LOCUS       NM_001398764            1251 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus retinol dehydrogenase 5 (Rdh5), transcript
            variant 1, mRNA.
ACCESSION   NM_001398764 XM_008765056
VERSION     NM_001398764.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1251)
  AUTHORS   Kiser,P.D., Golczak,M., Maeda,A. and Palczewski,K.
  TITLE     Key enzymes of the retinoid (visual) cycle in vertebrate retina
  JOURNAL   Biochim Biophys Acta 1821 (1), 137-151 (2012)
   PUBMED   21447403
  REMARK    Review article
REFERENCE   2  (bases 1 to 1251)
  AUTHORS   Huang,J., Possin,D.E. and Saari,J.C.
  TITLE     Localizations of visual cycle components in retinal pigment
            epithelium
  JOURNAL   Mol Vis 15, 223-234 (2009)
   PUBMED   19180257
REFERENCE   3  (bases 1 to 1251)
  AUTHORS   Liden,M., Tryggvason,K. and Eriksson,U.
  TITLE     The C-terminal region of cis-retinol/androgen dehydrogenase 1
            (CRAD1) confers ER localization and in vivo enzymatic function
  JOURNAL   Exp Cell Res 311 (2), 205-217 (2005)
   PUBMED   16223484
REFERENCE   4  (bases 1 to 1251)
  AUTHORS   Liden,M., Romert,A., Tryggvason,K., Persson,B. and Eriksson,U.
  TITLE     Biochemical defects in 11-cis-retinol dehydrogenase mutants
            associated with fundus albipunctatus
  JOURNAL   J Biol Chem 276 (52), 49251-49257 (2001)
   PUBMED   11675386
REFERENCE   5  (bases 1 to 1251)
  AUTHORS   Wang,J., Bongianni,J.K. and Napoli,J.L.
  TITLE     The N-terminus of retinol dehydrogenase type 1 signals cytosolic
            orientation in the microsomal membrane
  JOURNAL   Biochemistry 40 (42), 12533-12540 (2001)
   PUBMED   11601977
  REMARK    GeneRIF: The N-terminus of retinol dehydrogenase type 1 is a
            transmembrane region sufficient for enzyme targeting to the
            endoplasmic reticulum; the C-terminal hydrophobic segment enhances
            this association without directing the enzyme's orientation.
REFERENCE   6  (bases 1 to 1251)
  AUTHORS   Romert,A., Tuvendal,P., Tryggvason,K., Dencker,L. and Eriksson,U.
  TITLE     Gene structure, expression analysis, and membrane topology of RDH4
  JOURNAL   Exp Cell Res 256 (1), 338-345 (2000)
   PUBMED   10739682
REFERENCE   7  (bases 1 to 1251)
  AUTHORS   Gonzalez-Fernandez,F., Kurz,D., Bao,Y., Newman,S., Conway,B.P.,
            Young,J.E., Han,D.P. and Khani,S.C.
  TITLE     11-cis retinol dehydrogenase mutations as a major cause of the
            congenital night-blindness disorder known as fundus albipunctatus
  JOURNAL   Mol Vis 5, 41 (1999)
   PUBMED   10617778
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1251)
  AUTHORS   Gamble,M.V., Shang,E., Zott,R.P., Mertz,J.R., Wolgemuth,D.J. and
            Blaner,W.S.
  TITLE     Biochemical properties, tissue expression, and gene structure of a
            short chain dehydrogenase/ reductase able to catalyze cis-retinol
            oxidation
  JOURNAL   J Lipid Res 40 (12), 2279-2292 (1999)
   PUBMED   10588954
REFERENCE   9  (bases 1 to 1251)
  AUTHORS   Wang,J., Chai,X., Eriksson,U. and Napoli,J.L.
