LOCUS       NM_012642               1451 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus renin (Ren), mRNA.
ACCESSION   NM_012642
VERSION     NM_012642.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1451)
  AUTHORS   Huang,Q., Su,J., Xu,J., Yu,H., Jin,X., Wang,Y., Yan,M., Yu,J.,
            Chen,S., Wang,Y. and Lv,G.
  TITLE     Beneficial effects of Panax notoginseng (Burkill) F. H. Chen flower
            saponins in rats with metabolic hypertension by inhibiting the
            activation of the renin-angiotensin-aldosterone system through
            complement 3
  JOURNAL   BMC Complement Med Ther 23 (1), 13 (2023)
   PUBMED   36653797
  REMARK    Erratum:[BMC Complement Med Ther. 2023 Mar 8;23(1):76. doi:
            10.1186/s12906-023-03893-1.. PMID: 36890530]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1451)
  AUTHORS   Mondragon-Huerta,C.G., Bautista-Perez,R., Baiza-Gutman,L.A.,
            Escobar-Sanchez,M.L., Valle-Mondragon,L.D., Salas-Garrido,C.G.,
            Castro-Moreno,P. and Ibarra-Barajas,M.
  TITLE     Morphology and cyclooxygenase-2 and renin expression in the kidney
            of young spontaneously hypertensive rats
  JOURNAL   Vet Pathol 59 (2), 371-384 (2022)
   PUBMED   34841988
  REMARK    GeneRIF: Morphology and cyclooxygenase-2 and renin expression in
            the kidney of young spontaneously hypertensive rats.
REFERENCE   3  (bases 1 to 1451)
  AUTHORS   Coelho,N.R., Tomkiewicz,C., Correia,M.J., Goncalves-Dias,C.,
            Barouki,R., Pereira,S.A., Coumoul,X. and Monteiro,E.C.
  TITLE     First evidence of aryl hydrocarbon receptor as a druggable target
            in hypertension induced by chronic intermittent hypoxia
  JOURNAL   Pharmacol Res 159, 104869 (2020)
   PUBMED   32416216
REFERENCE   4  (bases 1 to 1451)
  AUTHORS   Hsu,C.N., Lin,I.C., Yu,H.R., Huang,L.T., Tiao,M.M. and Tain,Y.L.
  TITLE     Maternal Tryptophan Supplementation Protects Adult Rat Offspring
            against Hypertension Programmed by Maternal Chronic Kidney Disease:
            Implication of Tryptophan-Metabolizing Microbiome and Aryl
            Hydrocarbon Receptor
  JOURNAL   Int J Mol Sci 21 (12), 4552 (2020)
   PUBMED   32604820
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1451)
  AUTHORS   Chung,K.S., Song,J.H., Jung,W.J., Kim,Y.S., Kim,S.K., Chang,J. and
            Park,M.S.
  TITLE     Implications of Plasma Renin Activity and Plasma Aldosterone
            Concentration in Critically Ill Patients with Septic Shock
  JOURNAL   Korean J Crit Care Med 32 (2), 142-153 (2017)
   PUBMED   31723628
REFERENCE   6  (bases 1 to 1451)
  AUTHORS   Alderman,M.H., Madhavan,S., Ooi,W.L., Cohen,H., Sealey,J.E. and
            Laragh,J.H.
  TITLE     Association of the renin-sodium profile with the risk of myocardial
            infarction in patients with hypertension
  JOURNAL   N Engl J Med 324 (16), 1098-1104 (1991)
   PUBMED   1759997
REFERENCE   7  (bases 1 to 1451)
  AUTHORS   Annat,G., Raudrant,D., Chappe,J., Vincent,M., Thoulon,J., Dumont,M.
            and Sassard,J.
  TITLE     Maternal and fetal plasma renin and dopamine-beta-hydroxylase
            activities in toxemic pregnancy
  JOURNAL   Obstet Gynecol 52 (2), 219-224 (1978)
   PUBMED   683663
REFERENCE   8  (bases 1 to 1451)
  AUTHORS   Morris,B.J. and Johnston,C.I.
  TITLE     Isolation of renin granules from rat kidney cortex and evidence for
            an inactive form of renin (prorenin) in granules and plasma
  JOURNAL   Endocrinology 98 (6), 1466-1474 (1976)
   PUBMED   1278112
REFERENCE   9  (bases 1 to 1451)
  AUTHORS   Yamamoto,Y.
  TITLE     Effect of pressor agents on blood pressure, plasma renin activity
            and plasma aldosterone concentration in essential hypertension
  JOURNAL   Jpn Heart J 16 (4), 404-420 (1975)
   PUBMED   1152295
REFERENCE   10 (bases 1 to 1451)
  AUTHORS   Baggio,B., Favoro,S., Antonello,A., Zen,A., Zen,F. and Borsatti,A.
