LOCUS       NM_001130494            3860 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RecQ like helicase 4 (Recql4), mRNA.
ACCESSION   NM_001130494 XM_001073353 XM_216973
VERSION     NM_001130494.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3860)
  AUTHORS   Ng AJ, Walia MK, Smeets MF, Mutsaers AJ, Sims NA, Purton LE, Walsh
            NC, Martin TJ and Walkley CR.
  TITLE     The DNA helicase recql4 is required for normal osteoblast expansion
            and osteosarcoma formation
  JOURNAL   PLoS Genet 11 (4), e1005160 (2015)
   PUBMED   25859855
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3860)
  AUTHORS   Ghosh AK, Rossi ML, Singh DK, Dunn C, Ramamoorthy M, Croteau DL,
            Liu Y and Bohr VA.
  TITLE     RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions
            in telomere maintenance
  JOURNAL   J Biol Chem 287 (1), 196-209 (2012)
   PUBMED   22039056
REFERENCE   3  (bases 1 to 3860)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3860)
  AUTHORS   Xu X and Liu Y.
  TITLE     Dual DNA unwinding activities of the Rothmund-Thomson syndrome
            protein, RECQ4
  JOURNAL   EMBO J 28 (5), 568-577 (2009)
   PUBMED   19177149
REFERENCE   5  (bases 1 to 3860)
  AUTHORS   Yang J, Murthy S, Winata T, Werner S, Abe M, Prahalad AK and Hock
            JM.
  TITLE     Recql4 haploinsufficiency in mice leads to defects in osteoblast
            progenitors: Implications for low bone mass phenotype
  JOURNAL   Biochem Biophys Res Commun 344 (1), 346-352 (2006)
   PUBMED   16600186
REFERENCE   6  (bases 1 to 3860)
  AUTHORS   Mann MB, Hodges CA, Barnes E, Vogel H, Hassold TJ and Luo G.
  TITLE     Defective sister-chromatid cohesion, aneuploidy and cancer
            predisposition in a mouse model of type II Rothmund-Thomson
            syndrome
  JOURNAL   Hum Mol Genet 14 (6), 813-825 (2005)
   PUBMED   15703196
REFERENCE   7  (bases 1 to 3860)
  AUTHORS   Lindor NM, Furuichi Y, Kitao S, Shimamoto A, Arndt C and Jalal S.
  TITLE     Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report
            and clinical and molecular comparisons with Bloom syndrome and
            Werner syndrome
  JOURNAL   Am J Med Genet 90 (3), 223-228 (2000)
   PUBMED   10678659
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 27, 2008 this sequence version replaced
            XM_001073353.1, XM_216973.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3860
                     /gene="Recql4"
                     /note="RecQ like helicase 4"
                     /db_xref="GeneID:300057"
                     /db_xref="RGD:1307732"
     exon            1..118
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..3685
                     /gene="Recql4"
                     /EC_number="3.6.4.12"
                     /note="RecQ protein-like 4; RecQ helicase-like 4"
                     /codon_start=1
                     /product="ATP-dependent DNA helicase Q4"
                     /protein_id="NP_001123966.1"
                     /db_xref="GeneID:300057"
                     /db_xref="RGD:1307732"
                     /translation="MERLATVRAWLQDWERAFVRLHGRRPAKEDVEAAPEETRALYRE
                     YRNLKQAVSQADDGHRVQKQSLAKAAEEEQEPSCWGSHLNRAATQNTQSIPKQSPLSS
                     IQDYGKRLKANLKNTLQGGPTLSRKLQHQKRSLSIVPTSRPPGPRTESPCPEQANDAL
                     PQVPVPQPRQGQLQKLQSSLSLRLSSLDPGWLERCQNRVSDPLEVPGACGLDLSAKES
                     QPQMSGKVNVISPDILSEVSSQSPQALAQQPAQVLSQIPKSSNSKDRKRKRNEKGEDF
                     AQAQPSSQAGPLSEGAGATAHGQGPPGEPTQVTVPQHRCSSNQARTENAKSAAHLPMS
                     PRPASLDRGNYVRLNMKTKCFVRVGASRGRLLRKQVWKQKWKKKQEWFGKSGPRATVK
