LOCUS       NP_445999               1131 aa            linear   ROD 03-APR-2024
DEFINITION  replication factor C subunit 1 [Rattus norvegicus].
ACCESSION   NP_445999 XP_001078203 XP_214035
VERSION     NP_445999.1
DBSOURCE    REFSEQ: accession NM_053547.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1131)
  AUTHORS   Kasavi,C.
  TITLE     Idiopathic Pulmonary Arterial Hypertension: Network-Based
            Integration of Multi-Omics Data Reveals New Molecular Signatures
            and Candidate Drugs
  JOURNAL   OMICS 27 (7), 315-326 (2023)
   PUBMED   37410515
REFERENCE   2  (residues 1 to 1131)
  AUTHORS   Schmitt,G.D.S., Lima,F.D., Matos,P.C.A.A.P., Martinez,A.R.M.,
            Gonzalez-Salazar,C., Nucci,A., Marques,W. Jr., Barsottini,O.G.P.,
            Pedroso,J.L. and Franca,M.C. Jr.
  TITLE     Dysautonomia in RFC1-related disorder: Clinical and
            neurophysiological evaluation
  JOURNAL   Clin Neurophysiol 142, 68-74 (2022)
   PUBMED   35970061
REFERENCE   3  (residues 1 to 1131)
  AUTHORS   Cortese,A., Tozza,S., Yau,W.Y., Rossi,S., Beecroft,S.J.,
            Jaunmuktane,Z., Dyer,Z., Ravenscroft,G., Lamont,P.J., Mossman,S.,
            Chancellor,A., Maisonobe,T., Pereon,Y., Cauquil,C., Colnaghi,S.,
            Mallucci,G., Curro,R., Tomaselli,P.J., Thomas-Black,G.,
            Sullivan,R., Efthymiou,S., Rossor,A.M., Laura,M., Pipis,M.,
            Horga,A., Polke,J., Kaski,D., Horvath,R., Chinnery,P.F.,
            Marques,W., Tassorelli,C., Devigili,G., Leonardis,L., Wood,N.W.,
            Bronstein,A., Giunti,P., Zuchner,S., Stojkovic,T., Laing,N.,
            Roxburgh,R.H., Houlden,H. and Reilly,M.M.
  TITLE     Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to
            RFC1 repeat expansion
  JOURNAL   Brain 143 (2), 480-490 (2020)
   PUBMED   32040566
REFERENCE   4  (residues 1 to 1131)
  AUTHORS   Cortese,A., Simone,R., Sullivan,R., Vandrovcova,J., Tariq,H.,
            Yau,W.Y., Humphrey,J., Jaunmuktane,Z., Sivakumar,P., Polke,J.,
            Ilyas,M., Tribollet,E., Tomaselli,P.J., Devigili,G., Callegari,I.,
            Versino,M., Salpietro,V., Efthymiou,S., Kaski,D., Wood,N.W.,
            Andrade,N.S., Buglo,E., Rebelo,A., Rossor,A.M., Bronstein,A.,
            Fratta,P., Marques,W.J., Zuchner,S., Reilly,M.M. and Houlden,H.
  TITLE     Biallelic expansion of an intronic repeat in RFC1 is a common cause
            of late-onset ataxia
  JOURNAL   Nat Genet 51 (4), 649-658 (2019)
   PUBMED   30926972
  REMARK    Erratum:[Nat Genet. 2019 May;51(5):920. PMID: 31028356]
REFERENCE   5  (residues 1 to 1131)
  AUTHORS   Li,B., Sun,L., Cai,J., Wang,C., Wang,M., Qiu,H. and Zuo,Z.
  TITLE     Modulation of the DNA repair system and ATR-p53 mediated apoptosis
            is relevant for tributyltin-induced genotoxic effects in human
            hepatoma G2 cells
  JOURNAL   J Environ Sci (China) 27, 108-114 (2015)
   PUBMED   25597668
REFERENCE   6  (residues 1 to 1131)
  AUTHORS   Hong,S., Park,S.J., Kong,H.J., Shuman,J.D. and Cheong,J.
  TITLE     Functional interaction of bZIP proteins and the large subunit of
            replication factor C in liver and adipose cells
  JOURNAL   J Biol Chem 276 (30), 28098-28105 (2001)
   PUBMED   11356826
REFERENCE   7  (residues 1 to 1131)
  AUTHORS   Takeoka,H., Iehara,N., Uematsu-Yanagita,M., Abe,H., Sunamoto,M.,
            Yamada,Y., Kita,T. and Doi,T.
  TITLE     A multifunctional transcription factor (A1p145) regulates the
            smooth muscle phenotype in mesangial cells
  JOURNAL   Biochem Biophys Res Commun 252 (2), 290-295 (1998)
   PUBMED   9826522
REFERENCE   8  (residues 1 to 1131)
  AUTHORS   Pei,L.
