LOCUS       NM_022685               1835 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus RRAD and GEM like GTPase 2 (Rem2), mRNA.
ACCESSION   NM_022685
VERSION     NM_022685.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1835)
  AUTHORS   Moore,A.R., Richards,S.E., Kenny,K., Royer,L., Chan,U.,
            Flavahan,K., Van Hooser,S.D. and Paradis,S.
  TITLE     Rem2 stabilizes intrinsic excitability and spontaneous firing in
            visual circuits
  JOURNAL   Elife 7, e33092 (2018)
   PUBMED   29809135
  REMARK    GeneRIF: Rem2 stabilizes intrinsic excitability and spontaneous
            firing in visual circuits.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1835)
  AUTHORS   Parent,C., Wen,X., Dhir,S.K., Ryan,R., Diorio,J. and Zhang,T.Y.
  TITLE     Maternal care associates with differences in morphological
            complexity in the medial preoptic area
  JOURNAL   Behav Brain Res 326, 22-32 (2017)
   PUBMED   28259675
  REMARK    GeneRIF: When rats become maternal, they increase the expression of
            Rem2 in the medial preoptic area which inhibits dendritic
            complexity and associates with an enhancement of maternal
            responsiveness.
REFERENCE   3  (bases 1 to 1835)
  AUTHORS   Ghiretti,A.E., Moore,A.R., Brenner,R.G., Chen,L.F., West,A.E.,
            Lau,N.C., Van Hooser,S.D. and Paradis,S.
  TITLE     Rem2 is an activity-dependent negative regulator of dendritic
            complexity in vivo
  JOURNAL   J Neurosci 34 (2), 392-407 (2014)
   PUBMED   24403140
  REMARK    GeneRIF: Rem2 is regulated at the transcriptional level by calcium
            influx and inhibits dendritic arborization in cultured rat cortical
            neurons
REFERENCE   4  (bases 1 to 1835)
  AUTHORS   Reymond,P., Coquard,A., Chenon,M., Zeghouf,M., El Marjou,A.,
            Thompson,A. and Menetrey,J.
  TITLE     Structure of the GDP-bound G domain of the RGK protein Rem2
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (Pt 6), 626-631
            (2012)
   PUBMED   22684057
  REMARK    GeneRIF: structure of the Rem2 G domain bound to GDP is reported
            here in a monoclinic crystal form at 2.66 A resolution
REFERENCE   5  (bases 1 to 1835)
  AUTHORS   Flynn,R., Labrie-Dion,E., Bernier,N., Colicos,M.A., De Koninck,P.
            and Zamponi,G.W.
  TITLE     Activity-dependent subcellular cotrafficking of the small GTPase
            Rem2 and Ca2+/CaM-dependent protein kinase IIalpha
  JOURNAL   PLoS One 7 (7), e41185 (2012)
   PUBMED   22815963
  REMARK    GeneRIF: Rem2 has a role in neuronal plasticity hrough
            co-trafficking with CaMKIIa
REFERENCE   6  (bases 1 to 1835)
  AUTHORS   Ghiretti,A.E. and Paradis,S.
  TITLE     The GTPase Rem2 regulates synapse development and dendritic
            morphology
  JOURNAL   Dev Neurobiol 71 (5), 374-389 (2011)
   PUBMED   21485012
  REMARK    GeneRIF: our results suggest that Rem2 regulates dendritic
            branching and synapse development
REFERENCE   7  (bases 1 to 1835)
  AUTHORS   Correll,R.N., Botzet,G.J., Satin,J., Andres,D.A. and Finlin,B.S.
  TITLE     Analysis of the Rem2 - voltage dependant calcium channel beta
            subunit interaction and Rem2 interaction with phosphorylated
            phosphatidylinositide lipids
  JOURNAL   Cell Signal 20 (2), 400-408 (2008)
   PUBMED   18068949
  REMARK    GeneRIF: Voltage dependant calcium channels blockade by Rem2 is
            likely to be controlled by both the localized concentration of
            membrane phosphorylated phosphatidylinositide lipids and direct
            14-3-3 binding to the Rem2 C-terminus.
REFERENCE   8  (bases 1 to 1835)
  AUTHORS   Chen,H., Puhl,H.L. 3rd, Niu,S.L., Mitchell,D.C. and Ikeda,S.R.
  TITLE     Expression of Rem2, an RGK family small GTPase, reduces N-type
            calcium current without affecting channel surface density
  JOURNAL   J Neurosci 25 (42), 9762-9772 (2005)
   PUBMED   16237180
  REMARK    GeneRIF: Rem2 localizes to the plasma membrane via a C-terminal
            motif and interacts with calcium channel beta subunits in the
            preassembled N-type channel, thereby forming a nonconducting
            species.
REFERENCE   9  (bases 1 to 1835)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   10 (bases 1 to 1835)
  AUTHORS   Finlin,B.S., Shao,H., Kadono-Okuda,K., Guo,N. and Andres,D.A.
  TITLE     Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related
            GTPases
  JOURNAL   Biochem J 347 Pt 1 (Pt 1), 223-231 (2000)
   PUBMED   10727423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB706504.1 and BC127495.1.
