LOCUS       NM_001033884            2376 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus REX4 homolog, 3'-5' exonuclease (Rexo4), mRNA.
ACCESSION   NM_001033884 XM_231123
VERSION     NM_001033884.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Krishnamurthy N, Ngam CR, Berdis AJ and Montano MM.
  TITLE     The exonuclease activity of hPMC2 is required for transcriptional
            regulation of the QR gene and repair of estrogen-induced abasic
            sites
  JOURNAL   Oncogene 30 (47), 4731-4739 (2011)
   PUBMED   21602889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO563573.1, CB611468.1, CB800860.1, CB557415.1, BM391409.1 and
            AI059073.1.
            
            On Sep 30, 2005 this sequence version replaced XM_231123.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161820.1, SRR8487230.54348.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               CO563573.1         1-616
            617-1062            CB611468.1         102-547
            1063-1446           CB800860.1         18-401
            1447-1892           CB557415.1         212-657
            1893-2309           BM391409.1         59-475              c
            2310-2376           AI059073.1         1-67                c
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13-p12"
     gene            1..2376
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /note="REX4 homolog, 3'-5' exonuclease"
                     /db_xref="GeneID:311826"
                     /db_xref="RGD:1306220"
     exon            1..275
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1307
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /note="XPMC2 prevents mitotic catastrophe 2 homolog; REX4,
                     RNA exonuclease 4 homolog"
                     /codon_start=1
                     /product="RNA exonuclease 4"
                     /protein_id="NP_001029056.1"
                     /db_xref="GeneID:311826"
                     /db_xref="RGD:1306220"
                     /translation="MKTKATAPVPQPGPIRKLVRKKAKKKFKKSKALGGSGTPGSRPA
                     TVASRPPKAPENFSQNWKALQELLKRKSEAPEKPRISQLDDKIHHQIIQKNRKKTSDK
                     SKGDKRTEDDKPTRDSVTSAPKKVRKTPVPPTNASGTEQKKGAEKRTRSDLSSHQGDI
                     KHKGKAKEAAVILSQPTPTEEDIWFDDVDPDDIEAAVGPEAAMLVRKRLGQRTSTISL
                     VKEQAFGGLTKALALDCEMVGVGPKGEESIAARVSIVNQYGKCVYDKYVKPTEPVTDY
                     RTAVSGIRPENLKQGEEFEVVKKEVAAMLKGRILVGHALRNDLKVLFLEHPKKKIRDT
                     QKFKPFRSLVKSARPSLKQLSEKILGLRVQQAEHCSVQDAQAAMRLYIMVKRKWESIA
                     ADRRAPAATPHHCNEYA"
     exon            276..616
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            617..754
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            755..948
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1037
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1112
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1187
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..2360
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2337..2342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
     polyA_site      2360
                     /gene="Rexo4"
                     /gene_synonym="Xpmc2h"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 cacgcttgcc ccctgggtat gcttccgcgg tcaccagagt ctcttccttg ctggctcggg
       61 ctgcggagag cgagaagatg aagacgaagg ccaccgcgcc ggtgccccaa cctgggccta
      121 tccggaagct cgttaggaag aaagccaaga agaagttcaa gaagagcaaa gcgctgggag
      181 gaagtgggac tccgggaagc cgtcccgcaa ctgtggcaag ccgaccgccg aaggccccag
      241 agaacttttc tcaaaattgg aaggcgctgc aagagctgct gaaacgaaag tcagaggccc
      301 cagaaaaacc tcgtatctct caactggatg acaaaataca tcaccaaata atccagaaga
      361 acagaaaaaa aacctcagat aaatcaaagg gagacaagag gacagaagac gacaagccca
      421 ctagggattc tgttacatct gcacctaaga aggtcaggaa gacaccagta cctcccacaa
      481 atgcctctgg aacagagcag aagaaaggag ccgagaagag gacacgcagt gacctctctt
      541 ctcaccaagg ggacatcaag cataagggga aagctaagga ggcagctgtc atcctgagcc
      601 agcccacgcc cactgaggaa gacatctggt ttgatgatgt ggatccagat gatattgagg
      661 ctgctgtagg cccagaggca gccatgctgg tacggaagag actggggcag aggacaagta
      721 ccatctccct ggtgaaggaa caggcctttg gcggcttgac aaaagccttg gccctggatt
      781 gtgagatggt gggcgtgggt cccaaagggg aggagagcat cgcagcccgt gtgtccatcg
      841 tgaaccagta tgggaagtgt gtttatgaca agtacgtcaa gccaactgag ccagtgactg
      901 actacaggac agccgtcagt gggatccggc ctgagaacct gaagcaggga gaagagtttg
      961 aagttgtgaa gaaggaagtg gcagcaatgt tgaagggcag aatcctggtg gggcacgcgc
     1021 tccgcaatga tttaaaggtt ctgttccttg aacatccgaa aaagaaaatc agggacaccc
     1081 aaaaattcaa accgttcagg agtctagtaa agagtgcacg gccgtctctg aaacaacttt
     1141 ctgagaaaat tctggggctc agggtccaac aggcagagca ttgttcagtc caagatgccc
     1201 aagcagcaat gaggctttac atcatggtaa aacggaaatg ggagagcatt gctgcagacc
     1261 ggcgtgcccc agccgccact ccacaccact gcaacgagta tgcttagcac catcctgctg
     1321 tcgccgccac cctgtcctgc agtgactcct cgatccaggg gcagtgggat ggggttatga
     1381 agcctatcaa gtctctgctt agcagggact ctgtctctgg tgagcgttct cagagccatg
     1441 gctgcaggcc tgtggcatgt gagctactag aacttcctct tggactacta gggactggtc
     1501 ctgcacttgt gtgttgacgt agactggtca gatacagggc aggagtcagg ggtgtaggtt
     1561 cggaggagag agagcatcat tggaatgggt gagtgtgctg cagagcctgt gtctgctgac
     1621 cgcctgtgct accacttcac aaagagcaga gctggtttcc gccagagcac tcagcacctt
     1681 cccttaagga gcaagaagcg tcttctcttg caggtaaggg gaaaagctct gctggatcta
     1741 agggatccag gctaagggcg ttcagtttgc tgcaaaccag tctggcagcc cagcaactgc
     1801 ccattgagga tgttcttaaa gctactctgc tgaaggtact ttctcactcc tatgtccttt
     1861 gcttggccta agatgtcaaa gtccagtatg gtgttctcca agtagtcctt ggcgtgagcc
     1921 ttggggcaca ggtacaccca gaggtctaag accctatcta ccacctggaa aagtttaagc
     1981 agaaaggcca tcttcccact gtcctgccaa cagcttttct ggctagcaac aagtacagaa
     2041 tgaccagtga acttcatggg tttatgtgac aactcttaga acaggtgcag tcatgcatat
     2101 aatggcagat gtctgctttt ttttttttcc ctttcttttc ttttcttttc ttttcttttt
     2161 ttcggagctg gggaccgaac ccagggcctt gcgcttgtag gcaagcgctc taccactgag
     2221 ctaaatcccc aacccccgat gtctgctttt taacgtagct gtggactgag atgtgactca
     2281 gagagcactt gttcaatatg tatcagaccc tgggttcctt tcccagcact gtcaaaaata
     2341 aatagatgga taaaaatgga aaaaaaaaaa aaaaaa
//
