LOCUS       NM_001413766            3335 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus regulatory factor X2 (Rfx2), transcript variant
            1, mRNA.
ACCESSION   NM_001413766 XM_006244313
VERSION     NM_001413766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3335)
  AUTHORS   Wu,Y., Hu,X., Li,Z., Wang,M., Li,S., Wang,X., Lin,X., Liao,S.,
            Zhang,Z., Feng,X., Wang,S., Cui,X., Wang,Y., Gao,F., Hess,R.A. and
            Han,C.
  TITLE     Transcription Factor RFX2 Is a Key Regulator of Mouse
            Spermiogenesis
  JOURNAL   Sci Rep 6, 20435 (2016)
   PUBMED   26853561
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3335)
  AUTHORS   Shawlot,W., Vazquez-Chantada,M., Wallingford,J.B. and Finnell,R.H.
  TITLE     Rfx2 is required for spermatogenesis in the mouse
  JOURNAL   Genesis 53 (9), 604-611 (2015)
   PUBMED   26248850
REFERENCE   3  (bases 1 to 3335)
  AUTHORS   Kistler,W.S., Baas,D., Lemeille,S., Paschaki,M., Seguin-Estevez,Q.,
            Barras,E., Ma,W., Duteyrat,J.L., Morle,L., Durand,B. and Reith,W.
  TITLE     RFX2 Is a Major Transcriptional Regulator of Spermiogenesis
  JOURNAL   PLoS Genet 11 (7), e1005368 (2015)
   PUBMED   26162102
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3335)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 3335)
  AUTHORS   VanWert,J.M., Wolfe,S.A. and Grimes,S.R.
  TITLE     Binding of RFX2 and NF-Y to the testis-specific histone H1t
            promoter may be required for transcriptional activation in primary
            spermatocytes
  JOURNAL   J Cell Biochem 104 (3), 1087-1101 (2008)
   PUBMED   18247329
  REMARK    GeneRIF: RFX2 and NF-Y binding to the testis-specific histone H1t
            promoter may be required for transcriptional activation in primary
            spermatocytes
REFERENCE   6  (bases 1 to 3335)
  AUTHORS   Wolfe,S.A., van Wert,J. and Grimes,S.R.
  TITLE     Transcription factor RFX2 is abundant in rat testis and enriched in
            nuclei of primary spermatocytes where it appears to be required for
            transcription of the testis-specific histone H1t gene
  JOURNAL   J Cell Biochem 99 (3), 735-746 (2006)
   PUBMED   16676351
  REMARK    GeneRIF: These data support the hypothesis that RFX2 expression is
            upregulated in spermatocytes where it participates in activating
            transcription of the H1t gene and other testis genes.
REFERENCE   7  (bases 1 to 3335)
  AUTHORS   Wolfe,S.A., Wilkerson,D.C., Prado,S. and Grimes,S.R.
  TITLE     Regulatory factor X2 (RFX2) binds to the H1t/TE1 promoter element
            and activates transcription of the testis-specific histone H1t gene
  JOURNAL   J Cell Biochem 91 (2), 375-383 (2004)
   PUBMED   14743396
REFERENCE   8  (bases 1 to 3335)
  AUTHORS   Reith,W., Ucla,C., Barras,E., Gaud,A., Durand,B.,
            Herrero-Sanchez,C., Kobr,M. and Mach,B.
