LOCUS       NP_001382523             749 aa            linear   ROD 31-MAR-2024
DEFINITION  transcription factor RFX3 [Rattus norvegicus].
ACCESSION   NP_001382523 XP_006231295
VERSION     NP_001382523.1
DBSOURCE    REFSEQ: accession NM_001395594.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 749)
  AUTHORS   Bae,B.I., Tietjen,I., Atabay,K.D., Evrony,G.D., Johnson,M.B.,
            Asare,E., Wang,P.P., Murayama,A.Y., Im,K., Lisgo,S.N., Overman,L.,
            Sestan,N., Chang,B.S., Barkovich,A.J., Grant,P.E., Topcu,M.,
            Politsky,J., Okano,H., Piao,X. and Walsh,C.A.
  TITLE     Evolutionarily dynamic alternative splicing of GPR56 regulates
            regional cerebral cortical patterning
  JOURNAL   Science 343 (6172), 764-768 (2014)
   PUBMED   24531968
REFERENCE   2  (residues 1 to 749)
  AUTHORS   Ait-Lounis,A., Bonal,C., Seguin-Estevez,Q., Schmid,C.D., Bucher,P.,
            Herrera,P.L., Durand,B., Meda,P. and Reith,W.
  TITLE     The transcription factor Rfx3 regulates beta-cell differentiation,
            function, and glucokinase expression
  JOURNAL   Diabetes 59 (7), 1674-1685 (2010)
   PUBMED   20413507
REFERENCE   3  (residues 1 to 749)
  AUTHORS   Smith,S.B., Qu,H.Q., Taleb,N., Kishimoto,N.Y., Scheel,D.W., Lu,Y.,
            Patch,A.M., Grabs,R., Wang,J., Lynn,F.C., Miyatsuka,T.,
            Mitchell,J., Seerke,R., Desir,J., Vanden Eijnden,S., Abramowicz,M.,
            Kacet,N., Weill,J., Renard,M.E., Gentile,M., Hansen,I., Dewar,K.,
            Hattersley,A.T., Wang,R., Wilson,M.E., Johnson,J.D.,
            Polychronakos,C. and German,M.S.
  TITLE     Rfx6 directs islet formation and insulin production in mice and
            humans
  JOURNAL   Nature 463 (7282), 775-780 (2010)
   PUBMED   20148032
REFERENCE   4  (residues 1 to 749)
  AUTHORS   El Zein,L., Ait-Lounis,A., Morle,L., Thomas,J., Chhin,B.,
            Spassky,N., Reith,W. and Durand,B.
  TITLE     RFX3 governs growth and beating efficiency of motile cilia in mouse
            and controls the expression of genes involved in human ciliopathies
  JOURNAL   J Cell Sci 122 (Pt 17), 3180-3189 (2009)
   PUBMED   19671664
REFERENCE   5  (residues 1 to 749)
  AUTHORS   Ait-Lounis,A., Baas,D., Barras,E., Benadiba,C., Charollais,A.,
            Nlend Nlend,R., Liegeois,D., Meda,P., Durand,B. and Reith,W.
  TITLE     Novel function of the ciliogenic transcription factor RFX3 in
            development of the endocrine pancreas
  JOURNAL   Diabetes 56 (4), 950-959 (2007)
   PUBMED   17229940
REFERENCE   6  (residues 1 to 749)
  AUTHORS   Bonnafe,E., Touka,M., AitLounis,A., Baas,D., Barras,E., Ucla,C.,
            Moreau,A., Flamant,F., Dubruille,R., Couble,P., Collignon,J.,
            Durand,B. and Reith,W.
  TITLE     The transcription factor RFX3 directs nodal cilium development and
            left-right asymmetry specification
  JOURNAL   Mol Cell Biol 24 (10), 4417-4427 (2004)
   PUBMED   15121860
REFERENCE   7  (residues 1 to 749)
  AUTHORS   Nakayama,A., Murakami,H., Maeyama,N., Yamashiro,N., Sakakibara,A.,
            Mori,N. and Takahashi,M.
  TITLE     Role for RFX transcription factors in non-neuronal cell-specific
            inactivation of the microtubule-associated protein MAP1A promoter
  JOURNAL   J Biol Chem 278 (1), 233-240 (2003)
   PUBMED   12411430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 21, 2021 this sequence version replaced XP_006231295.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1350627.1,
                                           SRR26643293.8324.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     Protein         1..749
                     /product="transcription factor RFX3"
                     /note="regulatory factor X, 3 (influences HLA class II
                     expression)"
                     /calculated_mol_wt=83395
     Region          <51..138
                     /region_name="RFX1_trans_act"
                     /note="RFX1 transcription activation region; pfam04589"
                     /db_xref="CDD:461362"
     Region          184..258
                     /region_name="RFX_DNA_binding"
                     /note="RFX DNA-binding domain; pfam02257"
                     /db_xref="CDD:460512"
     CDS             1..749
                     /gene="Rfx3"
                     /coded_by="NM_001395594.1:117..2366"
                     /db_xref="GeneID:361746"
                     /db_xref="RGD:1307779"
ORIGIN      
        1 mqtsetgsdt gstvtlqtsv asqaavptqv vqqvpvqqqv qqvqtvqqvq hvypaqvqyv
       61 egsdtvytng airtttypyt etqmysqntg gnyfdtqgss aqvttvvssh smvgtggiqm
      121 gvtggqliss sggtyligns mensghsvth ttraspatie maietlqksd glsthrssll
      181 nshlqwlldn yetaegvslp rstlynhylr hcqehkldpv naasfgklir sifmglrtrr
      241 lgtrgnskyh yygirvkpds plnrlqedmq ymamrqqpmq qkqrykpmqk vdgvadgftg
      301 sgqqtgtsve qtviaqsqhh qqfldasral pefgeveiss lpdgttfedi kslqslyreh
      361 ceaildvvvn lqfslieklw qtfwryspst ptdgttites snlseiesrl pkaklitlck
      421 hesilkwmcn cdhgmyqalv eilipdvlrp ipsaltqair nfakslegwl snamnnipqr
      481 miqtkvaavs afaqtlrryt slnhlaqaar avlqntsqin qmlsdlnrvd fanvqeqasw
      541 vcqcddnmvq rletdfkmtl qqqstleqwa awldnvmmqa lkpyegrpsf pkaarqfllk
      601 wsfyssmvir dltlrsaasf gsfhlirlly deymfylveh rvaqvtgetp iavmgefgdl
      661 navspgnldk degsevesem dedlddssep qakrektels qafpvgcmqp vlesgvqpsl
      721 lnplhsehiv tspqtirqcs atgntytav
//
