LOCUS       NM_021849               1719 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus RFNG O-fucosylpeptide
            3-beta-N-acetylglucosaminyltransferase (Rfng), mRNA.
ACCESSION   NM_021849
VERSION     NM_021849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Kakuda,S. and Haltiwanger,R.S.
  TITLE     Deciphering the Fringe-Mediated Notch Code: Identification of
            Activating and Inhibiting Sites Allowing Discrimination between
            Ligands
  JOURNAL   Dev Cell 40 (2), 193-201 (2017)
   PUBMED   28089369
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Fiuza,U.M. and Arias,A.M.
  TITLE     Cell and molecular biology of Notch
  JOURNAL   J Endocrinol 194 (3), 459-474 (2007)
   PUBMED   17761886
  REMARK    Review article
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Yang,L.T., Nichols,J.T., Yao,C., Manilay,J.O., Robey,E.A. and
            Weinmaster,G.
  TITLE     Fringe glycosyltransferases differentially modulate Notch1
            proteolysis induced by Delta1 and Jagged1
  JOURNAL   Mol Biol Cell 16 (2), 927-942 (2005)
   PUBMED   15574878
REFERENCE   4  (bases 1 to 1719)
  AUTHORS   Mikami,T., Ohnaka,Y., Nakamura,A., Kurosaka,A. and Itoh,N.
  TITLE     Radical fringe negatively modulates Notch signaling in postmitotic
            neurons of the rat brain
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 138-144 (2001)
   PUBMED   11165380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 25, 2022 this sequence version replaced NM_021849.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016486.1, SRR26360186.2392402.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               JAXUCZ010000010.1  106548323-106548644 c
            323-371             JAXUCZ010000010.1  106548135-106548183 c
            372-474             JAXUCZ010000010.1  106547626-106547728 c
            475-628             JAXUCZ010000010.1  106547372-106547525 c
            629-717             JAXUCZ010000010.1  106547015-106547103 c
            718-883             JAXUCZ010000010.1  106546768-106546933 c
            884-969             JAXUCZ010000010.1  106546380-106546465 c
            970-1719            JAXUCZ010000010.1  106545543-106546292 c
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1719
                     /gene="Rfng"
                     /note="RFNG O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:60433"
                     /db_xref="RGD:621322"
     exon            1..322
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1051
                     /gene="Rfng"
                     /EC_number="2.4.1.222"
                     /note="O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase"
                     /codon_start=1
                     /product="beta-1,3-N-acetylglucosaminyltransferase radical
                     fringe"
                     /protein_id="NP_068621.1"
                     /db_xref="GeneID:60433"
                     /db_xref="RGD:621322"
                     /translation="MSRVRRVLCRACLALAAVLAVLLLLPLPLPLPLPLPRAPAPDPG
                     RVPTGSLTLEVSRLQPDDVFIAVKTTRKNHGPRLRLLLRTWISRAPRQTFIFTDGDDP
                     ELQLLAGSQMINTNCSAVRTRQALCCKMSVEYDKFIESGRKWFCHVDDDNYVNPKSLL
                     HLLSTFSSNQDIYLGRPSLDHPIEATERVQGGGTSNTVKFWFATGGAGFCLSRGLALK
                     MSPWASLGSFMSTAERVRLPDDCTVGYIVEGLLGARLLHSPLFHSHLENLQKLPSGAV
                     LQQVTLSYGGPENPHNVVNVAGSFSIRQDPTRFQSVHCLLYPDTHWCPMKNRGKEAFQ
                     "
     exon            323..371
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            372..474
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            475..628
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            629..717
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            718..883
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            884..969
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1719
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcaatcg caggcgggcg cccagcgccc gggcctgggc gatcgcatga gccgtgtgcg
       61 gcgagtgctg tgccgggcct gcctcgcgct ggccgcggtc ctggctgtgt tgctgctact
      121 accgctgccg ctaccactac cgctgccgct gcctcgcgct cccgcaccag acccaggtcg
      181 tgtcccgacc gggagcctga ccctcgaggt ctcccgcctg caaccggacg acgtcttcat
      241 tgcagtcaag accactcgga agaaccacgg cccgcgcctg cggctgctgt tgcgtacctg
      301 gatctcacga gccccacggc agacgttcat tttcaccgat ggagacgacc ctgagctcca
      361 gctgctggca ggcagccaaa tgatcaacac caattgttcc gctgtgcgaa cccgccaggc
      421 gctgtgctgt aagatgtcag tggagtatga caagttcata gagtctggac ggaaatggtt
      481 ctgccacgtg gatgatgaca actacgtgaa ccccaaaagc ctgctgcacc tgctttccac
      541 cttctcttcc aaccaggaca tctacctggg gcgacctagt ctggaccacc ccatcgaagc
      601 cacagagagg gtccagggcg gtggcacctc aaacacagtg aaattctggt ttgctactgg
      661 tggggctggg ttctgcctga gcaggggcct tgccctcaaa atgagcccgt gggccagcct
      721 aggcagtttc atgagcacag cagaacgggt tcgactgcct gacgactgca cggtgggata
      781 cattgtggaa gggctcctgg gtgcccgtct gcttcatagc cccctgttcc actcccacct
      841 ggagaacttg cagaagctgc cgtctggtgc tgttctgcag caggttaccc tgagctatgg
      901 gggtcctgag aacccgcaca acgtggtgaa tgtagctgga agtttcagca ttcgacagga
      961 ccctacacgg tttcagtcag tgcactgcct tctctaccca gacacccact ggtgtcctat
     1021 gaagaacagg ggtaaggaag cttttcagta actggtgacc cccggtggct gctttacctg
     1081 gctccctcag gccttggatt caggcagtca gcagaagctg cttgaaggcc tcccatgacc
     1141 tcggtcctgg ttggacacca ggtaccttgg gaaaatgaga caaccgggct gtgcctgctg
     1201 agatcatcca ggaagagaga gaagggccaa gctgctgaga cattgacgcc tctagccaag
     1261 cccagaggtc cttctcgtgg ataaggtcta ctaccccagc taccccatga ctgtggccca
     1321 ggaggggact ggttcccagc ctcccacagc tgcagcctgt cctcgactgc agaagatggt
     1381 gccaacgggt tggccattaa ggggtgggct tcagacctgg ccactggctc ttgctggagg
     1441 gctcaaagag ctaccactaa agccagaatg ctcagactgt gtggccggtg gacactgagg
     1501 accagcttca aggctgtgct cccacgcagg gctgttgttc ttccattacc cccatccttc
     1561 ctctaacctg gtattcagga tgcttcccct ctgagcttcc catcactaga gcctctcctt
     1621 tgggctcctc aggagcaaga tgcaggccca tcagctttta caggggttcc ccatggggaa
     1681 gtggttacag tgttgttgag taaaggcttg tcattctta
//
