LOCUS       NM_031788               6763 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus RE1-silencing transcription factor (Rest), mRNA.
ACCESSION   NM_031788 XM_006250848
VERSION     NM_031788.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6763)
  AUTHORS   Hall,A.M., Kamei,N., Shao,M., Mun,H.S., Chen,K., Chen,Y. and
            Baram,T.Z.
  TITLE     Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF)
            Chromatin Binding Attenuates Epileptogenesis
  JOURNAL   eNeuro 11 (5) (2024)
   PUBMED   38641413
  REMARK    GeneRIF: Inhibition of Neuron-Restrictive Silencing Factor
            (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6763)
  AUTHORS   Crews,F.T., Fisher,R.P., Qin,L. and Vetreno,R.P.
  TITLE     HMGB1 neuroimmune signaling and REST-G9a gene repression contribute
            to ethanol-induced reversible suppression of the cholinergic neuron
            phenotype
  JOURNAL   Mol Psychiatry 28 (12), 5159-5172 (2023)
   PUBMED   37402853
REFERENCE   3  (bases 1 to 6763)
  AUTHORS   Mampay,M., Velasco-Estevez,M., Rolle,S.O., Chaney,A.M., Boutin,H.,
            Dev,K.K., Moeendarbary,E. and Sheridan,G.K.
  TITLE     Spatiotemporal immunolocalisation of REST in the brain of healthy
            ageing and Alzheimer's disease rats
  JOURNAL   FEBS Open Bio 11 (1), 146-163 (2021)
   PUBMED   33185010
  REMARK    GeneRIF: Spatiotemporal immunolocalisation of REST in the brain of
            healthy ageing and Alzheimer's disease rats.
REFERENCE   4  (bases 1 to 6763)
  AUTHORS   Chmielewska,N., Wawer,A., Maciejak,P., Turzynska,D., Sobolewska,A.,
            Skorzewska,A., Osuch,B., Plaznik,A. and Szyndler,J.
  TITLE     The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms
            of different susceptibility to seizure in a PTZ model of epilepsy
  JOURNAL   Brain Res Bull 158, 108-115 (2020)
   PUBMED   32151715
  REMARK    GeneRIF: The role of REST/NRSF, TrkB and BDNF in neurobiological
            mechanisms of different susceptibility to seizure in a PTZ model of
            epilepsy.
REFERENCE   5  (bases 1 to 6763)
  AUTHORS   Casadei,E., Tacchi,L., Lickwar,C.R., Espenschied,S.T.,
            Davison,J.M., Munoz,P., Rawls,J.F. and Salinas,I.
  TITLE     Commensal Bacteria Regulate Gene Expression and Differentiation in
            Vertebrate Olfactory Systems Through Transcription Factor REST
  JOURNAL   Chem Senses 44 (8), 615-630 (2019)
   PUBMED   31403159
  REMARK    GeneRIF: Commensal Bacteria Regulate Gene Expression and
            Differentiation in Vertebrate Olfactory Systems Through
            Transcription Factor REST.
REFERENCE   6  (bases 1 to 6763)
  AUTHORS   Andres,M.E., Burger,C., Peral-Rubio,M.J., Battaglioli,E.,
            Anderson,M.E., Grimes,J., Dallman,J., Ballas,N. and Mandel,G.
  TITLE     CoREST: a functional corepressor required for regulation of
            neural-specific gene expression
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9873-9878 (1999)
   PUBMED   10449787
REFERENCE   7  (bases 1 to 6763)
  AUTHORS   Chen,Z.F., Paquette,A.J. and Anderson,D.J.
  TITLE     NRSF/REST is required in vivo for repression of multiple neuronal
            target genes during embryogenesis
  JOURNAL   Nat Genet 20 (2), 136-142 (1998)
   PUBMED   9771705
REFERENCE   8  (bases 1 to 6763)
  AUTHORS   Palm,K., Belluardo,N., Metsis,M. and Timmusk,T.
  TITLE     Neuronal expression of zinc finger transcription factor
            REST/NRSF/XBR gene
  JOURNAL   J Neurosci 18 (4), 1280-1296 (1998)
   PUBMED   9454838
REFERENCE   9  (bases 1 to 6763)
  AUTHORS   Scholl,T., Stevens,M.B., Mahanta,S. and Strominger,J.L.
