LOCUS       NM_001083966           10689 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus REV3 like, DNA directed polymerase zeta catalytic
            subunit (Rev3l), mRNA.
ACCESSION   NM_001083966 XM_228273
VERSION     NM_001083966.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10689)
  AUTHORS   Baranovskiy,A.G., Lada,A.G., Siebler,H.M., Zhang,Y., Pavlov,Y.I.
            and Tahirov,T.H.
  TITLE     DNA polymerase delta and zeta switch by sharing accessory subunits
            of DNA polymerase delta
  JOURNAL   J Biol Chem 287 (21), 17281-17287 (2012)
   PUBMED   22465957
REFERENCE   2  (bases 1 to 10689)
  AUTHORS   Takano,K., Lyons,M., Moyes,C., Jones,J. and Schwartz,C.E.
  TITLE     Two percent of patients suspected of having Angelman syndrome have
            TCF4 mutations
  JOURNAL   Clin Genet 78 (3), 282-288 (2010)
   PUBMED   20184619
REFERENCE   3  (bases 1 to 10689)
  AUTHORS   Hara,K., Hashimoto,H., Murakumo,Y., Kobayashi,S., Kogame,T.,
            Unzai,S., Akashi,S., Takeda,S., Shimizu,T. and Sato,M.
  TITLE     Crystal structure of human REV7 in complex with a human REV3
            fragment and structural implication of the interaction between DNA
            polymerase zeta and REV1
  JOURNAL   J Biol Chem 285 (16), 12299-12307 (2010)
   PUBMED   20164194
REFERENCE   4  (bases 1 to 10689)
  AUTHORS   Mekhail,K., Khacho,M., Carrigan,A., Hache,R.R., Gunaratnam,L. and
            Lee,S.
  TITLE     Regulation of ubiquitin ligase dynamics by the nucleolus
  JOURNAL   J Cell Biol 170 (5), 733-744 (2005)
   PUBMED   16129783
REFERENCE   5  (bases 1 to 10689)
  AUTHORS   Van Sloun,P.P., Varlet,I., Sonneveld,E., Boei,J.J., Romeijn,R.J.,
            Eeken,J.C. and De Wind,N.
  TITLE     Involvement of mouse Rev3 in tolerance of endogenous and exogenous
            DNA damage
  JOURNAL   Mol Cell Biol 22 (7), 2159-2169 (2002)
   PUBMED   11884603
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Apr 18, 2007 this sequence version replaced XM_228273.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               JAXUCZ010000020.1  44686940-44687395
            457-646             JAXUCZ010000020.1  44736427-44736616
            647-721             JAXUCZ010000020.1  44745558-44745632
            722-882             JAXUCZ010000020.1  44749557-44749717
            883-979             JAXUCZ010000020.1  44758267-44758363
            980-1074            JAXUCZ010000020.1  44763406-44763500
            1075-1179           JAXUCZ010000020.1  44764728-44764832
            1180-1264           JAXUCZ010000020.1  44765810-44765894
            1265-1413           JAXUCZ010000020.1  44765982-44766130
            1414-1533           JAXUCZ010000020.1  44773945-44774064
            1534-1771           JAXUCZ010000020.1  44777657-44777894
            1772-1914           JAXUCZ010000020.1  44781461-44781603
            1915-6061           JAXUCZ010000020.1  44782068-44786214
            6062-6993           JAXUCZ010000020.1  44788811-44789742
            6994-7076           JAXUCZ010000020.1  44791930-44792012
            7077-7202           JAXUCZ010000020.1  44793403-44793528
            7203-7395           JAXUCZ010000020.1  44798591-44798783
