LOCUS       NM_001415923            4269 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Rattus norvegicus reversion-inducing-cysteine-rich protein with
            kazal motifs (Reck), mRNA.
ACCESSION   NM_001415923 XM_006238068
VERSION     NM_001415923.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4269)
  AUTHORS   Wang,X., Jia,Y., Li,Q., Yang,Q., Liu,Y., Wei,B., Niu,X., Zhang,Y.,
            Luo,X., Zhao,Z. and Wang,P.
  TITLE     miR-200b-3p accelerates progression of pituitary adenomas by
            negatively regulating expression of RECK
  JOURNAL   Oncol Res 32 (5), 933-941 (2024)
   PUBMED   38686051
  REMARK    GeneRIF: miR-200b-3p accelerates progression of pituitary adenomas
            by negatively regulating expression of RECK.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4269)
  AUTHORS   Ferrigno,A., Di Pasqua,L.G., Palladini,G., Berardo,C., Verta,R.,
            Richelmi,P., Perlini,S., Collotta,D., Collino,M. and Vairetti,M.
  TITLE     Transient Expression of Reck Under Hepatic Ischemia/Reperfusion
            Conditions Is Associated with Mapk Signaling Pathways
  JOURNAL   Biomolecules 10 (5), 747 (2020)
   PUBMED   32403397
  REMARK    GeneRIF: Transient Expression of Reck Under Hepatic
            Ischemia/Reperfusion Conditions Is Associated with Mapk Signaling
            Pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4269)
  AUTHORS   Spindola,A., Targa,A.D.S., Rodrigues,L.S., Winnischofer,S.M.B.,
            Lima,M.M.S., Sogayar,M.C. and Trombetta-Lima,M.
  TITLE     Increased Mmp/Reck Expression Ratio Is Associated with Increased
            Recognition Memory Performance in a Parkinson's Disease Animal
            Model
  JOURNAL   Mol Neurobiol 57 (2), 837-847 (2020)
   PUBMED   31493243
  REMARK    GeneRIF: Increased Mmp/Reck Expression Ratio Is Associated with
            Increased Recognition Memory Performance in a Parkinson's Disease
            Animal Model.
REFERENCE   4  (bases 1 to 4269)
  AUTHORS   Levin,G., Coelho,T.M., Nobrega,N.G., Trombetta-Lima,M.,
            Sogayar,M.C. and Carreira,A.C.O.
  TITLE     Spatio-temporal expression profile of matrix metalloproteinase
            (Mmp) modulators Reck and Sparc during the rat ovarian dynamics
  JOURNAL   Reprod Biol Endocrinol 16 (1), 116 (2018)
   PUBMED   30424792
  REMARK    GeneRIF: Data suggest that reversion-inducing-cysteine-rich protein
            with kazal motifs (Reck) and SPARC Glycoprotein (Sparc) seem to
            play a role during ovarian dynamics: Reck as a possible inhibitor
            and Sparc as an inducer of matrix metalloproteinases (Mmps).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4269)
  AUTHORS   Eubelen,M., Bostaille,N., Cabochette,P., Gauquier,A., Tebabi,P.,
            Dumitru,A.C., Koehler,M., Gut,P., Alsteens,D., Stainier,D.Y.R.,
            Garcia-Pino,A. and Vanhollebeke,B.
  TITLE     A molecular mechanism for Wnt ligand-specific signaling
  JOURNAL   Science 361 (6403) (2018)
   PUBMED   30026314
REFERENCE   6  (bases 1 to 4269)
  AUTHORS   Chang,C.K., Hung,W.C. and Chang,H.C.
  TITLE     The Kazal motifs of RECK protein inhibit MMP-9 secretion and
            activity and reduce metastasis of lung cancer cells in vitro and in
            vivo
  JOURNAL   J Cell Mol Med 12 (6B), 2781-2789 (2008)
   PUBMED   18194466
REFERENCE   7  (bases 1 to 4269)
  AUTHORS   Lee,H., Lim,C., Lee,J., Kim,N., Bang,S., Lee,H., Min,B., Park,G.,
            Noda,M., Stetler-Stevenson,W.G. and Oh,J.
  TITLE     TGF-beta signaling preserves RECK expression in activated
            pancreatic stellate cells
  JOURNAL   J Cell Biochem 104 (3), 1065-1074 (2008)
   PUBMED   18300271
  REMARK    GeneRIF: TGF-beta signaling in activated PSCs may promote ECM
            accumulation via a mechanism that preserves the protease inhibitory
            activity of RECK
REFERENCE   8  (bases 1 to 4269)
  AUTHORS   Accorsi-Mendonca,T., Paiva,K.B., Zambuzzi,W.F., Cestari,T.M.,
            Lara,V.S., Sogayar,M.C., Taga,R. and Granjeiro,J.M.
