LOCUS       NM_001025753            1649 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RRAD and GEM like GTPase 1 (Rem1), mRNA.
ACCESSION   NM_001025753 XM_345457
VERSION     NM_001025753.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1649)
  AUTHORS   Jhun,B.S., O-Uchi,J., Wang,W., Ha,C.H., Zhao,J., Kim,J.Y., Wong,C.,
            Dirksen,R.T., Lopes,C.M.B. and Jin,Z.G.
  TITLE     Adrenergic signaling controls RGK-dependent trafficking of cardiac
            voltage-gated L-type Ca2+ channels through PKD1
  JOURNAL   Circ Res 110 (1), 59-70 (2012)
   PUBMED   22076634
  REMARK    GeneRIF: The alpha(1)-adrenergic stimulation releases Rem1
            inhibition of voltage-gated L-type calcium channels through direct
            phosphorylation of Rem1 at Ser18 by protein kinase D1, resulting in
            an increase of the channel activity and transverse-tubule
            expression.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098946.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001025753.2.
            
            On Jul 22, 2005 this sequence version replaced XM_345457.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1649
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1649
                     /gene="Rem1"
                     /note="RRAD and GEM like GTPase 1"
                     /db_xref="GeneID:366232"
                     /db_xref="RGD:1306560"
     exon            1..51
                     /gene="Rem1"
                     /inference="alignment:Splign:2.1.0"
     exon            52..590
                     /gene="Rem1"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1144
                     /gene="Rem1"
                     /EC_number="3.6.5.2"
                     /note="rad and gem related GTP binding protein 1; RAS (RAD
                     and GEM)-like GTP-binding 1"
                     /codon_start=1
                     /product="GTP-binding protein REM 1"
                     /protein_id="NP_001020924.1"
                     /db_xref="GeneID:366232"
                     /db_xref="RGD:1306560"
                     /translation="MTLNTQQEAKTTLRRRASTPLPLSSRGHQPGRLCTAPPAQSQHP
                     RLGQSASLNPPIRKPSPAQDGWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAE
                     KQERDLHEQLGGVYERTLSVDGEDTTLVVMDTWEAEKLDESWSQESCLQAGSAYVIVY
                     SIADRSSFESASELRIQLRRTHQAAHVPIILVGNKADLARCREVSVEEGRACAVVFDC
                     KFIETSATLQHNVTELFEGVVRQLRLRRQDNAAPETPSPRRRASLGQRARRFLARLTA
                     RSARRRALKARSKSCHNLAVL"
     exon            591..670
                     /gene="Rem1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..872
                     /gene="Rem1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1625
                     /gene="Rem1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtaccca gcagctgggg cagcggggac tcggagcctc cgcgtgtcaa ggcctgaaac
       61 cagcaatctc tgaacccaag gagctgaaag gtctatttcc agttgaacca gagaggactc
      121 tggaggaaat tatttccaca gtttatcagg cccgaagaag ggactccggg ctacagactt
      181 actgccaccc agcctacttc ttttggaagg aaggaaggag ccagggaagc cagagatttc
      241 ctcacagagg atgactctta acacccagca ggaagcaaag accactctgc gacgtcgagc
      301 cagcacacca ctacccctgt cgtccagggg ccaccagcct ggccgcctgt gcacagcacc
      361 ccctgctcaa tcccagcatc cccgactggg tcagtcagcc tccctcaacc ctcccattcg
      421 gaaaccctcc cctgcccagg atgggtggtc ctctgaatcc agcgactctg aaggctcttg
      481 ggaggcactc taccgggtgg tgcttcttgg agaccccggt gtcgggaaga ctagcttggc
      541 cagcctcttt gcagagaaac aagaacgaga ccttcacgag cagctgggag gtgtgtatga
      601 gagaacgctg tcggtggacg gagaggacac cacactggtg gtcatggaca cctgggaggc
      661 tgagaaactg gatgaaagct ggagccagga gtcatgcctg caggcgggca gcgcctatgt
      721 catcgtgtac tccatcgcag atcgcagcag ctttgagagt gcctccgagc tccgaatcca
      781 gctgaggcgc acgcaccagg ccgcccatgt gcctatcatc ctggtgggca acaaggccga
      841 cctggctcgt tgccgagaag tctctgtaga agagggccgc gcctgcgctg tggtgttcga
      901 ctgcaagttc atcgagacct cagccactct gcagcacaac gtgacagagc tcttcgaagg
      961 tgtggtgcgc caactgcgcc tgcgccgcca agacaatgcg gccccggaga caccttcacc
     1021 tcgacggcgg gccagcttgg gccagcgtgc ccgccgcttc ctggcacgcc tgacagcacg
     1081 cagcgcacga cgccgggcac tcaaagcccg ctccaagtcc tgccacaacc tggctgtgct
     1141 ctgaggccag cgtctctctg gggcgatagg acactgtggt gccactaagg acaaaaggtg
     1201 catcattaga gttctcgtga ttgacctctg ctgttgccag gatggccagg acgttgccag
     1261 gagctagggc tttggggatc cttcctgcct ggcaaagtga tgaatagaca gactatgggg
     1321 ctataaaccc tagctaggca caaggttttc tgtttttgtt tttctttttt acaggatggg
     1381 tgtctttttg ttaaaaaaaa aaaaaagaca aaaaaaaaaa agctttcttg tccctgggct
     1441 gtgaccaact ctcagaattt accacaataa gccagtttgg gatgtcttgt ctgatgtgtg
     1501 gatgtctctc agtgggttct tccaggcatc cacctcctcc ccaaacgtct aacttgactg
     1561 tagactgttt tggcctgctg gcctagatgt cttggacaat caataaagtc aatgaattaa
     1621 ttataaaaaa aaaaaaaaaa aaaaaaaaa
//
