LOCUS       NM_012641                766 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus regenerating family member 1 alpha (Reg1a), mRNA.
ACCESSION   NM_012641
VERSION     NM_012641.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 766)
  AUTHORS   Reding,T., Palmiere,C., Pazhepurackel,C., Schiesser,M., Bimmler,D.,
            Schlegel,A., Suss,U., Steiner,S., Mancina,L., Seleznik,G. and
            Graf,R.
  TITLE     The pancreas responds to remote damage and systemic stress by
            secretion of the pancreatic secretory proteins PSP/regI and
            PAP/regIII
  JOURNAL   Oncotarget 8 (18), 30162-30174 (2017)
   PUBMED   28415799
  REMARK    GeneRIF: The pancreas reacts to remote lesions and septic insults
            in mice and rats with increased PSP synthesis, while PAP is
            selectively responsive to septic events. Furthermore, our results
            suggest that serum PSP in septic patients is predominantly derived
            through an acute phase response of the pancreas.
REFERENCE   2  (bases 1 to 766)
  AUTHORS   Dranitsina,A.S., Morgaienko,O.O., Grebinyk,D.M. and
            Ostapchenko,L.I.
  TITLE     EXPRESSION OF REG1Alpha, GAST AND TGFB1 GENES IN CONDITIONS OF
            STRESSINDUCED GASTRIC MUCOUS LESIONS DEVELOPMENT AND HEALING IN
            RATS
  JOURNAL   Fiziol Zh (1994) 62 (1), 53-61 (2016)
   PUBMED   29537200
  REMARK    GeneRIF: The positive correlation between Reg1a and Tgfb1 genes
            expression was determined in the dynamics of stress-induced gastric
            lesions development and healing, which may indicate the involvement
            of Tgfb1 in acceleration of lesions healing.
REFERENCE   3  (bases 1 to 766)
  AUTHORS   Coffey,R., Nam,H. and Knutson,M.D.
  TITLE     Microarray analysis of rat pancreas reveals altered expression of
            Alox15 and regenerating islet-derived genes in response to iron
            deficiency and overload
  JOURNAL   PLoS One 9 (1), e86019 (2014)
   PUBMED   24465846
  REMARK    GeneRIF: Alox15 mRNA levels were 4 times higher in iron-deficient
            than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b
            mRNA levels were 17-36 times higher in iron-overloaded pancreas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 766)
  AUTHORS   Nakagawa,K., Takasawa,S., Nata,K., Yamauchi,A., Itaya-Hironaka,A.,
            Ota,H., Yoshimoto,K., Sakuramoto-Tsuchida,S., Miyaoka,T.,
            Takeda,M., Unno,M. and Okamoto,H.
  TITLE     Prevention of Reg I-induced beta-cell apoptosis by
            IL-6/dexamethasone through activation of HGF gene regulation
  JOURNAL   Biochim Biophys Acta 1833 (12), 2988-2995 (2013)
   PUBMED   23954444
  REMARK    GeneRIF: These results strongly suggest that the combined
            stimulation of IL-6 and glucocorticoids induces the activation of
            both Reg and HGF genes.
REFERENCE   5  (bases 1 to 766)
  AUTHORS   Ota,H., Itaya-Hironaka,A., Yamauchi,A., Sakuramoto-Tsuchida,S.,
            Miyaoka,T., Fujimura,T., Tsujinaka,H., Yoshimoto,K., Nakagawara,K.,
            Tamaki,S., Takasawa,S. and Kimura,H.
  TITLE     Pancreatic beta cell proliferation by intermittent hypoxia via
            up-regulation of Reg family genes and HGF gene
  JOURNAL   Life Sci 93 (18-19), 664-672 (2013)
   PUBMED   24055447
REFERENCE   6  (bases 1 to 766)
  AUTHORS   Bernard,J.P., Adrich,Z., Montalto,G., Multigner,L., Dagorn,J.C.,
            Sarles,H. and De Caro,A.
  TITLE     Immunoreactive forms of pancreatic stone protein in six mammalian
            species
  JOURNAL   Pancreas 6 (2), 162-167 (1991)
   PUBMED   1886885
REFERENCE   7  (bases 1 to 766)
  AUTHORS   Rouquier,S., Verdier,J.M., Iovanna,J., Dagorn,J.C. and Giorgi,D.
  TITLE     Rat pancreatic stone protein messenger RNA. Abundant expression in
            mature exocrine cells, regulation by food content, and sequence
            identity with the endocrine reg transcript
  JOURNAL   J Biol Chem 266 (2), 786-791 (1991)
   PUBMED   1985964
REFERENCE   8  (bases 1 to 766)
  AUTHORS   de la Monte,S.M., Ozturk,M. and Wands,J.R.
  TITLE     Enhanced expression of an exocrine pancreatic protein in
            Alzheimer's disease and the developing human brain
  JOURNAL   J Clin Invest 86 (3), 1004-1013 (1990)
   PUBMED   2394826
REFERENCE   9  (bases 1 to 766)
  AUTHORS   Watanabe,T., Yonekura,H., Terazono,K., Yamamoto,H. and Okamoto,H.
