LOCUS       NM_001013218            2152 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus receptor accessory protein 6 (Reep6), mRNA.
ACCESSION   NM_001013218 XM_343163
VERSION     NM_001013218.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2152)
  AUTHORS   Sun,Y., Chen,L., Xu,T., Gou,B., Mai,J.W., Luo,D.X., Xin,W.J. and
            Wu,J.Y.
  TITLE     MiR-672-5p-Mediated Upregulation of REEP6 in Spinal Dorsal Horn
            Participates in Bortezomib-Induced Neuropathic Pain in Rats
  JOURNAL   Neurochem Res 48 (1), 229-237 (2023)
   PUBMED   36064821
  REMARK    GeneRIF: MiR-672-5p-Mediated Upregulation of REEP6 in Spinal Dorsal
            Horn Participates in Bortezomib-Induced Neuropathic Pain in Rats.
REFERENCE   2  (bases 1 to 2152)
  AUTHORS   Arno,G., Agrawal,S.A., Eblimit,A., Bellingham,J., Xu,M., Wang,F.,
            Chakarova,C., Parfitt,D.A., Lane,A., Burgoyne,T., Hull,S.,
            Carss,K.J., Fiorentino,A., Hayes,M.J., Munro,P.M., Nicols,R.,
            Pontikos,N., Holder,G.E., Asomugha,C., Raymond,F.L., Moore,A.T.,
            Plagnol,V., Michaelides,M., Hardcastle,A.J., Li,Y., Cukras,C.,
            Webster,A.R., Cheetham,M.E. and Chen,R.
  CONSRTM   UKIRDC
  TITLE     Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa
  JOURNAL   Am J Hum Genet 99 (6), 1305-1315 (2016)
   PUBMED   27889058
REFERENCE   3  (bases 1 to 2152)
  AUTHORS   Hao,H., Veleri,S., Sun,B., Kim,D.S., Keeley,P.W., Kim,J.W.,
            Yang,H.J., Yadav,S.P., Manjunath,S.H., Sood,R., Liu,P., Reese,B.E.
            and Swaroop,A.
  TITLE     Regulation of a novel isoform of Receptor Expression Enhancing
            Protein REEP6 in rod photoreceptors by bZIP transcription factor
            NRL
  JOURNAL   Hum Mol Genet 23 (16), 4260-4271 (2014)
   PUBMED   24691551
REFERENCE   4  (bases 1 to 2152)
  AUTHORS   Bjork,S., Hurt,C.M., Ho,V.K. and Angelotti,T.
  TITLE     REEPs are membrane shaping adapter proteins that modulate specific
            g protein-coupled receptor trafficking by affecting ER cargo
            capacity
  JOURNAL   PLoS One 8 (10), e76366 (2013)
   PUBMED   24098485
  REMARK    Erratum:[PLoS One. 2013;8(12).
            doi:10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2152)
  AUTHORS   Krolewski,R.C., Packard,A., Jang,W., Wildner,H. and Schwob,J.E.
  TITLE     Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal
            cells in olfactory epithelium
  JOURNAL   PLoS One 7 (12), e51737 (2012)
   PUBMED   23284756
REFERENCE   6  (bases 1 to 2152)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   7  (bases 1 to 2152)
  AUTHORS   Sato,H., Tomita,H., Nakazawa,T., Wakana,S. and Tamai,M.
  TITLE     Deleted in polyposis 1-like 1 gene (Dp1l1): a novel gene richly
            expressed in retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 46 (3), 791-796 (2005)
   PUBMED   15728532
  REMARK    GeneRIF: TB2-like 1 is a membrane protein that belongs to the
            YOP1/TB2/DP1/HVA22 family, and it probably plays an important role
            in intracellular membrane trafficking in RGCs
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083830.1.