            7396-7507           JAXUCZ010000020.1  44800753-44800864
            7508-7623           JAXUCZ010000020.1  44802433-44802548
            7624-7742           JAXUCZ010000020.1  44808531-44808649
            7743-7861           JAXUCZ010000020.1  44810894-44811012
            7862-8003           JAXUCZ010000020.1  44813755-44813896
            8004-8248           JAXUCZ010000020.1  44814290-44814534
            8249-8357           JAXUCZ010000020.1  44815633-44815741
            8358-8564           JAXUCZ010000020.1  44819909-44820115
            8565-8674           JAXUCZ010000020.1  44822608-44822717
            8675-8789           JAXUCZ010000020.1  44827012-44827126
            8790-8927           JAXUCZ010000020.1  44831133-44831270
            8928-9118           JAXUCZ010000020.1  44832171-44832361
            9119-9365           JAXUCZ010000020.1  44832940-44833186
            9366-9575           JAXUCZ010000020.1  44835268-44835477
            9576-10689          JAXUCZ010000020.1  44843555-44844668
FEATURES             Location/Qualifiers
     source          1..10689
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..10689
                     /gene="Rev3l"
                     /note="REV3 like, DNA directed polymerase zeta catalytic
                     subunit"
                     /db_xref="GeneID:309812"
                     /db_xref="RGD:1307087"
     exon            1..456
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..9716
                     /gene="Rev3l"
                     /EC_number="2.7.7.7"
                     /note="REV3-like, polymerase (DNA directed), zeta,
                     catalytic subunit; REV3-like, catalytic subunit of DNA
                     polymerase zeta"
                     /codon_start=1
                     /product="DNA polymerase zeta catalytic subunit"
                     /protein_id="NP_001077435.1"
                     /db_xref="GeneID:309812"
                     /db_xref="RGD:1307087"
                     /translation="MFSVRIVTADYYMASPLPGLDICQSPLTQHPVKKVPVVRVFGAT
                     PAGQKTCLHLHGVFPYLYVPYDGYGQQPERYLSQMALSIDRALNVALGNPSSTAQHVF
                     KVSLVSGMPFYGYHEKERHFMKIYLYNPAMVKRICELLQSGAIMNKFYQPHEAHIPYL
                     LQLFIDYNLYGMNLINLAAVKFRKARRKGDASHATGLFKPQLSGNSPAGTLFRWEEDE
                     IPSSLLLEGVEPLSTCELEVDAVAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRN
                     ENSQISQPESQDCRLVPATESEKIFQKRLQEILKQNDFSVTLSGSVDYSSGSQEFSAE
                     LTLHSEILSPEMLPCSPANMIEVHRDNDWSKGNTKHKVEEALINEEAILNLIENSQTF
                     QPLTQRLSETPVFMDSSPDESLVHLLAGLESDGYQGEKNRMPLPRHTFGESQNPQNSD
                     DEENAPQMEKEEMELSVLMSQRWDSDTEEQCAKKRSLCRNAHRSSTEEDDSSSEEEME
                     WTDNSLLFANLSIPQLDGTADENSDNPLNNENSRAHSSVIATSKLSVRPSVFHKDAAT
                     LEPPSSAKITFQCKHTSALSSHGLNKDDLIEGLSQPNNTEKGRDSSVTFTKESTYSMK
                     YSGSLSSTVHSDNSHKEICKKDKSLPVPSCESSVFDYEEDIPSVTRQAPSRKYSNMRK
                     IEKDAPFIHANRHTSESTLGKNSFNFADLNHSKNKLSSEGNERGNSTALNSVFPSSLA
                     ESCDLLSSSGENRSVAHSLDSITDESGRSKLKIRYEEFQEHKMERPSLSQQAAHYMFF
