LOCUS       NP_001401847             923 aa            linear   ROD 03-APR-2024
DEFINITION  DNA-binding protein RFX6 [Rattus norvegicus].
ACCESSION   NP_001401847
VERSION     NP_001401847.1
DBSOURCE    REFSEQ: accession NM_001414918.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 923)
  AUTHORS   Chandra,V., Albagli-Curiel,O., Hastoy,B., Piccand,J.,
            Randriamampita,C., Vaillant,E., Cave,H., Busiah,K., Froguel,P.,
            Vaxillaire,M., Rorsman,P., Polak,M. and Scharfmann,R.
  TITLE     RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in
            human beta cells
  JOURNAL   Cell Rep 9 (6), 2206-2218 (2014)
   PUBMED   25497100
REFERENCE   2  (residues 1 to 923)
  AUTHORS   Smith,S.B., Qu,H.Q., Taleb,N., Kishimoto,N.Y., Scheel,D.W., Lu,Y.,
            Patch,A.M., Grabs,R., Wang,J., Lynn,F.C., Miyatsuka,T.,
            Mitchell,J., Seerke,R., Desir,J., Vanden Eijnden,S., Abramowicz,M.,
            Kacet,N., Weill,J., Renard,M.E., Gentile,M., Hansen,I., Dewar,K.,
            Hattersley,A.T., Wang,R., Wilson,M.E., Johnson,J.D.,
            Polychronakos,C. and German,M.S.
  TITLE     Rfx6 directs islet formation and insulin production in mice and
            humans
  JOURNAL   Nature 463 (7282), 775-780 (2010)
   PUBMED   20148032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760434
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     Protein         1..923
                     /product="DNA-binding protein RFX6"
                     /note="regulatory factor X domain containing 1;
                     DNA-binding protein RFX6-like"
                     /calculated_mol_wt=101935
     Region          119..194
                     /region_name="RFX_DNA_binding"
                     /note="RFX DNA-binding domain; pfam02257"
                     /db_xref="CDD:460512"
     Region          <652..>758
                     /region_name="PTZ00395"
                     /note="Sec24-related protein; Provisional"
                     /db_xref="CDD:185594"
     CDS             1..923
                     /gene="Rfx6"
                     /gene_synonym="Rfxdc1"
                     /coded_by="NM_001414918.1:46..2817"
                     /db_xref="GeneID:294395"
                     /db_xref="RGD:1307491"
ORIGIN      
        1 makvreleet fvheqpspql pseiaeecga qllgkgllvy seesaylvas arsseekdgd
       61 lglqvgvkse mhlnngnfss eeddadtqes ktkatdpqls qkksitqimk dkkkqtqltl
      121 qwlednyivc egvclprcil yahyldfcrk eklepacaat fgktirqkfp llttrrlgtr
      181 ghskyhyygi gikessayyh svysgkgltr fsgsklkneg gftrkyslss ktgtllpefp
      241 saqhlvypgc iakdkvdtli mmykthcqci ldnaingnfe eiqhfllhfw qgmpdhllpl
      301 lenpviidif cvcdsilykv ltdvlipatm qempesllad irnfaknweq wvvsslenlp
      361 ealidkkipi lrrfvsslkr qtsflhlaqi arpalfdqhv vnamvsdiek vdlnsigsqa
      421 lltisnstdt esdiyseyds itvfqelkdl lkknatveaf iewldtvveq rvikmskqng
      481 rslkkraqdf llkwsffgar vmhnltlnna ssfgslhlir mlldeyilla metqfnndke
      541 qelqnlldky mknseaskaa ftaspsscfl anrnkgssls sdpvkneshe etayvplpss
      601 qplavphalh sfpaestetm plsgqielsq stghlmtppi spaiasrgsv inqgpmagrp
      661 ssvgtalsap thcptyaepi yptlppanhd fygtnsnyqt vfraqshpas slyahraeng
      721 rcmawteqql srdffggsca gspynsrpps gygpspatqe shnmqflntg sfnflsnagt
      781 gscqgaalps nspngyygnn inypeahrlg smvnqhvsvi ssvrslppys dihdplnild
      841 dsgrkqsnlf yahtsspvtc rtpvvasnlq tqippsssqc mygtsgqypv qdnldsngas
      901 dremvsslpp intvfmgtaa ggt
//
