LOCUS       NM_001135011            2826 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus raftlin lipid raft linker 1 (Rftn1), mRNA.
ACCESSION   NM_001135011 XM_001062448 XM_576510
VERSION     NM_001135011.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2826)
  AUTHORS   Wang,J., Qu,D., An,J., Yuan,G. and Liu,Y.
  TITLE     Integrated microarray analysis provided novel insights to the
            pathogenesis of glaucoma
  JOURNAL   Mol Med Rep 16 (6), 8735-8746 (2017)
   PUBMED   28990066
REFERENCE   2  (bases 1 to 2826)
  AUTHORS   Tidwell,J.A., Schmidt,C., Heaton,P., Wilson,V. and Tucker,P.W.
  TITLE     Characterization of a new ARID family transcription factor
            (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated
            immunoglobulin gene transcription
  JOURNAL   Mol Immunol 49 (1-2), 260-272 (2011)
   PUBMED   21955986
REFERENCE   3  (bases 1 to 2826)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   4  (bases 1 to 2826)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 2826)
  AUTHORS   Saeki,K., Fukuyama,S., Ayada,T., Nakaya,M., Aki,D., Takaesu,G.,
            Hanada,T., Matsumura,Y., Kobayashi,T., Nakagawa,R. and Yoshimura,A.
  TITLE     A major lipid raft protein raftlin modulates T cell receptor
            signaling and enhances th17-mediated autoimmune responses
  JOURNAL   J Immunol 182 (10), 5929-5937 (2009)
   PUBMED   19414744
REFERENCE   6  (bases 1 to 2826)
  AUTHORS   Saeki,K., Miura,Y., Aki,D., Kurosaki,T. and Yoshimura,A.
  TITLE     The B cell-specific major raft protein, Raftlin, is necessary for
            the integrity of lipid raft and BCR signal transduction
  JOURNAL   EMBO J 22 (12), 3015-3026 (2003)
   PUBMED   12805216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Sep 17, 2008 this sequence version replaced
            XM_001062448.1, XM_576510.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.2292611.1,
                                           SRR26643290.31711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000009.1  18302378-18302522
            146-302             JAXUCZ010000009.1  18324118-18324274
            303-489             JAXUCZ010000009.1  18390830-18391016
            490-598             JAXUCZ010000009.1  18411209-18411317
            599-989             JAXUCZ010000009.1  18438817-18439207
            990-1193            JAXUCZ010000009.1  18445567-18445770
            1194-1309           JAXUCZ010000009.1  18456904-18457019
            1310-1413           JAXUCZ010000009.1  18489510-18489613
            1414-1495           JAXUCZ010000009.1  18491864-18491945
            1496-2826           JAXUCZ010000009.1  18498489-18499819
FEATURES             Location/Qualifiers
     source          1..2826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..2826
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /note="raftlin lipid raft linker 1"
                     /db_xref="GeneID:501095"
                     /db_xref="RGD:1563347"
     exon            1..145
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
     exon            146..302
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1822
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /note="raft-linking protein"
                     /codon_start=1
                     /product="raftlin"
                     /protein_id="NP_001128483.1"
                     /db_xref="GeneID:501095"
                     /db_xref="RGD:1563347"
                     /translation="MGCSLNKLEKREEKRPGNIYSTLKRPQVETKIDVTYEYCFLEFT
                     TLTAAELPRSSATRLASLRDLPDQLLELYQQGFSLAALHPFVQPTRRQEKIPLEHIFR
                     AILVKKTSRSQKAELPNEGYILELDHCSSLEHLADQKLVPEFIKKVQEAASRGLKFVS
                     VVPQYQTSVSSAGSTRFLPVTNSDEGARDGKNTFGDRPSLESDTPKAADVDDATAGVN
                     QRPEPNPGSAGEAPGAQQPGIPSPSEENEAVEFPLRGLRPALGGLEGDPSNGPEELPS
                     RKMEIFAFFNRPRSQQKCLQYYPVTIPLQVSKNGQTVSSLDASWLEHMSDHFRKGGVL
                     VNAVFQLGMANDSFYGLTDGVFIFEAVSTEDSKTTQGYDAIVVEQWTVLEGTEVQTDY
                     MPLLNSLAAYGWQLTCVLPTPILKTNREGNVCTKQIVFLQRPCLPQKTKKRESKFQWR
                     FSRNDIHSRQTRKSKGKPSAGDKQQAEENEKNLDDQFSRAGDAGNCVLGAQQWGRASE
                     VREQRPGSAAVQNGPAGHNRDSVTLRHSNPRAEAELVPGPAPTEAN"