                     PSVVLSNCLTRPQKLSPVTYKLQPGSKTSRLKLNKKKLISLQETSTKSSETGAAKDSC
                     THNHPYSGTPEKESGLSSDLIKATHGTFENKTPTEHFIDCHFGDGSLETEQSFGLYGN
                     KYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGENLDGTLKSRKRRKMSKKLPP
                     VIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSP
                     ATKYPIYPLTPKKSHRRKSKHKSAKRKPGKQHRASSENIKRTLSFRKKRTHAVLSPPS
                     PSYIAETEDCDLNYSDVMSKLGFLSERSTSPVNSSPPRCWSPTDPRAEEIMAAAEKES
                     VLFKGPNVCNTKTVSPRVGKASRARAQVKKSKARLAKSSVVTNKRNKRNQTNQLVDNG
                     KKKPRAKQKQRANEKGISRKPVIPTDETTKPPSEAELTPSQRSVPELTSSSGIHTLSK
                     QKEMTQTGPAMDHPLPPCQPTGINAQQRLSNCFSSFLESRKSVQFPTFPSSRGDSRSS
                     VYSSIGPGVSKVNTQRSHSQSAMFTRKETTLIQKSIFDLSNHLSQVAQSTQLCSGIIS
                     PKTEESSNTQKNCGSSIGKLNEYRSSLESKPEKVCAPNFLHCRDSQQQTVNVSEQSKP
                     SETCSPGNAASEESQTPNCFVTSLRSPIKQITWEQRQRGCILEMSSFKPEKVKQRSLS
                     EAISQTKALSQCKNQNVSTPSVFGEGQSGLAVLKELLQKRQQKAQTTNVQDSASSHQP
                     DKDISVSAEHKKTNKRTRAVASPRKPRAPRRTKPKEQTPRRLKVDPLNLQTSGHLDNS
                     LSDDSPILFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSLYSGSQFVPADQNL
                     PQKFLSDAVQDLFPGQAIEKNELLSHDRQSCTEEKHHVSDSGPWVRASTLNPELFEKV
                     GIDNNENHRHSQWKTSFHPLTSHSNSIMESFCVQQAESCLPEKSRLNRSSVSKEVFLS
                     LPQASSSDWIQGHNGKEIEQSLDSANTSFTTVLSSPDGELVDAASEDLELYVSRNNDV
                     LTPTPDSSPRSTSSPLQSKNGSFTPRTAHILKPLMSPPSREEIVATLLDHDLSEAIYQ
                     EPFCSNPSDVPEKPREIGGRLLMVETRLPNDLIEFEGDFSLEGLRLWKTAFSAMTQNP
                     RPGSPLRNGPAVVNKESSNSHKTVEDKKIVIMPCRYAPSRQLVQAWLQAKEEYVRSKR
                     LPRTESTPVIKSADNVSPSLNPGDTRAVAPQMDTCPHTLSSTAHAKEEVCQSQIALQT
                     SRTGCGQTVSASQTLLPAASAAVPEEEEEEEEEEEEEEEDENGYVSYSSPDSPGIPPW
                     QQAASPDFRALNGEHRCSSPVEELCSRAVENFLKPIKDGIQKASCCESQVISPIHART
                     RTEKCEPLCLHSTPVMPRKFLEKLPEATGLSPLSVEPKTQKLYNKKGSDTDHLRRVLL
                     TTQVENQFAAVNTPKKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVEL
                     HARTRRDLQPDPEFDPICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVTHQDIRCQ
                     TPLLIRSGVTGLEVTYAADEKALFQEVTNIMKRYDPDILLGYEIQMHSWGYLLQRAAA
                     LSVDLCQMISRVPDDKIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTN
                     YTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDL
                     IGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQC
                     VPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHIENLGKYDEFKFGCTS
                     LRVPPDLLYQIRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYRQD
                     RALSRMLNARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVN
                     DTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLP
                     CVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDIS
                     LIKQYVQRQCMKLVEGKASIQDFIFAKEYRGSFSYRPGACVPALELTRKMLAYDRRSE
                     PRVGERVPYVIVYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILPPLARIFSL
