LOCUS       NM_001414918            3560 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus regulatory factor X, 6 (Rfx6), mRNA.
ACCESSION   NM_001414918
VERSION     NM_001414918.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3560)
  AUTHORS   Chandra,V., Albagli-Curiel,O., Hastoy,B., Piccand,J.,
            Randriamampita,C., Vaillant,E., Cave,H., Busiah,K., Froguel,P.,
            Vaxillaire,M., Rorsman,P., Polak,M. and Scharfmann,R.
  TITLE     RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in
            human beta cells
  JOURNAL   Cell Rep 9 (6), 2206-2218 (2014)
   PUBMED   25497100
REFERENCE   2  (bases 1 to 3560)
  AUTHORS   Smith,S.B., Qu,H.Q., Taleb,N., Kishimoto,N.Y., Scheel,D.W., Lu,Y.,
            Patch,A.M., Grabs,R., Wang,J., Lynn,F.C., Miyatsuka,T.,
            Mitchell,J., Seerke,R., Desir,J., Vanden Eijnden,S., Abramowicz,M.,
            Kacet,N., Weill,J., Renard,M.E., Gentile,M., Hansen,I., Dewar,K.,
            Hattersley,A.T., Wang,R., Wilson,M.E., Johnson,J.D.,
            Polychronakos,C. and German,M.S.
  TITLE     Rfx6 directs islet formation and insulin production in mice and
            humans
  JOURNAL   Nature 463 (7282), 775-780 (2010)
   PUBMED   20148032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760434
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000020.1  31562490-31562742
            254-410             JAXUCZ010000020.1  31562993-31563149
            411-534             JAXUCZ010000020.1  31566316-31566439
            535-596             JAXUCZ010000020.1  31568148-31568209
            597-674             JAXUCZ010000020.1  31582259-31582336
            675-702             JAXUCZ010000020.1  31583543-31583570
            703-810             JAXUCZ010000020.1  31594073-31594180
            811-888             JAXUCZ010000020.1  31597183-31597260
            889-1002            JAXUCZ010000020.1  31597351-31597464
            1003-1052           JAXUCZ010000020.1  31599113-31599162
            1053-1212           JAXUCZ010000020.1  31600888-31601047
            1213-1357           JAXUCZ010000020.1  31603236-31603380
            1358-1467           JAXUCZ010000020.1  31605113-31605222
            1468-1585           JAXUCZ010000020.1  31606620-31606737
            1586-1708           JAXUCZ010000020.1  31608115-31608237
            1709-1915           JAXUCZ010000020.1  31609064-31609270
            1916-2428           JAXUCZ010000020.1  31610707-31611219
            2429-2641           JAXUCZ010000020.1  31612009-31612221
            2642-3560           JAXUCZ010000020.1  31615049-31615967
FEATURES             Location/Qualifiers
     source          1..3560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..3560
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /note="regulatory factor X, 6"
                     /db_xref="GeneID:294395"
                     /db_xref="RGD:1307491"
     exon            1..253
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2817
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /note="regulatory factor X domain containing 1;
                     DNA-binding protein RFX6-like"
                     /codon_start=1
                     /product="DNA-binding protein RFX6"
                     /protein_id="NP_001401847.1"
                     /db_xref="GeneID:294395"
                     /db_xref="RGD:1307491"
                     /translation="MAKVRELEETFVHEQPSPQLPSEIAEECGAQLLGKGLLVYSEES