  TITLE     A zinc finger protein that represses transcription of the human MHC
            class II gene, DPA
  JOURNAL   J Immunol 156 (4), 1448-1457 (1996)
   PUBMED   8568247
REFERENCE   10 (bases 1 to 6763)
  AUTHORS   Chong,J.A., Tapia-Ramirez,J., Kim,S., Toledo-Aral,J.J., Zheng,Y.,
            Boutros,M.C., Altshuller,Y.M., Frohman,M.A., Kraner,S.D. and
            Mandel,G.
  TITLE     REST: a mammalian silencer protein that restricts sodium channel
            gene expression to neurons
  JOURNAL   Cell 80 (6), 949-957 (1995)
   PUBMED   7697725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Dec 1, 2020 this sequence version replaced
            XM_006250848.1, NM_031788.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.971689.1,
                                           SRR21887620.971690.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840111,
                                           SAMN16676809 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000014.1  31233376-31233451   c
            77-979              JAXUCZ010000014.1  31231047-31231949   c
            980-1063            JAXUCZ010000014.1  31224797-31224880   c
            1064-6763           JAXUCZ010000014.1  31213415-31219114   c
FEATURES             Location/Qualifiers
     source          1..6763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..6763
                     /gene="Rest"
                     /gene_synonym="Nrsf"
                     /note="RE1-silencing transcription factor"
                     /db_xref="GeneID:83618"
                     /db_xref="RGD:621069"
     exon            1..76
                     /gene="Rest"
                     /gene_synonym="Nrsf"
                     /inference="alignment:Splign:2.1.0"
     exon            77..979
                     /gene="Rest"
                     /gene_synonym="Nrsf"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..3294
                     /gene="Rest"
                     /gene_synonym="Nrsf"
                     /note="neural-restrictive silencer factor; zinc finger
                     transcription factor REST protein"
                     /codon_start=1
                     /product="RE1-silencing transcription factor"
                     /protein_id="NP_113976.2"
                     /db_xref="GeneID:83618"
                     /db_xref="RGD:621069"
                     /translation="MATQVMGQSSGGGSLFNNSGNMGMALPNDMYDLHDLSKAELAAP
                     QLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNHFSDSEGEGLEESAELKGDP
                     SGLDNMELRSLELSVVEPQPVFEASAAPEVYSSNKDPAPEAPVAEDKCKNLKAKPFRC
                     KPCQYEAESEEQFVHHIRVHSAKKFFVEESAEKQAKARESGASPSEEGEFSKGPIRCD
                     RCGYNTNRYDHYTAHLKHHLRAGDNERVYKCIICTYTTVSEYHWRKHLRNHFPRKVYT
                     CSKCNYFSDRKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCD
                     QCNYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPV
                     CDYAASKKCNLQYHFKSKHPTCPSKTMDVSKVKLKKTKRREADLHRDAAAAATEQTDT
                     EQAKTKGVDASARRSERPVKGVGKDVPKEKKPCSNASVVQVTTRTRKSAVETKAAEGK
                     HTDGQTGNNAEKSSKAKKSKRKMDAEAHPSAEPVTEGPVTKKKKTESKPKTSGEVPKG