  TITLE     Expression of matrix metalloproteinases-2 and -9 and RECK during
            alveolar bone regeneration in rat
  JOURNAL   J Mol Histol 39 (2), 201-208 (2008)
   PUBMED   17987394
  REMARK    GeneRIF: Results show that RECK is differentially expressed by
            osteogenic and connective cells during several events of alveolar
            bone regeneration.
REFERENCE   9  (bases 1 to 4269)
  AUTHORS   Oh,J., Takahashi,R., Kondo,S., Mizoguchi,A., Adachi,E.,
            Sasahara,R.M., Nishimura,S., Imamura,Y., Kitayama,H.,
            Alexander,D.B., Ide,C., Horan,T.P., Arakawa,T., Yoshida,H.,
            Nishikawa,S., Itoh,Y., Seiki,M., Itohara,S., Takahashi,C. and
            Noda,M.
  TITLE     The membrane-anchored MMP inhibitor RECK is a key regulator of
            extracellular matrix integrity and angiogenesis
  JOURNAL   Cell 107 (6), 789-800 (2001)
   PUBMED   11747814
REFERENCE   10 (bases 1 to 4269)
  AUTHORS   Takahashi,C., Sheng,Z., Horan,T.P., Kitayama,H., Maki,M.,
            Hitomi,K., Kitaura,Y., Takai,S., Sasahara,R.M., Horimoto,A.,
            Ikawa,Y., Ratzkin,B.J., Arakawa,T. and Noda,M.
  TITLE     Regulation of matrix metalloproteinase-9 and inhibition of tumor
            invasion by the membrane-anchored glycoprotein RECK
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13221-13226 (1998)
   PUBMED   9789069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 5, 2023 this sequence version replaced XM_006238068.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.22607.1,
                                           SRR26643288.22003.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000005.1  62898717-62898848
            133-191             JAXUCZ010000005.1  62912330-62912388
            192-266             JAXUCZ010000005.1  62916980-62917054
            267-303             JAXUCZ010000005.1  62917982-62918018
            304-389             JAXUCZ010000005.1  62920041-62920126
            390-437             JAXUCZ010000005.1  62922107-62922154
            438-471             JAXUCZ010000005.1  62933474-62933507
            472-669             JAXUCZ010000005.1  62935827-62936024
            670-937             JAXUCZ010000005.1  62937665-62937932
            938-1117            JAXUCZ010000005.1  62942761-62942940
            1118-1330           JAXUCZ010000005.1  62944825-62945037
            1331-1467           JAXUCZ010000005.1  62947419-62947555
            1468-1608           JAXUCZ010000005.1  62949528-62949668
            1609-1797           JAXUCZ010000005.1  62952295-62952483
            1798-1920           JAXUCZ010000005.1  62954168-62954290
            1921-2092           JAXUCZ010000005.1  62955111-62955282
            2093-2285           JAXUCZ010000005.1  62958315-62958507
            2286-2496           JAXUCZ010000005.1  62959616-62959826
            2497-2570           JAXUCZ010000005.1  62961399-62961472
            2571-2726           JAXUCZ010000005.1  62962884-62963039
            2727-4269           JAXUCZ010000005.1  62963732-62965274
FEATURES             Location/Qualifiers
     source          1..4269
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4269
                     /gene="Reck"
                     /note="reversion-inducing-cysteine-rich protein with kazal
                     motifs"
                     /db_xref="GeneID:313488"
                     /db_xref="RGD:1308845"
     exon            1..132
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2951
                     /gene="Reck"
                     /note="reversion-inducing cysteine-rich protein with Kazal
                     motifs"
                     /codon_start=1
                     /product="reversion-inducing cysteine-rich protein with
                     Kazal motifs precursor"
                     /protein_id="NP_001402852.1"
                     /db_xref="GeneID:313488"
                     /db_xref="RGD:1308845"
                     /translation="MASVRASARGALLLLLSAAGVAKVTGGLAPGSAGAVCCNHSKDN