            
            On Apr 20, 2005 this sequence version replaced XM_343163.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083830.1, CK469420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2152
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2152
                     /gene="Reep6"
                     /gene_synonym="Dp1l1"
                     /note="receptor accessory protein 6"
                     /db_xref="GeneID:362835"
                     /db_xref="RGD:1309508"
     exon            1..142
                     /gene="Reep6"
                     /gene_synonym="Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..663
                     /gene="Reep6"
                     /gene_synonym="Dp1l1"
                     /note="polyposis locus protein 1-like 1; deleted in
                     polyposis 1-like 1"
                     /codon_start=1
                     /product="receptor expression-enhancing protein 6"
                     /protein_id="NP_001013236.1"
                     /db_xref="GeneID:362835"
                     /db_xref="RGD:1309508"
                     /translation="MDGLRQRFERFLEQKNVATDALGALEARTGVEKRYLAAGALTLL
                     GLYLLFGYGASLLCNVIGFVYPAYASVKAIESPNKEDDTVWLTYWVVYALFGLVEFFS
                     DLLLFWFPFYYAGKCAFLLFCMTPGPWNGALLLYHRVIRPLFLKHHVALDSAASQLSG
                     RALDIAAGITRDVLQALARGRTLVTPASASESPAALEPDPKSSQTTLLKHK"
     exon            143..236
                     /gene="Reep6"
                     /gene_synonym="Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..375
                     /gene="Reep6"
                     /gene_synonym="Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..544
                     /gene="Reep6"
                     /gene_synonym="Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..625
                     /gene="Reep6"
                     /gene_synonym="Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..2126
                     /gene="Reep6"
                     /gene_synonym="Dp1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcctgcc ccgcgcccgc cgctgccatg gacggtctgc gccagcgctt cgaacgtttt
       61 ctggaacaga agaacgtggc caccgacgcg ctgggggcgc tcgaagccag gaccggtgta
      121 gagaagcggt atctcgccgc gggagccctc acccttctag gcctgtatct tctgttcggc
      181 tacggggcgt ctctactttg caatgtcatc ggatttgtat accccgcata tgcttcagtc
      241 aaagctatcg agagcccaaa caaggaagac gacactgtgt ggctaaccta ctgggtggtg
      301 tacgccctgt tcggtctagt cgagttcttc agcgatctac tcctgttctg gttccctttc
      361 tactacgcgg gcaagtgcgc cttcctatta ttttgcatga cacccgggcc ctggaacggg
      421 gcattgctac tgtatcatcg cgtcataaga cctctgtttc taaagcacca cgtggctcta
      481 gacagcgccg cgagccagct aagcggaaga gcattggaca tagcagctgg gataaccagg
      541 gacgtgctac aggccttggc tcggggtcgg actctcgtaa ccccagcatc agcatcggag
      601 tccccagccg ctctggaacc ggaccccaag tcaagtcaga ccacactcct gaagcacaag
      661 tgaggtctgc tggcagtctg tgtgtagagc ccccaaccac tgacaaggaa cacatagccg
      721 atgatggcca gatctctgac agttcctcag actcccagat agaggagaca cagccacaac
      781 cgcagccaca gctacagccg caaccacagc cacagccgca acctcaacca caacctcaac
      841 ctcaacctca acctcaacct caacaaccac aacaaccaca accgcaacaa ccacaaccgc
      901 aacaaccaca accgcaacca caaccacaac cacaaccaca accacaacca caaccacaac
      961 cacaaccaca accacaacca cgccgaccct caagtccaag taaaccatta ggaagccctt
     1021 cacgggccac aaatgggcag tccccgtccc cagtcagccc aggctctgcg tctgcgtccc
     1081 ggggtcagct ggccactggt tctttcgtca tcggctccca gtttcccagc aagacccgga
     1141 cccatcgaag ccggggcagt ttgactccca gggccgcaca gcgcgcccgg ctgcccagtg
     1201 gaacactggg gtccattcag ctgcccatgc gctctgttgc tgccccacag tcagcaggcc
     1261 ggtccttggg acccagccgg acaacaggcc gccacacagg aacaaaccag cagacccccc
     1321 aggtctccac ggcaggccca ggccgagcgg cagccgcggt ggcggcagcg ccagccccag
     1381 ccccagcagc cccagcagcc ccagcagccc cagcagcccc agcagcgcca gtgccagcgc
     1441 cagcagccac atctgtaccc actcccacac agcgtgtcag tgtgtctgtc cagggctcac
     1501 ctagggtccc gtctccctgc acatcccctg acctcaacca gggggccggc aaggctccgg
     1561 ttgagtcagg gaatgcaggt cccaagatcg gcaagcgtaa ccagaagaca caggcggctg
     1621 gcagcacctc tgtgcccgag ctgttggtcc cctgtcactc tgacacctct ctggattatt
     1681 tgtccgagtc caccacggag atcacctgca aatggccaga ctacggtcac cagctgcgct
     1741 gccctagaca ctgctggctc ctgccacacc tggcatacta acgccacgcc tggacacccg
     1801 tgggccatga gaccgcaaga gacacctacc caggggagcc acaagaagca ctagacctcc
     1861 ggagcaccat acaagagcca cgttgaataa ctgcccgtcg tgcaaatagt ttaaacatct
     1921 gccacaatgc cacatgaaac acccaccagc caggccatca cacgtcaaac ctgcccgtgg
     1981 actcccgggt gagacaccaa ccacgaagcc ccatgtgaaa caccctcaac aaaacatcca
     2041 tcaaggtgca tgtgaaacac catccggggt cccccatgta acatctatcc tccgcggcac
     2101 gcaataaaat cacccgctca ggctcaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