  TITLE     Subcellular localization of renin and kallikrein in rat kidney
  JOURNAL   Ital J Biochem 24 (3-4), 199-206 (1975)
   PUBMED   1213875
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078878.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012642.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078878.1, X07033.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1451
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1451
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /note="renin"
                     /db_xref="GeneID:24715"
                     /db_xref="RGD:3554"
     exon            1..114
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1231
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /EC_number="3.4.23.15"
                     /note="angiotensinogenase; renin 1 structural"
                     /codon_start=1
                     /product="renin precursor"
                     /protein_id="NP_036774.4"
                     /db_xref="GeneID:24715"
                     /db_xref="RGD:3554"
                     /translation="MGGRRMPLWALLLLWTSCSFSLPTDTASFGRILLKKMPSVREIL
                     EERGVDMTRISAEWGEFIKKSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFD
                     TGSANLWVPSTKCGPLYTACEIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDV
                     VTVGGIIVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVDGVIPVFDHILSQRVLK
                     EEVFSVYYSRESHLLGGEVVLGGSDPQHYQGNFHYVSISKAGSWQITMKGVSVGPATL
                     LCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANNYVVNCSQVPTLPDISFYL
                     GGRTYTLSNMDYVQKNPFRNDDLCILALQGLDIPPPTGPVWVLGATFIRKFYTEFDRH
                     NNRIGFALAR"
     exon            115..265
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /inference="alignment:Splign:2.1.0"
     exon            266..389
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /inference="alignment:Splign:2.1.0"
     exon            390..508
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /inference="alignment:Splign:2.1.0"
     exon            509..705
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /inference="alignment:Splign:2.1.0"
     exon            706..825
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /inference="alignment:Splign:2.1.0"
     exon            826..970
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1069
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1425
                     /gene="Ren"
                     /gene_synonym="RATRENAA; Ren1; RENAA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaagcct tggctggacc agatgggcgg gaggaggatg cctctctggg cactcttgtt
       61 gctctggacc tcttgtagct tcagtctccc gacagacaca gccagctttg gacgaatctt
      121 gctcaagaaa atgccctcgg tccgggaaat cctggaggag cggggagtag acatgaccag
      181 gatcagtgct gaatggggtg aattcatcaa gaagtcttcc tttaccaatg ttacctcccc
      241 cgtggtcctc accaactact tggataccca gtactatggt gagatcggca ttggtacccc
      301 atcccagacc ttcaaagtca tctttgacac gggttcagcc aacctctggg tgccctccac
      361 caagtgtggt cccctctaca ctgcctgtga gattcacaac ctctatgact cctcggaatc
      421 ctctagctac atggagaatg ggactgaatt caccatccac tatggatcag ggaaggtcaa
      481 aggtttcctc agccaagatg tggtaactgt gggtggaatc attgtgacac agacctttgg
      541 agaggtcacc gagctgcccc tgataccctt catgctggcc aagtttgacg gggttctggg
      601 catgggcttc cctgctcagg ctgttgatgg agtcatccct gtcttcgacc acattctctc
      661 ccagagggtg ctaaaggagg aagtgttttc tgtctactac agcagggagt cccacctgct
      721 ggggggcgaa gtggtgctgg gaggcagtga ccctcaacat taccagggca actttcacta
      781 cgtgagcatc agcaaggccg gctcctggca gatcaccatg aagggggtct ctgtggggcc
      841 tgccaccttg ttgtgtgagg agggctgtat ggcagtggtg gacactggca catcctatat
      901 ctcgggccct accagctccc tgcagttgat catgcaagcc ctgggagtca aagagaagag
      961 agcaaataat tacgttgtga actgtagcca ggtacccacc ctccccgaca tctccttcta
     1021 cctgggaggc aggacctaca ctctcagcaa catggactat gtgcaaaaga atcccttcag
     1081 gaacgatgac ctgtgcatac tggctctcca aggcctggac atcccaccac ccactgggcc
     1141 tgtctgggtc ctgggtgcca ccttcatccg caagttctat acagagttcg accggcataa
     1201 caatcgcatc gggttcgcct tggcccgcta agctcctctg tcacccagtg accctagttt
     1261 taggccaagc caaagctggc gttcctgggg gccattctgt ctggctctgc ccccaacata
     1321 gggacactgg acacagagcc cttgatgagt gcttgtccct tcgcctgcct gcactcaccc
     1381 ttccctgctt tgaggaaaaa cagaataaag actgcatgtt tacaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa a
//