                     DTCFRCGQFGHWASQCSQPGSTLTIQPKGDRNDKHPISTLGGVAQKTGTTSCNHSGEE
                     TEPAGPVLPVPHCPTPVLPLYPPGPLGQVADTPAEVFQVLEQLGHHTFRPGQERAVMR
                     ILSGISTLLVLPTGAGKSLCYQLPALLYAKRSPCLTLVVSPLLSLMDDQVSDLPSCLK
                     AACLHSGMTKKQRESVLKKVRAAQVHVLIVSPEALVGCGAKGPANLPPAAQLPPVAFA
                     CIDEVHCLSQWSHNFRPCYLRVCKVLREHMGVRCFLGLTATATRSTARDVAQHLGIAE
                     ELEVSGSASIPANLHLSVSMDRDSDQALVTLLQGDRFRTLDSIIIYCARRKDTERVAA
                     LLRTCLSTVRDSKPRGRGPETLAEAYHAGMCSQERKRVQQAFMQGHLRMVVATVAFGM
                     GLDRPDVRAVLHLGLPPSFESYVQAIGRAGRDGKPAHCHLFLHPQGEDLWELSRHVHA
                     DSTDFLAVKKLVQRVFPACSCAQRPMSPLEEVKEHSGQQTYPVLGLACRGHKRALPVQ
                     STVLALDMKEEAIETLLCYLELHPRHWLELLPYTYAHCHLRCPGGSAQLQALVHRCPP
                     LAACWAKWPPKDTSQGSSALEFDVVELADSMGWELASVRQALHQLKWDPEPKKGAPQG
                     TGVLVEFSELAFHLHSRGDLTDEEKDQICDFLYSRVQAREHKALAHLHQMSKAFQSVA
                     FPSCGPCLEQSDEGHSNRVKTLVSYYFEEEEEEEEEETMKDTQDPKPGQTQLQDWEDQ
                     VRRDVHQLLSLRPEEKFSGRAVARIFHGIASPCYPAQVFGQDRRFWRKYLHLDFHALM
                     HLATEELLLRGR"
     exon            119..152
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            153..250
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            251..391
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            392..1141
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1268
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1376
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1475
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1568
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1705
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1789
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1978
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2158
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2300
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2563
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2810
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2940
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3110
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3291
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3451
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3560
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3860
                     /gene="Recql4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggatatt ccttaaactc aagcccgggc tgccatggag cggcttgcga ccgttcgcgc
       61 gtggctgcag gattgggaac gcgcttttgt acggctgcac gggcgacggc cagcaaagga
      121 ggatgtggag gcggcacccg aggagacccg cgcgctctac cgtgagtacc gtaacctaaa
      181 gcaggcagtg agtcaggccg acgacggaca ccgcgtccaa aagcaatcac ttgccaaggc
      241 agctgaggag gaacaggagc caagctgctg gggttcccac ctgaaccgag ctgcaaccca
      301 gaacacacag tctattccaa agcagagccc actgagttct atacaagact atgggaagag
      361 gctcaaagcc aatcttaaaa acacactaca gggcgggcca accctgagtc gaaaactcca
      421 gcatcagaag agatccttgt ccatagtgcc cacatcaagg ccaccaggcc caaggactga
      481 atccccctgt ccagaacaag ctaatgatgc tcttccccag gttcctgtgc cccagccaag
      541 gcaaggccaa ctccagaagc tccagtcatc cctgagcctg aggttgagtt ccctagaccc
      601 tggttggtta gagaggtgtc aaaacagagt ttcagatcct ctagaggttc caggtgcttg
      661 tgggcttgac ctgagtgcaa aggagtcaca acctcagatg tcaggcaagg tgaatgtcat
      721 tagtcctgac atcctttcag aagtatcttc acagagccca caggccctag cccaacagcc
      781 agcccaagtt ttgtcacaga tccccaaatc cagcaacagt aaagacagga agcggaaacg
      841 gaatgagaag ggggaggact ttgcacaagc ccagcccagc agccaagcag gacccctgtc
      901 tgagggagct ggggctacag cacatgggca aggccctcca ggagaaccca cacaagtgac