                     SRVEDRKADKQQSASIKKGGKKTALKTKTAKKGSKLAPKGVGHTEPSSEMAQGGESPV
                     PALTQAVVTPSGSTQTELSSPMDIAQTEPAQMDVSQTGPPQVQRPLPVEPAQLEPSPP
                     QEPPQVEPPACVEPPPPVEPPCPMEPAEMEPSPPMEPSQVEPPPHLEPPLPMELPQVE
                     LPPVEDCQKELPSVEHAQTKVAQTGPTQVGAVQEEPLSVSEPPQVKLTRRSSPRKDRA
                     KEKLSVLSEMARQEQVLIEVGLVPVRDSQLLKASKSAPDLPAPPSPLPKGHLRREETP
                     KDQEMFSDGEGNKVSPLEKGGTEEAGESRAELAAPMESTSALSSEQSSNAPDGETLHS
                     ECQADSTAVCEMEVDTEQKTDRVPLKDSAVEPVSPLNPRVDPEAAAPAVVASPPITLA
                     ESQEIDEDEGIHSHDGSDLSDNMSEGSDDSGLHGARPAPQEATSKSGKEGLAVKVTEG
                     EFVCIFCDRSFRKEKDYSKHLNRHLVNVYFLEEAAEEQE"
     exon            980..1063
                     /gene="Rest"
                     /gene_synonym="Nrsf"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..6763
                     /gene="Rest"
                     /gene_synonym="Nrsf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgaccgg gggccgacag cctcgggagg gcgccgcgga gccccggtac aggcccgatc
       61 ggacgccggt agcgagctac agttatggcc acccaggtga tggggcagtc ttctggagga
      121 ggaagtctct ttaacaacag tggcaacatg ggcatggcct tacccaacga catgtatgac
      181 ttgcacgacc tctcgaaagc tgaactggcg gcacctcagc tcattatgtt agccaacgtg
      241 gccctgactg gggaagtgaa tggcagctgc tgtgattacc tggttggtga agagagacag
      301 atggccgagt tgatgcctgt tggagacaac cacttttcag atagcgaagg agaaggcctt
      361 gaggagtcgg ctgaactaaa aggtgacccc agtgggctgg acaacatgga actgagaagt
      421 ttggagctaa gcgttgtaga gccccagcct gtatttgaag catcagctgc cccagaagtg
      481 tacagctcga ataaagatcc cgcccctgaa gcacccgtgg cggaggacaa atgcaagaat
      541 ttgaaggcca aacccttccg ttgtaagcca tgccagtatg aagcggagtc tgaagaacag
      601 ttcgtacatc acatccgggt tcacagtgct aagaagtttt ttgtggaaga gagtgcagag
      661 aagcaagcca aagccaggga atctggggct tccccgtctg aggagggcga gttctccaag
      721 ggtcccatcc gctgtgatcg ctgtggctac aataccaacc ggtatgatca ctacacggca
      781 cacctgaagc accacctgag agccggggat aacgagcgtg tctacaagtg tatcatttgc
      841 acgtacacga cggtcagcga ataccactgg cggaaacacc tgaggaacca ttttcccagg
      901 aaagtctaca cgtgtagcaa gtgcaactat ttttccgaca gaaaaaataa ttatgttcaa
      961 cacgttcgaa ctcacacagg agaacgccct tataaatgtg aactgtgtcc ttactcaagt
     1021 tctcagaaga ctcatctaac tcgacacatg cgtactcact caggtgagaa gccatttaaa
     1081 tgtgatcagt gcaattatgt ggcctctaat cagcacgaag tgacccgaca cgcaagacag
     1141 gttcacaacg ggcctaaacc tcttaattgc cctcactgtg actacaaaac agccgatagg
     1201 agcaacttca agaagcacgt cgagctgcac gtcaaccctc ggcagttcaa ctgccccgtg
     1261 tgtgactacg cggcctccaa gaagtgtaac ctgcagtacc atttcaagtc caagcacccc
     1321 acctgcccca gcaagacgat ggacgtgtcc aaagtgaagc tgaagaaaac caagaggagg
     1381 gaggctgacc tgcaccgtga cgccgccgcc gccgccactg agcagacgga cacagagcaa
     1441 gcgaaaacca agggggtgga cgcgtctgcg aggagaagtg agaggcctgt aaaaggcgtt
     1501 ggaaaagatg ttccaaaaga gaagaagccc tgtagcaatg cctctgtggt gcaggtaact
     1561 acccgaactc ggaaatcagc ggtggagact aaagcagcgg agggaaaaca cacagatgga
     1621 cagacaggaa acaacgcaga aaagtcctct aaagctaaga agagcaaaag gaagatggac
     1681 gccgaggccc atccctcggc tgaacctgtg actgagggac ccgtgacaaa gaagaaaaag
