LOCUS       NM_001398903            3230 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus replication initiator 1 (Repin1), transcript
            variant 1, mRNA.
ACCESSION   NM_001398903 XM_006236425
VERSION     NM_001398903.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Bahr,J., Kloting,N., Kloting,I. and Follak,N.
  TITLE     Gene expression profiling supports the role of Repin1 in the
            pathophysiology of metabolic syndrome
  JOURNAL   Endocrine 40 (2), 310-314 (2011)
   PUBMED   21701954
  REMARK    GeneRIF: Data on gene expression in epididymal/subcutaneous adipose
            tissue suggest that Repin1 is more highly expressed in a congenic
            rat model of metabolic syndrome; thus, Repin1 may affect
            development of facets of metabolic syndrome.
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Ruschke,K., Illes,M., Kern,M., Kloting,I., Fasshauer,M.,
            Schon,M.R., Kosacka,J., Fitzl,G., Kovacs,P., Stumvoll,M., Bluher,M.
            and Kloting,N.
  TITLE     Repin1 maybe involved in the regulation of cell size and glucose
            transport in adipocytes
  JOURNAL   Biochem Biophys Res Commun 400 (2), 246-251 (2010)
   PUBMED   20727851
REFERENCE   4  (bases 1 to 3230)
  AUTHORS   Kloting,N., Wilke,B. and Kloting,I.
  TITLE     Triplet repeat in the Repin1 3'-untranslated region on rat
            chromosome 4 correlates with facets of the metabolic syndrome
  JOURNAL   Diabetes Metab Res Rev 23 (5), 406-410 (2007)
   PUBMED   17173329
  REMARK    GeneRIF: The functional unknown gene, Repin1, may be a novel
            candidate gene for the development of facets of the metabolic
            syndrome.
            GeneRIF: It is concluded that the triplet repeat expansion in
            3'-UTR of Repin1 leads to metabolic disorders as found in hHTG and
            WOKW rats and that Repin1 could be a novel candidate gene in the
            development of metabolic disorders.
REFERENCE   5  (bases 1 to 3230)
  AUTHORS   Yap,C.C., Murate,M., Kishigami,S., Muto,Y., Kishida,H.,
            Hashikawa,T. and Yano,R.
  TITLE     Adaptor protein complex-4 (AP-4) is expressed in the central
            nervous system neurons and interacts with glutamate receptor delta2
  JOURNAL   Mol Cell Neurosci 24 (2), 283-295 (2003)
   PUBMED   14572453
  REMARK    GeneRIF: findings show that glutamate receptor delta2 interacted
            directly with AP-4; results suggest a potential involvement of AP-4
            in the trafficking of delta2 in the brain.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000142.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001398903.2.
            
            On Dec 28, 2021 this sequence version replaced XM_006236425.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               JACYVU010000142.1  782410-782750
            342-465             JACYVU010000142.1  783547-783670
            466-3230            JACYVU010000142.1  784878-787642
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..3230
                     /gene="Repin1"
                     /gene_synonym="Ap-4; Ap4"
                     /note="replication initiator 1"
                     /db_xref="GeneID:445541"
                     /db_xref="RGD:1549707"
     exon            1..341
                     /gene="Repin1"
                     /gene_synonym="Ap-4; Ap4"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..2126
                     /gene="Repin1"
                     /gene_synonym="Ap-4; Ap4"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="replication initiator 1 isoform 1"
                     /protein_id="NP_001385832.1"
                     /db_xref="GeneID:445541"
                     /db_xref="RGD:1549707"
                     /translation="MDGRRVPAEHAGEFSLTSGGYRSVGRSRRCSRSIPRNIPRRSWK
                     KPHPQLCSLQAEEEPMLERRCRGPTAMGPAHPWLFSGPSQESSQPNRGLRYQGKSVAQ
                     PGGPAPVKVHRCAHCRKRFPGWVALWLHTRRCQARLPLPCHECNQRFRHAPFLALHLQ
                     VHASAVPDLGFICHLCGHSFRGWVALVLHLRAHSASKRPITCPECNKRFWRQKQLRAH
                     LRRCQPPAPEARPFICGNCGRSFAQWDQLVVHKRVHVAEALEEAAAKALGPRPRGRPS
                     VTAPRPGGDAVDRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQCPECGKRFTNKPYL
                     TSHRRIHTGEKPYPCTECGRRFRHKPNLLSHSKIHKRSEVSAQAASHTGSHLIAAEPM
                     AQPALGVPLGSLRTPAEAPASLHSCTDCGRSFRLERFLRLHQRQHTGERPFTCTECGK
                     NFGKKTHLVAHSRVHSGERPFACEECGRRFSQGSHLAAHRRDHAPERPFVCPDCGKAF