      961 tgtccctcag caccgctgct cttcaaacca ggccaggaca gagaatgcta agagtgcggc
     1021 ccacctcccc atgtcccctc ggccagcttc cctagacaga gggaactatg ttcgacttaa
     1081 catgaaaacc aaatgctttg tacgagttgg ggccagtcgg ggcaggcttc tccgaaagca
     1141 ggtatggaag caaaagtgga agaagaaaca agagtggttt gggaaaagtg gacccagggc
     1201 cacagtcaag gacacttgtt tccggtgtgg gcagtttggt cactgggcat cccagtgttc
     1261 ccaaccaggc tccaccctga ccatccagcc aaaaggtgac aggaatgaca aacatcccat
     1321 ttccacgttg gggggagtag cacagaagac tggcaccact tcctgtaacc actctggtga
     1381 ggaaactgaa cctgctggac cagtgctacc ggtgcctcat tgccccacgc cagtgttacc
     1441 cctctaccca ccagggccct tgggacaggt agcagacacc cctgctgagg tattccaagt
     1501 cctggagcag ctagggcacc acaccttccg ccctgggcaa gagcgtgctg tcatgaggat
     1561 tctttctggc atctccacac tgttagtgtt gcccacgggt gctggcaagt ctctgtgcta
     1621 ccagcttcct gcactgctct atgccaagcg aagcccctgt ctcacactgg tcgtctctcc
     1681 tctcctgtca ctcatggatg accaggtgtc tgatctgcct tcatgtctga aggcggcctg
     1741 cctccactca ggaatgacca agaaacaacg agaatctgtc ttgaagaagg tacgggcagc
     1801 ccaggtgcat gtgctgattg tgtccccaga ggccttggtg ggatgcgggg ctaagggtcc
     1861 tgccaacctc cccccggccg ctcagctgcc tccagtcgcc tttgcctgca ttgatgaggt
     1921 ccactgcctc tctcagtggt cacataactt ccggccctgc tacttacgtg tttgtaaagt
     1981 acttcgggag catatgggtg tgcgctgctt tttgggtctc acagccacag ccacacgaag
     2041 cactgctcgt gatgtggccc agcacctggg catagctgaa gagcttgagg tcagtgggtc
     2101 agccagcatc cctgccaatc tgcacctctc cgtgtccatg gatcgagact cagaccaggc
     2161 tctggtgaca ctgctacaag gtgaccgctt ccgtaccctg gattcgatta tcatttactg
     2221 tgctcgacga aaggacacag agcgggtggc tgccctcctc cggacctgcc tgtccacagt
     2281 gagagattca aagccaagag gccgtggccc tgagacttta gcggaagcat accatgctgg
     2341 catgtgtagc caggaacgga aacgagtaca acaggccttc atgcagggcc acctgcgcat
     2401 ggtagtggcc acagtggcat ttgggatggg actggaccgt ccagatgttc gggctgtgct
     2461 acacctggga ctgcctccaa gcttcgagag ctacgtgcaa gctattggcc gtgcaggacg
     2521 tgatgggaag cctgcccatt gccacctgtt cctgcatcct cagggtgaag acctctggga
     2581 actgagcaga catgtccatg ctgatagcac tgacttcctg gctgtgaaga agctggtaca
     2641 gcgtgtgttc ccagcctgct catgcgccca gaggcctatg tccccacttg aggaagtcaa
     2701 agagcacagt ggccaacaaa cataccctgt actgggacta gcctgccggg gccataagcg
     2761 ggcactccca gtgcagtcta cagtactggc tctggacatg aaagaggagg ccattgagac
     2821 tttgctgtgc tatttggaac tacaccctcg gcactggttg gagctgctgc catacaccta
     2881 tgcccactgc catctgcgtt gccctggggg cagtgcccag ctgcaagctc tggtccacag
     2941 gtgtccccct ttggctgcat gctgggccaa gtggccacct aaagacacaa gtcagggtag
     3001 cagcgcctta gagtttgatg tggtggaact ggcagactcc atgggctggg agttggcctc
     3061 tgtacggcag gctctccacc agctgaagtg ggacccagag ccaaagaaag gtgcaccaca
     3121 gggcacagga gtgcttgtgg agttcagtga gttggccttt cacctgcaca gtcgtgggga
     3181 cctgacagat gaggagaagg accagatctg tgactttctg tacagccgtg tgcaggctcg
     3241 tgaacacaag gccctggccc acctacacca aatgtccaag gcctttcaaa gtgtagcatt
     3301 tcccagttgt ggaccctgtt tagagcagtc tgacgagggg cacagcaatc gggtgaagac
     3361 cctggtcagc tactactttg aggaggagga ggaggaggaa gaggaagaaa ctatgaagga
     3421 tactcaggat ccaaaacctg ggcagaccca gcttcaggat tgggaggacc aagttcgccg
     3481 cgatgtccac cagctcctgt ccctgaggcc agaagaaaag ttttcaggaa gggctgtggc
     3541 ccgcatcttc catggaattg caagtccatg ctacccagcc caggtgtttg ggcaggaccg
     3601 gcgcttctgg agaaagtacc tacacctgga cttccacgcc ctcatgcacc tagccacaga
     3661 ggagctcctg ctcagaggcc gatgaccacc aaacatggga ggggctacat gagggggcat
     3721 ggggcaagcc agactgccac tccacagagg ctgtcaggct caccaaggca atgatgtggc
     3781 catcactgac tgttaggcag aaccttctgg ctgcaggaag gggataagaa gatccaaaat
     3841 acagataaag agccttcagt
//
