LOCUS       NM_001005889            4233 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus radixin (Rdx), mRNA.
ACCESSION   NM_001005889 XM_236234
VERSION     NM_001005889.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4233)
  AUTHORS   Kawase,A., Nakasaka,M., Bando,H., Yasuda,S., Shimada,H. and
            Iwaki,M.
  TITLE     Changes in Radixin Expression and Interaction with Efflux
            Transporters in the Liver of Adjuvant-Induced Arthritic Rats
  JOURNAL   Inflammation 43 (1), 85-94 (2020)
   PUBMED   31654296
  REMARK    GeneRIF: Changes in Radixin Expression and Interaction with Efflux
            Transporters in the Liver of Adjuvant-Induced Arthritic Rats.
REFERENCE   2  (bases 1 to 4233)
  AUTHORS   Wu,Y., Zhang,S., Zhang,C., Xuan,Z., Li,S., Gao,Y. and Hu,Y.
  TITLE     [The transfection of lentiviral siRNA vectors targeting ezrin,
            radixin and moesin facilitates influenza virus replication in
            primary pulmonary microvascular endothelial cells]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31 (4), 456-461 (2015)
   PUBMED   25854562
  REMARK    GeneRIF: Overexpression ezrin, radixin and moesin facilitates
            influenza virus H1N1 replication in primary pulmonary microvascular
            endothelial cells.
REFERENCE   3  (bases 1 to 4233)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4233)
  AUTHORS   Baeyens,N., Latrache,I., Yerna,X., Noppe,G., Horman,S. and Morel,N.
  TITLE     Redundant control of migration and adhesion by ERM proteins in
            vascular smooth muscle cells
  JOURNAL   Biochem Biophys Res Commun 441 (3), 579-585 (2013)
   PUBMED   24184478
  REMARK    GeneRIF: These results indicate that ezrin, radixin, and moesin
            exert a redundant control on platelet derived growth factor-induced
            vascular smooth muscle cells migration by regulating focal adhesion
            turn-over and cell adhesion to substrate.
REFERENCE   5  (bases 1 to 4233)
  AUTHORS   Aranda,J.F., Reglero-Real,N., Marcos-Ramiro,B., Ruiz-Saenz,A.,
            Fernandez-Martin,L., Bernabe-Rubio,M., Kremer,L., Ridley,A.J.,
            Correas,I., Alonso,M.A. and Millan,J.
  TITLE     MYADM controls endothelial barrier function through ERM-dependent
            regulation of ICAM-1 expression
  JOURNAL   Mol Biol Cell 24 (4), 483-494 (2013)
   PUBMED   23264465
REFERENCE   6  (bases 1 to 4233)
  AUTHORS   Hugo,C., Hugo,C., Pichler,R., Gordon,K., Schmidt,R., Amieva,M.,
            Couser,W.G., Furthmayr,H. and Johnson,R.J.
  TITLE     The cytoskeletal linking proteins, moesin and radixin, are
            upregulated by platelet-derived growth factor, but not basic
            fibroblast growth factor in experimental mesangial proliferative
            glomerulonephritis
  JOURNAL   J Clin Invest 97 (11), 2499-2508 (1996)
   PUBMED   8647942
REFERENCE   7  (bases 1 to 4233)
  AUTHORS   Andreoli,C., Martin,M., Le Borgne,R., Reggio,H. and Mangeat,P.
  TITLE     Ezrin has properties to self-associate at the plasma membrane
  JOURNAL   J Cell Sci 107 (Pt 9), 2509-2521 (1994)
   PUBMED   7844168
REFERENCE   8  (bases 1 to 4233)
  AUTHORS   Funayama,N., Nagafuchi,A., Sato,N., Tsukita,S. and Tsukita,S.
  TITLE     Radixin is a novel member of the band 4.1 family
  JOURNAL   J Cell Biol 115 (4), 1039-1048 (1991)
   PUBMED   1955455
REFERENCE   9  (bases 1 to 4233)
  AUTHORS   Sato,N., Yonemura,S., Obinata,T., Tsukita,S. and Tsukita,S.
  TITLE     Radixin, a barbed end-capping actin-modulating protein, is
            concentrated at the cleavage furrow during cytokinesis
  JOURNAL   J Cell Biol 113 (2), 321-330 (1991)
   PUBMED   1707055
  REMARK    Erratum:[J Cell Biol 1991 Sep;114(5):1101-3]
REFERENCE   10 (bases 1 to 4233)
  AUTHORS   Tsukita,S., Hieda,Y. and Tsukita,S.