                     RHKPYLAAHRRIHTGEKPYVCPDCGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQ
                     KSNLITHRKSHIRDGAFCCAICGQTFDDEDRLLMHQKKHDA"
     exon            342..465
                     /gene="Repin1"
                     /gene_synonym="Ap-4; Ap4"
                     /inference="alignment:Splign:2.1.0"
     exon            466..3230
                     /gene="Repin1"
                     /gene_synonym="Ap-4; Ap4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaactga agctccgact cgtggctaaa ccggagctga tggctgccat ggcgacggag
       61 ccagggggcc ctccttggcc ttgtgcccga gcaggagagc agcggggtga cctggcccgc
      121 cccgccccca ggccgcggcc gcctagccga gactgaccct ccgcagctcc tgtagtcacg
      181 tggagctggg aacccggcgc gtggggggag gttggggacg ggcctggcag ttgtgaactc
      241 gaacctgctg ctgtcgccgc tgcagggcgg ggaaccggcc gcagaggccg gcttggtgct
      301 ctatggatgg gcgccgcgtc cctgcagagc acgcgggaga gttttctctg acatccgggg
      361 gctaccgaag tgtgggccga agcaggcgct gcagcagaag tatccccagg aacatcccca
      421 gaaggagctg gaaaaagcct catccccagc tctgcagtct tcaggcagag gaagaaccga
      481 tgctggaacg gcgctgcagg ggccccacgg ccatgggccc agcccatccc tggctttttt
      541 ctgggccctc ccaggagtcc tcccagccca acagagggtt gaggtatcaa ggcaaatcag
      601 tagcacagcc aggaggccca gccccagtca aggtccatcg ttgtgcccac tgtcggaagc
      661 gtttcccagg ctgggtggcc ctgtggcttc acactcggcg gtgccaggcc cggctgcctc
      721 tgccctgcca tgagtgcaac cagcgctttc gccacgcccc cttcttagcg ctgcatcttc
      781 aggttcatgc ttctgcagtc cctgacctgg gtttcatctg ccacctatgt gggcatagct
      841 tccgaggctg ggtagccctg gttctgcatc tgcgggctca ctcggcttca aagaggccca
      901 tcacttgccc tgaatgcaac aaacgcttct ggcgacaaaa acagcttcga gctcacctgc
      961 ggaggtgcca gccccctgcc cctgaggccc ggcccttcat atgtggcaac tgtggccgga
     1021 gcttcgccca atgggaccag ctcgttgttc acaagagggt gcacgtggct gaggccttgg
     1081 aggaggcagc agccaaggcc ctgggtcctc gcccgcgagg acgtccttca gtgactgctc
     1141 ccaggcctgg tggagatgct gtggaccgcc ccttccagtg tgcctgctgc ggcaagcgct
     1201 tccgccacaa gcccaacctg attgcccacc gccgcgtgca cactggcgag cgaccacacc
     1261 agtgcccaga gtgcgggaag cgtttcacca acaagcccta cctgacctcg caccgccgta
     1321 tacatacggg cgagaagccc tacccatgca ccgagtgtgg ccgccgcttc cgccacaaac
     1381 ccaacctgtt gtcgcacagt aaaatccaca agcgctcaga ggtctcagcg caggctgcct
     1441 cccacaccgg gagtcacttg attgcagcgg agcctatggc acaacctgcg cttggggtgc
     1501 ccctggggtc cctgaggacc ccggccgagg cacctgcgtc cctgcatagc tgcactgact
     1561 gcggccgcag cttccggctg gagcgtttcc tgcggctaca ccagcggcag cacacaggcg
     1621 agaggccctt cacctgcaca gagtgtggca agaacttcgg caagaaaacg cacctggtgg
     1681 cgcactcacg cgtgcactcg ggcgagcggc cctttgcctg cgaggagtgt ggtcgccgtt
     1741 tctcacaggg cagccacctg gcagcccacc ggcgcgacca tgcaccagag agaccctttg
     1801 tgtgcccaga ctgcggcaag gctttccgcc acaagcccta cctggccgcg caccgacgca
     1861 tccacacagg cgagaagccc tatgtgtgtc ccgactgtgg caaagctttc agccagaagt
     1921 ccaacctggt gtcccaccgg cgcatccaca caggtgagcg gccctacgcc tgccccgact
     1981 gtgatcgcag cttcagtcag aagtccaacc ttatcacaca ccggaagagc cacatccggg
     2041 atggcgcctt ctgctgtgcc atctgcggcc agacctttga cgatgaggac cgtctcttga
     2101 tgcaccagaa gaagcacgat gcctgagagg gacccaggaa gacaggccta gatgtccttg
     2161 gcaacagggt gtcagtggcc tgggtggggt acctacactg acactgttag agggacaggc
     2221 ggagatccca gagggataga ggagacagtg atctgggctc tgtttaggaa tggactttct
     2281 cccaggtgac cagggaaccc attttagaat gccgggatct gggtttgagc tagtcaggcc
     2341 cccagctggt ttttctaaag gtcaactgag actgccctgt accctggaaa aaatagcaat
     2401 agcagcccca tctacccttt gagtcctcaa ctagccacca gtgggaaggg agccactcca
     2461 tcctctggtg ttaacgcctt aatgtcccca gtctttacta tgagttactt caggtctttt
     2521 tttttttttt ttttttttaa agtaggtgtg gtatagtcgt tagcaaatga atcctggagc
     2581 agggaaaatg ggccagccgg ctgcaccttg gtgaacctgc tggcttgtta ggcagcagca
     2641 gacatgaagc tgagctgttt gtttccttcc ttccttcctt ccttccttcc ttccttcctt
     2701 ccttttttct tttttaccag aacctttctg caatgcctcc agcagaggta cccagatgtg
     2761 tagcgaccca tccacagcta gcaattccat ctcttttgtg catattatcc tcccagggca
     2821 tttatttact cctttacctg cctggctttt tatctgcccg ctcttcccca aatatacgcc
     2881 ttcctggtga ttttgtttaa acccctgacc ctccccaact cttttcagag cttcaggggt
     2941 tatgtgaaag actagctggg gggttggctg cagggaaagt cctgggtaga tttccttttt
     3001 aaggtttcca gggtatagat gccagcctct acccatgcac ctgggtgctg ggtcaccgtt
     3061 acctccagaa ggcattgctt ctactgtcta attgttagaa attcttacaa ggattgggtt
     3121 ctgctttcct atgacttctg cctactgggt cttgttttgt tccttggatc gaaacgtaac
     3181 aaccatttac cttcctttac aaactagaga ataaagattt ggttttagaa
//
