LOCUS       NM_001421314            7378 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus REL proto-oncogene, NF-kB subunit (Rel), mRNA.
ACCESSION   NM_001421314
VERSION     NM_001421314.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7378)
  AUTHORS   Burkitt,M.D., Hanedi,A.F., Duckworth,C.A., Williams,J.M.,
            Tang,J.M., O'Reilly,L.A., Putoczki,T.L., Gerondakis,S.,
            Dimaline,R., Caamano,J.H. and Pritchard,D.M.
  TITLE     NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate
            susceptibility to colitis-associated adenoma development in C57BL/6
            mice
  JOURNAL   J Pathol 236 (3), 326-336 (2015)
   PUBMED   25727407
REFERENCE   2  (bases 1 to 7378)
  AUTHORS   Gong,Z., Liu,T., Wan,Y., Hang,Z., Tong,X., Zhang,B., Yang,H.,
            Zhang,X., Zhang,L. and Jin,G.
  TITLE     Decreased c-rel activation contributes to aberrant interleukin-2
            expression in CD4(+)T cells of aged rats
  JOURNAL   Mol Immunol 61 (1), 1-6 (2014)
   PUBMED   24853588
  REMARK    GeneRIF: Data indicate that C-rel binding on the interleukin-2
            (IL-2) promoter region declined in the aged CD4+T cells.
REFERENCE   3  (bases 1 to 7378)
  AUTHORS   Burkitt,M.D., Williams,J.M., Duckworth,C.A., O'Hara,A., Hanedi,A.,
            Varro,A., Caamano,J.H. and Pritchard,D.M.
  TITLE     Signaling mediated by the NF-kappaB sub-units NF-kappaB1,
            NF-kappaB2 and c-Rel differentially regulate Helicobacter
            felis-induced gastric carcinogenesis in C57BL/6 mice
  JOURNAL   Oncogene 32 (50), 5563-5573 (2013)
   PUBMED   23975431
REFERENCE   4  (bases 1 to 7378)
  AUTHORS   Manecka,D.L., Mahmood,S.F., Grumolato,L., Lihrmann,I. and Anouar,Y.
  TITLE     Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes
            both survival and neuritogenesis in PC12 cells through activation
            of nuclear factor kappaB (NF-kappaB) pathway: involvement of
            extracellular signal-regulated kinase (ERK), calcium, and c-REL
  JOURNAL   J Biol Chem 288 (21), 14936-14948 (2013)
   PUBMED   23564451
  REMARK    GeneRIF: PACAP promotes both survival and neuritogenesis in PC12
            cells by activating NF-kappaB pathway, most likely via classical
            and alternative signaling cascades involving ERK1/2 kinases,
            Ca(2+), and c-Rel/p52 dimers.
REFERENCE   5  (bases 1 to 7378)
  AUTHORS   Samoilov,M.O., Churilova,A.V., Glushchenko,T.S. and Baranova,K.A.
  TITLE     [Pattern of neuronal expression of transcription factors NF-kappaB
            under different modes of hypobaric hypoxia]
  JOURNAL   Fiziol Zh (1994) 59 (6), 132-140 (2013)
   PUBMED   24605601
  REMARK    GeneRIF: Expression of p65 and c-Rel implies that these subunits of
            NF-kappaB appear to contribute to the mechanisms of brain
            adaptation to severe hypoxia.
REFERENCE   6  (bases 1 to 7378)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   7  (bases 1 to 7378)
  AUTHORS   Pizzi,M., Goffi,F., Boroni,F., Benarese,M., Perkins,S.E., Liou,H.C.
            and Spano,P.
  TITLE     Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the
            modulation of neuron survival elicited by glutamate and
            interleukin-1beta
  JOURNAL   J Biol Chem 277 (23), 20717-20723 (2002)
   PUBMED   11912207
REFERENCE   8  (bases 1 to 7378)
  AUTHORS   Xie,D.H., Tang,X.D., Xia,S.J., Tan,J.M., Wang,X.H. and Cai,Y.
  TITLE     [Expression of NF-kappa B in human bladder cancer and its clinical
            significance]
  JOURNAL   Ai Zheng 21 (6), 663-667 (2002)
   PUBMED   12452071
REFERENCE   9  (bases 1 to 7378)
  AUTHORS   Cogswell,P.C., Guttridge,D.C., Funkhouser,W.K. and Baldwin,A.S. Jr.
