LOCUS       NM_053289                781 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus regenerating family member 3 beta (Reg3b), mRNA.
ACCESSION   NM_053289
VERSION     NM_053289.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 781)
  AUTHORS   Li,J., Shi,H., Liu,H., Dong,F., Liu,Z., Lu,Y., Chen,L., Bao,L. and
            Zhang,X.
  TITLE     Nerve Injury-Induced Neuronal PAP-I Maintains Neuropathic Pain by
            Activating Spinal Microglia
  JOURNAL   J Neurosci 40 (2), 297-310 (2020)
   PUBMED   31744864
  REMARK    GeneRIF: after peripheral nerve injury, PAP-I can be transported to
            the spinal dorsal horn and is crucial in the progression of
            neuropathic pain
            Erratum:[J Neurosci. 2020 Mar 11;40(11):2381. doi:
            10.1523/JNEUROSCI.0064-20.2020.. PMID: 32086257]
REFERENCE   2  (bases 1 to 781)
  AUTHORS   Yu,J.H., Lim,J.W. and Kim,H.
  TITLE     Pancreatitis-associated protein-1 suppresses apoptosis in
            cerulein-stimulated pancreatic acinar cells in response to nuclear
            factor-kappa B activation
  JOURNAL   J Physiol Pharmacol 70 (6) (2019)
   PUBMED   32084646
  REMARK    GeneRIF: we used cerulein-induced pancreatic acinar cells to
            investigate the significance of PAP-1 up-regulation in acute
            pancreatitis and discovered that PAP-1 may function to prevent
            apoptosis in response to reactive oxygen species-induced NF-kappaB
            signaling in pancreatic acinar cells.
REFERENCE   3  (bases 1 to 781)
  AUTHORS   Villagarcia,H.G., Roman,C.L., Castro,M.C., Gonzalez,L.A.,
            Ronco,M.T., Frances,D.E., Massa,M.L., Maiztegui,B., Flores,L.E.,
            Gagliardino,J.J. and Francini,F.
  TITLE     Liver carbohydrates metabolism: A new islet-neogenesis associated
            protein peptide (INGAP-PP) target
  JOURNAL   Peptides 101, 44-50 (2018)
   PUBMED   29305881
  REMARK    GeneRIF: These results demonstrate a direct effect of INGAP-PP on
            the liver acting through P-Akt signaling pathway. INGAP-PP enhances
            liver glucose metabolism and deposit and reduces its
            production/output, thereby contributing to maintain normal glucose
            homeostasis.
REFERENCE   4  (bases 1 to 781)
  AUTHORS   Lorchner,H., Poling,J., Gajawada,P., Hou,Y., Polyakova,V.,
            Kostin,S., Adrian-Segarra,J.M., Boettger,T., Wietelmann,A.,
            Warnecke,H., Richter,M., Kubin,T. and Braun,T.
  TITLE     Myocardial healing requires Reg3beta-dependent accumulation of
            macrophages in the ischemic heart
  JOURNAL   Nat Med 21 (4), 353-362 (2015)
   PUBMED   25751817
  REMARK    GeneRIF: Reg3beta-dependent accumulation of macrophages in the
            ischemic heart has a role in myocardial healing
REFERENCE   5  (bases 1 to 781)
  AUTHORS   Calderari,S., Irminger,J.C., Giroix,M.H., Ehses,J.A.,
            Gangnerau,M.N., Coulaud,J., Rickenbach,K., Gauguier,D., Halban,P.,
            Serradas,P. and Homo-Delarche,F.
  TITLE     Regenerating 1 and 3b gene expression in the pancreas of type 2
            diabetic Goto-Kakizaki (GK) rats
  JOURNAL   PLoS One 9 (2), e90045 (2014)
   PUBMED   24587207
  REMARK    GeneRIF: Regenerating 1 and 3b gene expression in the pancreas of
            type 2 diabetic Goto-Kakizaki (GK) rats
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 781)
  AUTHORS   Sansonetti,A., Romeo,H., Berthezene,P., Scacchi,P., Dusetti,N.,
            Keim,V., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Developmental, nutritional, and hormonal regulation of the
            pancreatitis-associated protein I and III gene expression in the
            rat small intestine
  JOURNAL   Scand J Gastroenterol 30 (7), 664-669 (1995)
   PUBMED   7481529
REFERENCE   7  (bases 1 to 781)
  AUTHORS   Chakraborty,C., Katsumata,N., Myal,Y., Schroedter,I.C., Brazeau,P.,
            Murphy,L.J., Shiu,R.P. and Friesen,H.G.