                     AYLVASARSSEEKDGDLGLQVGVKSEMHLNNGNFSSEEDDADTQESKTKATDPQLSQK
                     KSITQIMKDKKKQTQLTLQWLEDNYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAAT
                     FGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGSKLKN
                     EGGFTRKYSLSSKTGTLLPEFPSAQHLVYPGCIAKDKVDTLIMMYKTHCQCILDNAIN
                     GNFEEIQHFLLHFWQGMPDHLLPLLENPVIIDIFCVCDSILYKVLTDVLIPATMQEMP
                     ESLLADIRNFAKNWEQWVVSSLENLPEALIDKKIPILRRFVSSLKRQTSFLHLAQIAR
                     PALFDQHVVNAMVSDIEKVDLNSIGSQALLTISNSTDTESDIYSEYDSITVFQELKDL
                     LKKNATVEAFIEWLDTVVEQRVIKMSKQNGRSLKKRAQDFLLKWSFFGARVMHNLTLN
                     NASSFGSLHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNSEASKAAFTASPS
                     SCFLANRNKGSSLSSDPVKNESHEETAYVPLPSSQPLAVPHALHSFPAESTETMPLSG
                     QIELSQSTGHLMTPPISPAIASRGSVINQGPMAGRPSSVGTALSAPTHCPTYAEPIYP
                     TLPPANHDFYGTNSNYQTVFRAQSHPASSLYAHRAENGRCMAWTEQQLSRDFFGGSCA
                     GSPYNSRPPSGYGPSPATQESHNMQFLNTGSFNFLSNAGTGSCQGAALPSNSPNGYYG
                     NNINYPEAHRLGSMVNQHVSVISSVRSLPPYSDIHDPLNILDDSGRKQSNLFYAHTSS
                     PVTCRTPVVASNLQTQIPPSSSQCMYGTSGQYPVQDNLDSNGASDREMVSSLPPINTV
                     FMGTAAGGT"
     exon            254..410
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..534
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..596
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..674
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..702
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..810
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..888
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1002
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1052
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1212
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1357
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1467
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1585
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1708
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1915
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2428
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2641
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..3560
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctccgcc aggctccggg tgccgaggtc cgggcggtgg gaaggatggc taaggtccgg
       61 gaactggagg aaaccttcgt gcacgagcag ccttcgcccc aacttccctc cgagatcgcg
      121 gaggagtgcg gcgctcagct gctcggcaag ggcttgctgg tctactccga ggagagcgct
      181 tacctggtgg ccagcgcccg gagcagcgag gagaaagacg gggatctcgg gctgcaggtt
      241 ggagttaaat cagaaatgca tttaaacaat ggcaactttt cctcggagga agacgatgca
      301 gacactcagg aaagcaagac caaagccacc gacccacagc tctctcagaa gaagagcatc
      361 acccagatca tgaaggacaa gaagaagcag actcagctca ccctgcagtg gcttgaagac
      421 aactacattg tatgtgaagg agtttgcctc ccacggtgca ttctttatgc tcactattta
      481 gatttctgca ggaaagagaa actggaacca gcctgtgcag ccacctttgg aaagacaatt
      541 cgccaaaaat ttcccctcct gacaacaaga agacttggaa caagaggtca ttcaaagtat
      601 cattactatg ggattggcat caaagaaagc agcgcctatt accactctgt ttattctgga
      661 aagggcttga caaggttttc ggggagcaaa ctgaagaatg agggtggttt tactcgtaaa
      721 tactcactca gctcaaaaac aggaaccctt cttccagaat tccccagcgc tcaacatctt
      781 gtgtacccag gatgcattgc taaggataag gttgacactc tcataatgat gtataagact
