFCAALRTYALCTRRTARTCRGDLAYHS
                     AVHGIEDLMSQHNCSKDGPTSQPRVRTLPPAGDSQERSDSPEICHYEKSFHKHSAAPN
                     YTHCGLFGDPHLRTFTDHFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSAATATSKLT
                     IIFKNFQECVDQKVYQAEMDELPSAFADGSKNGGDKHGANSLKITEKVSGQHVEIQAK
                     YIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDRDSQGLYLCLRGCPLNQQIDFQAFRAN
                     AESPRRPAAASPSPVVPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTLA
                     AYYALEDGKMLHSNKDKLHLFERTRELPGAVAAAAFPLAPEMLPGTVTLLVLLPLFW"
     exon            367..482
                     /gene="Rgma"
                     /inference="alignment:Splign:2.1.0"
     exon            483..1000
                     /gene="Rgma"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..3485
                     /gene="Rgma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgccgcgct cagcggtggc ggtggcggcg acaggccggg cgaggcagca ggttagcccg
       61 ggccgcccta ctctgcaggc ttctcggaag tacaagctgc gccgcccgag ccctgcgccc
      121 gggaagcact ggccagcggg ccgctcctga ggcccgctcc tccaggcgct cgcaggcatg
      181 cagccgggga gcaggcggag tgccccgggc cgctactgag tccgcggagc tgaggggatc
      241 agctccagcc gtgcccctcc cacctcaccc agggccccac gagcgaccgc cctacacctg
      301 gtcttcgcgc gcagccccgc cagtgccaac cccccgcggg ctggaggggc tcatgcagcc
      361 gccaagggag aggctagtgg taacaggccg agctggatgg atgggtatgg ggagaggggc
      421 aggacgttca gccctgggat tgtggccgac cctcgccttc cttctctgca gctttcccgc
      481 agctatctct ccctgcaaga tcctcaagtg caactctgag ttctggagcg ccacgtcgtc
      541 aggcagccac gcccctgcct ctgacgacgt gcccgagttc tgtgctgccc tgcgcaccta
      601 cgccctgtgc acgcgacgga cagcccgcac ctgccggggc gacctggctt accactcggc
      661 tgtccatggc atagaggacc tcatgagcca gcacaactgc tccaaggatg gccccacctc
      721 acagcctcga gtgcgcacgc tcccgccagc tggggacagc caggagcgct cagatagccc
      781 cgagatctgc cactatgaga agagtttcca caagcactca gctgccccca actacactca
      841 ctgcggcctc tttggggacc cacacctcag gactttcaca gaccacttcc agacatgtaa
      901 ggtgcaaggc gcttggcctc tcatcgacaa taattacctg aacgtgcagg tcaccaatac
      961 acctgtgctg cccggctctg ccgccactgc caccagcaag ctcaccatca tcttcaagaa
     1021 cttccaagag tgtgtggacc agaaagtata ccaagccgag atggacgagc ttccgtccgc
     1081 ctttgccgat ggctccaaaa acggtggaga taaacacgga gccaacagcc tgaagatcac
     1141 agagaaggtg tcaggccagc acgtggagat ccaggccaag tacatcggca ccaccatcgt
     1201 ggtgagacag gtgggccgct acctgacctt cgccgtccgg atgcccgagg aggtagtcaa
     1261 cgccgtggag gaccgtgaca gccaaggcct ctacctctgc ctgcggggct gcccgctcaa
     1321 ccagcagatc gacttccagg ctttccgtgc caacgccgag agccctcgca ggccagcagc
     1381 tgccagcccc tctcctgtgg tccccgagac atttccgtac gagacagctg tggccaagtg
     1441 caaagagaag ctgcctgtag aagacttgta ctaccaggcc tgtgtcttcg acctcctcac
     1501 gactggcgac gtgaacttca cgctggccgc ctactatgct ttggaggatg gcaagatgct
     1561 ccactccaac aaggacaagc tacacctgtt tgaaaggact cgggagctgc ctggcgctgt
     1621 ggccgctgca gcatttccct tggcccccga gatgctcccg ggcaccgtca cacttctggt
     1681 cctgctgcct ctgttctggt agacgtttgg ccatgtagga tacaaaggag ggtatagact
     1741 ctgccctgag ccttgggctc ctgcccttgg cttctccttc gtctgagggt ccaagtcagc
     1801 atcaggatgc agcccagccg gtgggcttcc tgtgacccag tgttttcagc agcggaggtg
     1861 gcctctagct gacggcctga acatggtgcc ctcagagccg tcctcaaatg ttatggccag
     1921 ggctaagggc gcgggacagc tctcccctct cgattagtgc acgcgacaag gttgtggtga
     1981 ttgatgctgt gtttttgtga cagtagagtt gtgtgaggga gagcagctcc ctccaccccg
     2041 accccaccgt gtgaatgttc gaaccagagc cccaccccta agctgaagcc ccacccccac
     2101 caccagagag acactgggaa agtcggctcc ttccacactc tcacaatgca ctgagacagg
     2161 cccggctgac tgctgcacac ccgctctggg gcctcctgtc ccctcccaca cacgcgcaca
     2221 cactgttaca caagcacact cgcacacact aagcccgtgg ggacacctcg agaccgccac
     2281 atcagtaggg cggaagcatc tacggatccc cagagggcct tgctcagtat ctttagcaaa
     2341 tggatgtaac cttgtagcca gtgggctatg tcctcttggt accacctacc cagtgctacg
     2401 tacccagaga cggtcctgtg catccagcta ctgtggatgt gattgaggtg ctgcttccga
     2461 ggacctgcct ggaaaggccc acagttgaag ggagggtgtg ttttggcctg aggtctaagc
     2521 agtacctctc atgggctcag atcccggctc caccctctgc ccctctccca ttgcacttaa
     2581 gaaatcaaag tgcttggttc tgaatgttac aacagagacg tgatcctcca gttcctgcca
     2641 tcgttgcccc taccctatcc ttcaccccta cccttgcccc ccaccagcag aggggccctg
     2701 ggacctcagg gcatgagcag cagacccagt ggatagggcc agctggtctg ccctgtcctc
     2761 tgctctcttt ctcttgcctc ttagattcct ggctgctggt cagcagctct gctccccaac
     2821 ccctttgtct gcatttcttt gtgggggttg gggggagcat catctaagag gccttcctgc
     2881 accctgtacc ctggcaggct ctcctcccac tagaaccttc tttcaactct ggccacagcc
     2941 agaggcctgt cactgggagc ctaggtctcc ttcagctcaa ggcgagagtc cacccacaga
     3001 gcccagagcc attcccaact ctgctgctgt tccagaggcc ccccaaggga ccagcacaac
     3061 agaacagcca gccccctggg ccacccagcc agcggccctg cagagcctac cctagcccca
     3121 ctcaatgttt atagcagccc tgtgctgctc cccagggacc tctccataca ctggccagga
     3181 ggctgcagaa cctgcctctc cctcccagag gtcccaaccc ctgccaaaac cacatgggta
     3241 gctgggaggg gtcagctccg cccctctcct ccctgctggt tttttagcta tccctatgtt
     3301 ggaagtaaaa gagtcgaagc actttatttt ggttgtgttt gatcacgttc tgcttggaag
     3361 tggggacccc tcactgagtc cacatgtctg cggcctgtgt ggagcaccac tgcgtgtaca
     3421 tactgtaaat tatttattaa tggctaaatg caagtaaagt ttggtttgtt ttgttatttt
     3481 ctttt
//
