LOCUS       NM_001011916            2025 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus REC8 meiotic recombination protein (Rec8), mRNA.
ACCESSION   NM_001011916 XM_224192
VERSION     NM_001011916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Fukuda,T., Fukuda,N., Agostinho,A., Hernandez-Hernandez,A.,
            Kouznetsova,A. and Hoog,C.
  TITLE     STAG3-mediated stabilization of REC8 cohesin complexes promotes
            chromosome synapsis during meiosis
  JOURNAL   EMBO J 33 (11), 1243-1255 (2014)
   PUBMED   24797475
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Ishiguro,K., Kim,J., Shibuya,H., Hernandez-Hernandez,A., Suzuki,A.,
            Fukagawa,T., Shioi,G., Kiyonari,H., Li,X.C., Schimenti,J., Hoog,C.
            and Watanabe,Y.
  TITLE     Meiosis-specific cohesin mediates homolog recognition in mouse
            spermatocytes
  JOURNAL   Genes Dev 28 (6), 594-607 (2014)
   PUBMED   24589552
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Jordan,P.W., Karppinen,J. and Handel,M.A.
  TITLE     Polo-like kinase is required for synaptonemal complex disassembly
            and phosphorylation in mouse spermatocytes
  JOURNAL   J Cell Sci 125 (Pt 21), 5061-5072 (2012)
   PUBMED   22854038
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Llano,E., Herran,Y., Garcia-Tunon,I., Gutierrez-Caballero,C., de
            Alava,E., Barbero,J.L., Schimenti,J., de Rooij,D.G.,
            Sanchez-Martin,M. and Pendas,A.M.
  TITLE     Meiotic cohesin complexes are essential for the formation of the
            axial element in mice
  JOURNAL   J Cell Biol 197 (7), 877-885 (2012)
   PUBMED   22711701
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Lee,J., Kitajima,T.S., Tanno,Y., Yoshida,K., Morita,T., Miyano,T.,
            Miyake,M. and Watanabe,Y.
  TITLE     Unified mode of centromeric protection by shugoshin in mammalian
            oocytes and somatic cells
  JOURNAL   Nat Cell Biol 10 (1), 42-52 (2008)
   PUBMED   18084284
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   8  (bases 1 to 2025)
  AUTHORS   Kouznetsova,A., Novak,I., Jessberger,R. and Hoog,C.
  TITLE     SYCP2 and SYCP3 are required for cohesin core integrity at
            diplotene but not for centromere cohesion at the first meiotic
            division
  JOURNAL   J Cell Sci 118 (Pt 10), 2271-2278 (2005)
   PUBMED   15870106
REFERENCE   9  (bases 1 to 2025)
  AUTHORS   Lee,J., Iwai,T., Yokota,T. and Yamashita,M.
  TITLE     Temporally and spatially selective loss of Rec8 protein from
            meiotic chromosomes during mammalian meiosis
  JOURNAL   J Cell Sci 116 (Pt 13), 2781-2790 (2003)
   PUBMED   12759374
REFERENCE   10 (bases 1 to 2025)
  AUTHORS   Eijpe,M., Offenberg,H., Jessberger,R., Revenkova,E. and Heyting,C.
  TITLE     Meiotic cohesin REC8 marks the axial elements of rat synaptonemal
            complexes before cohesins SMC1beta and SMC3
  JOURNAL   J Cell Biol 160 (5), 657-670 (2003)
   PUBMED   12615909
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001011916.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079023.1, SRR26360181.113019.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000015.1  33079818-33079976
            160-270             JAXUCZ010000015.1  33080185-33080295
            271-339             JAXUCZ010000015.1  33080374-33080442
            340-482             JAXUCZ010000015.1  33080524-33080666
            483-558             JAXUCZ010000015.1  33080747-33080822
            559-679             JAXUCZ010000015.1  33081205-33081325
            680-764             JAXUCZ010000015.1  33083354-33083438
            765-844             JAXUCZ010000015.1  33084063-33084142
            845-980             JAXUCZ010000015.1  33084297-33084432
            981-1053            JAXUCZ010000015.1  33084514-33084586
            1054-1145           JAXUCZ010000015.1  33084663-33084754
            1146-1195           JAXUCZ010000015.1  33085011-33085060
            1196-1333           JAXUCZ010000015.1  33085333-33085470
            1334-1400           JAXUCZ010000015.1  33085702-33085768
            1401-1567           JAXUCZ010000015.1  33085857-33086023
            1568-1616           JAXUCZ010000015.1  33086143-33086191
            1617-1683           JAXUCZ010000015.1  33086626-33086692
            1684-1803           JAXUCZ010000015.1  33086789-33086908
            1804-1910           JAXUCZ010000015.1  33086980-33087086
            1911-2025           JAXUCZ010000015.1  33087169-33087283
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..2025
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /note="REC8 meiotic recombination protein"
                     /db_xref="GeneID:290227"
                     /db_xref="RGD:1309376"
     exon            1..159
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..270
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1996