      841 cactgccagt gcatactcga caacgccatc aatgggaact ttgaggagat ccagcatttc
      901 ctactgcact tttggcaagg aatgccagac cacctccttc ccctgcttga aaatcctgta
      961 atcattgaca ttttctgtgt ttgtgactca attctgtata aggttcttac agatgtcctc
     1021 attcctgcaa ccatgcaaga aatgcctgaa agcttattag cagatataag aaattttgct
     1081 aaaaattggg aacagtgggt tgtctcatct ttggaaaact tgccagaagc cctcattgac
     1141 aagaaaatcc ccattttgcg aagattcgta tcttctctga agcgacagac atctttcttg
     1201 catcttgctc agattgccag accagctctc tttgaccagc atgtggtgaa cgccatggta
     1261 tctgatattg aaaaggttga cttaaatagt attggatctc aggctcttct taccatatcc
     1321 aacagcacag acacagaatc cgacatctac agtgaatatg actctatcac tgtgttccaa
     1381 gagctgaagg atctccttaa gaagaatgcg acagtggaag cttttattga atggttggat
     1441 actgtggtag aacagagagt tattaagatg agcaaacaga acggaagatc tctgaagaag
     1501 agagctcaag acttcctgct caaatggagc ttttttggtg cccgcgtaat gcataatctg
     1561 accttgaaca acgcatcgag ttttggttct ctccatttga tccggatgct tctggatgaa
     1621 tacattctcc tggctatgga gactcaattt aacaatgaca aagaacagga gctacagaat
     1681 ttattggaca agtatatgaa gaactcggag gcgagtaaag ctgccttcac agcttccccg
     1741 agctcatgct ttctggccaa ccgaaataag ggcagctcac tttccagtga ccctgtgaag
     1801 aatgaaagcc acgaggagac cgcctatgtt cccctgcctt ccagccagcc tctggccgta
     1861 ccccatgctc tgcactcatt cccagcggag agcactgaga ccatgcctct ctcaggtcaa
     1921 atagagctct cacaaagtac tggccatctg atgacgccac ctatttctcc agccatagca
     1981 agcagaggaa gtgttattaa ccaagggcca atggcgggca gaccctcgag cgtgggcaca
     2041 gctctctcag ctccaacgca ctgtccgacg tacgcagaac cgatttatcc taccctccct
     2101 ccagccaacc acgactttta cgggaccaac tctaactatc agactgtgtt tagggcacag
     2161 tctcaccctg cgtcaagtct ctatgctcac cgtgcagaga acgggcgatg catggcttgg
     2221 acggaacagc agctttctag agacttcttc gggggcagct gtgctgggtc tccgtataat
     2281 tccaggccgc cttccggtta tgggccatcc cccgcaaccc aagagtcaca caacatgcag
     2341 tttttgaaca cagggagctt caatttcctc agtaacgcag gaactggcag ctgccaagga
     2401 gcagccttac cttctaattc tcctaatggg tactatggaa acaatataaa ctacccagag
     2461 gcacataggc tcggatcaat ggtgaaccaa cacgtttcgg tcatcagcag tgttcgctcc
     2521 ctgcctccct acagtgacat ccatgatcca cttaacattt tagatgacag cggccggaag
     2581 cagagcaact tgttttatgc acacacatcc tctcctgtca catgtcggac tcctgtagtg
     2641 gcttccaatt tgcaaaccca gattcctccc tcttcatccc agtgtatgta tggaacttct
     2701 ggtcagtatc cagtgcaaga taatctggat tccaatggag caagtgacag agaaatggtg
     2761 tcctctttac ctcccatcaa cactgtgttt atggggacag cagctggagg cacttaaatg
     2821 aacaatgcag aatgcagatg aaactcaagg ctctgctgca tcggtgtcat tgtctacccc
     2881 cagctgccat gagagaagag acagtggaag gtggagtggc tgaatgttat tttcaggtca
     2941 ctgctgtgtt ggacaactcc atagtgaatg gaaatacttg tgttgcacac aattaggcaa
     3001 aaatgtgaag ccattattaa tcgtaacttc aaggactatc gaatgaagcc gatggaaatt
     3061 taaagatgca gacactacaa agatgtaata tttcactttc taacttattg aaaattctct
     3121 attttccttc acctttggtt tctaaaagaa gaaaagtgta ttcaatgcct tcacaagatc
     3181 tttaatttat aatcattgtt tactatcacc ttttgaccaa agtcaaatgt ctaagttcta
     3241 cctcctgtga gaatgtttac aaggtcaaga ctttttcgta tgtagcctag atccaagtga
     3301 cttgaccttc ttctatccct gtgcactagt gtggtgactt ctgttacata gcagtgttct
     3361 aattctatgt aactgaaaac aaatgataaa cgctttcctt ctttatttaa aatgataaga
     3421 ggaaataaaa ggagtgtgtg gaaacatttt caaggctgtg attgctttgg ggattgattc
     3481 tgtttctgga gaacgtgaag acttcaggcc aaagtacaat ggatatgaaa tgaaaaaaat
     3541 aaataaagct tgctgcttaa
//