  TITLE     RFX1, a transactivator of hepatitis B virus enhancer I, belongs to
            a novel family of homodimeric and heterodimeric DNA-binding
            proteins
  JOURNAL   Mol Cell Biol 14 (2), 1230-1244 (1994)
   PUBMED   8289803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 8, 2022 this sequence version replaced XM_006244313.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.48633.1,
                                           SRR26643429.32910.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000009.1  1758046-1758146     c
            102-193             JAXUCZ010000009.1  1726169-1726260     c
            194-283             JAXUCZ010000009.1  1723638-1723727     c
            284-354             JAXUCZ010000009.1  1722598-1722668     c
            355-616             JAXUCZ010000009.1  1721569-1721830     c
            617-691             JAXUCZ010000009.1  1712376-1712450     c
            692-873             JAXUCZ010000009.1  1702225-1702406     c
            874-993             JAXUCZ010000009.1  1701224-1701343     c
            994-1109            JAXUCZ010000009.1  1700464-1700579     c
            1110-1228           JAXUCZ010000009.1  1699874-1699992     c
            1229-1341           JAXUCZ010000009.1  1699510-1699622     c
            1342-1496           JAXUCZ010000009.1  1698772-1698926     c
            1497-1594           JAXUCZ010000009.1  1697434-1697531     c
            1595-1744           JAXUCZ010000009.1  1695957-1696106     c
            1745-1953           JAXUCZ010000009.1  1695089-1695297     c
            1954-2107           JAXUCZ010000009.1  1693767-1693920     c
            2108-2150           JAXUCZ010000009.1  1693314-1693356     c
            2151-3335           JAXUCZ010000009.1  1691764-1692948     c
FEATURES             Location/Qualifiers
     source          1..3335
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..3335
                     /gene="Rfx2"
                     /note="regulatory factor X2"
                     /db_xref="GeneID:301121"
                     /db_xref="RGD:1588579"
     exon            1..101
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            102..193
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2263
                     /gene="Rfx2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-binding protein RFX2; regulatory factor X 2;
                     regulatory factor X, 2 (influences HLA class II
                     expression)"
                     /codon_start=1
                     /product="DNA-binding protein RFX2 isoform 1"
                     /protein_id="NP_001400695.1"
                     /db_xref="GeneID:301121"
                     /db_xref="RGD:1588579"
                     /translation="MQNSEGGADSPATVALRPAAQPVPASPQRVLVQAAGSTPKGTPM
                     QTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYTYNPDPQLYAPSSAAS
                     YFETPGGAQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGTYLIHGGMDSTRHSLA
                     HTARSSPATLEMAIETLQKSEGLAPHKGGLLNSHLQWLLDNYETAEGVSLPRSSLYNH
                     YLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRL
                     QEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHSTPEQAMAAQGQHHQQYID
                     VSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWL
                     SFWNCKATSSDGRASLPASDEEPEVTLLPKDKLISLCKCEPILQWMRSCDHILYQALV
                     ETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRR
                     YTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDF
                     KVTLQQQSSLDQWASWLDNVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTL
                     RSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKED
                     IGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI"
     exon            194..283
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..354
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            355..616
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..691
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..873
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..993
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1109
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1228
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1341
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1496
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1594
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1744