                     IGIDVFSWYQELPRIQKATSSSRSDLEGRKGTISQYFTTLHCPVCDGLTQHGICSQCR
                     SQPQHVAIILNQEIRELERQQEQLVKICRNCTGSFDRHIPCVSLNCPVLFKLSRVNRE
                     LSKAPYLRQLLDQF"
     exon            457..646
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            647..721
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            722..882
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            883..979
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1074
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1179
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1264
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1413
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1533
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1771
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1914
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..6061
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            6062..6993
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            6994..7076
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            7077..7202
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            7203..7395
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            7396..7507
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            7508..7623
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            7624..7742
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            7743..7861
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            7862..8003
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            8004..8248
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            8249..8357
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            8358..8564
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            8565..8674
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            8675..8789
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            8790..8927
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            8928..9118
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            9119..9365
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            9366..9575
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
     exon            9576..10689
                     /gene="Rev3l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccgaggag cccgtgtgat tcccggcggc ggcggccgtg gcggcagcag cagcggcacc
       61 acccgacccg acgaccgcgc gagggtttct ctccggctgc ctcttgccgg gagcgcctga
      121 ggaggcggcg gcagcccaca gtccccgcag cctctgcgcg ccgccgctcg tctcggcgtc
      181 cgtgcgaggg gcggggggcg gggaggtggg ggaagccgaa ccgaggagga aggggaggag
      241 gcgcctgtgc ggagcccgcc gccgccgctg ctgccaggtc gctgagtgga ggggaggcgg
      301 tggcggcggc ggcgaacatg ttttctgtga ggatagtgac tgccgactac tacatggcca
      361 gcccgctgcc ggggctggat atctgccaat cccccctcac ccagcaccct gtcaagaagg
      421 tgccggtggt acgagtcttc ggggcgaccc cggcaggtca gaagacgtgt cttcatctac
      481 atggcgtctt tccttacctc tatgtgccat acgatggcta tggacagcag ccagaacgct
      541 atctctctca gatggcactc agtatcgaca gagcacttaa tgtggcttta ggcaatccat