  TITLE     Selective activation of NF-kappa B subunits in human breast cancer:
            potential roles for NF-kappa B2/p52 and for Bcl-3
  JOURNAL   Oncogene 19 (9), 1123-1131 (2000)
   PUBMED   10713699
REFERENCE   10 (bases 1 to 7378)
  AUTHORS   Kunsch,C., Ruben,S.M. and Rosen,C.A.
  TITLE     Selection of optimal kappa B/Rel DNA-binding motifs: interaction of
            both subunits of NF-kappa B with DNA is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 12 (10), 4412-4421 (1992)
   PUBMED   1406630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.1270923.1,
                                           SRR26643292.53047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               JAXUCZ010000014.1  101921661-101921938 c
            279-421             JAXUCZ010000014.1  101914520-101914662 c
            422-570             JAXUCZ010000014.1  101910304-101910452 c
            571-662             JAXUCZ010000014.1  101906591-101906682 c
            663-803             JAXUCZ010000014.1  101902605-101902745 c
            804-908             JAXUCZ010000014.1  101900108-101900212 c
            909-1121            JAXUCZ010000014.1  101899791-101900003 c
            1122-1190           JAXUCZ010000014.1  101898382-101898450 c
            1191-1277           JAXUCZ010000014.1  101898184-101898270 c
            1278-7378           JAXUCZ010000014.1  101891238-101897338 c
FEATURES             Location/Qualifiers
     source          1..7378
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..7378
                     /gene="Rel"
                     /note="REL proto-oncogene, NF-kB subunit"
                     /db_xref="GeneID:305584"
                     /db_xref="RGD:1311231"
     exon            1..278
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..2056
                     /gene="Rel"
                     /note="reticuloendotheliosis oncogene; v-rel
                     reticuloendotheliosis viral oncogene homolog; v-rel avian
                     reticuloendotheliosis viral oncogene homolog"
                     /codon_start=1
                     /product="proto-oncogene c-Rel"
                     /protein_id="NP_001408243.1"
                     /db_xref="GeneID:305584"
                     /db_xref="RGD:1311231"
                     /translation="MASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPGERSTDNN
                     RTYPSIQIMNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGPERRPLFF
                     QNLGIRCVKKKEVKEAIILRISAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEH
                     GNFTTALPPIVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEV
                     RFVLNDWEAKGIFSQADVHRQVAIVFRTPPYCRAIVEPVTVKMQLRRPSDQEVSESMD
                     FRYLPDEKDAYGNKSKKQKTTLIFQKLLQDCEKRIIPSHFPEKTRAVPLESIGETRFI
                     KKESNLFSHGTVLPETPRSSGVPGQAEPYYSSSGSISNALPHHPSAMPSMVHQPASWS
                     PVTHPTSHPGSTNTLSSFPAGQLSSNSQGVLPFLDGAGMNDLSASNACLFSTDNLARM
                     ETPSMSPTDLYSISDVNMLTNRPVSVMTSSTDGMGDTDHPRLVSVNLENPSCNSRLDP
                     RDPRQLHQMSTASMSAAGTSSSSVFVSQSDTFNRPHFSCIDNGLTNEPGLANDAHHPN
                     FAQSSQYSGIDALQSEQLGDSFEYSFFKI"
     exon            279..421
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
     exon            422..570
