LOCUS       NM_173097                773 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus regenerating family member 3 gamma (Reg3g), mRNA.
ACCESSION   NM_173097
VERSION     NM_173097.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 773)
  AUTHORS   Shea,K. and Rouse,R.
  TITLE     Detection of Reg3gamma by Immunohistochemistry in Cerulein-Induced
            Model of Acute Pancreatic Injury in Mice and Rats
  JOURNAL   Pancreas 48 (8), 1015-1025 (2019)
   PUBMED   31404030
  REMARK    GeneRIF: Findings indicate that regenerating islet-derived 3 gamma
            (Reg3gamma) staining quantified through image analysis showed a
            time- and dose-response in cerulein-treated mice and rats.
REFERENCE   2  (bases 1 to 773)
  AUTHORS   Klasan,G.S., Ivanac,D., Erzen,D.J., Picard,A., Takasawa,S.,
            Peharec,S., Arbanas,J., Girotto,D. and Jerkovic,R.
  TITLE     Reg3G gene expression in regenerating skeletal muscle and
            corresponding nerve
  JOURNAL   Muscle Nerve 49 (1), 61-68 (2014)
   PUBMED   23588857
  REMARK    GeneRIF: The Reg3G gene plays a major role in communication between
            injured axons and muscle and may play a significant role in
            skeletal muscle and peripheral nerve regeneration.
REFERENCE   3  (bases 1 to 773)
  AUTHORS   Konishi,H., Matsumoto,S., Namikawa,K. and Kiyama,H.
  TITLE     N-terminal cleaved pancreatitis-associated protein-III (PAP-III)
            serves as a scaffold for neurites and promotes neurite outgrowth
  JOURNAL   J Biol Chem 288 (15), 10205-10213 (2013)
   PUBMED   23426365
  REMARK    GeneRIF: released PAP-III might be cleaved and forms DeltaN-PAP-III
            fibers at the nerve injury sites. Consequently, these resulting
            fibers would provide regenerating axons with a platform for
            extension.
REFERENCE   4  (bases 1 to 773)
  AUTHORS   Madrid,V., Borelli,M.I., Maiztegui,B., Flores,L.E.,
            Gagliardino,J.J. and Zotto,H.D.
  TITLE     Islet neogenesis-associated protein (INGAP)-positive cell mass,
            beta-cell mass, and insulin secretion: their relationship during
            the fetal and neonatal periods
  JOURNAL   Pancreas 42 (3), 422-428 (2013)
   PUBMED   23303201
  REMARK    GeneRIF: Findings suggest that islet neogenesis-associated protein
            (INGAP) exerts a positive modulatory effect on beta-cell mass and
            its secretory function in fetal and neonatal rats, thus becoming a
            new component in the multifactorial regulation of such processes.
REFERENCE   5  (bases 1 to 773)
  AUTHORS   Choi,S.M., McAleer,J.P., Zheng,M., Pociask,D.A., Kaplan,M.H.,
            Qin,S., Reinhart,T.A. and Kolls,J.K.
  TITLE     Innate Stat3-mediated induction of the antimicrobial protein
            Reg3gamma is required for host defense against MRSA pneumonia
  JOURNAL   J Exp Med 210 (3), 551-561 (2013)
   PUBMED   23401489
REFERENCE   6  (bases 1 to 773)
  AUTHORS   Namikawa,K., Okamoto,T., Suzuki,A., Konishi,H. and Kiyama,H.
  TITLE     Pancreatitis-associated protein-III is a novel macrophage
            chemoattractant implicated in nerve regeneration
  JOURNAL   J Neurosci 26 (28), 7460-7467 (2006)
   PUBMED   16837594
  REMARK    GeneRIF: results demonstrate that PAP-III is a novel macrophage
            chemoattractant that is involved in peripheral nerve regeneration
REFERENCE   7  (bases 1 to 773)
  AUTHORS   Bimmler,D., Schiesser,M., Perren,A., Scheele,G., Angst,E.,
            Meili,S., Ammann,R. and Graf,R.
