LOCUS       NM_001034912            3140 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus reticulophagy regulator 1 (Retreg1), mRNA.
ACCESSION   NM_001034912
VERSION     NM_001034912.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Luo,R., Li,G., Zhang,W., Liang,H., Lu,S., Cheung,J.P.Y., Zhang,T.,
            Tu,J., Liu,H., Liao,Z., Ke,W., Wang,B., Song,Y. and Yang,C.
  TITLE     O-GlcNAc transferase regulates intervertebral disc degeneration by
            targeting FAM134B-mediated ER-phagy
  JOURNAL   Exp Mol Med 54 (9), 1472-1485 (2022)
   PUBMED   36056188
  REMARK    GeneRIF: O-GlcNAc transferase regulates intervertebral disc
            degeneration by targeting FAM134B-mediated ER-phagy.
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Wang,C., Li,Y., Li,Y., Du,L., Zhang,J., Li,N., Hu,X., Zhang,W.,
            Xie,N. and Ming,L.
  TITLE     FAM134B-Mediated ER-Phagy in Mg2+-Free Solution-Induced
            Mitochondrial Calcium Homeostasis and Cell Death in Epileptic
            Hippocampal Neurons
  JOURNAL   Neurochem Res 46 (9), 2485-2494 (2021)
   PUBMED   34212292
  REMARK    GeneRIF: FAM134B-Mediated ER-Phagy in Mg(2+)-Free Solution-Induced
            Mitochondrial Calcium Homeostasis and Cell Death in Epileptic
            Hippocampal Neurons.
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Xie,N., Li,Y., Wang,C., Lian,Y., Zhang,H., Li,Y., Meng,X. and Du,L.
  TITLE     FAM134B Attenuates Seizure-Induced Apoptosis and Endoplasmic
            Reticulum Stress in Hippocampal Neurons by Promoting Autophagy
  JOURNAL   Cell Mol Neurobiol 40 (8), 1297-1305 (2020)
   PUBMED   32086669
  REMARK    GeneRIF: FAM134B Attenuates Seizure-Induced Apoptosis and
            Endoplasmic Reticulum Stress in Hippocampal Neurons by Promoting
            Autophagy.
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Cinque,L., De Leonibus,C., Iavazzo,M., Krahmer,N., Intartaglia,D.,
            Salierno,F.G., De Cegli,R., Di Malta,C., Svelto,M., Lanzara,C.,
            Maddaluno,M., Wanderlingh,L.G., Huebner,A.K., Cesana,M., Bonn,F.,
            Polishchuk,E., Hubner,C.A., Conte,I., Dikic,I., Mann,M.,
            Ballabio,A., Sacco,F., Grumati,P. and Settembre,C.
  TITLE     MiT/TFE factors control ER-phagy via transcriptional regulation of
            FAM134B
  JOURNAL   EMBO J 39 (17), e105696 (2020)
   PUBMED   32716134
  REMARK    GeneRIF: MiT/TFE factors control ER-phagy via transcriptional
            regulation of FAM134B.
REFERENCE   5  (bases 1 to 3140)
  AUTHORS   Khaminets,A., Heinrich,T., Mari,M., Grumati,P., Huebner,A.K.,
            Akutsu,M., Liebmann,L., Stolz,A., Nietzsche,S., Koch,N., Mauthe,M.,
            Katona,I., Qualmann,B., Weis,J., Reggiori,F., Kurth,I., Hubner,C.A.
            and Dikic,I.
  TITLE     Regulation of endoplasmic reticulum turnover by selective autophagy
  JOURNAL   Nature 522 (7556), 354-358 (2015)
   PUBMED   26040720
REFERENCE   6  (bases 1 to 3140)
  AUTHORS   Kurth,I., Pamminger,T., Hennings,J.C., Soehendra,D., Huebner,A.K.,
            Rotthier,A., Baets,J., Senderek,J., Topaloglu,H., Farrell,S.A.,
            Nurnberg,G., Nurnberg,P., De Jonghe,P., Gal,A., Kaether,C.,
            Timmerman,V. and Hubner,C.A.