                     QMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWSCMNSSLPGVFKKSDGWVGL
                     GCCELAIGLECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTN
                     CREFCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCD
                     RAEEHACQSACRRILTSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVT
                     VHPPPSTGLDGAKLHCCSKANTSVCRELCTKLYSMSWGNTQSWQEFDRICEYNPGEVS
                     MLACLADVREPCQLGCTNLTYCTNFNNRPTELFRSCTAQSDQGAMSDMRLWEKGSIKM
                     PFISIPVLDIRTCQPDLWKAVACSLQIKPCHRKSRGSIICKSDCVEILKKCGDQNKFP
                     EAHTAESICEFLSPADDVENCIPLDTYLRPSALGNIIEEVTHPCNPNPCPANELCEVN
                     RKGCPSGDPCLPYSCVQGCKLGEASDFIVRQGALIQVPSSAGEVGCYKICSCGQSGLL
                     ENCMEMHCIDLQKSCIVGGKRKSHGTSFTIDCNVCSCFAGNLVCSTRLCLSEHSSDDD
                     RRAFTGLPCNCADQFVPVCAQNGRTYPSACIARCVGLQDHQFEFGPCISKDPCNPNLC
                     PKSQRCVPKPQVCLTTFDKFGCSQYECVPRQLTCDQARDPVCDTDHVEHSNLCTLYQR
                     GKSLSYRGPCQPFCRTTEPVCGHNGETYSSVCAAYSDRVAVDYYGRCQAVGVLSEHSA
                     VTECAAVKCPSLSAIGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVL
                     EILQKIRMHVSVPQCDVFGYLSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLIN
                     SDSPTLASHVPLSALIISQVQVSSSLPSSAVVGRLPPVHSLPLFLSLGLTVHLLQTCP
                     "
     exon            133..191
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            192..266
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            267..303
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            304..389
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            390..437
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            438..471
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            472..669
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            670..937
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1117
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1330
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1467
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1608
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1797
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1920
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2092
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2285
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2496
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2570
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2726
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..4269
                     /gene="Reck"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcccgcggc ttcggacccg cccggcccgg acatggcgag cgtccgggcc tccgcgagag
       61 gcgcgctgct gcttctgctg tccgcggcgg gggtcgcgaa ggtgaccggg ggcctggccc
      121 cgggcagcgc gggtgctgtg tgctgtaatc attcaaagga taaccaaatg tgccgtgatg
      181 tgtgtgagca gattttctcc tcaaaaagtg aatcccgact gaaacatctg ttgcagagag
      241 ccccagatta ttgcccagag acaatggttg aaatttggag ttgcatgaac tcatctttgc
      301 caggtgtatt taagaagtcg gatggctggg ttggcttagg ctgctgtgag ctagccattg
      361 gcttggagtg ccgccaggca tgcaagcagg catcttcaaa gaatgatatt tccaaagttt
      421 gcaggaaaga atatgagaac gctcttttca gttgcattag cagaaatgaa atgggctcgg
      481 tgtgctgcag ttacgcgggg catcacacca actgccgaga attctgtcaa gccatttttc
      541 gaacagactc ctctcctgga ccatctcaga tcaaagcagt ggaaaattat tgtgcgtcta
      601 ttagtccaca gttgatacac tgtgtgaaca attacaccca gtcgtatcca atgagaaacc
      661 caactgacag tttgtactgc tgtgacagag ctgaagagca tgcttgccag agcgcctgca
      721 ggaggattct aacgtctaag aagacagaaa tggagattgt ggacggcctc attgagggtt
      781 gcaagaccca gcccttgcct caagatcctc tttggcagtg ttttctcgaa agctcacagt
      841 cagttcaccc tggagtcacc gtgcaccctc ctccctcaac cggccttgat ggggccaaat
      901 tgcattgttg ctctaaagca aacacctcag tgtgtaggga attgtgcacg aaactctaca
      961 gcatgagctg gggaaacaca cagagctggc aggagtttga ccgcatctgt gaatataacc
     1021 ccggggaagt gtccatgctg gcctgtctgg ctgatgtccg ggagccttgc cagttgggtt
