LOCUS       NP_001077435            3132 aa            linear   ROD 29-MAR-2024
DEFINITION  DNA polymerase zeta catalytic subunit [Rattus norvegicus].
ACCESSION   NP_001077435 XP_228273
VERSION     NP_001077435.1
DBSOURCE    REFSEQ: accession NM_001083966.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 3132)
  AUTHORS   Baranovskiy,A.G., Lada,A.G., Siebler,H.M., Zhang,Y., Pavlov,Y.I.
            and Tahirov,T.H.
  TITLE     DNA polymerase delta and zeta switch by sharing accessory subunits
            of DNA polymerase delta
  JOURNAL   J Biol Chem 287 (21), 17281-17287 (2012)
   PUBMED   22465957
REFERENCE   2  (residues 1 to 3132)
  AUTHORS   Takano,K., Lyons,M., Moyes,C., Jones,J. and Schwartz,C.E.
  TITLE     Two percent of patients suspected of having Angelman syndrome have
            TCF4 mutations
  JOURNAL   Clin Genet 78 (3), 282-288 (2010)
   PUBMED   20184619
REFERENCE   3  (residues 1 to 3132)
  AUTHORS   Hara,K., Hashimoto,H., Murakumo,Y., Kobayashi,S., Kogame,T.,
            Unzai,S., Akashi,S., Takeda,S., Shimizu,T. and Sato,M.
  TITLE     Crystal structure of human REV7 in complex with a human REV3
            fragment and structural implication of the interaction between DNA
            polymerase zeta and REV1
  JOURNAL   J Biol Chem 285 (16), 12299-12307 (2010)
   PUBMED   20164194
REFERENCE   4  (residues 1 to 3132)
  AUTHORS   Mekhail,K., Khacho,M., Carrigan,A., Hache,R.R., Gunaratnam,L. and
            Lee,S.
  TITLE     Regulation of ubiquitin ligase dynamics by the nucleolus
  JOURNAL   J Cell Biol 170 (5), 733-744 (2005)
   PUBMED   16129783
REFERENCE   5  (residues 1 to 3132)
  AUTHORS   Van Sloun,P.P., Varlet,I., Sonneveld,E., Boei,J.J., Romeijn,R.J.,
            Eeken,J.C. and De Wind,N.
  TITLE     Involvement of mouse Rev3 in tolerance of endogenous and exogenous
            DNA damage
  JOURNAL   Mol Cell Biol 22 (7), 2159-2169 (2002)
   PUBMED   11884603
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Apr 18, 2007 this sequence version replaced XP_228273.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3132
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     Protein         1..3132
                     /product="DNA polymerase zeta catalytic subunit"
                     /EC_number="2.7.7.7"
                     /note="REV3-like, polymerase (DNA directed), zeta,
                     catalytic subunit; REV3-like, catalytic subunit of DNA
                     polymerase zeta"
                     /calculated_mol_wt=351769
     Region          41..>195
                     /region_name="PTZ00166"
                     /note="DNA polymerase delta catalytic subunit;
                     Provisional"
                     /db_xref="CDD:240301"
     Region          752..1132
                     /region_name="DUF4683"
                     /note="Domain of unknown function (DUF4683); pfam15735"
                     /db_xref="CDD:464832"
     Region          1868..1890
