LOCUS       NM_199267               2472 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus RELA proto-oncogene, NF-kB subunit (Rela), mRNA.
ACCESSION   NM_199267 XM_238994
VERSION     NM_199267.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2472)
  AUTHORS   Zhou,F., Zhou,P., Jiang,X., Yang,Z., Cui,W., Liu,W. and Liu,R.
  TITLE     Fengshi Liuhe Decoction treatment for rheumatoid arthritis via the
            Fzd6/NF-kappaB signaling axis
  JOURNAL   Gene 920, 148538 (2024)
   PUBMED   38710294
  REMARK    GeneRIF: Fengshi Liuhe Decoction treatment for rheumatoid arthritis
            via the Fzd6/NF-kappaB signaling axis.
REFERENCE   2  (bases 1 to 2472)
  AUTHORS   Ahmed,M.A., Kamel,E.O. and Abd-Eldayem,A.M.
  TITLE     Role of cAMP/pCREB and GSK-3beta/NF-kappaB p65 signaling pathways
            in the renoprotective effect of mirabegron against renal
            ischemia-reperfusion injury in rats
  JOURNAL   Eur J Pharmacol 974, 176617 (2024)
   PUBMED   38679120
  REMARK    GeneRIF: Role of cAMP/pCREB and GSK-3beta/NF-kappaB p65 signaling
            pathways in the renoprotective effect of mirabegron against renal
            ischemia-reperfusion injury in rats.
REFERENCE   3  (bases 1 to 2472)
  AUTHORS   Wu,Q., Qin,B., Wu,X., Zhang,M., Gan,Z., Lan,Y., Ma,C. and Fu,W.
  TITLE     Allograft inflammatory factor-1 enhances inflammation and oxidative
            stress via the NF-kappaB pathway of bladder urothelium in diabetic
            rat model
  JOURNAL   Cytokine 173, 156438 (2024)
   PUBMED   37976702
  REMARK    GeneRIF: Allograft inflammatory factor-1 enhances inflammation and
            oxidative stress via the NF-kappaB pathway of bladder urothelium in
            diabetic rat model.
REFERENCE   4  (bases 1 to 2472)
  AUTHORS   Li,S., Ma,Q., Ma,Z., Shi,Y., Yu,X., Gu,B., Sun,S., Yu,C. and
            Pang,L.
  TITLE     Renal ischaemia-reperfusion injury is promoted by transcription
            factor NF-kB p65, which inhibits TRPC6 expression by activating
            miR-150
  JOURNAL   Clin Hemorheol Microcirc 86 (3), 369-382 (2024)
   PUBMED   37980653
  REMARK    GeneRIF: Renal ischaemia-reperfusion injury is promoted by
            transcription factor NF-kB p65, which inhibits TRPC6 expression by
            activating miR-150.
REFERENCE   5  (bases 1 to 2472)
  AUTHORS   DU,Y., Liu,X., Xiao,C., Li,J., Sheng,Z., Wang,Y., Wang,R. and Yu,X.
  TITLE     TIPE2 regulates periodontal inflammation by inhibiting NF-kappaB
            p65 phosphorylation
  JOURNAL   J Appl Oral Sci 31, e20230162 (2023)
   PUBMED   37493703
  REMARK    GeneRIF: TIPE2 regulates periodontal inflammation by inhibiting
            NF-kappaB p65 phosphorylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2472)
  AUTHORS   Beg,A.A., Sha,W.C., Bronson,R.T., Ghosh,S. and Baltimore,D.
  TITLE     Embryonic lethality and liver degeneration in mice lacking the RelA
            component of NF-kappa B
  JOURNAL   Nature 376 (6536), 167-170 (1995)
   PUBMED   7603567
REFERENCE   7  (bases 1 to 2472)
  AUTHORS   Brockman,J.A., Scherer,D.C., McKinsey,T.A., Hall,S.M., Qi,X.,
            Lee,W.Y. and Ballard,D.W.
  TITLE     Coupling of a signal response domain in I kappa B alpha to multiple
            pathways for NF-kappa B activation
  JOURNAL   Mol Cell Biol 15 (5), 2809-2818 (1995)
   PUBMED   7739562
REFERENCE   8  (bases 1 to 2472)
  AUTHORS   Kunsch,C., Ruben,S.M. and Rosen,C.A.
  TITLE     Selection of optimal kappa B/Rel DNA-binding motifs: interaction of
            both subunits of NF-kappa B with DNA is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 12 (10), 4412-4421 (1992)
   PUBMED   1406630
REFERENCE   9  (bases 1 to 2472)
  AUTHORS   Baeuerle,P.A. and Baltimore,D.
  TITLE     I kappa B: a specific inhibitor of the NF-kappa B transcription
            factor
  JOURNAL   Science 242 (4878), 540-546 (1988)
   PUBMED   3140380
REFERENCE   10 (bases 1 to 2472)
  AUTHORS   Sen,R. and Baltimore,D.
  TITLE     Multiple nuclear factors interact with the immunoglobulin enhancer
            sequences
  JOURNAL   Cell 46 (5), 705-716 (1986)
   PUBMED   3091258
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079457.1.
