LOCUS       NM_054008                890 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus regulator of cell cycle (Rgcc), mRNA.
ACCESSION   NM_054008 XM_001072931
VERSION     NM_054008.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 890)
  AUTHORS   Shen,Y.L., Liu,H.J., Sun,L., Niu,X.L., Kuang,X.Y., Wang,P., Hao,S.
            and Huang,W.Y.
  TITLE     Response gene to complement 32 regulates the G2/M phase checkpoint
            during renal tubular epithelial cell repair
  JOURNAL   Cell Mol Biol Lett 21, 19 (2016)
   PUBMED   28536621
  REMARK    GeneRIF: RGC-32 probably has an important impact on the repair
            process of renal tubular epithelial cells in vitro by regulating
            the G2/M phase checkpoint, cell fibrosis and cell adhesion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 890)
  AUTHORS   Li,Z., Xie,W.B., Escano,C.S., Asico,L.D., Xie,Q., Jose,P.A. and
            Chen,S.Y.
  TITLE     Response gene to complement 32 is essential for fibroblast
            activation in renal fibrosis
  JOURNAL   J Biol Chem 286 (48), 41323-41330 (2011)
   PUBMED   21990365
REFERENCE   3  (bases 1 to 890)
  AUTHORS   Wang,J.N., Shi,N., Xie,W.B., Guo,X. and Chen,S.Y.
  TITLE     Response gene to complement 32 promotes vascular lesion formation
            through stimulation of smooth muscle cell proliferation and
            migration
  JOURNAL   Arterioscler Thromb Vasc Biol 31 (8), e19-e26 (2011)
   PUBMED   21636805
  REMARK    GeneRIF: Using a carotid artery balloon-injury model, we documented
            for the first time that neointima formation was closely associated
            with a significantly increased expression of RGC-32 protein.
REFERENCE   4  (bases 1 to 890)
  AUTHORS   Guo,X., Jose,P.A. and Chen,S.Y.
  TITLE     Response gene to complement 32 interacts with Smad3 to promote
            epithelial-mesenchymal transition of human renal tubular cells
  JOURNAL   Am J Physiol Cell Physiol 300 (6), C1415-C1421 (2011)
   PUBMED   21307346
REFERENCE   5  (bases 1 to 890)
  AUTHORS   An,X., Jin,Y., Guo,H., Foo,S.Y., Cully,B.L., Wu,J., Zeng,H.,
            Rosenzweig,A. and Li,J.
  TITLE     Response gene to complement 32, a novel hypoxia-regulated
            angiogenic inhibitor
  JOURNAL   Circulation 120 (7), 617-627 (2009)
   PUBMED   19652095
REFERENCE   6  (bases 1 to 890)
  AUTHORS   Saigusa,K., Imoto,I., Tanikawa,C., Aoyagi,M., Ohno,K., Nakamura,Y.
            and Inazawa,J.
  TITLE     RGC32, a novel p53-inducible gene, is located on centrosomes during
            mitosis and results in G2/M arrest
  JOURNAL   Oncogene 26 (8), 1110-1121 (2007)
   PUBMED   17146433
REFERENCE   7  (bases 1 to 890)
  AUTHORS   Jo,M. and Curry,T.E. Jr.
  TITLE     Luteinizing hormone-induced RUNX1 regulates the expression of genes
            in granulosa cells of rat periovulatory follicles
  JOURNAL   Mol Endocrinol 20 (9), 2156-2172 (2006)
   PUBMED   16675540
REFERENCE   8  (bases 1 to 890)
  AUTHORS   Wang,S.F., Liang,Q., Li,G.W. and Gao,K.
  TITLE     Gene expression profile in rat small intestinal allografts after
            cold preservation/reperfusion
  JOURNAL   World J Gastroenterol 11 (6), 885-889 (2005)
   PUBMED   15682487
REFERENCE   9  (bases 1 to 890)
  AUTHORS   Badea,T., Niculescu,F., Soane,L., Fosbrink,M., Sorana,H., Rus,V.,
            Shin,M.L. and Rus,H.