      601 cttccactgc tcagcatgtg ttcaaagtgt cattagtatc aggaatgcct ttttatggtt
      661 atcatgagaa ggaaagacac tttatgaaga tctatcttta caatcctgca atggtgaaaa
      721 ggatctgtga acttttgcaa agtggagcca taatgaataa attttaccag cctcacgaag
      781 cgcatattcc ctacctccta cagctcttca ttgactacaa tctttatgga atgaatttaa
      841 taaacctggc tgctgtcaag ttccgaaaag caagaaggaa aggtgatgcc tcgcatgcaa
      901 ctggattatt caagcctcag ttgtcaggaa attctcctgc tggcacttta tttaggtggg
      961 aagaggatga aataccaagt tctctactgc tggaaggtgt ggagcccctg agtacctgtg
     1021 agttagaagt ggacgccgta gctgctgaca tcttgaatag gctggatatt gaggctcaaa
     1081 ttggtggaaa ccctgggctg caggccatat gggaagatga aaaacagcga cgaagaaaca
     1141 ggaatgaaaa ctctcaaatt agccagccag aatcacaaga ttgcagactc gtgccagcaa
     1201 cagaaagtga aaaaattttt cagaagagac ttcaagaaat tctcaaacag aatgatttct
     1261 cagtaacact atcaggatct gtggactaca gcagtgggtc ccaggagttc tctgctgagt
     1321 taacattgca ctctgagatt ctgtctcctg aaatgcttcc ctgttcaccg gccaacatga
     1381 tagaagtcca cagagacaac gattggagca aaggtaacac taaacataaa gtagaagaag
     1441 cactcattaa tgaagaagca attttgaacc tcatagaaaa tagtcagact tttcagcctt
     1501 tgactcaaag actgagtgag acaccggttt tcatggacag tagtcctgac gagtcgctgg
     1561 tccatcttct tgctggtttg gaaagtgatg gataccaagg agaaaagaat aggatgccat
     1621 tacctcgtca cacgtttggg gaatctcaaa acccccaaaa cagtgacgat gaagagaatg
     1681 cgccccagat ggagaaggaa gagatggagc ttagtgtgct gatgtcccag agatgggaca
     1741 gcgatactga agaacagtgt gccaaaaaga ggtccctgtg cagaaatgcc cacagaagtt
     1801 ctactgaaga agatgactcg tcctctgagg aggaaatgga gtggactgat aatagtttgc
     1861 tttttgccaa tctctctata cctcagttag atggaactgc agatgaaaat agtgacaatc
     1921 cattgaacaa tgaaaattct agagcccact cttctgtgat cgcaacaagc aagctgtcag
     1981 taaggccctc cgtctttcac aaagatgctg ctacattaga acctccgtct tctgctaaga
     2041 ttaccttcca gtgtaaacac acaagtgccc tttcttccca tggtttaaac aaagatgact
     2101 taattgaagg cctctcacag ccaaacaata cagaaaaagg tcgagatagt tcagtcactt
     2161 ttacaaagga aagtacttac tccatgaaat actctggctc tttaagtagt actgttcatt
     2221 cagataattc tcataaagag atttgtaaga aagacaagtc tttgccggta ccttcctgtg
     2281 aaagcagtgt ttttgattat gaagaagata ttccatctgt tacaagacaa gcaccaagta
     2341 gaaagtactc gaacatgagg aagatcgaga aggatgcccc tttcatacat gctaaccgtc
     2401 acactagtga gagtacactg gggaaaaact ctttcaactt tgctgactta aatcattcaa
     2461 aaaataaatt gtcctctgaa ggaaacgaga ggggaaacag cacagctctc aatagtgtct
     2521 ttccctcgtc actagctgag agctgtgact tgttgtcgtc ctcaggggag aatagaagtg
     2581 tggctcattc cctcgatagc atcactgatg agagtggacg aagtaaactt aaaatcagat
     2641 acgaagagtt tcaagagcat aaaatggaga ggccaagcct cagccagcag gcagcacatt
     2701 atatgttttt ccccagtgtc gttctttcta attgtctcac caggccacag aaactgtctc
     2761 ctgtcaccta caaactacaa cctggcagta aaacatcccg gttaaaattg aataaaaaga
     2821 aattgataag tcttcaggaa acttctacca aaagtagtga aaccggagcc gcaaaagaca
     2881 gttgtacaca taatcatccg tacagcggta ctcctgagaa ggagagtggg ttgagcagtg
     2941 acttaattaa agccactcat gggacatttg aaaataaaac acctacagaa cactttatag
     3001 actgtcattt tggagatgga tctttagaaa ctgaacagtc ttttggacta tatggaaata
     3061 aatatactct tagagccaaa cgcaaggtga attatgaaac agaagacagt gagtcaagtt