                     /region_name="REV3L_RBD"
                     /note="REV7 binding domain found in protein reversionless
                     3-like (REV3L) and similar proteins; cd22287"
                     /db_xref="CDD:412083"
     Site            order(1870..1880,1882,1885..1886,1889)
                     /site_type="other"
                     /note="REV7 binding site [polypeptide binding]"
                     /db_xref="CDD:412083"
     Region          2296..2534
                     /region_name="DNA_polB_zeta_exo"
                     /note="inactive DEDDy 3'-5' exonuclease domain of
                     eukaryotic DNA polymerase zeta, a family-B DNA polymerase;
                     cd05778"
                     /db_xref="CDD:99821"
     Region          2560..3008
                     /region_name="POLBc_zeta"
                     /note="DNA polymerase type-B zeta subfamily catalytic
                     domain. DNA polymerase (Pol) zeta is a member of the
                     eukaryotic B-family of DNA polymerases and distantly
                     related to DNA Pol delta. Pol zeta plays a major role in
                     translesion replication and the production...; cd05534"
                     /db_xref="CDD:99917"
     Site            order(2616,2619..2621,2699,2727,2731,2785)
                     /site_type="active"
                     /db_xref="CDD:99917"
     Site            order(2783,2785..2786)
                     /site_type="metal-binding"
                     /db_xref="CDD:99917"
     Region          3044..3111
                     /region_name="zf-C4pol"
                     /note="C4-type zinc-finger of DNA polymerase delta;
                     pfam14260"
                     /db_xref="CDD:464119"
     CDS             1..3132
                     /gene="Rev3l"
                     /coded_by="NM_001083966.1:318..9716"
                     /db_xref="GeneID:309812"
                     /db_xref="RGD:1307087"
ORIGIN      
        1 mfsvrivtad yymasplpgl dicqspltqh pvkkvpvvrv fgatpagqkt clhlhgvfpy
       61 lyvpydgygq qperylsqma lsidralnva lgnpsstaqh vfkvslvsgm pfygyheker
      121 hfmkiylynp amvkricell qsgaimnkfy qpheahipyl lqlfidynly gmnlinlaav
      181 kfrkarrkgd ashatglfkp qlsgnspagt lfrweedeip sslllegvep lstcelevda
      241 vaadilnrld ieaqiggnpg lqaiwedekq rrrnrnensq isqpesqdcr lvpateseki
      301 fqkrlqeilk qndfsvtlsg svdyssgsqe fsaeltlhse ilspemlpcs panmievhrd
      361 ndwskgntkh kveealinee ailnliensq tfqpltqrls etpvfmdssp deslvhllag
      421 lesdgyqgek nrmplprhtf gesqnpqnsd deenapqmek eemelsvlms qrwdsdteeq
      481 cakkrslcrn ahrssteedd ssseeemewt dnsllfanls ipqldgtade nsdnplnnen
      541 srahssviat sklsvrpsvf hkdaatlepp ssakitfqck htsalsshgl nkddliegls
      601 qpnntekgrd ssvtftkest ysmkysgsls stvhsdnshk eickkdkslp vpscessvfd
      661 yeedipsvtr qapsrkysnm rkiekdapfi hanrhtsest lgknsfnfad lnhsknklss
      721 egnergnsta lnsvfpssla escdllsssg enrsvahsld sitdesgrsk lkiryeefqe