  TITLE     Mutations in FAM134B, encoding a newly identified Golgi protein,
            cause severe sensory and autonomic neuropathy
  JOURNAL   Nat Genet 41 (11), 1179-1181 (2009)
   PUBMED   19838196
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089887.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089887.1, SRR8487231.59863.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q22"
     gene            1..3140
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /note="reticulophagy regulator 1"
                     /db_xref="GeneID:619558"
                     /db_xref="RGD:1565003"
     exon            1..356
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1530
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /note="protein FAM134B; reticulophagy receptor FAM134B;
                     reticulophagy receptor 1; family with sequence similarity
                     134, member B"
                     /codon_start=1
                     /product="reticulophagy regulator 1"
                     /protein_id="NP_001030084.1"
                     /db_xref="GeneID:619558"
                     /db_xref="RGD:1565003"
                     /translation="MASPAPEEHATQGCPATEEQEPRPGVPGEEAGPEGAGPQVEEAA
                     GRVAAALTWLLGEPVLWLGWRADELLSWKRPLRSLLAFLGANLLFWFLALTPWRVYHL
                     ISVMILGRVIMQIIKDMVLSRARGAQLWRSLSESWEVINSKPDERPRLSHCIAESWMN
                     FSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLFAFLCPLFKC
                     NDIGQKIYSKVKSILLKLDFGIGEYINQKKRERSEADKEKSHKDDSEIDFSALCPKIS
                     LTVAAKELSVSDTDVSEVSWTDNGTFNLSEGYTPQTDTSDDLDRPSEEVFSRDLSDFP
                     SLENGAGTNDEDELSLGLPTELKTKKQQLNSAHRPSKDRQSAAGLSLPLKSDQALHLM
                     SNLAGDVITAAMTAAIKDQLEGARQALAQAAPTPGDDTDTEEGDDFELLDQAELDQIE
                     SELGLTQDQGAEAQQSKKSSGFLSNLLGGH"
     exon            357..463
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /inference="alignment:Splign:2.1.0"
     exon            464..494
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /inference="alignment:Splign:2.1.0"
     exon            495..621
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /inference="alignment:Splign:2.1.0"
     exon            622..706
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /inference="alignment:Splign:2.1.0"
     exon            707..844
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /inference="alignment:Splign:2.1.0"
     exon            845..909
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1036
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..3112
                     /gene="Retreg1"
                     /gene_synonym="Fam134b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccaggcgc gcgcgcgcgc gtgcccgccc gcctccctcc ctgtccccgt ccccatcccc
       61 gtccccgcca gcaaaacacc gctgaagatg gcgagcccgg cgccggagga gcacgccacg
      121 cagggatgcc cagctacgga ggagcaggaa ccgcgacccg gggttcccgg ggaggaggca
      181 gggccggagg gcgccgggcc gcaggtggag gaggccgcgg gcagagtggc cgccgccctg
      241 acctggctac tcggggagcc cgtgctgtgg ctgggctggc gcgccgacga gctcctgagc
      301 tggaagaggc cgctgcgcag cctgctcgcc ttcctgggtg ccaacctgct gttctggttc
      361 cttgccttga ctccgtggag agtgtatcat ctcatttctg tcatgatact tggtcgtgtt
      421 atcatgcaaa tcatcaagga catggttttg tccagggcaa gaggtgcaca gttgtggagg