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /note="meiosis specific sister chromatid cohesion protein;
                     cohesin Rec8p; REC8-like 1; REC8 homolog"
                     /codon_start=1
                     /product="meiotic recombination protein REC8 homolog"
                     /protein_id="NP_001011916.1"
                     /db_xref="GeneID:290227"
                     /db_xref="RGD:1309376"
                     /translation="MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLKVNVVKTCEE
                     ILNYVLVRVQPPMPGLPRPRFSLYLSAQLQIGVIRVYFQQCQYLVEDIQHILEHLHRA
                     QLRIRIDMEEADLPSLLLPNCLAMMETLEDAPEPFFGTMSVDPTLPSPFDIPQIRHLL
                     EAATPEKIREETLPEATPEPRKPDRTLAMVQSPEVITLQEAEPIRMLRIEGEQDLPEI
                     SRGDLDLLIAEEDDAILLEERQRGRLLRQRRASPPLDESKEEPRALEGDGLVSSLSPP
                     APAQVEGIREPLPDQAFPPEVQKMPGWEPGVLLTEVTPPQELRLPAPPSIEKRPPSPQ
                     RPPRRRRRGRQLLFWDKETQISREKFEEQLQTGAHCCEYPVVQPPKRKLMSPAELFRT
                     PTLSGWLSPELLALWTHCAQVPPRMLRQRPQLETEETVEEERVADKEERRKTEALSEI
                     EVLREAQEPSGPLMLSSELSLEVAEEEKSRTSFIPPEERWAWIEERQPEPPALPMLPE
                     LPEVPMEMPPGPELLSSEAVLRAVALELQANREPDFSSLVPPLSSRKLASRVFYLLLV
                     LSAQKILLVDQQKPYGRLLIRLGPKFP"
     exon            271..339
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..482
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..558
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..679
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..764
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..844
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..980
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1053
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1145
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1195
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1333
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1400
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1567
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1616
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1683
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1803
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1910
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2025
                     /gene="Rec8"
                     /gene_synonym="Rec8L1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgacagcg acaacggtgg tggcggcggg cgacctcgag cttgaggaac aaaggttttt
       61 tgacaaagta agaactcagt cttgcctgaa gatctgttct gtgtctctgc ctgggtttct
      121 cttggagctt cgcatttcta cttggacgca atcctgaaga atttggattg agatccaaac
      181 gggattggtg ccgagcgaga accccagagc gaagatgttc tactatccca acgtgcttca
      241 gcgccacaca ggctgcttcg ccactatctg gctggccgct acccggggca gccgtttggt
      301 gaagcgggaa tacctgaaag tgaacgtggt aaagacctgc gaggaaatcc tcaattatgt
      361 gctcgtacga gtgcaacctc cgatgcctgg gctgccccgc ccccgcttct ccctctatct
      421 ctccgcccag cttcagattg gtgtgataag ggtctacttt caacagtgcc agtaccttgt
      481 ggaagacatc cagcatatcc tagagcacct acaccgggcc cagctgcgga ttcgcattga
      541 tatggaggag gctgacttac ctagcttgct tcttcccaat tgcctggcca tgatggagac
      601 gctggaggac gccccagaac ccttttttgg gacgatgtct gtggacccta cacttcccag
      661 tccttttgat attcctcaga ttcgacacct tttagaggct gcaaccccgg agaaaattcg
      721 tgaggagacc cttcctgaag ccacgccgga gcccaggaag cctgacagga ccttggccat
      781 ggtacagtcc cctgaggtca tcaccttgca ggaggcagag cccatccgaa tgctgcggat
      841 tgagggagag caggatctcc cagagatcag cagaggagac ttagacctgc tgatcgcaga
      901 ggaagatgac gccatattgc tggaggaacg tcagagaggc agacttctcc ggcagcggag
      961 ggcttcccca ccactggatg aatccaagga agagccccgg gccctggaag gagatggttt
     1021 ggtctcctca ctctcacctc cagctcctgc acaggttgaa gggataagag aaccacttcc
     1081 agaccaggcc tttccccctg aggtacagaa gatgccaggc tgggagcctg gggtcctact
     1141 cactgaggtg accccacctc aggagctgcg tctgcctgcc ccaccgagta tagagaagag
     1201 gcccccgtct cctcagaggc cacctcgccg gcgccgccgg gggcgccagt tattgttctg
     1261 ggacaaggag acccagatct cccgggagaa gtttgaggaa cagctgcaga ctggggctca
     1321 ctgctgcgag tatccagtgg tccagcctcc caagaggaag ctcatgagcc cagcggagct
     1381 cttcagaacc ccaactctct ctggctggtt atctccagaa ctactagctt tatggaccca
     1441 ttgtgcccag gttcccccaa gaatgctcag acaaaggcca cagctggaga ctgaagagac
     1501 agttgaggaa gagagagtgg cagacaagga agaaaggaga aagactgaag ctctgagtga
     1561 gattgaggtt ctgagagagg cccaggagcc cagtggtccc ctcatgttgt cttcagagct
     1621 ctccctagaa gtagcagaag aagaaaaatc tcgaactagc ttcatccctc cagaagaacg
     1681 gtgggcctgg attgaggaga ggcagccaga gccccctgca ctgcccatgc tgcctgaact
     1741 tcctgaagtg cccatggaga tgcccccagg gcctgaacta ctctcttcag aggctgtgct
     1801 tagggcagtg gctctggagc tgcaggctaa cagggagcct gacttcagca gcctggtgcc
     1861 ccctctcagc tcccgaaagt tggcttctcg ggtcttctat ctgctcttgg tgctgtccgc
     1921 acagaagatc cttcttgtgg accaacagaa gccatatggg cgcctcctga ttcgtctagg
     1981 acccaaattc ccctgagcaa gttcattaaa ccatatcctg cctca
//