  TITLE     A new 82-kD barbed end-capping protein (radixin) localized in the
            cell-to-cell adherens junction: purification and characterization
  JOURNAL   J Cell Biol 108 (6), 2369-2382 (1989)
   PUBMED   2500445
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087147.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by
            NM_001005889.3.
            
            On Dec 26, 2004 this sequence version replaced NM_001005889.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4233
                     /gene="Rdx"
                     /note="radixin"
                     /db_xref="GeneID:315655"
                     /db_xref="RGD:1359472"
     exon            1..149
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            150..221
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1961
                     /gene="Rdx"
                     /codon_start=1
                     /product="radixin"
                     /protein_id="NP_001005889.2"
                     /db_xref="GeneID:315655"
                     /db_xref="RGD:1359472"
                     /translation="MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWF
                     FGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLF
                     FLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQ
                     HKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWL
                     GVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRI
                     NKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAE
                     KEKERIEREKEELMERLRQIEEQTMKAQKELEEQTRKALELEQERQRAKEEAERLDRE
                     RRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAF
                     AAQEDLEKTKEELKTVMCAPPPPPPPAVVPPTENEHDEQDEHSAEASAELSSEGVTNH
                     RSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLR
                     QIRQGNTKQRIDEFEAM"
     exon            222..305
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            306..401
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            402..676
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            677..760
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            761..907
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1004
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1168
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1299
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1460
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1553
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1796
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..4200
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgcggcg gctgcggcgc gtcttctctc aggcggccca gggctcgcac cgccgactct
       61 ccgctcgctc gccgccagcc gcgacgcccc cgccgagccc cgcctcagcc agccggcggc
      121 gggcaaggaa ggagccgctc atttttgggg cgataattgt ttatagaagt gaagagtttc
      181 tgaagaaggt aacaaacaag aaaaggaaaa tgccgaaacc aataaatgta agagtaacta
      241 caatggatgc tgaactagag tttgccattc agcccaatac aactggcaaa caactttttg
      301 accaggttgt aaaaacagtt ggtttacgtg aggtctggtt ttttgggctg caatatgtag
      361 acagcaaagg atattccaca tggcttaaac tgaataaaaa ggtaacacag caagatgtta
      421 aaaaagaaaa tcctttacag ttcaagttta gagctaaatt ctttcctgaa gatgtttctg
      481 aggaattgat tcaagaaata acacagagac ttttcttctt gcaagttaaa gaagccatct
      541 taaatgatga gatatattgc ccaccagaaa ctgcagttct tttggcttcg tatgctgttc
      601 aagccaagta tggagattat aataaagaga ttcataaacc aggctatctg gctaatgaca
      661 gactcctacc acagcgtgtt ttggaacaac ataaactgac caaagagcag tgggaggaga
      721 gaatacagaa ctggcatgaa gaacacaggg ggatgctaag ggaagattca atgatggaat
      781 acttgaagat tgcacaagat ctagagatgt atggtgtcaa ctactttgaa atcaagaata
      841 agaagggtac tgagctgtgg ctgggcgttg atgctttggg tctgaatatt tatgagcatg
      901 atgacaagtt aacacctaaa attggttttc cctggagtga aatccgaaat atttcgttta
      961 atgacaaaaa atttgttata aagccaattg acaaaaaggc acctgatttt gttttctatg
     1021 cacctcgtct gagaatcaat aagcgaattt tggccttatg tatgggaaac catgagctgt