      481 agcctcagtg aaagctggga agttatcaat tccaagccag atgaaagacc cagactgagc
      541 cactgcattg cagaatcatg gatgaatttc agcatatttc ttcaagaaat gtctcttttc
      601 aaacagcaga gccctggcaa gttttgcctc ctggtctgca gtgtgtgcac attttttaca
      661 atcttgggaa gttacattcc tggggtcatt ctcagctacc tactgttact gtttgctttt
      721 ttgtgtccac tgtttaaatg taatgatatt ggacaaaaaa tatacagcaa agtcaagtcc
      781 attctattaa aactagattt tggaattgga gaatatatta accagaagaa acgtgagaga
      841 tctgaagcag ataaagaaaa aagccacaag gatgacagtg aaatagactt ttcggctctt
      901 tgtcctaaga ttagcctcac agttgctgcc aaagagttat ccgtgtcaga cacagatgtg
      961 tcagaagtct cttggactga taatgggacc ttcaaccttt cagaggggta cactccacag
     1021 acagacactt ctgatgatct tgaccggccc agtgaggaag tgttctctcg agatctttca
     1081 gattttccat ctctggaaaa tggcgcggga acaaatgatg aagatgagtt aagccttggc
     1141 ttacccacag agctcaagac aaagaagcaa cagttgaaca gtgctcacag accaagcaaa
     1201 gacaggcagt cagcagctgg cctctcactt cctctcaaga gcgaccaagc ccttcacttg
     1261 atgagcaacc tggctgggga tgtcatcaca gctgccatga cagctgccat caaagaccag
     1321 ctagaagggg cccggcaggc cctcgctcag gcggcgccca ctccagggga cgacacagac
     1381 actgaggagg gggatgattt tgaactactt gaccaggcag agctagatca aattgagagt
     1441 gagctgggac taacacaaga ccaaggggca gaagcccagc aaagtaagaa gtcctcaggc
     1501 ttcctttcaa acctgcttgg aggccattag ccgggaatca gcttgccgca aagcacagat
     1561 aaaccaccca aacatttcaa acaagcaggg ggaaaaatgg aaaaaaaatt gaattgtaag
     1621 ctttaattac tttagatttt ttgttttctt ttcccttcta tagtgagttg gatatgtatc
     1681 agctgataat gatagactga catttctggt agttattttt atgtaataag catggaaatg
     1741 aactttatag ttacatatat acatactgtg gtgtcataag tgcttagggg ctgtttgtaa
     1801 agagaaacaa aaaaaccaca tcaaacccca tcaaactgag gtctttctat aagtaatctt
     1861 tttctttata attttcaagc atgcagagat cgacagctgt gaacacacat ggcatcggcc
     1921 ccctaattac tcctcttgga agtggtttat caaattctga tagatttcaa tgtaaaaaag
     1981 gagaaatatc aaaatgtttg tagttgaagg gctatggaaa tgctatcaaa attaattttc
     2041 taggaaaaac tttaaaaata agtactatct ataggctgaa atatttccat gttatttcta
     2101 cagttgtaga cagaggctta cttgtcaggt ggcatgctcc actgactgcc acatctagtc
     2161 ttgaaaagag gtggtactga cccacagaaa gcagccagtt ctgtgtctct tcatgatgct
     2221 cttgtaatgt ttgcaatggt aagtgcacac tattttgcac actcagatgt aagcaaaacc
     2281 tgacgtttct gtaatgtgtt ccagtctcct aggattgtga atctagttat aggtatgtcc
     2341 atgagtgatg tgctcattgg tgatcatcaa caccccccct ttttttttca gtttacaaat
     2401 gcagaacaga ggaacttgct tgaactttaa agtttatttc tctgccgctg cactctcaat
     2461 atgcaatccg tttcttactg ggaagctagt gtatgctttt tcctttaaac tgtttttttt
     2521 tgatcacttt tacataatca aatttgactt acagtggaaa ccaagatagt tgtttttgtg
     2581 aaacaatctt ttagaaggac tgagggacca tgtcagcaaa tatcttagat cttcagttat
     2641 agctggcatt tctacacaga cacacaagat ccttacaaag gaagggtaat ctaagactgt
     2701 agaagtctgt gtttcagttt catctctttt atttctaaag actaattaca ggtaacttga
     2761 ccttttaatg caccatctcc tatttattta tttttttctc tctgaggtat taaaaatatc
     2821 aagactgaat tttgccaaat gtaagaggga ggaaagtccc tgaagactct gactacttgc
     2881 ttatttttga ttgaccttct atgcttatgt cattagtgcc tcacaactgt gtttgacgtc
     2941 ctttattgat acagagtgag cctgtgcctt cattttcttg cccattttgg tactgatgta
     3001 aatttgtgtt agaaaatctt ggaactctgt gagtctggga agaatatatc tgaatcctat
     3061 tcaatacatt tgctggatgt gaagaaaaat acagccacat atttataaaa caaaaaaaaa
     3121 aaaaaaaaaa aaaaaaaaaa
//
