LOCUS       NM_053333                503 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus resistin like alpha (Retnla), mRNA.
ACCESSION   NM_053333
VERSION     NM_053333.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Zeng,X., Zhu,L., Xiao,R., Liu,B., Sun,M., Liu,F., Hao,Q., Lu,Y.,
            Zhang,J., Li,J., Wang,T., Wei,X. and Hu,Q.
  TITLE     Hypoxia-Induced Mitogenic Factor Acts as a Nonclassical Ligand of
            Calcium-Sensing Receptor, Therapeutically Exploitable for
            Intermittent Hypoxia-Induced Pulmonary Hypertension
  JOURNAL   Hypertension 69 (5), 844-854 (2017)
   PUBMED   28348014
  REMARK    GeneRIF: The binding of HIMF enhanced the activity of extracellular
            CaSR and mediated hypoxia-evoked proliferation of pulmonary artery
            smooth cells and the development of pulmonary vascular remodeling
            and pulmonary hypertension
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Wang,W.Y., Chen,Y., Su,X., Tang,D., Ben,Q.W., Yao,W.Y., Chen,P. and
            Yuan,Y.Z.
  TITLE     Resistin-Like Molecule-alpha Causes Lung Injury in Rats with Acute
            Pancreatitis by Activating the PI-3K/Akt-NF-kappaB Pathway and
            Promoting Inflammatory Cytokine Release
  JOURNAL   Curr Mol Med 16 (7), 677-687 (2016)
   PUBMED   27492801
  REMARK    GeneRIF: RELMalpha augments inflammatory activity by increasing
            inflammatory cytokine release.
REFERENCE   3  (bases 1 to 503)
  AUTHORS   Li,X., Yang,Y., Fang,J. and Zhang,H.
  TITLE     FIZZ1 could enhance the angiogenic ability of rat aortic
            endothelial cells
  JOURNAL   Int J Clin Exp Pathol 6 (9), 1847-1853 (2013)
   PUBMED   24040449
  REMARK    GeneRIF: FIZZ1 could enhance angiogenesis of rat aortic endothelial
            cells by up-regulating Gng8 and Atg9a.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 503)
  AUTHORS   Luan,B., Feng,X.X., Yang,Y.X. and Zhang,Z.Y.
  TITLE     [Roles of FIZZ1 and NOTCH1 in asthma]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 13 (3), 219-222 (2011)
   PUBMED   21426641
  REMARK    GeneRIF: FIZZl and NOTCH1 may induce an increase in a-SMA
            expression. FIZZl and NOTCH1 play a critical role in the process of
            airway remodeling.
REFERENCE   5  (bases 1 to 503)
  AUTHORS   Angelini,D.J., Su,Q., Yamaji-Kegan,K., Fan,C., Skinner,J.T.,
            Champion,H.C., Crow,M.T. and Johns,R.A.
  TITLE     Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) induces the
            vascular and hemodynamic changes of pulmonary hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 296 (4), L582-L593 (2009)
   PUBMED   19136574
  REMARK    GeneRIF: HIMF represents a critical cytokine-like growth factor in
            the development of pulmonary hypertension.
REFERENCE   6  (bases 1 to 503)
  AUTHORS   Steppan,C.M., Brown,E.J., Wright,C.M., Bhat,S., Banerjee,R.R.,
            Dai,C.Y., Enders,G.H., Silberg,D.G., Wen,X., Wu,G.D. and Lazar,M.A.
  TITLE     A family of tissue-specific resistin-like molecules
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 502-506 (2001)
   PUBMED   11209052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_053333.3.
            
            On Nov 26, 2020 this sequence version replaced NM_053333.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF323085.1, BF283739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000011.1  65426040-65426186   c
            148-228             JAXUCZ010000011.1  65425512-65425592   c
            229-503             JAXUCZ010000011.1  65424687-65424961   c
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..503
                     /gene="Retnla"
                     /gene_synonym="Himf"
                     /note="resistin like alpha"
                     /db_xref="GeneID:81712"
                     /db_xref="RGD:68349"
     exon            1..147
                     /gene="Retnla"
                     /gene_synonym="Himf"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..356
                     /gene="Retnla"
                     /gene_synonym="Himf"
                     /note="RELMalpha; cysteine-rich secreted protein FIZZ1;
                     hypoxia-induced mitogenic factor"
                     /codon_start=1
                     /product="resistin-like alpha precursor"
                     /protein_id="NP_445785.1"
                     /db_xref="GeneID:81712"
                     /db_xref="RGD:68349"
                     /translation="MKTATCSLLICVFLLQLMVPVNTDGTLDIIGKKKVKELLAHQDN
                     YPSAVRKTLSCTNVKSMSKWASCPAGMTATGCSCGFACGSWEIQNENICNCLCLIVDW
                     AYARCCQLS"
     exon            148..228
                     /gene="Retnla"
                     /gene_synonym="Himf"
                     /inference="alignment:Splign:2.1.0"
     exon            229..503
                     /gene="Retnla"
                     /gene_synonym="Himf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacactgac tttcaacagg atgaagactg caacctgttc ccttctcatc tgcgtcttcc
       61 ttctccagct gatggtccca gtgaatactg atggaacctt agacattatt gggaagaaaa
      121 aggtcaagga acttctagcc catcaagata actatccctc tgctgtaagg aagaccctct
      181 catgcactaa tgtcaagtct atgagcaaat gggcctcctg ccctgctggg atgactgcta
      241 ctggttgttc ttgtggcttt gcctgtggat cttgggaaat ccagaatgaa aatatttgca
      301 actgcctgtg cttaatcgtt gactgggcct atgcccgctg ctgccaactg tcctaagaat
      361 ggagaggcac agaactcagc tttgatatga tgagtctaac aaaactgcaa tctcaacttg
      421 gaaatctgac tcatgcgcat ttgatgtatt catattgccc attaaccccg cttcttgaaa
      481 aaataaagac aaatttacat ctt
//
