LOCUS       NM_001004096            1107 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus regenerating family member 4 (Reg4), mRNA.
ACCESSION   NM_001004096 XM_579122
VERSION     NM_001004096.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1107)
  AUTHORS   Takasawa,S., Itaya-Hironaka,A., Makino,M., Yamauchi,A.,
            Sakuramoto-Tsuchida,S., Uchiyama,T., Shobatake,R., Takeda,Y. and
            Ota,H.
  TITLE     Upregulation of Reg IV and Hgf mRNAs by Intermittent Hypoxia via
            Downregulation of microRNA-499 in Cardiomyocytes
  JOURNAL   Int J Mol Sci 23 (20), 12414 (2022)
   PUBMED   36293268
  REMARK    GeneRIF: Upregulation of Reg IV and Hgf mRNAs by Intermittent
            Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1107)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 1107)
  AUTHORS   Azman,J., Starcevic Klasan,G., Ivanac,D., Picard,A.,
            Jurisic-Erzen,D., Nikolic,M., Malnar,D., Arbanas,J. and Jerkovic,R.
  TITLE     Reg IV protein and mRNA expression in different rat organs
  JOURNAL   Acta Histochem 113 (8), 793-797 (2011)
   PUBMED   21168191
  REMARK    GeneRIF: Reg IV expression in different rat organs, which may help
            elucidate a potential role in growth and proliferation of different
            cells like other members of the Reg family genes which act as
            growth factors in the different organs
REFERENCE   4  (bases 1 to 1107)
  AUTHORS   Ho,M.R., Lou,Y.C., Wei,S.Y., Luo,S.C., Lin,W.C., Lyu,P.C. and
            Chen,C.
  TITLE     Human RegIV protein adopts a typical C-type lectin fold but binds
            mannan with two calcium-independent sites
  JOURNAL   J Mol Biol 402 (4), 682-695 (2010)
   PUBMED   20692269
REFERENCE   5  (bases 1 to 1107)
  AUTHORS   Namikawa,K., Fukushima,M., Murakami,K., Suzuki,A., Takasawa,S.,
            Okamoto,H. and Kiyama,H.
  TITLE     Expression of Reg/PAP family members during motor nerve
            regeneration in rat
  JOURNAL   Biochem Biophys Res Commun 332 (1), 126-134 (2005)
   PUBMED   15896308
REFERENCE   6  (bases 1 to 1107)
  AUTHORS   Kamarainen,M., Heiskala,K., Knuutila,S., Heiskala,M., Winqvist,O.
            and Andersson,L.C.
  TITLE     RELP, a novel human REG-like protein with up-regulated expression
            in inflammatory and metaplastic gastrointestinal mucosa
  JOURNAL   Am J Pathol 163 (1), 11-20 (2003)
   PUBMED   12819006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 6, 2022 this sequence version replaced NM_001004096.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.10888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050745 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000002.1  188507684-188507730
            48-219              JAXUCZ010000002.1  188509843-188510014
            220-314             JAXUCZ010000002.1  188514886-188514980
            315-452             JAXUCZ010000002.1  188516209-188516346
            453-558             JAXUCZ010000002.1  188518093-188518198
            559-1107            JAXUCZ010000002.1  188521442-188521990
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1107
                     /gene="Reg4"
                     /note="regenerating family member 4"
                     /db_xref="GeneID:445583"
                     /db_xref="RGD:1303341"
     exon            1..47
                     /gene="Reg4"
                     /inference="alignment:Splign:2.1.0"
     exon            48..219
                     /gene="Reg4"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..626
                     /gene="Reg4"
                     /note="regenerating islet-derived protein 4; REG-4;
                     regenerating islet-derived family, member 4"
                     /codon_start=1
                     /product="regenerating islet-derived protein 4 precursor"
                     /protein_id="NP_001004096.1"
                     /db_xref="GeneID:445583"
                     /db_xref="RGD:1303341"
                     /translation="MASKCVRLLLLLSWVAGPEVLSDILRPSCASGWFNYRSHCYGYF
                     RKLRNWSHAELECQSYGNGSHLASVLNPKEASVISKYITGYQRSLPVWIGLHDPQKNA
                     SWQWIDGSTNQYRPWSPRTKSEARHCTEMNPKDKFLTWNKNGCTKRQHFLCKYRP"
     exon            220..314
                     /gene="Reg4"
                     /inference="alignment:Splign:2.1.0"
     exon            315..452
                     /gene="Reg4"
                     /inference="alignment:Splign:2.1.0"
     exon            453..558
                     /gene="Reg4"
                     /inference="alignment:Splign:2.1.0"
     exon            559..1107
                     /gene="Reg4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcaagctg aagaaggcag ggttctcgga gtcttggttc caatcaggtc taggagaatc
       61 caggggggaa aaaggaaaaa gaaaaagctg gaataggccg caaggacctt gaaatcaaag
      121 cgtcgaagta ttgtctccat caaaagagga agatggcttc caaatgcgtg aggctactcc
      181 ttctgctgag ctgggtagct ggccctgaag tcctgagtga tatcttgaga cccagctgtg
      241 cttctggatg gttcaactat aggtcccact gttatgggta cttccggaag ctaagaaact
      301 ggtctcatgc tgagctggaa tgccagtcat atggaaacgg atcccatctg gcatctgtgt
      361 tgaatccaaa ggaagccagc gtcatatcaa agtacataac tggctatcag agaagcctgc
      421 ctgtgtggat tggcctgcat gacccacaga agaatgcatc atggcagtgg attgatgggt
      481 ctacaaacca gtacagaccc tggagcccca ggacaaaaag tgaagccagg cactgcactg
      541 agatgaaccc caaggataaa tttttaactt ggaacaaaaa tggatgcacc aagcgccaac
      601 acttcctgtg caagtacagg ccatagagca aaaatcaggc atctaccagc ttcgtacaag
      661 ctctttccac ttccctctca cctggtggct gatctaatca ttatcccaga gagtaaacac
      721 agcagcaaac attgatgaag cctccagtgc actgactatc aagcccggct tagcatggtg
      781 ggacagtggc ttctggtctc agagtttagc atgatgggac agtggcttcc cgtctcagag
      841 aatagcatgg tgaagcagta gcttctgctc taagagatta gcatggtagg gcagtagctt
      901 tctgtcttgg agttcagcat ggtgggacaa cagcttctgg tctctgagct tagaatggtg
      961 ggacagtggc ttctggtctc agtgttcact ctataatcct ttctggtact tctcttccct
     1021 ctcattgtct caaagaatgc tagaaatgtg ttttcttgac cactgtgtct ctgtcaaacc
     1081 agtaaagttt tggagccaag aaacagc
//