     1741 acggagagca aacccaagac cagcggcgaa gtgccgaagg gcagcagagt ggaggacagg
     1801 aaggcggaca aacagcaaag tgcttccatt aagaaaggcg ggaagaagac ggctctcaag
     1861 actaagacag ctaaaaaagg cagcaaactt gctcctaagg gggtggggca cacagaacct
     1921 tcctcggaga tggctcaagg aggggagtct ccagttcctg ctctcactca ggcggtggtc
     1981 accccatcag gatctactca gacagagctc tcttctccca tggatattgc tcagacagag
     2041 cctgcccaga tggacgtttc ccagacaggg ccgcctcagg tgcagcggcc tcttcctgtg
     2101 gagcctgctc aattggagcc gtctcctcct caggagcctc cccaggtaga gccacctgcc
     2161 tgtgtggagc ctccccctcc cgtggagcct ccatgtccca tggagcctgc tgagatggaa
     2221 ccgtcccctc ccatggagcc ttcccaggtg gagccacctc ctcatttgga gcctccgctt
     2281 cccatggagc tgcctcaggt ggagctgcct cctgtggagg attgtcagaa ggagctgcct
     2341 tctgtggagc atgctcagac taaggttgct cagacaggtc ctactcaggt gggagctgtt
     2401 caggaggagc ccctttctgt ctccgagcca cctcaagtca agctaaccag aaggtcatct
     2461 ccccggaaag accgtgccaa ggagaagttg agcgtgctga gtgagatggc gaggcaggag
     2521 caggttctta ttgaggttgg cttagtgcct gtcagagata gccagcttct gaaggccagc
     2581 aagagcgcac cggacctccc agccccaccg tcaccactgc caaagggaca cttgagaaga
     2641 gaagagacac ccaaggacca agaaatgttc tctgacgggg aaggaaataa agtatcccct
     2701 ctcgagaaag gaggaacaga ggaagctggt gagagtcgag ctgagctggc tgctcccatg
     2761 gaatctacca gtgctttatc ctctgaacaa agctcaaatg caccagatgg tgaaacatta
     2821 cacagcgagt gtcaggctga ctccactgcg gtttgtgaaa tggaagtgga cactgagcag
     2881 aagacagacc gtgtccctct gaaagactca gcagtagaac cagtgtcacc tcttaaccca
     2941 agagtggacc ctgaagcagc ggcaccagct gtggtggcct cccctcctat cactttggcc
     3001 gagtctcagg aaattgatga ggatgaaggc attcacagcc atgatggaag tgacctgagc
     3061 gacaacatgt ctgaggggag tgatgactca ggactgcatg gggctcggcc agcaccacag
     3121 gaagctacgt caaaaagtgg aaaggaaggg ttggctgtca aagtaactga gggagagttt
     3181 gtttgtattt tttgtgatcg ttcttttaga aaggaaaaag actatagcaa acacctcaat
     3241 cgccatttgg tgaatgtgta cttccttgaa gaagcagctg aggagcagga gtagagtagc
     3301 tgatcctcag gagaagcaca atgcggactt tgtaagcatg cctctaattt tagtttgact
     3361 gtagacaaat gtaagttgct ttggtcagtc tccagtgctg tcttcagtaa cattcttttt
     3421 cttatttagt ggttgttgga taaatcttag caaattctag agagttggtg taaggagaca
     3481 gatacctaac caaatcatgc agtcgggtgc aaggagaagg gtaagatggt ggaacacgcc
     3541 cttgtctgcc tacaagtgtt ttctgtcagg ttttctgttc ttttcactgt agttcctaat
     3601 ttttagttct tgtttagatt gataaaaatt ggcttagtaa attacttgaa gaatttgcct
     3661 gctttatata aataagttag cactttacag tttctttaga gatgaaaaag gatttaaatt
     3721 ggagagaaat ttcctacatt ggacattgta tctgtccaga taatggcttc ctaacttgct
     3781 atcaatattc tgtgtttata tgttaatcat tataaaaagt gatttttggt attttttact
     3841 ttggtgcttt tctggcttaa gatgttgcac atggttcttg tttttgtttc tttaacctat
     3901 gcagttaatc tcccttcccc agaaacagca ttgtgttaaa tagtaacact agacatatat
     3961 atgcatggtt tttgtttttc cctttttgga gggatgcttt taggcttgtt tgcaaagggc
     4021 cattttcctt ttctttgctg caattgtctt ttttgcagaa caatagtgcg tgtgcaagtt
     4081 tataaacaat ggaacatgca ggttcaatcc attgttttgg gttttgtttt attatttttt
     4141 tattttaaat ttcacctctt acctatgcca ggattagttt catataagtt attttgaatg
     4201 gtgaagaaat gtgtaattcc acagctttcc agtctgagat atatatatat atatattata