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
     exon            571..662
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
     exon            663..803
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
     exon            804..908
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1121
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1190
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1277
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..7378
                     /gene="Rel"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actagtgacc ggagcgcgaa gattcggggg tgggaaggtg tgagccgcaa acccagaggg
       61 gccgggaaag aagaggaggc ccgggggtgg tcggaggact ggggtcgcgg ctgcagaggc
      121 tgctcggcct cctccctggc tggctggcta gttggctgac tgacgggcta gctggctggc
      181 tgactcactc actcactgac tggctggctg gcttgcagcc tctggcccga cgctggaagc
      241 tgcggcgagc ggcgcgcgaa gcggagccat ggcctcgagc ggatataatc cctacgtgga
      301 aatcattgaa cagccaaggc agaggggcat gcggtttagg tacaagtgtg aaggtcgctc
      361 agccggcagc atcccagggg agcgcagcac agacaacaac cggacttacc cgtctatcca
      421 gattatgaac tactatggaa aaggaaaagt aagaattaca ttagtgacaa agaatgaccc
      481 ctataagccc caccctcacg atttagttgg aaaagattgc agagatgggt actatgaagc
      541 agaatttgga ccggaacgca gacctctgtt ttttcaaaat ttgggtattc ggtgtgtaaa
      601 gaaaaaagaa gtgaaagaag ctatcatttt aagaattagc gcaggaatca atcctttcaa
      661 tgtccctgaa cagcagctgc tggacattga agactgcgac ctcaatgtgg tgaggctgtg
      721 cttccaagtt ttccttcctg atgaacatgg taacttcaca accgcgctgc ctcccattgt
      781 ttccaacccg atttacgaca accgtgcccc aaatactgca gaattaagga tctgtcgtgt
      841 gaacaagaac tgtggcagtg tcaggggagg agacgaaata tttctgctct gtgacaaagt
      901 tcagaaagat gatatagaag ttcgtttcgt gttgaatgac tgggaagcca aaggtatttt
      961 ttcacaagct gatgtgcacc gccaagttgc cattgttttc aggacgcctc catactgcag
     1021 agccatagtg gagcccgtga cagtgaaaat gcagctgcgg aggccttccg accaggaagt
     1081 cagcgagtct atggacttca gatacctgcc agatgaaaaa gatgcctatg gcaataaatc
     1141 aaagaagcaa aagacgactc tcatttttca gaaactgctg caagattgtg aaaaacgtat
     1201 cataccaagt cacttccctg agaaaacaag agctgtccct ctggagtcaa ttggagaaac
     1261 aagattcatc aaaaaagaat ccaacttgtt ttctcatggt acagttttac cggaaacgcc
     1321 caggtcttca ggagttccag ggcaagctga accctactat tcttcttccg ggtccatctc
     1381 aaatgcattg ccacatcacc cgtcagccat gccctccatg gtccatcagc ctgcaagctg
     1441 gtcaccggtg acacacccca cctcacaccc aggcagtact aacaccctga gcagcttccc
     1501 ggccggacag ctttcctcta actcacaagg tgtccttccg ttcctagacg gggctggcat
     1561 gaacgactta agtgcctcta atgcttgcct ttttagtact gataacctgg ctaggatgga
     1621 gacgccgtcc atgtcaccga ccgacttata cagtatttct gacgtcaaca tgctgacgaa
     1681 tcggcctgtg agtgtgatga caagcagcac tgatggcatg ggggacactg atcacccaag
     1741 acttgtgagt gtcaatcttg aaaacccctc ctgtaactcc aggttagacc caagagaccc
     1801 gagacaactg catcagatgt ctactgccag tatgtcagca gcaggcacca gttccagttc
     1861 tgtttttgtt tcacagtcgg atacattcaa tagaccccac ttcagttgta tagataatgg
     1921 tctgacaaat gaacccggat tagcaaacga cgcacatcat cctaactttg cccagagcag
     1981 tcagtactca ggtatcgatg ctctgcagag tgagcagttg ggcgactcct tcgagtatag
     2041 ttttttcaaa atataagttg taggacttaa ataggtgtac agactattaa gaggaagttc
     2101 agatgtcaga actttaaagc tgccactgtt tcttactttg aaaaagatat gcctgaagta