  TITLE     Age-related changes in peptide-23/pancreatitis-associated protein
            and pancreatic stone protein/reg gene expression in the rat and
            regulation by growth hormone-releasing hormone
  JOURNAL   Endocrinology 136 (5), 1843-1849 (1995)
   PUBMED   7720628
REFERENCE   8  (bases 1 to 781)
  AUTHORS   Chakraborty,C., Vrontakis,M., Molnar,P., Schroedter,I.C.,
            Katsumata,N., Murphy,L.J., Shiu,R.P. and Friesen,H.G.
  TITLE     Expression of pituitary peptide 23 in the rat uterus: regulation by
            estradiol
  JOURNAL   Mol Cell Endocrinol 108 (1-2), 149-154 (1995)
   PUBMED   7758828
REFERENCE   9  (bases 1 to 781)
  AUTHORS   Kamimura,T., West,C. and Beutler,E.
  TITLE     Sequence of a cDNA clone encoding a rat Reg-2 protein
  JOURNAL   Gene 118 (2), 299-300 (1992)
   PUBMED   1511905
REFERENCE   10 (bases 1 to 781)
  AUTHORS   Iovanna,J., Orelle,B., Keim,V. and Dagorn,J.C.
  TITLE     Messenger RNA sequence and expression of rat
            pancreatitis-associated protein, a lectin-related protein
            overexpressed during acute experimental pancreatitis
  JOURNAL   J Biol Chem 266 (36), 24664-24669 (1991)
   PUBMED   1722211
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L07127.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ232415.1, FQ233015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840112
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q33"
     gene            1..781
                     /gene="Reg3b"
                     /gene_synonym="Pap; Pap1"
                     /note="regenerating family member 3 beta"
                     /db_xref="GeneID:24618"
                     /db_xref="RGD:3254"
     exon            1..54
                     /gene="Reg3b"
                     /gene_synonym="Pap; Pap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..587
                     /gene="Reg3b"
                     /gene_synonym="Pap; Pap1"
                     /note="regenerating islet-derived protein 3-beta; REG-2;
                     peptide 23; reg III-beta; REG-3-beta; regenerating
                     islet-derived protein III-beta; Pancreatitis-associated
                     protein 1; regenerating islet-derived 3 beta; pancreatic
                     beta cell growth factor"
                     /codon_start=1
                     /product="regenerating islet-derived protein 3-beta
                     precursor"
                     /protein_id="NP_445741.1"
                     /db_xref="GeneID:24618"
                     /db_xref="RGD:3254"
                     /translation="MMRVKMLHRLAFPVMSWMLLSCLMLLSQVQGEDSPKKIPSARIS
                     CPKGSQAYGSYCYALFQIPQTWFDAELACQKRPEGHLVSVLNVAEASFLASMVKNTGN
                     SYQYTWIGLHDPTLGGEPNGGGWEWSNNDIMNYVNWERNPSTALDRGFCGSLSRSSGF
                     LRWRDTTCEVKLPYVCKFTG"
     exon            55..135
                     /gene="Reg3b"
                     /gene_synonym="Pap; Pap1"
                     /inference="alignment:Splign:2.1.0"
     exon            136..254
                     /gene="Reg3b"
                     /gene_synonym="Pap; Pap1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..392
                     /gene="Reg3b"
                     /gene_synonym="Pap; Pap1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..519
                     /gene="Reg3b"
                     /gene_synonym="Pap; Pap1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..781
                     /gene="Reg3b"
                     /gene_synonym="Pap; Pap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaccatcca gatctctgca agacagctaa ggaggagcag aaagatgatg agagttaaga
       61 tgttgcatcg cttggccttc ccagtcatgt cctggatgct gctctcctgc ctgatgctct
      121 tatcacaggt gcaaggagaa gactctccga agaaaatacc ctctgcacgc attagttgcc
      181 ccaaaggctc ccaggcatat ggctcctact gctatgccct gtttcagata ccacagacct
      241 ggtttgatgc agaactggcc tgccagaaga gacctgaagg acaccttgta tctgtgctca
      301 atgtagctga agcttcattc ttggcatcca tggtcaagaa cactggaaac agctaccaat
      361 atacctggat tggactccat gaccccactc ttggtggaga acccaatgga ggtggatggg
      421 agtggagtaa caatgacata atgaattatg tcaactggga gaggaaccca tctactgcct
      481 tagaccgcgg attctgtggc agcttgtcaa gatcttctgg atttctaaga tggagagata
      541 ccacatgtga agtgaagttg ccctacgtct gcaaatttac aggttaaaat taccagacag
      601 caaacagctt tagtttgtcc tgaagcacat cctgtcaagg ggcaaaatat gaagacttgc
      661 gtagaaaaag tgtattctat ctacagtcca cattggagct ctaatcattc tttagccaat
      721 tttgtataag ttgtgtcctc atgtcttgga aagcagtaat aaacctcagt ctctcttcga
      781 a
//
