LOCUS       NP_775120                174 aa            linear   ROD 03-APR-2024
DEFINITION  regenerating islet-derived protein 3-gamma precursor [Rattus
            norvegicus].
ACCESSION   NP_775120
VERSION     NP_775120.1
DBSOURCE    REFSEQ: accession NM_173097.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 174)
  AUTHORS   Shea,K. and Rouse,R.
  TITLE     Detection of Reg3gamma by Immunohistochemistry in Cerulein-Induced
            Model of Acute Pancreatic Injury in Mice and Rats
  JOURNAL   Pancreas 48 (8), 1015-1025 (2019)
   PUBMED   31404030
  REMARK    GeneRIF: Findings indicate that regenerating islet-derived 3 gamma
            (Reg3gamma) staining quantified through image analysis showed a
            time- and dose-response in cerulein-treated mice and rats.
REFERENCE   2  (residues 1 to 174)
  AUTHORS   Klasan,G.S., Ivanac,D., Erzen,D.J., Picard,A., Takasawa,S.,
            Peharec,S., Arbanas,J., Girotto,D. and Jerkovic,R.
  TITLE     Reg3G gene expression in regenerating skeletal muscle and
            corresponding nerve
  JOURNAL   Muscle Nerve 49 (1), 61-68 (2014)
   PUBMED   23588857
  REMARK    GeneRIF: The Reg3G gene plays a major role in communication between
            injured axons and muscle and may play a significant role in
            skeletal muscle and peripheral nerve regeneration.
REFERENCE   3  (residues 1 to 174)
  AUTHORS   Konishi,H., Matsumoto,S., Namikawa,K. and Kiyama,H.
  TITLE     N-terminal cleaved pancreatitis-associated protein-III (PAP-III)
            serves as a scaffold for neurites and promotes neurite outgrowth
  JOURNAL   J Biol Chem 288 (15), 10205-10213 (2013)
   PUBMED   23426365
  REMARK    GeneRIF: released PAP-III might be cleaved and forms DeltaN-PAP-III
            fibers at the nerve injury sites. Consequently, these resulting
            fibers would provide regenerating axons with a platform for
            extension.
REFERENCE   4  (residues 1 to 174)
  AUTHORS   Madrid,V., Borelli,M.I., Maiztegui,B., Flores,L.E.,
            Gagliardino,J.J. and Zotto,H.D.
  TITLE     Islet neogenesis-associated protein (INGAP)-positive cell mass,
            beta-cell mass, and insulin secretion: their relationship during
            the fetal and neonatal periods
  JOURNAL   Pancreas 42 (3), 422-428 (2013)
   PUBMED   23303201
  REMARK    GeneRIF: Findings suggest that islet neogenesis-associated protein
            (INGAP) exerts a positive modulatory effect on beta-cell mass and
            its secretory function in fetal and neonatal rats, thus becoming a
            new component in the multifactorial regulation of such processes.
REFERENCE   5  (residues 1 to 174)
  AUTHORS   Choi,S.M., McAleer,J.P., Zheng,M., Pociask,D.A., Kaplan,M.H.,
            Qin,S., Reinhart,T.A. and Kolls,J.K.
  TITLE     Innate Stat3-mediated induction of the antimicrobial protein
            Reg3gamma is required for host defense against MRSA pneumonia
  JOURNAL   J Exp Med 210 (3), 551-561 (2013)
   PUBMED   23401489
REFERENCE   6  (residues 1 to 174)
  AUTHORS   Namikawa,K., Okamoto,T., Suzuki,A., Konishi,H. and Kiyama,H.
  TITLE     Pancreatitis-associated protein-III is a novel macrophage
            chemoattractant implicated in nerve regeneration
  JOURNAL   J Neurosci 26 (28), 7460-7467 (2006)
   PUBMED   16837594
  REMARK    GeneRIF: results demonstrate that PAP-III is a novel macrophage
            chemoattractant that is involved in peripheral nerve regeneration
REFERENCE   7  (residues 1 to 174)
  AUTHORS   Bimmler,D., Schiesser,M., Perren,A., Scheele,G., Angst,E.,
            Meili,S., Ammann,R. and Graf,R.