     2161 catgtgcttg atgcgaattg tttttctgta tttccccaag accagctatg ggtctttata
     2221 atgtattagt taaatgaaag gatatttgct ttcaagcaga tttaaagtaa aacatgtaat
     2281 ggctatgcca ttgggaaata aactcattgt tgttgaggcc cataggccaa agtgacccct
     2341 aaggggtttt ctgaggtttc ttggtatttt agagggtgtg tgtgtgtgtg tgtgtgtgtg
     2401 tgtgtgtgtg tgtgtgttaa agtaagcttt caaggtatgg aaggtttttg ttctatttta
     2461 tattatttag accctttaaa gttacatgtg aaattagctt gatatctgta ttttcaagaa
     2521 aaagttttct tgagcctttt ctttttagat gctctcactc cctttgattt cttaaagcct
     2581 gtctacttat ctataaagaa tctgaccagg catcctgggc tcatgtctgt gatctctgta
     2641 tgtgagattg taggttcaca gatgcctgaa cacatggcaa gctcaatacc agctagagcg
     2701 gcttacggaa agcttgtccc aaagaagaga aaagaccaag cgtgtgactc agtgctggag
     2761 cttgcttaat gtgtacaagg cccatgttca gccctgtgta ggagagacta agtaacaaac
     2821 ttatttcagc tcaatatatc catacagagt gttgaacttt tctcaggact cgtttcttct
     2881 tcagccttta ccactctgca catttctatg ccatgcttcc agttcctgag gcaaaagcct
     2941 tggtgtcacc tctatgcttc tccctcccac atctttctca tccatcatta aacgcagaag
     3001 gccatttcct ctgagtgcct ccaaagctcc ccgtctcctc tgaccttctg atcttcctgc
     3061 tctgcctctg cagcgctggg attgcttgcg tgctccacca cactagattt gtgtggtact
     3121 agggatgaaa gatgggtctc tgctgggaga agtcttctca cagttgagat acttgctcag
     3181 ctcagactaa ctgcagtcac tctgtattag tgacactgac agacctggac atagctacta
     3241 aggagctcag cagatgttac ttgcacatcg acttatttca gtttttcctg taaggtgaac
     3301 taaggtatgt ctacatctgt gtttagagca ttttcaattg atgttttatt ctcaggtgct
     3361 acttactgat cacagcattc agtgtataac ttccaatgca tttatcgacc cgtttttcct
     3421 ttgcgtctgg ctgcatttgt atctcacgtg ttttgagaga attggccttc ttttccagat
     3481 ctcacttgtg cactacatcc ctcctcctgt tcccagtagc ctcgtatcac cagttagttc
     3541 ttgctctctt tgaacagaat aaatatcttc ttgagcttaa aaggaaaggc tgaaaaatat
     3601 tcccatccaa gtaccaagaa cccttcccct atcacaccct gtccttccac gtcttcacct
     3661 ggaaagtgtc cgtgcctcca tctctctcac tccctccttc tccatccacc tcggccttta
     3721 gtccgcccca ccccgtccct tatcagcctt caccctcttc atctgtgctg tccacagcct
     3781 atcacctttt gatgaacagg atcctgtgcg ttcctaaccc cagcccagcc tgcatgggct
     3841 gttctgtgtg catctcagca ccacaacttc tcctgctatc cgaatgctca tgacattact
     3901 gctgtcacgg agagaattca gtagagactt caaagtcata tctggttgac ctgcttttga
     3961 gtctgcctac tcagtgtcat gcatctgccc cttctgttac tggcaagtct ttattctttt
     4021 tcttcaatga atatcttttc catttgttta agttttttta atagcttatt cctcttacac
     4081 tttgtagttg ggacctgttg aatttattcc cacaggtagt gtgtgtgtgt gtgtgtgtgt
     4141 gtgtgtatgt atgtatatat atatatatat atatatatat atatatatat atataacctt
     4201 ttctgcctct gctcccaaca cttaccagca ggcttctctg cagggtttgg tcatgctgcc
     4261 acagttgaga ggggcagggt agtcagttaa gtgtttctca cttatctctg ggactctagc
     4321 acttgacgta gactctggcc taaccggtgc tgaataaatg tttagaaagg ggggatgatt
     4381 atacatataa tgatcatatt tgattttaat gggaaaggtg cttcaccctg cagggaaact
     4441 aatgatgcca gatcatcttt cctgtgagat atacttctct tctggccaac cgctgctgct
     4501 gctgctgctc ctcctcctcc ttctcttcct cttcctcttc ttcctcctct tcctctccct
     4561 cctcctcttc ctcctccatt ctcctcctcc cccttcaaaa actatgcaaa gactgggaca
     4621 tagcttcatg gtagagcatg gccctgtgtt tgatacccag aattgcaaca ataataaaat
     4681 tataatagga aagtatgtaa actaccctga ggctctttga tacccaaagc agctctctca