            
            On Sep 25, 2009 this sequence version replaced NM_022685.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127495.1, AY916790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132269, SAMD00132270
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CB706504.1         34-48
            16-1835             BC127495.1         1-1820
FEATURES             Location/Qualifiers
     source          1..1835
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1835
                     /gene="Rem2"
                     /note="RRAD and GEM like GTPase 2"
                     /db_xref="GeneID:64626"
                     /db_xref="RGD:69081"
     exon            1..187
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1110
                     /gene="Rem2"
                     /EC_number="3.6.5.2"
                     /note="GEM, REM, Kir family small G-protein; rad and
                     Gem-like GTP-binding protein 2; GTP-binding protein REM2;
                     rad and gem related GTP binding protein 2; Ras-related
                     GTP-binding protein of the Rad/Gem/Kir family, member 2;
                     RAS (RAD and GEM) like GTP binding 2"
                     /codon_start=1
                     /product="GTP-binding protein REM 2"
                     /protein_id="NP_073176.2"
                     /db_xref="GeneID:64626"
                     /db_xref="RGD:69081"
                     /translation="MHTDLDTDMDADTETVALCSSSSRQASPSGTPTPEADTTLLKQK
                     PEKLLAELDRGGPPPAPGVPRRRGSMPVPYKHQLRRAQAVDELDWPPQASSSGSSDSL
                     GSGEAALAQKDGVFKVMLLGESGVGKSTLAGTFGGLQGDNAHEMENSEDTYERRIMVD
                     KEEVTLIVYDIWEQGDAGGWLQDHCLQTGDAFLIVFSVTDRRSFSKVPETLLRLRAGR
                     PHHDLPVILVGNKSDLARSREVSLEEGRHLAGTLSCKHIETSAALHHNTRELFEGAVR
                     QIRLRRGRGHAGGQRPEPSSPDGPAPPTRRESLTKKAKRFLANLVPRNAKFFKQRSRS
                     CHDLSVL"
     exon            188..532
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..606
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..814
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1810
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtatttaaag ggaaaagctg acagtgctgc tgagtgagga tccggtgctg tgagccgccg
       61 ggctgcactc gcacatgcac gtcaatgcac acggaccttg acaccgacat ggacgcggac
      121 accgaaaccg tagcactttg ttcttctagc agccgccagg cctccccatc agggacaccc
      181 acaccagaag ccgatacgac acttctgaag cagaagccag agaaactgtt ggcagagttg
      241 gacagaggtg ggccacctcc tgctcctggg gtccccagac gaagaggaag tatgcctgtg
      301 ccctacaaac accagctgcg gcgggctcaa gctgtggatg agcttgactg gccacctcag
      361 gcctcttcct ctggctcctc tgactcgttg ggctcagggg aggcagccct ggcccaaaaa
      421 gatggtgtct ttaaggtcat gctcctggga gagagtggcg tgggcaagag cactctagca
      481 ggcactttcg gaggtctcca gggagacaat gctcacgaga tggagaactc agaggacacc
      541 tatgagagac ggatcatggt ggacaaagaa gaagtgactt taattgttta tgacatctgg
      601 gaacagggag acgcaggagg atggctgcag gaccactgcc ttcagacggg ggacgccttt
      661 ctcatcgtct tttcagtcac agatcgacga agcttctcca aagttcctga aacccttctt
      721 cgactccggg ctgggaggcc ccaccacgac ctacctgtca tccttgttgg aaataagagt
      781 gacctggccc gttcccggga ggtgtcactg gaggagggtc gccatctggc cgggacgctg
      841 agctgcaagc acatagagac atcagccgct ctccaccaca acactcgtga gctcttcgag
      901 ggcgctgtgc gtcagatcag gctgcggcgg ggccggggtc atgccggggg ccagcggccg
      961 gaacctagca gcccggacgg ccccgcgccg cctacgcgcc gcgagagcct caccaagaaa
     1021 gctaagcgct tcctcgccaa cctggtgccg cgcaacgcca agttcttcaa gcaacgctcc
     1081 aggtcgtgtc acgacctctc tgtgctctga gccacggtcg ccatggtcac tgcagtcgcc
     1141 atggtcaccg tgccctccgc tcgccccctc accccactcc agtccgtcta ggaaaccaaa
     1201 aatacccagg atgccctggt gtgatgggga ggcggggccg ggtagctggt aggtccacca
     1261 ccaccacctc gcctggtctg aacagccaac cccacactgc gcctcaagac ctgcaagaca
     1321 gggaagaaat ccgtgctgca aggtattttt ttattgttat tattaacttg caagaaacca
     1381 cctctcccgg aagagactcc aacagctaga actggaaaag tgctttgtaa gcctcctgga
     1441 tggagttgac ctcctcagta ctctgaacat gccttacctt taagcaagtt ttaaaggtag
     1501 aaacccagag atgactcttc cagagatgac tgaaaatatt tctcttgtcc tctgtcctgg
     1561 tccactttgc ccttaagacg ttcttaaaag aaagggctgg aagttattct tgaaattgga
     1621 ctctgactta gcaatctacg atagcatgtt tcgtttaagg ttactgaagt gaagatgtgg
     1681 gcagactctc gacatttaga taccctaagg tagagctgag cgctagaaac ccctgtggcc
     1741 agggactagg aggcaccagc aagggccacc ctttcccctt tccaataaat tttttttcta
     1801 ttgcactgtg aaaaaaaaaa aaaaaaaaaa aaaaa
//
