LOCUS       NM_053547               4741 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus replication factor C subunit 1 (Rfc1), mRNA.
ACCESSION   NM_053547 XM_001078203 XM_214035
VERSION     NM_053547.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4741)
  AUTHORS   Kasavi,C.
  TITLE     Idiopathic Pulmonary Arterial Hypertension: Network-Based
            Integration of Multi-Omics Data Reveals New Molecular Signatures
            and Candidate Drugs
  JOURNAL   OMICS 27 (7), 315-326 (2023)
   PUBMED   37410515
REFERENCE   2  (bases 1 to 4741)
  AUTHORS   Schmitt,G.D.S., Lima,F.D., Matos,P.C.A.A.P., Martinez,A.R.M.,
            Gonzalez-Salazar,C., Nucci,A., Marques,W. Jr., Barsottini,O.G.P.,
            Pedroso,J.L. and Franca,M.C. Jr.
  TITLE     Dysautonomia in RFC1-related disorder: Clinical and
            neurophysiological evaluation
  JOURNAL   Clin Neurophysiol 142, 68-74 (2022)
   PUBMED   35970061
REFERENCE   3  (bases 1 to 4741)
  AUTHORS   Cortese,A., Tozza,S., Yau,W.Y., Rossi,S., Beecroft,S.J.,
            Jaunmuktane,Z., Dyer,Z., Ravenscroft,G., Lamont,P.J., Mossman,S.,
            Chancellor,A., Maisonobe,T., Pereon,Y., Cauquil,C., Colnaghi,S.,
            Mallucci,G., Curro,R., Tomaselli,P.J., Thomas-Black,G.,
            Sullivan,R., Efthymiou,S., Rossor,A.M., Laura,M., Pipis,M.,
            Horga,A., Polke,J., Kaski,D., Horvath,R., Chinnery,P.F.,
            Marques,W., Tassorelli,C., Devigili,G., Leonardis,L., Wood,N.W.,
            Bronstein,A., Giunti,P., Zuchner,S., Stojkovic,T., Laing,N.,
            Roxburgh,R.H., Houlden,H. and Reilly,M.M.
  TITLE     Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to
            RFC1 repeat expansion
  JOURNAL   Brain 143 (2), 480-490 (2020)
   PUBMED   32040566
REFERENCE   4  (bases 1 to 4741)
  AUTHORS   Cortese,A., Simone,R., Sullivan,R., Vandrovcova,J., Tariq,H.,
            Yau,W.Y., Humphrey,J., Jaunmuktane,Z., Sivakumar,P., Polke,J.,
            Ilyas,M., Tribollet,E., Tomaselli,P.J., Devigili,G., Callegari,I.,
            Versino,M., Salpietro,V., Efthymiou,S., Kaski,D., Wood,N.W.,
            Andrade,N.S., Buglo,E., Rebelo,A., Rossor,A.M., Bronstein,A.,
            Fratta,P., Marques,W.J., Zuchner,S., Reilly,M.M. and Houlden,H.
  TITLE     Biallelic expansion of an intronic repeat in RFC1 is a common cause
            of late-onset ataxia
  JOURNAL   Nat Genet 51 (4), 649-658 (2019)
   PUBMED   30926972
  REMARK    Erratum:[Nat Genet. 2019 May;51(5):920. PMID: 31028356]
REFERENCE   5  (bases 1 to 4741)
  AUTHORS   Li,B., Sun,L., Cai,J., Wang,C., Wang,M., Qiu,H. and Zuo,Z.
  TITLE     Modulation of the DNA repair system and ATR-p53 mediated apoptosis
            is relevant for tributyltin-induced genotoxic effects in human
            hepatoma G2 cells
  JOURNAL   J Environ Sci (China) 27, 108-114 (2015)
   PUBMED   25597668
REFERENCE   6  (bases 1 to 4741)
  AUTHORS   Hong,S., Park,S.J., Kong,H.J., Shuman,J.D. and Cheong,J.
  TITLE     Functional interaction of bZIP proteins and the large subunit of
            replication factor C in liver and adipose cells
  JOURNAL   J Biol Chem 276 (30), 28098-28105 (2001)
   PUBMED   11356826
REFERENCE   7  (bases 1 to 4741)
  AUTHORS   Takeoka,H., Iehara,N., Uematsu-Yanagita,M., Abe,H., Sunamoto,M.,
            Yamada,Y., Kita,T. and Doi,T.
  TITLE     A multifunctional transcription factor (A1p145) regulates the
            smooth muscle phenotype in mesangial cells
  JOURNAL   Biochem Biophys Res Commun 252 (2), 290-295 (1998)
   PUBMED   9826522
REFERENCE   8  (bases 1 to 4741)
  AUTHORS   Pei,L.
