LOCUS       NM_001012098            2427 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RecQ like helicase (Recql), mRNA.
ACCESSION   NM_001012098 XM_232510
VERSION     NM_001012098.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2427)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 2427)
  AUTHORS   Cotton,R.T., Li,D., Scherer,S.E., Muzny,D.M., Hodges,S.E.,
            Catania,R.L., Witkiewicz,A.K., Brody,J.R., Kennedy,E.P., Yeo,C.J.,
            Brunicardi,F.C., Gibbs,R.A., Gingras,M.C. and Fisher,W.E.
  TITLE     Single nucleotide polymorphism in RECQL and survival in resectable
            pancreatic adenocarcinoma
  JOURNAL   HPB (Oxford) 11 (5), 435-444 (2009)
   PUBMED   19768149
REFERENCE   3  (bases 1 to 2427)
  AUTHORS   Xu,X. and Liu,Y.
  TITLE     Dual DNA unwinding activities of the Rothmund-Thomson syndrome
            protein, RECQ4
  JOURNAL   EMBO J 28 (5), 568-577 (2009)
   PUBMED   19177149
REFERENCE   4  (bases 1 to 2427)
  AUTHORS   Futami,K., Kumagai,E., Makino,H., Sato,A., Takagi,M., Shimamoto,A.
            and Furuichi,Y.
  TITLE     Anticancer activity of RecQL1 helicase siRNA in mouse xenograft
            models
  JOURNAL   Cancer Sci 99 (6), 1227-1236 (2008)
   PUBMED   18422747
REFERENCE   5  (bases 1 to 2427)
  AUTHORS   Li,D., Liu,H., Jiao,L., Chang,D.Z., Beinart,G., Wolff,R.A.,
            Evans,D.B., Hassan,M.M. and Abbruzzese,J.L.
  TITLE     Significant effect of homologous recombination DNA repair gene
            polymorphisms on pancreatic cancer survival
  JOURNAL   Cancer Res 66 (6), 3323-3330 (2006)
   PUBMED   16540687
REFERENCE   6  (bases 1 to 2427)
  AUTHORS   Kume,T., Jiang,H., Topczewska,J.M. and Hogan,B.L.
  TITLE     The murine winged helix transcription factors, Foxc1 and Foxc2, are
            both required for cardiovascular development and somitogenesis
  JOURNAL   Genes Dev 15 (18), 2470-2482 (2001)
   PUBMED   11562355
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079026.1.
            
            On Feb 11, 2005 this sequence version replaced XM_232510.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2427
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..2427
                     /gene="Recql"
                     /note="RecQ like helicase"
                     /db_xref="GeneID:312824"
                     /db_xref="RGD:1311071"
     exon            1..117
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            118..229
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..2079
                     /gene="Recql"
                     /EC_number="5.6.2.4"
                     /note="DNA-dependent ATPase Q1; recQ protein-like 1; RecQ
                     protein-like (DNA helicase Q1-like); RecQ helicase-like;
                     DNA 3'-5' helicase Q1"
                     /codon_start=1
                     /product="ATP-dependent DNA helicase Q1"
                     /protein_id="NP_001012098.1"
                     /db_xref="GeneID:312824"
                     /db_xref="RGD:1311071"
                     /translation="MASIPALTDELESVSSELHAVDIQIQELTERQHELLQRKSVLTK
                     RIKQCLEDSAAEASGDCDTSPAAWSKEDFPWSGKVKHVLRDVFKLQKFRPLQLETVNA
                     TMARKDIFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLQQLGISATM
                     LNSSSSKEHVKCVHTEMMNKNSHLKLIYVTPEKIAKSKMFMSRLEKAYEAGRLTGVAV
                     DEVHCCSQWGHDFRPDYKALGILKRQFPNISLIGLTATATNHVLKDAQKILCVEKCLT
                     FTASFNRPNLYYEVRQKPSSAEDFIENIANLINGRYKGKSGIIYCFSQKDSEQVTISL
                     QKLGVRAGTYHANMEPEDRTKVHTQWSANELQVVVATVAFGMGIDKPDVRFVIHHSMS
                     KSMENYYQESGRAGRDDWRADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNI
                     SKCRRALIAQHFDEVWNADACNKMCDNCCKDDSFEKKNITEHCQALIKILKQAEGLNE
                     KLTPLKLIDAWMGKGAAKFRVAGVAVPALPREDLEKIIVHALLQQYLKEDYSFTAYAT
                     ISYLKVGPRASLLSNEGHAVTMQVKRSTQSSVRAASPEACEVDSKGKEKSSAVLC"
     exon            230..427