     1081 acatgcgaag gagaaagcct gatactattg aagtacagca gatgaaggct caggcccggg
     1141 aggagaaaca ccagaagcag ctagaacggg cacaattaga gaatgaaaag aagaaacgag
     1201 aaatagcaga aaaggaaaag gaaagaatag aacgggaaaa ggaagagctg atggaacgtc
     1261 taaggcaaat tgaagagcag acaatgaaag cccagaaaga actagaagaa cagactcgga
     1321 aagccctgga actggagcag gagcgccagc gagcaaaaga ggaggcagag cggctagaca
     1381 gggagcgccg ggctgcggaa gaggccaagt ccgcaatagc caagcaagct gctgaccaaa
     1441 tgaagaacca ggagcagctg gcagcagaac ttgccgaatt cactgccaag attgcacttt
     1501 tagaagaagc caagaagaaa aaggaagagg aagctacgga gtggcagcat aaagcttttg
     1561 cagctcagga agacttggaa aagaccaaag aagagttaaa aactgtgatg tgtgcgcccc
     1621 ctccgccgcc ccctcccgca gtcgtccctc ccacagagaa cgagcatgat gagcaggacg
     1681 agcacagtgc cgaggccagc gccgagctgt ccagtgaggg cgtgacgaac cacaggagcg
     1741 aggaggagcg ggtgacggag acccagaaga acgaacgcgt gaagaagcag ctccaggcat
     1801 taagttcaga attagcccaa gcgagagatg aaaccaagaa gacacagaat gatgttctcc
     1861 atgctgagaa cgtcaaggca ggccgtgata agtacaagac tctgcggcag attcgacaag
     1921 gcaacaccaa gcagcgcatc gatgagtttg aagcaatgtg agagccgttc ttgtgatcca
     1981 tgtcctccct gagctgaacc acagcagaga aaagcaggcc tgtgcgggtg cagtgcgatg
     2041 catcccgcct tgccaaagca ctcagacagt tgactgtgct cactagcaga acccgagggg
     2101 cgcgcttcag cattaagcag cagtgtgatg tcatgtgtgg tcacttttct tttgtccagg
     2161 gaatggataa tggcattctg tcaccttttt gtacattttt cactttttgt ttcctctttc
     2221 tcggttgact attaacacta atgaccatgt ctgacaaatg tgtgtgtgct ttgagcactg
     2281 tgtacatttt aggataatgg tggacatttc agtgcatgtt tagttaatga actccatttt
     2341 ctttgccctt tccatgttgt aggctacata catctccatg ttcattctca tgttttgtca
     2401 gtgtggcctt ctcatgcctt gtcatgctag agctgtaatt ctggtgtcac acagatcact
     2461 tactggaggt ttttaaaatg agatagcggg gcaaacagac agacatgagg ctacatcaca
     2521 aggcaattag aaggttggac agcagagtat gcagcggtgg ttaattatta cagagatccc
     2581 ttacctgatt gaatgtttgc tttacttaag tacagtcatc tctgataagt tgagtgatgg
     2641 tgtctcacat cctgtagtcc tctggtggct ttccttgcct gtcactttag agacatagcc
     2701 actaggcagt tttttctagg aaaattattg atgaaacact gcctgcaagt acgtgatctc
     2761 tgaaaaaaat tcaagttttg ttcttaggtt gattagaaac acagatgtcc aacagaagat
     2821 aactgttgat gatagctgat tccgattgtt gaaggggaaa aaaccaacca aaccttggcc
     2881 tttctgcaag ggtggcatat ggatcagttc caagaacata ctactacctc actccacaca
     2941 tggtgactgc tcacccagtc tgtgtgctgc atgtctgtta cccatgggca gtctcaatca
     3001 tgtctctcat tgaatatagg tttgagattc cagtgcttat gttctaactg cctctttgtt
     3061 gacttgtggg gctctgattc gtgtttagat tgtatattct cactggtaaa tgctgttccc
     3121 tgagggtgtt ctgtgtctga ggaagtgacc ctttgtgaga aagacattgc ctttgcagca
     3181 cgtgaagcat tcccactctt cattcttgat gggatgggta acaccatttt agcatatttg
     3241 gtttctaaat cactgcctat tttctttgca atctctaaaa gcaaatttta tttcaattat
     3301 gtcttactga agaagtcttt tccagctaga aagatgctct tacattctct gatcatgaag
     3361 cccctgaatt tgaagctcca gaaagccttg ttttctctgt gtggttcagc tcctttccat
     3421 ttggtattat gcactcagac ttaacactta ccgattacaa ttacatttta ttaagcagtt
     3481 ttcacgcaca gtagattcaa cttggttttg tgcttttttt ttttttaatt ttgatttttt
     3541 ttgctgactt aaaaaggatt aatttgggca aacattataa aaaagaaagg gttaatatat
     3601 tttttggact ctgtaggaca aaagacaact ggttaacctt gaagtgactg ttgtacagtg
     3661 gttgtgcaca tgcttcaaaa tcagcgaggg aattgccttc cacatgtgag agggagagac
     3721 ggtcagcctt accactcaga ctttgaagta tgagtgttca cttttccaaa gcatcagagt
     3781 aatagtcctt attgctaaaa gaatcgactt ccctcgggtt ttactgtttt cttttctatt
     3841 tgcattgtgt acattatcgc tgcaccagtt gttacagtgt tgagaggcta ccagttatat
     3901 ttgctgttaa tagtctattt gtaggttagg attaaagtgg gtttagtcca tttttatagc
     3961 tatatgaatt tttctaaaca gggacagcca tttgcaaaat gggttttcat agtgatcgaa
     4021 tcagttataa cgtttatcat tagcagttga gagcacatgt tcatatagca atgtgaaaac
     4081 acactaatga gtatttggta atttcccatt agcataattt catgttgtac aagtaaatta
     4141 caattacatc tctaattttg gataatattc attggttaac aataaagtga caaaagctca
     4201 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