     1081 gtacaaacct tacttactgt acaaacttta acaacaggcc aacagaactt ttcaggagct
     1141 gcacggcgca gtctgaccag ggcgccatga gtgacatgag gctgtgggag aagggcagca
     1201 taaagatgcc cttcatcagc atccccgtcc tggacattag aacctgccag ccagacctgt
     1261 ggaaggccgt cgcctgctcc ctgcagatca agccgtgcca caggaagtcc cgagggagca
     1321 tcatctgcaa atcagattgt gtagagattc tcaagaaatg tggagaccag aataaattcc
     1381 ctgaagccca cacagctgaa agtatctgtg agttcctgtc ccctgcagat gatgtggaga
     1441 actgtatacc tctggacaca tacctcaggc caagtgcttt aggcaacatc atagaggaag
     1501 tgactcatcc ctgtaatcca aatccttgcc cagccaatga gctctgtgaa gtaaaccgaa
     1561 aggggtgtcc gtctggagat ccctgccttc cgtactcctg tgttcaaggc tgcaaattgg
     1621 gagaagcgtc tgacttcatt gtccgccaag gggcactgat ccaggtgcca tcctctgcag
     1681 gggaagttgg ttgttacaaa atctgttcct gtggacaaag tggcctcttg gaaaactgca
     1741 tggaaatgca ctgtattgac ctccagaagt cttgcattgt tggagggaaa agaaagagtc
     1801 atggaacatc ctttaccatc gactgcaatg tctgttcttg ttttgccggc aatttagtgt
     1861 gttccacccg tctgtgcctc agtgagcaca gttcagacga tgaccgccgc gccttcacag
     1921 gtctgccctg taactgcgca gatcagtttg tcccagtgtg tgcacagaat ggacgcactt
     1981 accccagtgc ctgcatcgct cgctgtgtgg gtctccagga ccatcagttt gagtttggac
     2041 cttgtatctc caaggatccc tgtaatccta acctctgccc caaaagccaa agatgtgtgc
     2101 ccaaaccgca agtctgcctg actacttttg ataaatttgg atgtagccag tatgagtgcg
     2161 tgcccagaca gctcacgtgt gaccaggccc gagatcctgt gtgtgacaca gatcatgtgg
     2221 agcacagcaa cctctgcact ttgtaccaaa gaggaaaaag cctgtcctac agaggcccgt
     2281 gccagccttt ctgcagaacc acggagcctg tttgtgggca caatggtgag acgtacagca
     2341 gtgtgtgcgc tgcctactcg gatcgtgtgg cagtggatta ctatgggcgc tgccaggctg
     2401 tcggggtcct ctcggaacac agtgctgtga ccgagtgtgc tgctgtgaag tgtccttccc
     2461 tctcagctat aggttgcaaa cccatcattc caccaggggc ttgctgccca ttatgtgctg
     2521 ggatgctacg ggttttattt gacaaagaaa agttggacac aattgctaag gtgacaaaca
     2581 agaagccgat aaccgttctg gagattctcc agaagatccg catgcacgtg tctgtgccgc
     2641 agtgcgatgt gttcgggtac ttgagcatcg agtcagagat tgtgatcctg attattcctg
     2701 tggaccatta tcccaaagct ttgcagattg aggcctgcaa taaggaagca gagaaaatcg
     2761 agtccctcat caactccgac agccccacgc tggcatccca cgtcccgctg tccgccctca
     2821 tcatctccca ggtgcaggtg tccagcagtc tcccgtcatc cgctgttgtg ggcaggcttc
     2881 ctcccgtcca ctcgttgccc ctcttcctca gcctgggcct cactgtgcac ctgctccaga
     2941 cctgtccctg accaccctgc aaagccttcc tccacccagc cgtcccagcc tgtgaaagac
     3001 attcaggact gcaagacggt gaccaagcaa aaacacgtgc gggtcacctc ttagcaccac
     3061 acagtatttt ttaatctgcc aatattaggg gttttgcctt gatttttaaa tggtaaacta
     3121 gactgcccca atgtaacaga agacaacgac gctcactggt ggatcactgg gcagtttacg
     3181 attgctcagt agaggactcc cctggcccaa agccagcttg ccatcgctga tcaatacatg
     3241 gccacttaca ggaggaggcc ctgctttgtg ccctagtccc ctcagagtcc ccgtgagtgc
     3301 tgaggctgcc gtgtgcttgt ttctgtccgg aagctgaggg ctcaggagaa gccacagccg
     3361 tgacggagtg ggaggagaga aacacggttg aagtatcact agttcatcag ggctgactcc
     3421 gtagaaatgt aaggcaggct ctagtgtgtc acaaaagcac tcatgtgcct gtctcacaac
     3481 tggccctctc agcagctgcc cttctgtgcc tgtgatggga gtggccccaa gcgagcggcc
     3541 aagcacctgt atcatgcagc cttggattag cagagacact cggcagtact cccacgttca
     3601 cagggtcaga ggtcaggctt taaaccactt gctgctacta tgtaattgcc aaaagtaagg
     3661 taactagtcg tccgtgtagg tagtacatga taattttatt ctgaaggtga atagccatat
     3721 gtgtaaatga caatcatgtg ttagccatgc ttccgttcat gaagacacat ctgctcttat
     3781 aatgtgcgca gtgtggatat gtgtgtgtct gactttcctt ttatatagaa ctataaagaa
     3841 tgtggtttat atatttaaag tgtcaggcta aatattagaa tgtttgcatg ttatctaaga
     3901 aattgaatac tttgaatgtt ttacagtttg aaataagcta ttaatgtaat acttcctgtt
     3961 tgtatgcacc tgaacttaga ttttatatga agtatttttc agtgttgtat gtaccctctg
     4021 agatactcaa tatgcttgtc ataccaaatg ttgtcgagca gtgggcactt agtgctttcg
     4081 gaggagctca gtgctgatgt tctgtacctc tggcagttgc ctgtttctgt ctaagtgtcc
     4141 tcaacatact agactttatt atatgtatat tccaaatata gtattacaga atatactata
     4201 tatattctat atatacagca atatactaga aagcttttct attttaataa aagtaatttt
     4261 atatgatca
//