  TITLE     RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth
            muscle cells into S-phase
  JOURNAL   J Biol Chem 277 (1), 502-508 (2002)
   PUBMED   11687586
REFERENCE   10 (bases 1 to 890)
  AUTHORS   Badea,T.C., Niculescu,F.I., Soane,L., Shin,M.L. and Rus,H.
  TITLE     Molecular cloning and characterization of RGC-32, a novel gene
            induced by complement activation in oligodendrocytes
  JOURNAL   J Biol Chem 273 (41), 26977-26981 (1998)
   PUBMED   9756947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 26, 2020 this sequence version replaced NM_054008.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF036548.1, FN800497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JAXUCZ010000015.1  61084267-61084408   c
            143-328             JAXUCZ010000015.1  61083532-61083717   c
            329-436             JAXUCZ010000015.1  61074922-61075029   c
            437-499             JAXUCZ010000015.1  61073217-61073279   c
            500-890             JAXUCZ010000015.1  61071574-61071964   c
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q12"
     gene            1..890
                     /gene="Rgcc"
                     /gene_synonym="Rgc32"
                     /note="regulator of cell cycle"
                     /db_xref="GeneID:117183"
                     /db_xref="RGD:619721"
     exon            1..142
                     /gene="Rgcc"
                     /gene_synonym="Rgc32"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..507
                     /gene="Rgcc"
                     /gene_synonym="Rgc32"
                     /note="response gene to complement 32 protein; RGC-32"
                     /codon_start=1
                     /product="regulator of cell cycle RGCC"
                     /protein_id="NP_446460.1"
                     /db_xref="GeneID:117183"
                     /db_xref="RGD:619721"
                     /translation="MKPPSTQSSPAAVAAAAPAMDSAAAADLTDVLCEFDAVLADFAS
                     PFHERHFHYEEHLERMKRRSSASVSDSSGFSDSESADSLYRDSFTFSDEKLNSPTDST
                     PALLSSAVTPRKAKLGDTKELEDFIADLDRTLASM"
     exon            143..328
                     /gene="Rgcc"
                     /gene_synonym="Rgc32"
                     /inference="alignment:Splign:2.1.0"
     exon            329..436
                     /gene="Rgcc"
                     /gene_synonym="Rgc32"
                     /inference="alignment:Splign:2.1.0"
     exon            437..499
                     /gene="Rgcc"
                     /gene_synonym="Rgc32"
                     /inference="alignment:Splign:2.1.0"
     exon            500..890
                     /gene="Rgcc"
                     /gene_synonym="Rgc32"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaaccaccc gagcggaccg cagtgcaggc ggcagccacc agggccaaca cctctcagca
       61 tctctactac acgtgtcact gagcaacctc tccatgaagc cgccctccac gcagagcagc
      121 cccgcggccg tggcggccgc agccccggcc atggactccg cggccgctgc agacctgacg
      181 gacgtgctgt gcgagttcga cgcggtgctg gccgacttcg cgtcgccctt ccacgagcgc
      241 cacttccact atgaggagca cctggagcgc atgaagcggc gcagcagcgc cagcgtcagt
      301 gacagcagcg gcttcagcga ctccgagagt gcagactcgt tgtacaggga cagcttcacc
      361 ttcagtgatg agaagctgaa ttctccgacg gactccactc cagccctctt gtcctccgct
      421 gtcactcctc ggaaagccaa attaggtgac actaaagagc tcgaagactt catcgctgat
      481 ctggacagaa ccttagcaag tatgtgaagc aaggagtttg agattcttat gccacaagag
      541 tgaaactcca gaaggctacg ccaggccctg gcaaaatcgg ctactaagtc tgctgcggga
      601 gcgggcagag ctcgaggcat ccggccgttc ttggttcgcc ataactttag ccattgggtc
      661 catctctggg cagttcagac aatgaggctg actttgttta cctgcctgca ccatattcaa
      721 cagatgatct atctaatgtg tttttactcc ttaaacatag ctcttctata aattaaagtg
      781 cttttatgga aatatttgta attacttata tatagttgga ggtcataata agctttccca
      841 tcataatata tttttgtata caaataaaat ttaaactggg atctgtacct
//