  TITLE     Complete nucleotide sequence of human reg gene and its expression
            in normal and tumoral tissues. The reg protein, pancreatic stone
            protein, and pancreatic thread protein are one and the same product
            of the gene
  JOURNAL   J Biol Chem 265 (13), 7432-7439 (1990)
   PUBMED   2332435
REFERENCE   10 (bases 1 to 766)
  AUTHORS   Terazono,K., Yamamoto,H., Takasawa,S., Shiga,K., Yonemura,Y.,
            Tochino,Y. and Okamoto,H.
  TITLE     A novel gene activated in regenerating islets
  JOURNAL   J Biol Chem 263 (5), 2111-2114 (1988)
   PUBMED   2963000
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012641.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M62930.1, FQ232485.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                JAXUCZ010000004.1  112450466-112450491
            27-133              JAXUCZ010000004.1  112450768-112450874
            134-252             JAXUCZ010000004.1  112451383-112451501
            253-390             JAXUCZ010000004.1  112451795-112451932
            391-502             JAXUCZ010000004.1  112452572-112452683
            503-766             JAXUCZ010000004.1  112452867-112453130
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q33"
     gene            1..766
                     /gene="Reg1a"
                     /gene_synonym="LITHOST; RATLITHOST; RATRGPI; Reg; Reg1;
                     Rgp1; RGPI"
                     /note="regenerating family member 1 alpha"
                     /db_xref="GeneID:24714"
                     /db_xref="RGD:3552"
     exon            1..26
                     /gene="Reg1a"
                     /gene_synonym="LITHOST; RATLITHOST; RATRGPI; Reg; Reg1;
                     Rgp1; RGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            27..133
                     /gene="Reg1a"
                     /gene_synonym="LITHOST; RATLITHOST; RATRGPI; Reg; Reg1;
                     Rgp1; RGPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..570
                     /gene="Reg1a"
                     /gene_synonym="LITHOST; RATLITHOST; RATRGPI; Reg; Reg1;
                     Rgp1; RGPI"
                     /note="lithostathine; PSP; PTP; ICRF; pancreatic stone
                     protein; pancreatic thread protein; islet cells
                     regeneration factor; islet of Langerhans regenerating
                     protein; regenerating islet-derived mouse homolog 1;
                     regeneration protein, lithostatin, pancreatic stone
                     protein; regenerating islet-derived 1 alpha"
                     /codon_start=1
                     /product="lithostathine precursor"
                     /protein_id="NP_036773.1"
                     /db_xref="GeneID:24714"
                     /db_xref="RGD:3552"
                     /translation="MTRNKYFILLSCLMVLSPSQGQEAEEDLPSARITCPEGSNAYSS
                     YCYYFMEDHLSWAEADLFCQNMNSGYLVSVLSQAEGNFLASLIKESGTTAANVWIGLH
                     DPKNNRRWHWSSGSLFLYKSWDTGYPNNSNRGYCVSVTSNSGYKKWRDNSCDAQLSFV
                     CKFKA"
     exon            134..252
                     /gene="Reg1a"
                     /gene_synonym="LITHOST; RATLITHOST; RATRGPI; Reg; Reg1;
                     Rgp1; RGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            253..390
                     /gene="Reg1a"
                     /gene_synonym="LITHOST; RATLITHOST; RATRGPI; Reg; Reg1;
                     Rgp1; RGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            391..502
                     /gene="Reg1a"
                     /gene_synonym="LITHOST; RATLITHOST; RATRGPI; Reg; Reg1;
                     Rgp1; RGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            503..766
                     /gene="Reg1a"
                     /gene_synonym="LITHOST; RATLITHOST; RATRGPI; Reg; Reg1;
                     Rgp1; RGPI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacagactt ttgtctcagc ctgcagagat tgttgacttg catcctaagc agaagacagt
       61 ctgctgctca tcatgactcg caacaaatat ttcattctgc tttcatgcct gatggtcctt
      121 tctccaagcc aaggccagga ggctgaagaa gatctaccat ctgccaggat cacttgtcca
      181 gaaggttcca atgcctacag ttcctactgt tactacttca tggaagacca tttatcttgg
      241 gctgaggcag atcttttttg ccagaacatg aattcaggct acttggtgtc agtgctcagc
      301 caggctgagg gcaactttct ggcctctctg attaaggaga gtggtactac agctgccaat
      361 gtctggattg gcctccatga tcccaaaaat aatcgccgct ggcactggag cagtgggtct
      421 ctgtttctct acaaatcctg ggacactggg tatcctaaca attccaatcg tggctactgt
      481 gtatctgtga cttcaaactc aggatacaag aaatggagag ataacagttg tgatgcccaa
      541 ttatcatttg tctgcaagtt caaagcctga aatcatctga aaaaaatagt catacagagc
      601 cagacaagaa aatactatgg agtcaaaagt gaaactagac catctatcaa aagcaaagtc
      661 aaccccctct tcctagacaa acattcttgc ctcactgccc tatggtattt ttatctccat
      721 tattgtatgt aaccctgcac atttaaataa aaataccttc acaata
//