  TITLE     Molecular cloning of a novel transcriptional repressor protein of
            the rat type 1 vasoactive intestinal peptide receptor gene
  JOURNAL   J Biol Chem 273 (31), 19902-19908 (1998)
   PUBMED   9677428
REFERENCE   9  (bases 1 to 4741)
  AUTHORS   Ellison,V. and Stillman,B.
  TITLE     Reconstitution of recombinant human replication factor C (RFC) and
            identification of an RFC subcomplex possessing DNA-dependent ATPase
            activity
  JOURNAL   J Biol Chem 273 (10), 5979-5987 (1998)
   PUBMED   9488738
REFERENCE   10 (bases 1 to 4741)
  AUTHORS   Levavasseur,F., Burbelo,P.D., Cariou,S., Lietard,J., Yamada,Y. and
            Clement,B.
  TITLE     Nuclear recruitment of A1p145 subunit of replication factor C in
            the early G1 phase of the cell cycle in Faza 567 hepatoma cell line
            and hepatocyte primary cultures
  JOURNAL   FEBS Lett 363 (1-2), 132-136 (1995)
   PUBMED   7729533
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF059678.1, CV110819.1, AF030050.1, AW144844.1, BM391856.1,
            CO559697.1, CB608083.1 and BM385730.1.
            
            On or before Jun 5, 2008 this sequence version replaced
            XM_214035.4, XM_001078203.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1824              AF059678.1         8-1831
            1825-2450           CV110819.1         69-694
            2451-2615           AF030050.1         2371-2535
            2616-2919           AW144844.1         120-423
            2920-3452           BM391856.1         13-545              c
            3453-3926           CO559697.1         169-642
            3927-4468           CB608083.1         34-575
            4469-4741           BM385730.1         1-273               c
FEATURES             Location/Qualifiers
     source          1..4741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4741
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /note="replication factor C subunit 1"
                     /db_xref="GeneID:89809"
                     /db_xref="RGD:620619"
     exon            1..86
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..3479
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /note="replication factor C 1; replication factor C
                     (activator 1) 1"
                     /codon_start=1
                     /product="replication factor C subunit 1"
                     /protein_id="NP_445999.1"
                     /db_xref="GeneID:89809"
                     /db_xref="RGD:620619"
                     /translation="MDIRKFFGVISSGKKPVNETVKKNEKTKPSEGTVKGKQGVKEAK
                     VNNPCKEDASRPKQHNKKKRIIYDSDSESEETVQVKNAKKKSEKLPVSCKPGKISRKD
                     PVTYISETDEDDDFLCKKAASKSKENGVSTNSYLGASNVKKNEENTKTKSKPLSPIKL
                     TPTSVLDYFGTESVQRSGKKMVASKKKESSQTPDDSRLNDEAIAKQLQLDEDAELERQ
                     LHEDEEFARTLALLDEEPKTKKARKDSEEGESFSPAKAELSKAAKQKSPANEHFSIGR
                     KTYSPAKYGKGRGSEGTKQPCRSAHQKEACSSLKASSKSALMKAQEENSYKETELLAA
                     KRESAIEPKGEKTTPRKTKGSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALGSK
                     EIPKGAENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSG
                     QSKSDKAAALGTKILDEDGLLDLIRTMPGKKSKYEIAAEAEMKKEKSKLERTPQKNDQ
                     GKRKLSPTKRELEPKKSKLTPLKHSPRKAVKEEERVCPRGLDAKEPHGSHSASREECL
                     LWVDKYKPTSLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAAKFGKVASKDDGS
                     SFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAIVAESLNNTSIK
                     GFYTSGASPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHP
                     KIRSLVHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLH
                     NLSMWCAQSKVLTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGEETAHMSLMDKSDLF
                     FHDYSIAPLFVQENYLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWS
                     LLPTQAIYASVVPGELMRGYMSQFPSFPSWLGKHSSMGKHDRTVQDLSLHMSLRTYSS
                     KRTVNMDYLSHIRDALVRPLTSQGVEGVQRVVTLMDTYYLVKEDFDNIMEVSSWGGKP
                     STFSKLDPKVKAAFTRAYNKEAHLTPYSLQVVKASRPSIGPALDSEYNEESQEDATQS
                     DEKEQDALETDAMIKQKKTRSSKPSKSEKEKESKKGKGKNSKK"
     exon            87..215
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..291
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..414
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..647
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..725
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..803
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..891
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1163
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1271
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1451
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1556
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1914
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2027
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2142
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2234
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2372
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2468
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2567
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2722
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2840
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2986
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3200
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3392
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..4725
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaatgtat tccgagcggc gataacggat acccctccag tcacgggcct gcccacctgc
       61 tcctgttcgg tcgtggggct gcgatggaca ttcggaaatt ctttggggtt atatcaagtg
      121 gaaaaaagcc tgtaaatgag acagtaaaga agaatgagaa gacaaaacct tcggagggca
      181 ctgtcaaagg aaagcaagga gtaaaggaag ccaaggttaa taatccctgc aaagaggatg
      241 cctccagacc aaagcagcac aacaagaaaa agaggatcat ctatgactca gattcagaat
      301 cagaggagac agtgcaagta aaaaatgcta aaaagaaatc agaaaaattg ccagtgtctt
      361 gtaaacctgg taaaatctct cggaaggatc ctgttaccta tatttctgag acagatgaag
      421 acgatgactt tttatgtaaa aaggcagcct ccaaatcaaa agagaatgga gtatctacaa
      481 acagttacct tggagcatca aacgtgaaaa agaatgaaga aaacactaag actaagagta
      541 aaccgttatc accaataaaa ctaacaccga catcagtgct tgattatttt ggaactgaaa
      601 gtgtccagag atctgggaag aagatggtgg cgagcaaaaa gaaagagtct tctcaaaccc
      661 cagatgattc cagattaaat gatgaggcca tcgccaagca gcttcagctt gatgaagatg
      721 cagagctgga gaggcagttg catgaagatg aagaatttgc aagaacactg gccttgttgg
      781 atgaagaacc taagaccaaa aaggctcgaa aggactctga agagggagaa tcattttcac
      841 ctgccaaagc tgagttaagc aaagcagcaa agcagaagag ccctgctaac gagcatttct
      901 caattggaag aaagacctac agtcctgcta agtacggcaa gggtagaggc tcagaaggca
      961 ccaagcagcc ctgcagatca gctcaccaga aggaagcctg ctcctctctc aaggccagct
     1021 ccaagtcggc tcttatgaaa gcacaagaag aaaattctta caaagaaaca gaactgctgg
     1081 ctgcaaaaag agaaagtgcc attgagccca aaggagagaa aacaactcct aggaaaacga
     1141 aaggctctcc aactaaaaga gagtctgtaa gcccagaaga ttctgaaaag aagcgcacca
     1201 attatcaagc ttatcgaagc tacttaaatc gagaaggtcc caaagccctg ggctccaaag
     1261 aaatacccaa gggagctgaa aactgcttgg agggcctgac gttcgtgatc accggagtgc
     1321 tggagtccat cgaacgagaa gaagccaagt ctctaattga acgttatggg gggaaagtaa
     1381 caggaaacgt gagcaagaaa accagctacc tcgtcatggg ccgggacagc gggcagtcca
     1441 agagtgacaa ggcagcagct ctgggaacaa aaatccttga tgaagacggc ctgttggatc
     1501 tgattcgaac tatgccgggc aaaaaatcca agtacgaaat cgctgctgag gctgagatga
     1561 agaaagaaaa gtccaaattg gagagaacac cccaaaaaaa tgatcaggga aaaagaaaac
     1621 ttagtccaac caagagggag ttggagccta aaaagagcaa gctgactccc cttaagcaca
