LOCUS       NM_031095               1292 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Rattus norvegicus renin binding protein (Renbp), mRNA.
ACCESSION   NM_031095
VERSION     NM_031095.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1292)
  AUTHORS   Bergfeld,A.K., Pearce,O.M., Diaz,S.L., Pham,T. and Varki,A.
  TITLE     Metabolism of vertebrate amino sugars with N-glycolyl groups:
            elucidating the intracellular fate of the non-human sialic acid
            N-glycolylneuraminic acid
  JOURNAL   J Biol Chem 287 (34), 28865-28881 (2012)
   PUBMED   22692205
REFERENCE   2  (bases 1 to 1292)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1292)
  AUTHORS   Munkholm,J., Thomsen,A.H. and Lynnerup,N.
  TITLE     [Fatal bicycle accidents involving right turning heavy goods
            vehicles--forensic pathological findings]
  JOURNAL   Ugeskr Laeger 169 (3), 232-235 (2007)
   PUBMED   17234101
REFERENCE   4  (bases 1 to 1292)
  AUTHORS   Takahashi,S., Ogasawara,H., Hiwatashi,K., Hata,K., Hori,K.,
            Koizumi,Y. and Sugiyama,T.
  TITLE     Amino acid residues conferring the nucleotide binding properties of
            N-acetyl-D-glucosamine 2-epimerase (renin binding protein)
  JOURNAL   Biomed Res 26 (3), 117-121 (2005)
   PUBMED   16011304
REFERENCE   5  (bases 1 to 1292)
  AUTHORS   Zurcher,H., Van Vooren,P., Szpirer,J., Szpirer,C. and Kreutz,R.
  TITLE     Assignment of the gene encoding renin binding protein (Renbp) to
            rat chromosome Xq37 by in situ hybridization and radiation hybrid
            mapping
  JOURNAL   Cytogenet Genome Res 97 (3-4), 277H (2002)
   PUBMED   12866502
  REMARK    GeneRIF: The gene encoding renin binding protein (Renbp) has been
            assigned to rat chromosome Xq37.
REFERENCE   6  (bases 1 to 1292)
  AUTHORS   Takahashi,S., Hori,K., Takahashi,K., Ogasawara,H., Tomatsu,M. and
            Saito,K.
  TITLE     Effects of nucleotides on N-acetyl-d-glucosamine 2-epimerases
            (renin-binding proteins): comparative biochemical studies
  JOURNAL   J Biochem 130 (6), 815-821 (2001)
   PUBMED   11726282
REFERENCE   7  (bases 1 to 1292)
  AUTHORS   Schmitz,C., Gotthardt,M., Hinderlich,S., Leheste,J.R., Gross,V.,
            Vorum,H., Christensen,E.I., Luft,F.C., Takahashi,S. and
            Willnow,T.E.
  TITLE     Normal blood pressure and plasma renin activity in mice lacking the
            renin-binding protein, a cellular renin inhibitor
  JOURNAL   J Biol Chem 275 (20), 15357-15362 (2000)
   PUBMED   10809771
REFERENCE   8  (bases 1 to 1292)
  AUTHORS   Tada,M., Takahashi,S., Miyano,M. and Miyake,Y.
  TITLE     Tissue-specific regulation of renin-binding protein gene expression
            in rats
  JOURNAL   J Biochem 112 (2), 175-182 (1992)
   PUBMED   1400260
REFERENCE   9  (bases 1 to 1292)
  AUTHORS   Inoue,H., Takahashi,S., Fukui,K. and Miyake,Y.
  TITLE     Genetic and molecular properties of human and rat renin-binding
            proteins with reference to the function of the leucine zipper motif
  JOURNAL   J Biochem 110 (4), 493-500 (1991)
   PUBMED   1723410
REFERENCE   10 (bases 1 to 1292)
  AUTHORS   Takahashi,S., Ohsawa,T., Miura,R. and Miyake,Y.