     4261 tataatatat atatattata tatatatatt ttggcagtaa gccattagat gcatattgaa
     4321 caaaatttgt ctcgaaaatc agccatcaag agtttatttt gctgtttcta gcttattaca
     4381 gagtgatcat cctttgagga gttctcttca gtagatggtt gatgttggga tcatctgtac
     4441 tgagtagata tttggaagca gaaacctgga aggagacata attatccttc agactgtaga
     4501 ccatcagctg tgagaaagcc attatggtca catgactagt ctagtttaag tgctgagtcc
     4561 cagcaagcag ctgctgcttc ttccagtgag tactgaaaag gctggtgtta actaagtaca
     4621 gtccggattt taagtatcac attttctcag ggatctccac aaactagtgg gtgtcctcgc
     4681 tgtccctgtg agacagcctc tgtacaggag aggccttaag tgatttgtag ctgtcctggt
     4741 gttcctctgg ggacactgag aaactgcatg tactccagaa caggttctca gtgttctcca
     4801 gagtgtgaca gagcccagca tggactttct tactggtagt agtaatgaag tacgatcccc
     4861 gtagggattt gtgacatttt gctggaataa cctctgtgta tttcacttat tttacctggc
     4921 gatctctgag caggcttcag attttgacag ttcatgaaag atatgacgag cattaatgtg
     4981 tgggtgaaaa gcttggtgaa attctgagtg aagttttagt taaagttggt tgaacttgga
     5041 attgactggg aggccaaaga tttaaaaagc agaagattct ctcaagacac aagttgtgtg
     5101 atgatggtgt gtgttttatg tgtgtgcatg agactttgta aatgttgaat tctaggctcc
     5161 gacaatcatt gtagtgcaga tcagactgca agtatttatg ttttaaattt aaattataaa
     5221 gctagttaag tctttctaac aactagtttt aatgtttatg agcagatgtt tgcctacatt
     5281 accttttcaa gatgttgaga aagatgcttt gcaagcacag gttggaggct gggagctggt
     5341 tggttcttac taaggttttg tgaagtcttt gttgcagagg aaaacaatgc cttctggggc
     5401 ttgactagtt ttaatctagt ctttaagatt agaagtaaaa aaacaaaaat acaaaggaaa
     5461 ttaaaacctc attaaattag tctttaaaaa cattgttacc tgaaattgag tgggactttt
     5521 gagggctttc ttccagaaaa caaggacttg gtcctcaggc ctatattagg cctgaccctt
     5581 ggtgccatgt aagtgtactt aaagtctttt cagtggaaag tatcttagcg atcggaactt
     5641 ctagtacagt tgggagttct tccatttgaa actgatattt gcatgggatt gtttgaatct
     5701 tgttttctag tctctccccc atcactaccc tcatagtctc aaggtagatt tttttctctt
     5761 gataaaggaa cacaaaaaac gaacatcttg taaattgata tttagtaact agtggtaaac
     5821 gtgaaatggt agaattcttt acagcctaat cctaggtagc cttagagcaa tgtatcttaa
     5881 ttatttttga acctgtattc tccttgtctt ttcaagatat cttaagttat attttctttt
     5941 tcagagctgc tttttatttt ggggctactt ttttttaaaa attgaggcgt aattcataag
     6001 actacactgc tttgacgaga ctttttacaa cttagtcagg ttgtctttgt ccagtcttcc
     6061 aagaagggtc attttactgt tttagattta cttttaaagt catgggttac ttcaaatgta
     6121 gaaatgcaaa gtaaagccca agctcacctc atcggtttcg ctctgaatgt ggacaacgga
     6181 aggaacgacc tacctgttag catcctgtta ctcgtaaact gaaacgctga agaaactccg
     6241 ttttctttgc agaaatcaag gtctatctaa ggtttcctga ctgcctgagc acatgaggtg
     6301 agctgacgtc ttagttcaga acaatctgac tgtagattca gtgtgtgtcc tgctggctga
     6361 gggcaagcga gggcttctac agctgtgtgt atgtcccgca ggctcccgtc agttactgga
     6421 ctctcagaac tggtcttgtg acatcacaac aatgctttgc gccaatttta taaaccttta
     6481 cagtgcaata tgtgttactt tcctgaggca aaccaaaggt atatttctca aggttctgct
     6541 gccttcagca gcatttgatg gaagattttt ttttatacat ttgtaacaga tgaagcagat
     6601 tgcagtttgt tttttgttat tatttttttt taaattgtaa accatgtacc aagtttctgg
     6661 tcaagactgt ataggataag ttgaacgtga ttgcattcta ttaaccgata tgagtgtgtt
     6721 tcctatgcat atagttacat tgaaataaag ttctaaacca tca
//