     3121 ttgtaacaca caactcgaaa attagcctac ctcatcccat ggaaattggt gaaaacttag
     3181 atggaactct caaatcccga aaacgaagaa aaatgtctaa aaagctgccc cctgtcatta
     3241 taaagtatat tattattaat agatttagag ggaggaaaaa tatgcttgtg aagctaggta
     3301 aaatagattc taaagaaaaa caagtaatat taactgagga aaaaatggaa ctttataaaa
     3361 agcttgcacc tttgaaggat ttctggccaa aagttcctga ctcccccgca accaaatacc
     3421 ccatttatcc actaacacca aagaaaagtc acagaaggaa gtccaaacat aagtctgcta
     3481 agaggaagcc tggtaagcag cacagagcaa gcagtgaaaa cattaaaaga acgttatctt
     3541 tcagaaagaa acggacacac gctgttcttt ctcctccttc cccatcgtac attgctgaaa
     3601 ccgaagactg tgacttgaat tatagtgatg ttatgtcgaa gctaggcttt ctttctgaga
     3661 gaagcacaag ccctgtcaat tcttctccgc ctcgatgctg gtctcccaca gaccccagag
     3721 ccgaagaaat aatggctgct gcagaaaagg aatcagtgct ttttaagggt cctaatgtat
     3781 gtaatactaa gaccgtgagt cctcgagtgg gaaaagctag tcgagcaaga gcacaggtta
     3841 agaagtcaaa agcaagactc gctaagtcct ctgtagtcac taacaaaaga aacaagcgga
     3901 atcagacaaa tcaactagta gacaatggga aaaagaaacc aagggcaaag cagaagcaga
     3961 gagccaatga gaagggtata tcaaggaagc ctgtaatacc cacggacgag actacgaagc
     4021 ctccgtctga ggccgagctc acaccgagcc agcggagcgt gcctgagctt acgagtagtt
     4081 ctggcattca cacactttcc aaacagaaag agatgacaca gaccggtcct gccatggatc
     4141 atccacttcc tccttgccag cccactggga ttaatgctca acagcggctg tccaactgct
     4201 tttcctcttt cttagaaagc aggaagtctg tacagtttcc aacattcccc agttcaagag
     4261 gtgattcccg ttcctctgtt tatagttcta tagggcctgg agtctcaaaa gttaatactc
     4321 agagatctca tagtcaaagt gctatgttta ctcgaaagga aacaaccttg attcagaaaa
     4381 gcatatttga cctttctaac catttgtctc aggtagcaca gagcacgcag ttatgttcag
     4441 gtataatatc tccaaagaca gaggagagtt caaatacaca aaagaactgt gggtcatcta
     4501 ttggaaagtt aaatgagtat cgcagttccc tagagtcaaa gccagagaaa gtctgtgccc
     4561 ctaatttttt gcactgcaga gacagtcagc agcagactgt gaatgtgtca gaacagtcaa
     4621 aacccagtga aacctgttct ccgggaaatg cagcttctga ggagagccag acacctaact
     4681 gttttgtaac ttctttgaga agtcccatca aacaaataac atgggagcag agacagaggg
     4741 gctgtatttt agagatgtca agttttaagc ctgaaaaggt aaaacagagg tcattgtcag
     4801 aagcaatttc acaaaccaaa gcactatctc aatgtaaaaa tcaaaatgtg tcaacacctt
     4861 cagtatttgg tgaaggacag tctgggttag ctgttctaaa agaattgtta caaaaaagac
     4921 agcagaaagc acaaaccaca aatgtacaag attcggcatc tagtcatcag ccagataagg
     4981 atatttctgt ttctgctgag cacaagaaga caaataaacg gacacgagca gtagcatctc
     5041 caaggaaacc tcgagctccc aggagaacaa agcctaagga acaaaccccc agacgtctga
     5101 aagtggaccc tctaaacctg cagacctctg gccacttgga taactccctg tcagatgaca
     5161 gtcccatcct tttctcagat ccaggcttcg aaagttgtta ctcacttgaa gacagcctgt
     5221 ctcctgaaca taattataat tttgatatta acacaattgg tcagactggg ttttgcagct
     5281 tgtactctgg cagtcagttt gttccagctg accagaattt gccccagaag tttctaagcg
     5341 acgccgttca ggatctgttc ccaggacagg ctatagaaaa gaacgagctt ttaagtcatg
     5401 acagacagag ttgtactgag gaaaagcatc acgtctctga ctcaggccca tgggttagag
     5461 ccagtacttt gaaccctgaa ctttttgaga aagtaggtat agataacaat gagaatcatc
     5521 ggcacagcca atggaaaact agctttcacc ctctgacctc tcactctaac tcaataatgg
     5581 agtctttctg tgtccagcaa gcagaaagct gtctacctga aaaatcgaga ctgaatagga
