LOCUS       NM_144741                608 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus resistin (Retn), mRNA.
ACCESSION   NM_144741
VERSION     NM_144741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 608)
  AUTHORS   Sabry,M.M., Dawood,A.F., Rashed,L.A., Sayed,S.M., Hassan,S. and
            Younes,S.F.
  TITLE     Relation between resistin, PPAR-gamma, obesity and atherosclerosis
            in male albino rats
  JOURNAL   Arch Physiol Biochem 126 (5), 389-398 (2020)
   PUBMED   30612469
  REMARK    GeneRIF: Relation between resistin, PPAR-gamma, obesity and
            atherosclerosis in male albino rats.
REFERENCE   2  (bases 1 to 608)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 608)
  AUTHORS   Nogueira,A.V.B., Nokhbehsaim,M., Tekin,S., de Molon,R.S.,
            Spolidorio,L.C., Memmert,S., Damanaki,A., Jager,A., Eick,S.,
            Deschner,J. and Cirelli,J.A.
  TITLE     Resistin Is Increased in Periodontal Cells and Tissues: In Vitro
            and In Vivo Studies
  JOURNAL   Mediators Inflamm 2020, 9817095 (2020)
   PUBMED   32410876
  REMARK    GeneRIF: Resistin Is Increased in Periodontal Cells and Tissues: In
            Vitro and In Vivo Studies.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 608)
  AUTHORS   Shirvani,H., Rahmati-Ahmadabad,S., Broom,D.R. and Mirnejad,R.
  TITLE     Eccentric resistance training and beta-hydroxy-beta-methylbutyrate
            free acid affects muscle PGC-1alpha expression and serum irisin,
            nesfatin-1 and resistin in rats
  JOURNAL   J Exp Biol 222 (Pt 10) (2019)
   PUBMED   31085594
  REMARK    GeneRIF: Significant correlations were observed between PGC-1alpha
            gene expression and serum concentrations of irisin, nesfatin-1 and
            resistin. beta-hydroxy-beta-methylbutyrate free acid
            supplementation with eccentric resistance training may induce
            crosstalk between peptide release from other tissues and increases
            maximal muscle strength. The combination of the two interventions
            had a more substantial effect than each in isolat...
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 608)
  AUTHORS   Small,H.Y., McNeilly,S., Mary,S., Sheikh,A.M. and Delles,C.
  TITLE     Resistin Mediates Sex-Dependent Effects of Perivascular Adipose
            Tissue on Vascular Function in the Shrsp
  JOURNAL   Sci Rep 9 (1), 6897 (2019)
   PUBMED   31053755
  REMARK    GeneRIF: Resistin Mediates Sex-Dependent Effects of Perivascular
            Adipose Tissue on Vascular Function in the Shrsp.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 608)
  AUTHORS   Kreier,F., Fliers,E., Voshol,P.J., Van Eden,C.G., Havekes,L.M.,
            Kalsbeek,A., Van Heijningen,C.L., Sluiter,A.A., Mettenleiter,T.C.,
            Romijn,J.A., Sauerwein,H.P. and Buijs,R.M.
  TITLE     Selective parasympathetic innervation of subcutaneous and
            intra-abdominal fat--functional implications
  JOURNAL   J Clin Invest 110 (9), 1243-1250 (2002)
   PUBMED   12417562
REFERENCE   7  (bases 1 to 608)
  AUTHORS   Lu,S.C., Shieh,W.Y., Chen,C.Y., Hsu,S.C. and Chen,H.L.
  TITLE     Lipopolysaccharide increases resistin gene expression in vivo and
            in vitro
  JOURNAL   FEBS Lett 530 (1-3), 158-162 (2002)
   PUBMED   12387885
  REMARK    GeneRIF: investigation of role in inflammatory processes and
            induction by inflammatory stimuli
REFERENCE   8  (bases 1 to 608)
  AUTHORS   Delhanty,P.J., Mesotten,D., McDougall,F. and Baxter,R.C.
  TITLE     Growth hormone rapidly induces resistin gene expression in white
            adipose tissue of spontaneous dwarf (SDR) rats
  JOURNAL   Endocrinology 143 (6), 2445-2448 (2002)
   PUBMED   12021211
  REMARK    GeneRIF: unexpected, marked, rapid and sustained up-regulation of
            resistin by Growth Hormone indicated a role for resistin in
            GH-dependent metabolic and differentiative effects in white adipose
            tissue.
REFERENCE   9  (bases 1 to 608)
  AUTHORS   Steppan,C.M., Bailey,S.T., Bhat,S., Brown,E.J., Banerjee,R.R.,
            Wright,C.M., Patel,H.R., Ahima,R.S. and Lazar,M.A.
  TITLE     The hormone resistin links obesity to diabetes
  JOURNAL   Nature 409 (6818), 307-312 (2001)
   PUBMED   11201732
REFERENCE   10 (bases 1 to 608)
  AUTHORS   Steppan,C.M., Brown,E.J., Wright,C.M., Bhat,S., Banerjee,R.R.,
            Dai,C.Y., Enders,G.H., Silberg,D.G., Wen,X., Wu,G.D. and Lazar,M.A.
  TITLE     A family of tissue-specific resistin-like molecules
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 502-506 (2001)
   PUBMED   11209052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF378366.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF378366.1, FM043210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="OLETF"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..608
                     /gene="Retn"
                     /note="resistin"
                     /db_xref="GeneID:246250"
                     /db_xref="RGD:628781"
     exon            1..69
                     /gene="Retn"
                     /inference="alignment:Splign:2.1.0"
     exon            70..210
                     /gene="Retn"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..425
                     /gene="Retn"
                     /codon_start=1
                     /product="resistin precursor"
                     /protein_id="NP_653342.1"
                     /db_xref="GeneID:246250"
                     /db_xref="RGD:628781"
                     /translation="MKNLSFLLLFLFFLVLGLLGPSMSLCPMDEAISKKINQDFSSLL
                     PAAMKNTVLHCWSVSSRGRLASCPEGTTVTSCSCGSGCGSWDVREDTMCHCQCGSIDW
                     TAARCCTLRVGS"
     exon            211..288
                     /gene="Retn"
                     /inference="alignment:Splign:2.1.0"
     exon            289..602
                     /gene="Retn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taagaaggag ctgtgggaca ggagctcatg cccagaaccg agttgtgccc tgctgagctc
       61 tctgccacgt acttaacagg atgaagaacc tttcatttct cctccttttc cttttcttcc
      121 ttgtcctggg gctgctgggc cccagcatgt cactgtgtcc catggatgaa gccatcagca
      181 agaagatcaa tcaagacttc agctccctac tgccagctgc aatgaagaac actgtcctac
      241 attgctggtc agtctcctcc agagggaggc tggcctcctg cccagaaggc acaaccgtca
      301 ctagctgctc ctgtggctct ggctgtggct catgggacgt ccgtgaggat acaatgtgtc
      361 actgccagtg cggaagcata gactggacag cggcccgctg ctgtaccctg cgggttggtt
      421 cctgaggacg gttgattgag aactgagctt gccctccgag tgctgccgag ggatgagctt
      481 gcccaccatg ccctgcagag gagggatggg gatggggaga gcgcaggggg caggaaacga
      541 gatgagggtc tggaaataca caatgggatg atggtggtga taaagatgca cggtaaagtg
      601 gaaaaaaa
//