  TITLE     Purification and characterization of renin binding protein (RnBP)
            from porcine kidney
  JOURNAL   J Biochem 93 (6), 1583-1594 (1983)
   PUBMED   6885739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D10233.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10233.1, FQ228819.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1292
                     /gene="Renbp"
                     /note="renin binding protein"
                     /db_xref="GeneID:81759"
                     /db_xref="RGD:621688"
     exon            1..14
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     exon            15..124
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1277
                     /gene="Renbp"
                     /EC_number="5.1.3.8"
                     /note="AGE; rnBP; glcNAc 2-epimerase;
                     N-acetyl-D-glucosamine 2-epimerase"
                     /codon_start=1
                     /product="N-acylglucosamine 2-epimerase"
                     /protein_id="NP_112357.1"
                     /db_xref="GeneID:81759"
                     /db_xref="RGD:621688"
                     /translation="MEKERETLQVWKQRVGQELDSVIAFWMEHSHDQEHGGFFTCLGR
                     DGQVYDHLKYVWLQGRQVWMYCRLYRTFERFRRVELLDAAKAGGEFLLSYARVAPPGK
                     KCAFVLTQDGRPVKVQRTIFSECFYTMAMNELWKVTGEMHYQREAVEMMDQIIHWVRE
                     DPAGLGRPQLSGTLATEPMAVPMMLLNLVEQLGEEDEEMTDKYAELGDWCAHRILQHV
                     QRDGQVVLENVSEDGKELPGCLGRHQNPGHTLEAGWFLLQYALRKGDPKLQRHIIDKF
                     LLLPFHSGWDPEHGGLFYFQDADDLCPTQLEWNMKLWWPHTEAMIAFLMGYRDSGDPA
                     LLNLFYQVAEYTFHQFRDPEYGEWFGYLNQEGKVALTIKGGPFKGCFHVPRCLAMCEQ
                     ILGALLQRLGPAPLGSLPAVPTREGSK"
     exon            125..200
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     exon            201..276
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     exon            277..449
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     exon            450..674
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     exon            675..756
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     exon            757..932
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1064
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1152
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1292
                     /gene="Renbp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1292
                     /gene="Renbp"
ORIGIN      
        1 tcctagtgtt acaggacatg gagaaggaac gggagacact gcaggtctgg aagcaacgtg
       61 tgggacaaga gctcgattct gtgatcgctt tctggatgga gcattcccat gaccaggaac
      121 acgggggctt cttcacatgc cttggccgcg atgggcaggt atatgatcac ctcaaatatg
      181 tctggctgca ggggaggcag gtatggatgt attgtcgctt ataccgcact tttgagcgct
      241 tccgccgtgt cgagcttctg gatgcagcaa aagcaggtgg tgaatttttg ttgagttatg
      301 cccgggtggc accgcctggc aagaaatgtg cttttgtgct gacccaggac ggccgtccag
      361 tgaaggtgca gcggaccatt ttcagcgagt gcttttacac catggccatg aatgaactgt
      421 ggaaagtaac aggggaaatg cattatcaga gagaagccgt agagatgatg gatcagatca
      481 tccactgggt aagggaggac ccagctgggc tgggccggcc tcagctctcg ggaacactgg
      541 ccacagagcc catggcagtg cccatgatgc tgctcaacct ggtggagcag cttggagaag
      601 aagatgagga gatgaccgac aagtatgcag aactagggga ctggtgtgcc cataggattc
      661 ttcagcatgt ccagagggat ggacaagttg tactggagaa tgtatcagag gatggcaaag
      721 agctccctgg ttgccttgga agacatcaga acccaggcca cacactggaa gctggctggt
      781 ttctgctcca gtatgccctc aggaaaggtg atcccaaact tcaaaggcac attattgaca
      841 agtttctctt actgcctttc cactctggat gggaccctga gcacggaggc ctcttctact
      901 tccaggatgc tgatgatctc tgccctaccc agctggaatg gaacatgaag ctgtggtggc
      961 cacacactga agccatgatt gccttcctca tgggttacag ggacagcggg gacccagcct
     1021 tgctgaacct cttctaccaa gtggctgaat acaccttcca ccagtttcgt gatcctgagt
     1081 acggggaatg gtttggctac ctgaaccaag agggaaaggt ggcccttacc atcaaaggag
     1141 gtccttttaa aggctgcttc catgtgccgc ggtgcctggc catgtgcgag cagattttgg
     1201 gagccctact ccaacgcctt gggcccgccc ccctcggctc cttgcccgct gtccccactc
     1261 gcgaaggctc gaaataaagc tgaccctgtt cc
//