     5641 gttcggtgag taaggaagtg tttctcagtc tcccgcaggc aagcagttca gactggattc
     5701 aaggtcataa cggaaaagaa atagaacagt cccttgactc agctaatacc tctttcacta
     5761 ccgtactttc ctcccctgat ggggaacttg tggatgcagc ttctgaagat ttagaattgt
     5821 acgtctcaag aaacaacgac gtgctgacac caacccctga tagttcaccc cggtctacca
     5881 gttctccctt acaatctaag aacggcagtt ttactcctcg aactgctcac attctgaaac
     5941 cgcttatgtc tccaccaagt agggaagaaa tcgtggcaac tttgctagac catgatcttt
     6001 cagaagctat atatcaggaa ccattttgca gtaatccttc ggatgtgcca gagaagccca
     6061 gggagattgg tggacggctc ctaatggtgg aaactcggct ccccaatgac ctgattgaat
     6121 ttgaaggaga cttctccttg gaaggacttc gcctatggaa aacagcgttc tcagcaatga
     6181 cgcagaatcc cagaccaggg tccccacttc gtaatggccc agcagttgtc aataaagagt
     6241 cgagcaatag ccataagacg gtggaagata aaaaaattgt aattatgcct tgcagatatg
     6301 ccccaagtag gcagctggtt caggcatggc ttcaggccaa agaagagtat gtgcgttcaa
     6361 agagactccc tagaacggag tcaactccag tgataaagtc cgctgacaac gtcagccctt
     6421 cacttaatcc gggtgacacc cgtgcagtgg ctccacaaat ggatacatgc ccacacacac
     6481 tgtcctctac agcacatgcc aaggaggaag tctgtcagtc tcagattgct ttgcagacat
     6541 caaggacagg ttgtggtcag acagtaagtg ccagtcagac actgctacca gctgcctctg
     6601 cagccgttcc tgaggaggag gaggaggagg aggaggagga ggaggaggag gaggaagatg
     6661 agaacggtta cgtgagttac agctcccctg attctccagg cattccacct tggcaacaag
     6721 cagcatcccc agatttcaga gcactaaacg gagagcatcg atgttcgtca ccggtcgagg
     6781 agctttgttc ccgagctgtt gagaacttct taaagcccat caaagatggt atccaaaaag
     6841 cctcctgttg tgagtctcaa gtaatctctc caatccatgc taggacaaga actgagaaat
     6901 gtgagcctct ttgccttcat agtacaccag ttatgccgag aaaatttctg gaaaagcttc
     6961 ctgaagcaac tggccttagc cctttatccg tagaaccaaa aacccagaag ttgtacaata
     7021 agaagggaag tgacactgac catcttcgga gagttctcct gacaacacaa gtggagaatc
     7081 agtttgcagc agtaaatact ccaaagaaag aaacttctca gattgatggg ccgtccttaa
     7141 acaacaccta tggtttcaaa gtcagcatac agaacttaca agaggcaaag gctttacacg
     7201 agatacaaaa tcttacctta atcagtgtgg agttacacgc acgaactaga agagacttac
     7261 aacctgatcc tgagtttgac ccaatctgtg ctttgttcta ctgcatttca tctgacactc
     7321 cactcccaga cacagaaaaa acagaactga ccggtgtaat agtgattgat aaagacaaga
     7381 cagtcaccca tcaagatatc agatgtcaga ccccattact tatcagatct ggagtcacag
     7441 gattagaagt gacctatgct gctgatgaga aggctctctt tcaagaagtt acgaatataa
     7501 tgaagaggta tgaccctgac attctactag gctatgagat tcagatgcac tcctggggct
     7561 acctcttgca gagggcggct gctctgagtg tggatttatg tcagatgatc tctcgagtgc
     7621 cagatgacaa aattgaaaac agattcgcag cggaaagaga tgactacggg tcagatacaa
     7681 tgagcgagat aaatattgtt ggaagaatta cgctgaacct ttggagaatc atgagaaatg
     7741 aggttgctct gactaactac acttttgaaa atgtgagctt tcatgttctg catcagcgtt
     7801 tccccctttt taccttccga gtcttgtcag actggtttga taacaagaca gatctctaca
     7861 gatggaaaat ggtcgatcat tatgttagcc gtgtccgtgg aaatctccag atgttagaac
     7921 agctggacct aattggaaaa accagtgaaa tggccagact ttttggcatt cagtttttac
     7981 atgtattaac aagagggtca cagtaccgtg tggagtcgat gatgttacgt attgctaaac
     8041 caatgaacta tatccctgtg acacctagtg ttcaacagag atcccaaatg agagctccac
     8101 agtgtgtgcc cctcattatg gaacctgaat ctcgtttcta tagcaactct gtgcttgtct