      781 hkmerpslsq qaahymffps vvlsncltrp qklspvtykl qpgsktsrlk lnkkklislq
      841 etstkssetg aakdscthnh pysgtpekes glssdlikat hgtfenktpt ehfidchfgd
      901 gsleteqsfg lygnkytlra krkvnyeted sessfvthns kislphpmei genldgtlks
      961 rkrrkmskkl ppviikyiii nrfrgrknml vklgkidske kqvilteekm elykklaplk
     1021 dfwpkvpdsp atkypiyplt pkkshrrksk hksakrkpgk qhrassenik rtlsfrkkrt
     1081 havlsppsps yiaetedcdl nysdvmsklg flserstspv nsspprcwsp tdpraeeima
     1141 aaekesvlfk gpnvcntktv sprvgkasra raqvkkskar lakssvvtnk rnkrnqtnql
     1201 vdngkkkpra kqkqranekg isrkpviptd ettkppseae ltpsqrsvpe ltsssgihtl
     1261 skqkemtqtg pamdhplppc qptginaqqr lsncfssfle srksvqfptf pssrgdsrss
     1321 vyssigpgvs kvntqrshsq samftrkett liqksifdls nhlsqvaqst qlcsgiispk
     1381 teessntqkn cgssigklne yrssleskpe kvcapnflhc rdsqqqtvnv seqskpsetc
     1441 spgnaasees qtpncfvtsl rspikqitwe qrqrgcilem ssfkpekvkq rslseaisqt
     1501 kalsqcknqn vstpsvfgeg qsglavlkel lqkrqqkaqt tnvqdsassh qpdkdisvsa
     1561 ehkktnkrtr avasprkpra prrtkpkeqt prrlkvdpln lqtsghldns lsddspilfs
     1621 dpgfescysl edslspehny nfdintigqt gfcslysgsq fvpadqnlpq kflsdavqdl
     1681 fpgqaiekne llshdrqsct eekhhvsdsg pwvrastlnp elfekvgidn nenhrhsqwk
     1741 tsfhpltshs nsimesfcvq qaesclpeks rlnrssvske vflslpqass sdwiqghngk
     1801 eieqsldsan tsfttvlssp dgelvdaase dlelyvsrnn dvltptpdss prstssplqs
     1861 kngsftprta hilkplmspp sreeivatll dhdlseaiyq epfcsnpsdv pekpreiggr
     1921 llmvetrlpn dliefegdfs leglrlwkta fsamtqnprp gsplrngpav vnkessnshk
     1981 tvedkkivim pcryapsrql vqawlqakee yvrskrlprt estpviksad nvspslnpgd
     2041 travapqmdt cphtlsstah akeevcqsqi alqtsrtgcg qtvsasqtll paasaavpee
     2101 eeeeeeeeee eeedengyvs ysspdspgip pwqqaaspdf ralngehrcs spveelcsra
     2161 venflkpikd giqkascces qvispihart rtekceplcl hstpvmprkf leklpeatgl
     2221 splsvepktq klynkkgsdt dhlrrvlltt qvenqfaavn tpkketsqid gpslnntygf
     2281 kvsiqnlqea kalheiqnlt lisvelhart rrdlqpdpef dpicalfyci ssdtplpdte
     2341 kteltgvivi dkdktvthqd ircqtpllir sgvtglevty aadekalfqe vtnimkrydp
     2401 dillgyeiqm hswgyllqra aalsvdlcqm isrvpddkie nrfaaerddy gsdtmseini
     2461 vgritlnlwr imrnevaltn ytfenvsfhv lhqrfplftf rvlsdwfdnk tdlyrwkmvd
     2521 hyvsrvrgnl qmleqldlig ktsemarlfg iqflhvltrg sqyrvesmml riakpmnyip
     2581 vtpsvqqrsq mrapqcvpli mepesrfysn svlvldfqsl ypsiviayny cfstclghie
     2641 nlgkydefkf gctslrvppd llyqirhdit vspngvafvk psvrkgvlpr mleeilktrf
     2701 mvkqsmkayr qdralsrmln arqlglklia nvtfgytsan fsgrmpciev gdsivhkare
     2761 tleraiklvn dtkkwgarvv ygdtdsmfvl lkgatkeqsf kigqeiaeav tatnpkpvkl
     2821 kfekvylpcv lqtkkryvgy myetldqkdp vfdakgietv rrdscpavsk ilerslkllf
     2881 etrdislikq yvqrqcmklv egkasiqdfi fakeyrgsfs yrpgacvpal eltrkmlayd
     2941 rrseprvger vpyvivygtp glpliqlirr paevlqdptl rlnatyyitk qilpplarif
     3001 sligidvfsw yqelpriqka tsssrsdleg rkgtisqyft tlhcpvcdgl tqhgicsqcr
     3061 sqpqhvaiil nqeirelerq qeqlvkicrn ctgsfdrhip cvslncpvlf klsrvnrels
     3121 kapylrqlld qf
//