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1953
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2107
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2150
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..3335
                     /gene="Rfx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagagactg tagccgtgga gactgttact taccaacgcg gagcgacacg cagcggccaa
       61 cgccgcggga gccgctaccc gaactccctg ccgaactcca gatcccagca tgcagaactc
      121 cgagggagga gcagactcgc ctgccacagt ggctctgcgt cctgcagccc agcctgtacc
      181 agcctcccca cagagggtgc tggtacaagc cgcaggctcc actcccaagg gtaccccgat
      241 gcagacactc accctcccca gagtccagcc agtgccacca caggtgcagc acgtgtaccc
      301 cgcacaggtg cagtacgtgg agggtgggga tgctgtctac gccaacggag ccatccgagc
      361 cgcctatacc tacaacccag accctcagct ctacgccccc agcagcgcag cttcttactt
      421 tgagactcca ggtggcgctc aggtgacggt ggcagcctcg tccccaccag cggttccctc
      481 ccacggcatg gtgggcatca ccatggatgt ctcagggacc cccattgtgt ctggcgcagg
      541 aacctacctc atccacgggg gcatggacag cacaagacac tccctggccc acactgcccg
      601 ctcgtcacct gccacgcttg aaatggcgat tgagactctc caaaaaagtg aaggcctcgc
      661 cccccacaaa ggcggcctgc tcaacagcca tctccagtgg cttctggaca attacgagac
      721 agcagagggt gtgagcctgc cccgcagctc cctgtacaac cactacctgc gccactgcca
      781 ggagcacaag ctggagccag tcaatgctgc atccttcggc aagctcatcc gctctgtatt
      841 catgggcctg cgcacacgac gcttggggac caggggcaac tcaaagtacc attactatgg
      901 gatccgcctg aagccagact caccactgaa tcgactgcag gaagacacac agtacatggc
      961 catgaggcag cagcccacgc accagaagcc taggtatcgg ccagcccaga agtcagacag
     1021 cctcggggat ggcagtgctc acagcaacat gcacagcaca cccgagcaag ccatggccgc
     1081 ccagggccag catcaccagc agtacataga tgtgtcccac gtcttcccag agttcccagc
     1141 acctgaccta ggcagcacgt tactgcagga gagtgtcacc cttcatgatg tgaaggccct
     1201 gcagctggtg tatcgcaggc actgtgaggc caccttagat gtcgtcatga acctccagtt
     1261 tcagtacatt gagaagctgt ggttgtcctt ctggaactgc aaggccacct ccagtgatgg
     1321 ccgtgcctcg ctgcctgcca gcgacgagga gcctgaagtc accctcctcc ccaaggacaa
     1381 gctcatctct ctgtgtaagt gtgagcccat cctgcagtgg atgcgcagct gcgatcacat
     1441 cctgtaccag gcgctggtgg agaccctcat cccagacgtg ctacggcccg tgcccagttc
     1501 cctcacacag gccatcagga acttcgccaa gagcctggag ggctggctca tcaatgccat
     1561 gagtggcttc cctcagcagg tcatccagac caaggtgggt gttgtaagtg cctttgcaca
     1621 gacactgcgg cgctacacgt ccctcaacca cctggcacag gcagcacgtg ccgtgctaca
     1681 gaatacgtca cagattaacc agatgctgag tgacctcaac cgcgtggact ttgccaatgt
     1741 gcaggagcag gcctcatggg tgtgccagtg tgaggagagc ctggtgcagc gtttggagca
     1801 tgacttcaag gtcaccctgc agcagcagag ctcgctggac caatgggcca gctggctgga
     1861 caatgtggtc acccaggtac tgaagcagca tgcaggcagc cccagcttcc ccaaggctgc
     1921 acggcagttc ctgctcaagt ggtccttcta cagctccatg gtaatccggg acctgaccct
     1981 gcgcagcgct gccagctttg gctccttcca cctcatccgc ctgttgtatg acgagtacat
     2041 gttctacctg gtggagcacc gtgtggccca ggccaccggg gagacaccca ttgctgtcat
     2101 gggcgagttc aatgacctgg cgtccctgtc gctgaccctg ctggacaaag aggacattgg
     2161 ggacggacac agcagtgagg cagatgtgga tggccgcagc ctgggcgagc ccctggtgaa
     2221 gcgggaacgg agtgacccca gccacccact gcagggcatc tagcccctgg cctaggcgtc
     2281 ttccacatgc ttctggaagg cgtcacctgg ccctctaggg acctgggctc tcagctgttt
     2341 cacactagtg cctcttcaat gacatgttta ctgtgaccca aggtggcctg gggtgcccca
     2401 cccacagggt gccagaggct gtgggagcta agatggtcac tcacgctgcc atactctgct
     2461 aaagtgcccc taatcctggg atgtcccccc acaccaagga cacagtgacc tgtgtggaca
     2521 cctcccctgc tgcgtgtgtg acttctgagg cacatcccca gaaatgcccc agccaccttg
     2581 gtggcttttc cactcagctg ctcccaacat aacctccatt tcaaagaaaa cccactctag
     2641 cacagagtgg gaggaaccat actactctga agccactgag tggggactct gtggtcccct
     2701 gtgccgtggt ctccatgcac ttcatagctt cttatggaca ggcaaggcct ccaggcacag
     2761 gccctggacc ccagatgcta atggcatctc atctcatcct ggacaggtcc aaccaagccc
     2821 ccaaaagata acagactcca agcagggcca gtcaaacgta gatgctttct gtccaattca
     2881 tagttaacac caagataacg tgggggcagg agactgggtt gggtttcccc aagcagccac
     2941 atgggtcagc accatgggcc tcccagaaga accccaaaag ctgtgtttgt ggcagtcctg
     3001 ggtccctgca gtcttccaga cacctccccc aaaactagcc atgcttgctg ctggcctgtg
     3061 gccaacccct tctcaaccct agaccatgag atctctgtgg acaaatgaac accaaggtct
     3121 atcgggccct gagttctaga ggccccaaca cgtcacacct tgctgctgtc accacttcag
     3181 aattctgccc tacacaagcc ctgccctcgc acacctagga agcacctaat gaaatacgat
     3241 agtttctctc tttttggaaa aaaaaaaatg ttcccccaat agttttgtgc tgtaattgtt
     3301 cttagaaggt tcttgtgaat gtgtccatca caaca
//