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            428..607
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            608..714
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            715..913
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1080
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1162
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1311
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1429
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1568
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1660
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1880
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2010
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2065
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2389
                     /gene="Recql"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggggttt aggagccggg cgcctctgcc gtctgccgac ggtttcagga gccctggccg
       61 ccgcggcatg tgcttctgcc tcctgtggag ccggcgcggt ggagggatgc gctcaggggc
      121 ccctgccgac ctcgacagta ctgctggtgg acatgttacc atatttgttc tctcacttca
      181 gaaggacgtt tggatctccg gttcagtttt agaatggctt ccatcccagc tctaacggat
      241 gaactggagt ctgtgtccag tgagctccat gcagttgaca tccagattca agaacttaca
      301 gagaggcagc acgagctcct tcagagaaag tcagtcctga caaagagaat caagcagtgc
      361 ttagaggact ctgctgccga ggcgagcggc gactgtgaca cgtctccagc tgcatggagt
      421 aaagaagatt tcccatggtc cggaaaggta aaacatgtgc tgcgagatgt gtttaaactg
      481 cagaagttca gacctctgca gctggagact gtcaatgcca ccatggcgag aaaggacatc
      541 tttcttgtca tgcccacagg aggagggaag agcttgtgct accagctgcc agcgctgtgc
      601 tcagacggtt ttacactggt gatttgtcca ctcatctctc ttatggaaga tcagctgatg
      661 gttttacaac agttggggat ttcagctact atgttgaatt cttctagctc taaggaacat
      721 gtaaaatgtg tgcacactga aatgatgaat aaaaactccc acttaaagct gatttatgtg
      781 actccagaga aaattgcaaa aagcaagatg ttcatgtcga ggctagagaa agcctatgag
      841 gccgggagac tgactggagt ggcggtggat gaagtgcatt gctgcagtca gtggggacat
      901 gacttcaggc cggattacaa agcactcggc atcttgaagc gccagtttcc caacatctca
      961 ctgattgggc tgacagcaac agcaaccaac catgttttga aggatgcaca gaaaatccta
     1021 tgtgtggaga aatgtttgac atttacagcg tctttcaaca gaccaaatct ctactatgag
     1081 gttcggcaga agccctcgag tgctgaagac tttatcgaaa acattgcaaa ccttattaat
     1141 ggacggtaca aaggaaagtc aggaatcata tactgttttt ctcagaaaga ctctgaacaa
     1201 gtcaccatta gcttacagaa gctgggggtc cgtgcaggca cttaccatgc caacatggag
     1261 ccggaggaca ggaccaaggt tcacacgcag tggtcagcca atgagcttca ggtggtagtg
     1321 gcaacagtcg catttggcat gggaattgat aagcctgacg tgaggtttgt catccatcat
     1381 tcaatgagca aatccatgga gaattactac caagagagtg ggcgtgccgg tcgagatgac
     1441 tggagagcag actgtattct gtattacggc ttcggagaca tattcaggat cagctcgatg
     1501 gtggtcatgg agaatgtggg acagcagaag ctgtatgaga tggtgtcata ctgccagaat
     1561 atcagcaagt gtcgccgtgc gttaatagcc caacattttg atgaagtgtg gaatgcagac
     1621 gcctgtaaca aaatgtgtga caactgctgt aaagacgact cgtttgagaa aaagaatata
     1681 accgagcact gccaagccct gatcaagatt ctgaagcagg cagaaggact gaatgaaaag
     1741 ctcaccccac tgaagctgat tgatgcttgg atgggaaagg gagcagccaa gttcagagtg
     1801 gctggcgttg ctgtcccagc ccttccccga gaagacctgg agaaaatcat cgtacatgct
     1861 ctcctgcagc agtatctcaa ggaagactac agcttcacgg cttatgctac catctcgtat
     1921 ctgaaggtgg gacccagagc tagtcttctt agcaacgaag gccatgctgt cactatgcaa
     1981 gtgaagaggt ccacacagag cagcgttagg gctgcgtcac ctgaagcttg tgaagtggat
     2041 tcaaagggga aagaaaagag ctcagcagta ctatgctgac atgggctcac ctttccaagt
     2101 gggtgacatt ttaagctgag caatgtggat gacttctggt gagaaaagct gctgttcttg
     2161 ttcagataga aacagtaagt cgacagtaat gaatgtatca gcaagaaggc tctgcacaat
     2221 ctgcactctg atctaagtaa accgagacag caagcctcct gaaaccccag ccttactatg
     2281 atgttcaggc aaacaaagga tctggtgctt tgtatgagtc aaggtttatt gtcaactgtg
     2341 tactaggagt gttcatctgc aaatcagtca ttaaatggat ccatcctaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