     1681 gccctcggaa ggcagtgaag gaggaggaac gtgtgtgtcc gaggggcttg gacgccaagg
     1741 agcctcatgg cagccacagt gccagcagag aggagtgcct gctctgggtg gataagtaca
     1801 agcccacctc actcaagaac ataatcggac agcagggtga ccagagctgt gccaacaaac
     1861 tgctacgctg gctcagaaac tggcacaaga gttctccaga agagaaaaag catgcagcaa
     1921 aatttggcaa agttgccagc aaagatgatg gctccagttt caaggcagca ctgctgtctg
     1981 gccctccagg tgttggcaaa accactacag cttctcttgt gtgtcaggaa ttgggctaca
     2041 gttatgtgga actaaatgcg agtgatactc ggagtaagaa cagtctgaaa gcaattgttg
     2101 ctgagtcatt gaacaacacc agcatcaaag gcttttatac aagtggagca tctccttctg
     2161 taagtgcgag gcatgctctc atcatggatg aagttgatgg catggcgggc aatgaggaca
     2221 ggggtggaat tcaggagcta ataggcctga taaagcatac gaaaattccc atcatttgta
     2281 tgtgcaatga tagaaatcac cccaaaatcc gctcattggt tcattattgt tttgatcttc
     2341 gtttccaaag acctcgagtt gaacagatta agagtgcaat gctgtctatt gcatttaaag
     2401 agggattaaa gatcccacct ccagctatga atgaaataat tttgggagct aatcaagatg
     2461 tcagacaggt tttacacaat ctcagtatgt ggtgtgcaca gagtaaggtc ctaacctatg
     2521 accaagccaa ggctgattct cagagggcca agaaggacat cagattgggc ccatttgatg
     2581 tcacccggaa agtgtttgca gctggagagg agactgcaca catgtcactg atggacaaat
     2641 cggatctctt tttccatgac tattccattg cacccctctt tgtccaggag aactacctcc
     2701 atgtaaagcc tgtggctgca gggggtgaca tgaaaaagca cttgatgctt ttaagccggg
     2761 cagcagatag catatgtgac ggtgacttag tggacaatca gatccggagt aagcaaaact
     2821 ggagtcttct gcccacacag gccatttacg ccagcgttgt tcctggagag ttgatgaggg
     2881 gctacatgtc tcagtttccc agcttcccaa gctggctggg aaagcactcg tctatgggca
     2941 agcatgatcg gactgttcag gacctgtcct tgcacatgag tcttagaact tactccagca
     3001 aaaggacagt gaacatggat tacctgtcac acatcagaga cgcacttgta cgacccttga
     3061 cctcacaagg agtagaaggg gttcagcgtg ttgtcacact tatggataca tactatttgg
     3121 tgaaagaaga ttttgacaac atcatggaag ttagcagctg ggggggcaag cccagtacct
     3181 tttccaagct ggaccccaag gtgaaagcag ccttcacaag agcctataat aaggaggccc
     3241 acctgacccc atactcactt caggtggtaa aggcatcgag gcccagcata ggtccagcac
     3301 tggattctga gtacaatgaa gagtcacagg aagatgccac tcagtctgat gagaaagagc
     3361 aggatgccct agagactgat gccatgatca agcagaaaaa gacgagatct tcaaagcctt
     3421 caaaatcaga aaaagagaag gagtccaaaa aaggaaaagg aaaaaattcg aagaaatgaa
     3481 gcccttgttc attaccaata actgctttta acttaccctc tcgactaatt cagctggtct
     3541 agagaccgaa agcctcaccc tttgccagag taacaggttt ggtgtagcac agtggagtgg
     3601 cctggtggtc tcattgtaaa ggacggtaca gcgagaaggt ctatagccag ctctcgtgca
     3661 cctcttatag aggaggacag gactgtctca gccctgcagt gcccttgcca actgttagac
     3721 tgctgggact cgaggtgact taagactcaa aagtagaagt gcacaggtgt tggagtcaga
     3781 ttttagttga ccataccaag actgggtgca gcaggactga ggcctcttct gtagcttaag
     3841 tctatcccag tggccttaga gggccaacgc ttaagtttat tccaatggcc ttagagggct
     3901 gatgctgttt ttttgttttt tttttttgtt ttttttttta aaaaacatgg tagctcttat
     3961 tttatggtca aactgtaaat aaaccttaat ccaaagcacc catcagctgg agccgagcat
     4021 tcttggtctg tagtcaggta tctcgcaaag agtgcatcag gaatcaggtg tccatgtgat
     4081 gcatgggtca cttttgtcac cttgaagagc aaactattat gctggtataa tactctcctt
     4141 attaatttgg ttggattaca atattcagca tttcttacta actctgtgaa ttgcagttct
     4201 gcaagtgaag ggtcagagct caagttccca gcatcccttt gcactgacca cattgctgct
     4261 gtaggtagtc tcaggccact tggctagtca gggtgagtag acacgggact gctacacatt
     4321 cctgtccccg tgcagtctta accctcaggt tgaaacagag tctaggctgg gtcagaccca
     4381 caggctcatt ctggccggga aatgctgtcc tgtgatggcg tctataagcc ctactggaat
     4441 ttcagattgt gtctagaact gtgcttgttg aaggaccctg agctgtggcc ataacctggc
     4501 ctttagctgt ttagttcttt ttaaatcaga aagtgctcag aggtctatgc tgcctctgtg
     4561 aggtaaatgc caaaaagaat ataaaggaag gaccatgctc tgtctctgag gactcatggc
     4621 attgttggga gacgagacct ggagacgttg aaagtgtgtt aaccagtgga gtgtgtttcg
     4681 tggagatcgg ttcattatgg aaataaaaca ctgcttaagc ctgagaaaaa aaaaaaaaaa
     4741 a
//