  TITLE     Coordinate regulation of PSP/reg and PAP isoforms as a family of
            secretory stress proteins in an animal model of chronic
            pancreatitis
  JOURNAL   J Surg Res 118 (2), 122-135 (2004)
   PUBMED   15100001
  REMARK    GeneRIF: There is a tight spatial and temporal association between
            pre-inflammatory changes or inflammation and PAP-expression
REFERENCE   8  (bases 1 to 773)
  AUTHORS   Yoshioka,S., Fujii,S., Richards,J.S. and Espey,L.L.
  TITLE     Gonadotropin-induced expression of pancreatitis-associated
            protein-III mRNA in the rat ovary at the time of ovulation
  JOURNAL   J Endocrinol 174 (3), 485-492 (2002)
   PUBMED   12208669
REFERENCE   9  (bases 1 to 773)
  AUTHORS   Dusetti,N.J., Frigerio,J.M., Szpirer,C., Dagorn,J.C. and
            Iovanna,J.L.
  TITLE     Cloning, expression and chromosomal localization of the rat
            pancreatitis-associated protein III gene
  JOURNAL   Biochem J 307 (Pt 1) (Pt 1), 9-16 (1995)
   PUBMED   7717998
REFERENCE   10 (bases 1 to 773)
  AUTHORS   Frigerio,J.M., Dusetti,N.J., Garrido,P., Dagorn,J.C. and
            Iovanna,J.L.
  TITLE     The pancreatitis associated protein III (PAP III), a new member of
            the PAP gene family
  JOURNAL   Biochim Biophys Acta 1216 (2), 329-331 (1993)
   PUBMED   8241280
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L20869.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q33"
     gene            1..773
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
                     /note="regenerating family member 3 gamma"
                     /db_xref="GeneID:24620"
                     /db_xref="RGD:3256"
     exon            1..20
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            21..101
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..550
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
                     /note="regenerating islet-derived 3 gamma; regenerating
                     islet-derived protein 3-gamma; reg III-gamma; REG-3-gamma;
                     regenerating islet-derived protein III-gamma;
                     pancreatitis-associated protein 3"
                     /codon_start=1
                     /product="regenerating islet-derived protein 3-gamma
                     precursor"
                     /protein_id="NP_775120.1"
                     /db_xref="GeneID:24620"
                     /db_xref="RGD:3256"
                     /translation="MLPRVALTTMSWMLLSSLMLLSQVQGEDAKEDVPTSRISCPKGS
                     RAYGSYCYALFSVSKSWFDADLACQKRPSGHLVSVLSGSEASFVSSLIKSSGNSGQNV
                     WIGLHDPTLGQEPNRGGWEWSNADVMNYFNWETNPSSVSGSHCGTLTRASGFLRWREN
                     NCISELPYVCKFKA"
     exon            102..220
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            221..358
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            359..482
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            483..773
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      773
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
ORIGIN      
        1 atcccaggtt cacaagacag acaagatgct gcctcgtgta gccctcacca ccatgtcctg
       61 gatgctgctg tccagcctga tgctcttatc tcaggtgcaa ggtgaagatg ccaaggaaga
      121 tgtgcccact tcacgtatca gctgccccaa gggctcgcgt gcctatggct cctattgcta
      181 tgccttgttt agtgtatcca aatcttggtt tgatgcagat ctggcctgcc agaagaggcc
      241 atcaggacac cttgtgtctg tgctcagtgg atctgaagct tcctttgtgt cctccttgat
      301 taaaagcagt ggtaacagtg gccaaaacgt gtggattggg ctccatgatc caacactggg
      361 ccaagaaccc aacagaggtg gatgggagtg gagtaatgct gatgtgatga attacttcaa
      421 ctgggagacg aatccttctt ctgtctctgg aagtcactgt gggaccctga cacgagcctc
      481 aggatttctg aggtggagag agaataattg tatctcagaa ttgccatatg tctgcaagtt
      541 caaggcctag agtacagaga tgacaccatg tgttgatata tacctcacca aatcaagaac
      601 cccaatggga agatcaacaa caacaacaaa aagaatattc tcctcacagt caacatctga
      661 cctcctattt ttctcctcat ctgccccttc cttcctctca tttgaggctc ttctgtgtgt
      721 actgtggcct gagatctcac agcacaataa taaaatatat aactcacgct cat
//