     4741 gaaactgtag taccaacagt atatatagta tcaggtagaa atcccaagta ccccagtggt
     4801 accccttgac agtttactgt gcatagacat gttagtagcc tgtattcatg taagccatgt
     4861 gacatttttg taactgtata ttatacaatg taccatgttc catgtagaat ataagaggag
     4921 aatggtattc aactcttgtt ctcaaagagg aatcacacat acagtcaatc acataaacat
     4981 ggacagagtt taaggtataa tttgaagaat tttggattat gtaaagacta tgtaactact
     5041 atgtttggga ccccagaagt tctcctccat tcctcctggt tctgctgttc tgattctatc
     5101 atgagagcct gctgacttcc aatcctagcc accttttcat ttgcctgcta gttctccatt
     5161 caaaaatctt agtgtggagt aactggcctg tcagtttgtc ttcctatgct gtgttgtgtt
     5221 tctgcagcct cggccacatg atattttccc tggtgagact taaaattggt gatccaggtt
     5281 gtctctacca taccaagttc taatcataag ttgaaaattt gccataagct atcagacagc
     5341 atgaaacaag gtaaagaaga aagactgact gtagtcagtt agcctagatg gagctgttgg
     5401 tcctctgaca ctcagacaga agatcacaag ttcaaggcct gcagagtgtg cagagtgagc
     5461 gcaagggaac agctttgtga gctcttacct cagaatataa agtggaaaac aggttgcgat
     5521 gcagccgggt gatagagcac ctatgattta cagctgaaga cccagagaaa tgaaaacctg
     5581 gccttcctac gtcccaggtg tgttttgtgt tgtctgaact gaaacactga gttaacgaaa
     5641 ccgatagctg tttctcatgg gccctgatta gtgtattacc caaacattcc tagtcactca
     5701 aacccagaga aaaatcacgg ggtgggtaaa cgctttgtga gattatgaca ggtttctctt
     5761 tagacagacg tctaaactgc cccctatgga gaaggtcttt ttttggacct cgctctgtca
     5821 gagcacactt tcttaccgag ggaagtcagt tactggcttt ccttttggaa ttttgtgact
     5881 tgatttcttt gtagaagttg agagttttgg ggagtccttt gacttttgtg atgccgccac
     5941 tgcaagattt cgggtttgct cagaggttgg atgtgtaaag aaggggctag aatgcttttg
     6001 tatctatgaa tgagaagccc atgcagcagt gggccaggag gcacaaaggc actccttgtg
     6061 ttcatccctt taattgaata tttaagctga gcgcagaatt taaacctcga ggtcaatggt
     6121 ggagaagacc taattttttt catgtatgca aaaagaccac aaacccacac atgtcctcac
     6181 cacctttttg tctgtgtttt gttttgtttt agggaggttg agtttgtttt gtttttttcc
     6241 aaacagggtt ttctctgtgt tgccctgact gttctggaac tcacagaagt catcttctgt
     6301 ctcccaaaca acttcaggaa attttttttt tgttgttttt attttatttt attttatttt
     6361 atcttttgga actttaaaga atcacaaaca agccaggtgg cagtagcaca ctcctaaatt
     6421 taatcccagc acccagtggg cagaggcagg catatttctg ttacttcgag gccaacgggt
     6481 ctacagagtg agtttgaggc cagctgggga tacacagaga aaacctgtcg caaaaaatag
     6541 caacaaaccc aaaaccaaaa caacaacaac aaaagaatca taaacaaaat aaaagaaatg
     6601 tttacttctt aaattgagtt tttagcagat acataatatt tgatgaaaca ccaaattgca
     6661 gatacataat atttgatgaa acaccaaatt tatctaggct aatttcttcc taagcttctt
     6721 taaccaaaat gcaactcttc ctgtaaacgg agtgagataa ggctggggta ccgtgggctc
     6781 tcgatggcat tcgtcgctgc tcttagtgaa ccagctgtgg caatacatcc tgtagctcca
     6841 acccgtggaa gacggagacc tcagccaatc agtcatcagt ccaagaactt taaaacgctg
     6901 ttggctaggg ctaatagact gcaacaaaac ggtgaaccct ttgctgttgt tttgacttta
     6961 agttgagtat cgacctgcct ctctctctct ctcctttcta agtactagga ctacaggcat
     7021 atgccacaca cctccccgga tgtaaaatac ttagattgtg gagaggagag gagcctcacg
     7081 ctgggattga acccagggtt gcatacaact tagggttagt gtcagtactc caccactaag
     7141 ttgcctgcat ttgaaaatga ttgtataggc ttgatgatga atgaatttta aggctctgat
     7201 aaaaatattt tttaagttct cagatgttgg tcctaagaag ttaagctttg tatcaagatg
     7261 aaatattttt ttaaatgtca agataccctt tattatatag aatgaatatt gtgttacttt
     7321 tgtaatatct ttgtatactg tgattttttt cttgatgtaa taaactattt tctaaaaa
//