     exon            303..489
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
     exon            490..598
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
     exon            599..989
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1193
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1309
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1413
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1495
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..2826
                     /gene="Rftn1"
                     /gene_synonym="2310015n21rik; RGD1310777; RGD1563347"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcgcc ccgcgctctg cccccacccc cggggccgcg tcgtccgcgc gccgccctgc
       61 tctgcatggc acaaactttc atcccgggac gcagcacgct gtctccggga acccgcgcca
      121 gggtcgccgc tgctggtcgc ctaagacagc tgtcgagatg ggttgcagtt tgaacaagct
      181 ggagaaacgt gaagagaagc ggcctggtaa catttactct actctgaaga gacctcaggt
      241 ggagaccaag atagatgtga cctatgaata ctgctttcta gagttcacca ccctgactgc
      301 cgcggagctg ccgagatcct cagccacaag gttagcttct ctgcgggatc tgcctgacca
      361 gctgctggag ctgtaccagc agggcttctc gctggccgcc ctgcacccgt ttgtgcagcc
      421 gacgcgcagg caagagaaga tacccctgga gcacatcttc agggccatcc tggtcaagaa
      481 aaccagcagg tcccagaagg cagagcttcc caatgaaggg tacatcttgg aactggatca
      541 ctgctcctcc ttagaacacc tggcagacca gaagctcgtc ccggagttca ttaagaaggt
      601 acaggaggct gcgagtcgtg gcttgaagtt cgttagtgtg gtgcctcagt accagacctc
      661 tgtgagctcg gcaggcagca cgcgcttcct gcctgtcacc aacagtgacg aaggtgccag
      721 ggatgggaag aacacctttg gggaccggcc atctttggaa agtgataccc caaaggctgc
      781 ggatgtggac gatgccactg cgggagtgaa ccagagacca gagcccaacc cgggatccgc
      841 aggggaggcg cccggtgccc agcagcctgg cattccctct ccctcagaag agaatgaggc
      901 tgtcgagttt ccactgcggg gtttgaggcc agcactgggt ggcttggagg gtgacccctc
      961 caatgggcct gaagagctgc cttccaggaa aatggagatc ttcgcctttt tcaacagacc
     1021 aaggagccag cagaaatgtc tgcaatacta ccccgtcacc atccccctcc aggtctccaa
     1081 gaacggccag acagtgagca gtctggacgc cagctggctg gagcacatga gtgaccactt
     1141 ccggaaaggc ggtgtgctgg tgaacgccgt cttccagctt ggcatggcca acgattcctt
     1201 ctatggcctg acagatggag tattcatctt tgaagctgtt tccacagaag atagcaaaac
     1261 cacacagggc tatgacgcca ttgttgtgga acaatggaca gtcctggaag gtacagaggt
     1321 gcagaccgac tacatgcccc tgctgaactc gctggcagcc tatgggtggc agctcacctg
     1381 tgtgctgcca acacccatac tcaagactaa cagggaaggg aacgtgtgca ccaagcagat
     1441 tgtgtttctc cagagaccat gtctacctca gaaaaccaag aagagggagt ccaagttcca
     1501 gtggcggttc tcccggaacg acatccacag caggcagaca aggaaatcca aagggaaacc
     1561 cagcgccgga gacaagcagc aagcggaaga gaacgagaag aatctagacg accagttctc
     1621 cagggctgga gatgcgggaa actgtgtgct gggggcacag cagtggggca gagcctctga
     1681 ggtcagggag caaaggccgg gctcagccgc cgtgcagaac ggccccgctg gccacaacag
     1741 ggactcggtg acccttaggc actcgaatcc cagagcagag gctgagctgg ttccaggccc
     1801 cgctccaaca gaagcaaatt gagtcagtag tttgtgccag gcctgcattg tgattgcaaa
     1861 ccttgggaag cttgctagca gctggtttgt tctgtgttgt taccgtttgg cttgacctcc
     1921 cattgttagc ccaatggccc tgtgagggcg ggtctccgaa ggtggtgttt tctgcacatc
     1981 cactggaaag ctgtcttaat gacccactta tattagaggg caaggttggg ccgttcctcc
     2041 tagacctcag ggctggaggc ctggctccgg tcccgcccct tccacaaggg aaggtatggg
     2101 ccacagtgcc tgcgctgccc cacagggcgc cagagcacat ctgggtcaac ttctgggaca
     2161 tccttcgcta caaaccaagg tttttctgct cactcctacg tgctgctgct ctgggcaaga
     2221 acttagtgac tttaaccctg cagcctgccg gctggcctct ccacctgaac tctggagacc
     2281 ctgctgatgt ggaaggcaga gatgttggag aggaagcctc ctgcctgtct taagatagtt
     2341 ataaataggg gttggggatt tggctcagtg gtagagcact tgcctagcaa gcgcaaggcc
     2401 ctgggttcgg tccccagctc cagaaaaaaa aaaaaaaaga agaagaaaaa gatagttata
     2461 aatactggcg atctggaagc aaacaggtaa ttccctacgg cccggctctt gttcaagaaa
     2521 gtattctgtg ttaatgttaa tgccaaaaaa aatgttttta aattttgtct tcaacacatg
     2581 tacgaatatg ttgtcatttt tgagcagttg gtaactgggt gccctcgtgt gctatttctg
     2641 ttgacgtgtc attgactgag ttgtacgccg tgcctgtcac atgtttaaac tgtccataaa
     2701 gtgttgttaa ggctttaagt agaagcatct ggcaaaccgt ggagagagaa caccagttgt
     2761 ctcaatggaa acagccctgt ctctttcttg tttagttatt taaagcaata aaatgacctg
     2821 agttta
//