            
            On Aug 8, 2004 this sequence version replaced NM_199267.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079457.1, SRR8487230.3296.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2472
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2472
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /note="RELA proto-oncogene, NF-kB subunit"
                     /db_xref="GeneID:309165"
                     /db_xref="RGD:727889"
     exon            1..68
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1714
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /note="nuclear factor kappa B subunit p65; v-rel
                     reticuloendotheliosis viral oncogene homolog A; v-rel
                     avian reticuloendotheliosis viral oncogene homolog A;
                     nuclear factor kappaB subunit p65"
                     /codon_start=1
                     /product="transcription factor p65"
                     /protein_id="NP_954888.1"
                     /db_xref="GeneID:309165"
                     /db_xref="RGD:727889"
                     /translation="MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAG
                     SIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEA
                     ELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLC
                     FQVTVRDPSGRPLRLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDK
                     VQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPS
                     DRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPPRRIAVP
                     SRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVLPPGQISNQALALAPSSAPVLAQTM
                     VPSSAMVPSLAQPPAPVPVLAPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDL
                     GALLGNNTDPGVFTDLASVDNSEFQQLLNQGVAMSHSTAEPMLMEYPEAITRLVTGSQ
                     RPPDPAPATLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS"
     exon            69..95
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     exon            96..247
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     exon            248..396
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     exon            397..488
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..620
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..725
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..938
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1019
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1094
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..2443
                     /gene="Rela"
                     /gene_synonym="NFkB; nos2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgcttta gcgcgccgtg ggctcagctg cgaccccggc cccgcccccg ggaccctggc
       61 catggacgat ctgtttcccc tcatctttcc ctcagagcca gcccaggctt ctgggccata
      121 tgtggagatc attgagcagc ccaagcagcg gggcatgcgt ttccgttaca agtgcgaggg
      181 ccgctctgca ggcagtattc ctggggagag aagcacagat accactaaga cgcaccccac
      241 catcaagatc aatggctaca cgggaccagg aacagttcga atctccctgg tcaccaaaga
      301 cccacctcac cggcctcatc cacatgaact tgtggggaag gactgccggg atggcttcta
      361 tgaggctgaa ctctgcccag accgatgcat ccacagcttc cagaacctgg ggatccagtg
      421 tgtgaagaag cgagacctgg agcaagccat tagccagcgc atccagacca acaataaccc
      481 ctttcaagtt cccatagagg agcagcgcgg ggactatgac ttgaatgcgg tccgcctctg
      541 cttccaggtg acagtgcggg acccatcagg caggcccctc cgcctgaccc ctgtcctctc
      601 gcatccgatt tttgataacc gtgcccccaa cactgccgag ctcaagatct gccgagtaaa
      661 ccggaactct gggagctgcc ttggtgggga tgagatcttc ttgctgtgtg acaaagtgca
      721 gaaagaagac attgaggtgt atttcacggg acctggctgg gaggcacgag gctccttttc
      781 tcaagccgat gtgcaccggc aagtggccat tgtgttccga actcccccat acgctgaccc
      841 tagcctgcag gctcctgtgc gagtgtccat gcagcttcgg cggccttctg atcgggagct
      901 cagtgagccc atggagttcc agtacttgcc agacacagac gatcgccacc ggattgaaga
      961 aaaacgcaaa aggacctacg agaccttcaa gagcatcatg aagaagagtc ctttcaatgg
     1021 accaactgaa ccccggcctc caccccgacg tattgctgtg ccttcccgag gcccaacttc
     1081 tgtccccaag ccagcacccc agccctatgc cttttcaaca tccctcagca ccatcaactt
     1141 tgatgagttt tcccccatgg tgttaccacc tgggcagatc tcaaaccagg ccttggccct
     1201 ggcaccatcc tctgccccag tcctggccca gaccatggtc ccctcctcag ccatggtacc
     1261 aagtctggct cagcccccag ctcctgtccc agttctagcc ccaggtcctc cccaatccct
     1321 gtctgcacct gttccaaaga gcacccaggc aggggaaggc accctgtctg aagccctgct
     1381 acacctgcag ttcgatgctg atgaagactt gggggccttg cttggcaaca acacagaccc
     1441 aggagtgttc acagacctgg catctgtcga caactcagag tttcagcagc ttctgaacca
     1501 gggtgtggcc atgtcccact ccacagctga gcccatgctg atggagtacc ctgaagctat
     1561 aactcgcctg gtgacaggat cccagaggcc ccctgatcca gctcctgcaa ccctggggac
     1621 ctcagggctt cccaatggcc tctcagggga tgaagacttc tcctccattg cggacatgga
     1681 cttctcagct cttctgagtc agatcagctc ctaaggcact gatggtgacc ctgctcagag
     1741 tggggcactg aagccttcct gaagcatgta cagattctgg ggagtgtgca ccaactgccc
     1801 ccaacttctt tgggtgatat ctcctggggg tggcacattt tattctttta tcagcaatat
     1861 ctcactctct ttttggaggt gcttaagcag aagcattaac ttccctgaag tggagctagg
     1921 aggactcggg ctcttcccct gtacgatagt cggctcttct tttggtaggg aactcttgag
     1981 accctgcttc catcctccag cttctagcac tctcctagag aggggcagac tggagctgtg
     2041 gccttcaggc cgtaaagcct tatatccagt gtcttcctcg acatggatcc ctgcacacct
     2101 tgatccaaag caacgctcct aggagcagcc cccatgaggt ctgcctgaca ccagcatttg
     2161 aggggccact tttctgtcct gtggagctcc tgccctgcca actctccatg ctgagcagtg
     2221 gctgagggga ccaggagggg acattgctgg ctgccttcag gaccgtgagg ctgtttggtt
     2281 tgagacatcc ctgcttcccc tttctcaagt gccttaatag cagggcaaat tgagtagagt
     2341 caggagggca gaccagacct cagccataag acagtcttta ctcaaaaagc tattggactc
     2401 ttgctctttc tagctctgaa ctaataaatg tattaccacg ctgaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa aa
//