  TITLE     Molecular cloning of a novel transcriptional repressor protein of
            the rat type 1 vasoactive intestinal peptide receptor gene
  JOURNAL   J Biol Chem 273 (31), 19902-19908 (1998)
   PUBMED   9677428
REFERENCE   9  (residues 1 to 1131)
  AUTHORS   Ellison,V. and Stillman,B.
  TITLE     Reconstitution of recombinant human replication factor C (RFC) and
            identification of an RFC subcomplex possessing DNA-dependent ATPase
            activity
  JOURNAL   J Biol Chem 273 (10), 5979-5987 (1998)
   PUBMED   9488738
REFERENCE   10 (residues 1 to 1131)
  AUTHORS   Levavasseur,F., Burbelo,P.D., Cariou,S., Lietard,J., Yamada,Y. and
            Clement,B.
  TITLE     Nuclear recruitment of A1p145 subunit of replication factor C in
            the early G1 phase of the cell cycle in Faza 567 hepatoma cell line
            and hepatocyte primary cultures
  JOURNAL   FEBS Lett 363 (1-2), 132-136 (1995)
   PUBMED   7729533
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF059678.1, CV110819.1, AF030050.1, AW144844.1, BM391856.1,
            CO559697.1, CB608083.1 and BM385730.1.
            
            On or before Jun 5, 2008 this sequence version replaced
            XP_214035.4, XP_001078203.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1131
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     Protein         1..1131
                     /product="replication factor C subunit 1"
                     /note="replication factor C 1; replication factor C
                     (activator 1) 1"
                     /calculated_mol_wt=125658
     Region          <19..562
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          397..475
                     /region_name="BRCT_RFC1"
                     /note="BRCT domain of replication factor C subunit 1
                     (RFC1) and similar proteins; cd17752"
                     /db_xref="CDD:349383"
     Site            order(409..411,418,431..435,447..453,456)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:349383"
     Region          566..>985
                     /region_name="PRK04195"
                     /note="replication factor C large subunit; Provisional"
                     /db_xref="CDD:235250"
     Region          897..1050
                     /region_name="RFC1"
                     /note="Replication factor RFC1 C terminal domain;
                     pfam08519"
                     /db_xref="CDD:462507"
     CDS             1..1131
                     /gene="Rfc1"
                     /gene_synonym="Recc1"
                     /coded_by="NM_053547.1:84..3479"
                     /db_xref="GeneID:89809"
                     /db_xref="RGD:620619"
ORIGIN      
        1 mdirkffgvi ssgkkpvnet vkknektkps egtvkgkqgv keakvnnpck edasrpkqhn
       61 kkkriiydsd seseetvqvk nakkkseklp vsckpgkisr kdpvtyiset dedddflckk
      121 aaskskengv stnsylgasn vkkneentkt kskplspikl tptsvldyfg tesvqrsgkk
      181 mvaskkkess qtpddsrlnd eaiakqlqld edaelerqlh edeefartla lldeepktkk
      241 arkdseeges fspakaelsk aakqkspane hfsigrktys pakygkgrgs egtkqpcrsa
      301 hqkeacsslk assksalmka qeensykete llaakresai epkgekttpr ktkgsptkre
      361 svspedsekk rtnyqayrsy lnregpkalg skeipkgaen clegltfvit gvlesieree
      421 akslierygg kvtgnvskkt sylvmgrdsg qsksdkaaal gtkildedgl ldlirtmpgk
      481 kskyeiaaea emkkekskle rtpqkndqgk rklsptkrel epkkskltpl khsprkavke
      541 eervcprgld akephgshsa sreecllwvd kykptslkni igqqgdqsca nkllrwlrnw
      601 hksspeekkh aakfgkvask ddgssfkaal lsgppgvgkt ttaslvcqel gysyvelnas
      661 dtrsknslka ivaeslnnts ikgfytsgas psvsarhali mdevdgmagn edrggiqeli
      721 glikhtkipi icmcndrnhp kirslvhycf dlrfqrprve qiksamlsia fkeglkippp
      781 amneiilgan qdvrqvlhnl smwcaqskvl tydqakadsq rakkdirlgp fdvtrkvfaa
      841 geetahmslm dksdlffhdy siaplfvqen ylhvkpvaag gdmkkhlmll sraadsicdg
      901 dlvdnqirsk qnwsllptqa iyasvvpgel mrgymsqfps fpswlgkhss mgkhdrtvqd
      961 lslhmslrty sskrtvnmdy lshirdalvr pltsqgvegv qrvvtlmdty ylvkedfdni
     1021 mevsswggkp stfskldpkv kaaftraynk eahltpyslq vvkasrpsig paldseynee
     1081 sqedatqsde keqdaletda mikqkktrss kpsksekeke skkgkgknsk k
//
