LOCUS       NM_001108888            2917 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus receptor accessory protein 5 (Reep5), mRNA.
ACCESSION   NM_001108888 XM_001060998 XM_344661
VERSION     NM_001108888.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Yao,L., Xie,D., Geng,L., Shi,D., Huang,J., Wu,Y., Lv,F., Liang,D.,
            Li,L., Liu,Y., Li,J. and Chen,Y.H.
  TITLE     REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic
            Reticulum Membrane Sculptor to Modulate Cardiac Function
  JOURNAL   J Am Heart Assoc 7 (3), e007205 (2018)
   PUBMED   29431104
  REMARK    GeneRIF: REEP5 modulates cardiac function by shaping the
            sarcoplasmic reticulum. REEP5 defect deforms the SR architecture to
            depress cardiac contractility in heart failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Hashimoto,Y., Shirane,M., Matsuzaki,F., Saita,S., Ohnishi,T. and
            Nakayama,K.I.
  TITLE     Protrudin regulates endoplasmic reticulum morphology and function
            associated with the pathogenesis of hereditary spastic paraplegia
  JOURNAL   J Biol Chem 289 (19), 12946-12961 (2014)
   PUBMED   24668814
REFERENCE   3  (bases 1 to 2917)
  AUTHORS   Chang,J., Lee,S. and Blackstone,C.
  TITLE     Protrudin binds atlastins and endoplasmic reticulum-shaping
            proteins and regulates network formation
  JOURNAL   Proc Natl Acad Sci U S A 110 (37), 14954-14959 (2013)
   PUBMED   23969831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE126660.1, BC167013.1, FM032375.1, BP503102.1 and AA819308.1.
            
            On Dec 5, 2009 this sequence version replaced NM_001108888.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214399.1, FQ213205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BE126660.1         1-75
            76-1349             BC167013.1         1-1274
            1350-1883           FM032375.1         34-567
            1884-2434           BP503102.1         198-748
            2435-2917           AA819308.1         1-483               c
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2917
                     /gene="Reep5"
                     /gene_synonym="Dp1"
                     /note="receptor accessory protein 5"
                     /db_xref="GeneID:364838"
                     /db_xref="RGD:1306047"
     exon            1..213
                     /gene="Reep5"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..665
                     /gene="Reep5"
                     /gene_synonym="Dp1"
                     /note="polyposis locus protein 1 homolog; deleted in
                     polyposis 1"
                     /codon_start=1
                     /product="receptor expression-enhancing protein 5"
                     /protein_id="NP_001102358.2"
                     /db_xref="GeneID:364838"
                     /db_xref="RGD:1306047"
                     /translation="MSAAMRERFDRFLHEKNCMTDLLAKLEAKTGVNRSFIALGVIGL
                     VALYLVFGYGASLLCNLIGFGYPAYISMKAIESPNKDDDTQWLTYWVVYGVFSIAEFF
                     SDLFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYRRVIRPIFLKHESQVDSVVKDVK
                     DKAKETADAISKEVKKATVNLLGDEKKST"
     exon            214..307
                     /gene="Reep5"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..446
                     /gene="Reep5"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..615
                     /gene="Reep5"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..2902
                     /gene="Reep5"
                     /gene_synonym="Dp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgcggcg ccgcccgccc ccgccccgcc ccggtcagct gggttccgcg tccagccagc
