LOCUS       NP_001041512             254 aa            linear   ROD 23-MAR-2023
DEFINITION  receptor expression-enhancing protein 2 [Rattus norvegicus].
ACCESSION   NP_001041512 XP_001062164
VERSION     NP_001041512.1
DBSOURCE    REFSEQ: accession NM_001048047.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 254)
  AUTHORS   Esteves T, Durr A, Mundwiller E, Loureiro JL, Boutry M, Gonzalez
            MA, Gauthier J, El-Hachimi KH, Depienne C, Muriel MP, Acosta
            Lebrigio RF, Gaussen M, Noreau A, Speziani F, Dionne-Laporte A,
            Deleuze JF, Dion P, Coutinho P, Rouleau GA, Zuchner S, Brice A,
            Stevanin G and Darios F.
  TITLE     Loss of association of REEP2 with membranes leads to hereditary
            spastic paraplegia
  JOURNAL   Am J Hum Genet 94 (2), 268-277 (2014)
   PUBMED   24388663
REFERENCE   2  (residues 1 to 254)
  AUTHORS   Bjork S, Hurt CM, Ho VK and Angelotti T.
  TITLE     REEPs are membrane shaping adapter proteins that modulate specific
            g protein-coupled receptor trafficking by affecting ER cargo
            capacity
  JOURNAL   PLoS One 8 (10), e76366 (2013)
   PUBMED   24098485
  REMARK    Erratum:[PLoS One. 2013;8(12).
            doi:10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 254)
  AUTHORS   Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z
            and Chen J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
REFERENCE   4  (residues 1 to 254)
  AUTHORS   Ilegems E, Iwatsuki K, Kokrashvili Z, Benard O, Ninomiya Y and
            Margolskee RF.
  TITLE     REEP2 enhances sweet receptor function by recruitment to lipid
            rafts
  JOURNAL   J Neurosci 30 (41), 13774-13783 (2010)
   PUBMED   20943918
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105630.1.
            
            On Sep 14, 2006 this sequence version replaced XP_001062164.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     Protein         1..254
                     /product="receptor expression-enhancing protein 2"
                     /calculated_mol_wt=28248
     Region          19..94
                     /region_name="TB2_DP1_HVA22"
                     /note="TB2/DP1, HVA22 family; pfam03134"
                     /db_xref="CDD:460820"
     CDS             1..254
                     /gene="Reep2"
                     /coded_by="NM_001048047.1:116..880"
                     /db_xref="GeneID:682105"
                     /db_xref="RGD:1586980"
ORIGIN      
        1 mvswiisrlv vlifgtlypa yssykavktk nvkeyvkwmm ywivfafftt aetltdiils
       61 wfpfyfelki afviwllspy tkgssvlyrk fvhptlsnke keideyitqa rdksyetmmr
      121 vgkrglnlaa naavtaaakg qgvlseklrs fsmqdltlir dedalplqgp dgrlqpgpvg
      181 lldtiedlgd epalslrsss sqadprtets eddlgdkapk rtkpikkvpk aeppasktlk
      241 trpkkkspgg gdsa
//