     8161 tggatttcca gtccctatat ccttcaattg tgattgcata taactactgt ttttccactt
     8221 gccttggcca tatagagaat ttgggaaagt atgatgagtt caaatttggc tgtacctctc
     8281 taagagtacc tccagattta ctttaccaaa ttaggcatga catcacagtg tcccccaatg
     8341 gagtagcttt cgtcaagcct tctgtacgaa agggtgttct accaagaatg cttgaagaaa
     8401 ttttgaagac tagattcatg gtgaagcagt caatgaaggc ttataggcaa gaccgagccc
     8461 tgtcacgaat gctcaacgcc cggcagctag gactcaagct aatagcaaac gtcacgtttg
     8521 gctatacgtc tgctaacttc tcggggagga tgccgtgcat cgaggttggc gatagcattg
     8581 ttcacaaagc cagagagacc ctggaacgag caattaaact agtgaacgat accaagaaat
     8641 ggggcgccag ggttgtttat ggtgatactg acagtatgtt tgtactactg aaaggagcca
     8701 ccaaggagca gtcttttaag attggtcagg aaattgctga agccgttact gcgactaatc
     8761 ctaagccagt gaaactgaag tttgaaaagg tatatttgcc ttgtgttttg caaacaaaaa
     8821 agagatatgt gggttacatg tatgaaacac tggatcagaa ggacccagtg tttgacgcaa
     8881 aaggaataga aacagtgaga agagactctt gccccgctgt ttccaagata cttgagcgtt
     8941 ctctaaagct gctgtttgaa accagagata tcagcctaat taaacagtac gtacagcgac
     9001 aatgtatgaa acttgtggaa ggaaaggcca gcatacaaga ttttatcttt gccaaggagt
     9061 accgaggaag tttttcttac aggcctggag cctgtgtccc agcccttgag cttacaagga
     9121 aaatgcttgc ttatgaccgg cgctctgagc ctcgagttgg agaacgagtg ccgtacgtca
     9181 ttgtttatgg gacccctgga ctacccctta tccagttgat aaggcgccca gcagaagtct
     9241 tacaagatcc gactctgaga ctgaatgcca cttactatat caccaagcaa attcttccac
     9301 cgctggcaag aatcttctct cttattggga ttgatgtctt cagctggtat caagaattac
     9361 caaggatcca gaaagccacc agctcttcca gaagtgacct tgaggggcgg aaaggcacga
     9421 tctcacagta cttcactacc ctgcactgtc ctgtgtgtga cggcctgact cagcacggca
     9481 tctgcagtca gtgtcggagc cagcctcagc atgtagccat catcctcaac caggaaattc
     9541 gagaactgga gcgccaacag gagcagcttg tgaagatatg caggaactgt acgggttcct
     9601 tcgaccgaca tatcccttgt gtttctctca actgcccagt acttttcaaa ctctcacgag
     9661 taaacagaga attatccaag gcaccgtacc tgcggcagtt actggaccag ttctaggtta
     9721 gcagagtcag tgtcacagag ctcccggtgc tattcgttca gtgtttacca ctcaactcct
     9781 ctgcatggtg ctttctcaac ctccatcaag tcaaagatgt ccatcgtctg tctgccatcg
     9841 agactgtgaa gactcctgct aacctgttgc tctctgaata gctcacttct tacagtgtac
     9901 aaacccccat tatctcacct gtgaacattg ttttctaata tgcaggtgtt gggtttgctc
     9961 cagtctatgt accatcttgt aaatccattt gaacagatca tgtttactcc ctgtggaagg
    10021 aacacggaac ctcgtacaga aagtcattcg tgtgtgttcc ttaaactgtc tgtatcaaga
    10081 cgtgttgctt agagatatcc actcacttta taattttgac tgcaaaatat tttgtaaata
    10141 cactttttta cttttcaaac aactgagtaa attaatgtgc aatgactttt atacaatgat
    10201 cttcacgttg ttggtatatc tcctctaggc tttgcttgac tgaaaggtag atttgttact
    10261 ttgatcaaac tgtgcaaata gtaccatgtg tagcattttt gaaacattct tttctaaaga
    10321 cgctgtcttg ctttagctac taatggggca ttgtgaggaa ctgtgcaaag acatttttgt
    10381 tacaaacctg tgggcctgtt gcaatacttt aaaaataaaa ttaaaaaatt tattccattt
    10441 tgcttgtttt gtatagacat ttctattgct tctaaatatg cttaagatat tttctttcct
    10501 tctgtactgt acagttaatc ttatttgcca tccttgaaca caaatgtgta tttaggatat
    10561 ttgtataact gtataaatga aaaaggaatt atgtggtcag tgcattgttt tttaaactgg
    10621 aaatcctttt gttttgagag ttaataatgg aaaccaaatt aaaaattgaa taaaatatga
    10681 aataccatg
//