       61 tgaggagcat cccgggcggc gcgaacggcc cagccatgtc cgcagccatg agggagaggt
      121 tcgaccggtt cctgcacgag aagaactgca tgactgatct cctggccaag ctcgaggcca
      181 agactggagt gaaccggagc ttcatcgcgc tcggtgtcat cggactggtg gctttgtatc
      241 tggtgttcgg ttatggagcc tctctcctct gcaacctgat aggtttcgga tacccagcct
      301 acatctcaat gaaagccatc gagagcccca acaaagatga tgacacccag tggctgacgt
      361 actgggtggt gtatggtgtg ttcagcatcg ccgagttctt ctccgacctt ttcctgtcct
      421 ggttcccctt ctactacatg ctgaagtgcg gcttcctgtt gtggtgcatg gctcccagcc
      481 cgtccaacgg ggctgaactg ctgtaccggc gtgtcatccg tcccatcttc ctgaagcacg
      541 agtcccaggt agacagtgtg gtgaaggacg tgaaggacaa agccaaagag actgcagacg
      601 ccatcagcaa agaagtcaag aaggctacgg tgaacttgct gggcgacgag aagaagagca
      661 cctgagtcct ggctgggcgg cccctccccc actcaccccc ttagagctcc gtgttatgct
      721 agggacagtg gcacaggtgt tggataatgt tgccttggaa actttctgat gtattaaaaa
      781 tggaatgtgt tgtaaggtgt ttcgctttta ttgtcatata tgtagggaac gttttcattt
      841 aaatctaaca gagtgggcag tacctaaaat ttttaaatat gagtctgaag acacgtcact
      901 atattccagg aaattcaaac cgagattgga aatctctgtc cgtaggccct gtgctctgcg
      961 gggctcacct gcatgcgtct tcctgtgctt acagtttgga aacctttgtg ttgtgcttca
     1021 ctcggtgtat gattttatat agttctgtgt tttaatgtat ctgtgtatat acatatatat
     1081 ggaaaatgtt atagtttggc tagaacatgc gtagtgcttg tgagaagagg ccaaggaagg
     1141 ttgcagacac cacctgtgac ctgtgaagca agatcccccc ccccccaagg ctggaatgct
     1201 gtcgtgatga gtgcacttcc aaataccatt tcagaaagtg atacagatgg gattggggat
     1261 ttagctcagt ggtagagcgc ttgcctagga agcgcaaggc cctgggttcg gtccccagct
     1321 ctgaaaaaaa gagccaaaaa aaaaaaaaag tgatacagat gagtaagaca tcccatcccc
     1381 caagacagcc catcccccaa gacagcccat cccccaagac ttcccacccc cccaagacag
     1441 cccatccccc aagacagccc acctcccaag acttcccgcc tcccattgca tacctcagtt
     1501 tttaaaaaca tgatcccatg tagcccagga gaactctgaa gtcctgatcc tcctgctgcc
     1561 tccacctccc agcttctgct cactgcaggc tggtgcccca tggtggctta cgtgtgccgt
     1621 cttgttcgtg taacagcaca ttgtatactg atagcatcca gctctaagag cagttctgga
     1681 caagtgaggg gcagcggcgg ctgggatgaa cttttcactc tttgttttta tggccaacct
     1741 caagaggtct ccctacttta taatttgtaa ttattagcat tcccttacag atgcttcagt
     1801 ctatgtttcg tttaagtgac cgcctgtcaa agtggcttgc tgggtcagag gtttggatct
     1861 aagagtctgt gctttgcacc tcaggccagc ttttcagcct ttgagttggt ctgaaggagc
     1921 tgtctgccaa agccaacagc aggagttacc ttcaggacaa tgggcaatga ttctcctaca
     1981 gatgactcag atcacaataa tatacaatac taacaataca aaataagagg gtcacagggt
     2041 tcgttttcct gggaatacta gtaatcatta ggcatcttct gacttaaggt ggggggatct
     2101 ttttagaaaa taaaaacagt tgtttataga aaaccaattg ttaggtctta aaaatattta
     2161 ggtccttata agtaaaagca cgtttttctt gttggcagag tgaaaattaa catcgacgat
     2221 gtaatctata agaacagtgt taatatacaa catactctat gtgaggggat gggcaggcag
     2281 ggactcacag ttacttagag gttcttggtg gaaacactgc tgcagtgaag taaaccccaa
     2341 aagcaatttt gccctatcaa ccccacagct ttcaccagag caggcgccgg gaagtcatta
     2401 cttctagcag ctgttagtag gagaaatcat tgacttctgc ctgcccgtcc ttcccaaata
     2461 aaacagtgtc atgactacga gtgttgacag tgagctggct ggaaacaaag tgtttatttg
     2521 tatctgagtg gtatttcaaa gacatataaa gttccagaat tcttgctaca ctttaaagct
     2581 tgctgttgta gggcaattct ttcctgtcag tcatttggac tgcattgctg ctgttgtggg
     2641 gaagaatcct ccatccacac ctcagaaaac agtcacggcc taaataaaat atcgcctggc
     2701 ctcagatgtg aataggagtg cccgggcctt ccttacgtgt tcccagactc ccctggctgc
     2761 catacctgga gagaacactg aactctgtgt ggactgttcc ttcctgtgcg tgtatctctg
     2821 acaaaagtta ctgactggac aaagtgagaa tgagaattac aacatatact caaataaaga
     2881 ttatgtttat gtggtctgtc aaaaaaaaaa aaaaaaa
//