  TITLE     Coordinate regulation of PSP/reg and PAP isoforms as a family of
            secretory stress proteins in an animal model of chronic
            pancreatitis
  JOURNAL   J Surg Res 118 (2), 122-135 (2004)
   PUBMED   15100001
  REMARK    GeneRIF: There is a tight spatial and temporal association between
            pre-inflammatory changes or inflammation and PAP-expression
REFERENCE   8  (residues 1 to 174)
  AUTHORS   Yoshioka,S., Fujii,S., Richards,J.S. and Espey,L.L.
  TITLE     Gonadotropin-induced expression of pancreatitis-associated
            protein-III mRNA in the rat ovary at the time of ovulation
  JOURNAL   J Endocrinol 174 (3), 485-492 (2002)
   PUBMED   12208669
REFERENCE   9  (residues 1 to 174)
  AUTHORS   Dusetti,N.J., Frigerio,J.M., Szpirer,C., Dagorn,J.C. and
            Iovanna,J.L.
  TITLE     Cloning, expression and chromosomal localization of the rat
            pancreatitis-associated protein III gene
  JOURNAL   Biochem J 307 (Pt 1) (Pt 1), 9-16 (1995)
   PUBMED   7717998
REFERENCE   10 (residues 1 to 174)
  AUTHORS   Frigerio,J.M., Dusetti,N.J., Garrido,P., Dagorn,J.C. and
            Iovanna,J.L.
  TITLE     The pancreatitis associated protein III (PAP III), a new member of
            the PAP gene family
  JOURNAL   Biochim Biophys Acta 1216 (2), 329-331 (1993)
   PUBMED   8241280
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L20869.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q33"
     Protein         1..174
                     /product="regenerating islet-derived protein 3-gamma
                     precursor"
                     /note="regenerating islet-derived 3 gamma; regenerating
                     islet-derived protein 3-gamma; reg III-gamma; REG-3-gamma;
                     regenerating islet-derived protein III-gamma;
                     pancreatitis-associated protein 3"
                     /calculated_mol_wt=16254
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2908
     mat_peptide     27..174
                     /product="regenerating islet-derived protein 3-gamma"
                     /calculated_mol_wt=16254
     Region          40..172
                     /region_name="CLECT_REG-1_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in Human REG-1 (lithostathine), REG-4, and avian
                     eggshell-specific proteins: ansocalcin,
                     structhiocalcin-1(SCA-1), and -2(SCA-2); cd03594"
                     /db_xref="CDD:153064"
     Region          103..118
                     /region_name="Sufficient to activate EXTL3.
                     /evidence=ECO:0000250|UniProtKB:Q06141"
                     /note="propagated from UniProtKB/Swiss-Prot (P42854.1)"
     Region          114..116
                     /region_name="EPN. /evidence=ECO:0000250|UniProtKB:Q06141"
                     /note="propagated from UniProtKB/Swiss-Prot (P42854.1)"
     Site            order(143,158..159)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153064"
     CDS             1..174
                     /gene="Reg3g"
                     /gene_synonym="Pap3; PAPIII"
                     /coded_by="NM_173097.1:26..550"
                     /db_xref="GeneID:24620"
                     /db_xref="RGD:3256"
ORIGIN      
        1 mlprvalttm swmllsslml lsqvqgedak edvptsrisc pkgsraygsy cyalfsvsks
       61 wfdadlacqk rpsghlvsvl sgseasfvss likssgnsgq nvwiglhdpt lgqepnrggw
      121 ewsnadvmny fnwetnpssv sgshcgtltr asgflrwren nciselpyvc kfka
//