  TITLE     Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids
            and retinoids and expression of its mRNA in extra-ocular human
            tissue
  JOURNAL   Biochem J 338 (Pt 1) (Pt 1), 23-27 (1999)
   PUBMED   9931293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 22, 2021 this sequence version replaced XM_008765056.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218828.1, SRR26360176.670434.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               JAXUCZ010000007.1  1931226-1931354     c
            130-474             JAXUCZ010000007.1  1930200-1930544     c
            475-733             JAXUCZ010000007.1  1929814-1930072     c
            734-897             JAXUCZ010000007.1  1926203-1926366     c
            898-1251            JAXUCZ010000007.1  1925664-1926017     c
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1251
                     /gene="Rdh5"
                     /gene_synonym="Rdh1"
                     /note="retinol dehydrogenase 5"
                     /db_xref="GeneID:366791"
                     /db_xref="RGD:1308849"
     exon            1..129
                     /gene="Rdh5"
                     /gene_synonym="Rdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            130..474
                     /gene="Rdh5"
                     /gene_synonym="Rdh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1121
                     /gene="Rdh5"
                     /gene_synonym="Rdh1"
                     /EC_number="1.1.1.105"
                     /note="11-cis retinol dehydrogenase; retinol dehydrogenase
                     1 (11-cis); retinol dehydrogenase type 5; 9-cis-retinol
                     dehydrogenase; retinol dehydrogenase 5 (11-cis/9-cis)"
                     /codon_start=1
                     /product="retinol dehydrogenase 5"
                     /protein_id="NP_001385693.1"
                     /db_xref="GeneID:366791"
                     /db_xref="RGD:1308849"
                     /translation="MWLPLLLGALLWAVLWLLRDRQSLPARDAVIFITGCDSGFGRLL
                     ALQLDQKGFQVLAGCLTPSGAEDLQQMASSRLHTTLLDITDPQNVQQVAKWVKTRVGE
                     TGLFGLVNNAGVAGIIGPTPWLTQDDFQRVLNVNTLGPIGVTLALLPLLQQARGRVVN
                     ITSVLGRIAANGGGYCVSKFGLEAFSDSLRRDMAPFGVQVSIVEPGFFRTPVTNLESL
                     ENTLKACWARLPPATQAHYGEAFLTTYLQVQRRIMNLICDPDLTKVTSCLEHALTARH
                     PRTRYSPGWDAKLLWLPASYLPARVVDAVLAWVLPRPAQSIY"
     exon            475..733
                     /gene="Rdh5"
                     /gene_synonym="Rdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..897
                     /gene="Rdh5"
                     /gene_synonym="Rdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1251
                     /gene="Rdh5"
                     /gene_synonym="Rdh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccactcca gactttggcc ttagctgtag ctagtgtggg atcctgggaa gtctaggagc
       61 aaagtctctt aggcagactg agaaggctac agcttcacac actgtgctgc ctgccagctt
      121 tccccagagc ctaggcctcc ctcagcaggg catctcatcc caccatgtgg ctgcctctgc
      181 ttctgggtgc cttgctgtgg gcagtactgt ggttgctcag agaccggcag agcctgccgg
      241 cccgagacgc tgtcatcttc atcaccggct gtgactcggg ctttgggcgc cttctggcac
      301 tgcaacttga ccagaagggc ttccaagtgc tggccggctg cctgaccccc tctggggcag
      361 aagacctaca acagatggcc tcctcccgcc tccacacaac actgctggat atcactgatc
      421 cccagaatgt ccagcaagtt gccaagtggg tgaagacacg tgttggagaa actgggctct
      481 ttggtctggt gaataacgct ggtgtagctg gtatcatcgg gcccacacca tggctgacac
      541 aggatgattt ccagagagtg ctgaatgtga acacactggg ccccattggg gtcacccttg
      601 ccctgctgcc cctgctacaa caggccaggg ggcgggtggt caacatcacc agtgtcttgg
      661 gccgaatagc agccaatggc gggggctact gtgtctccaa gtttggcctg gaggccttct
      721 ctgacagcct gaggcgggac atggctccat ttggagtaca agtctccatt gtggagcctg
      781 gcttcttccg aaccccagtg accaacctgg agagtctgga gaacaccctg aaggcttgtt
      841 gggcccggct acctccagct acacaggccc actacggaga agccttcctc actacttatc
      901 ttcaagtgca gcgccgcatc atgaacctaa tctgtgaccc agacctaacg aaggtgacaa
      961 gctgcctgga gcatgccctg actgcccgcc atccccgaac acggtacagc ccaggctggg
     1021 atgccaagct tctctggctg cctgcctcct accttccagc cagggtggtg gatgctgtgc
     1081 tcgcctgggt ccttccccgg cctgcccagt caatctactg actccagctt tacagcaaga
     1141 ggctggtttc ggaggacaag gcatctcctt ctgtctctat ccgcgctggc tggcttctga
     1201 cacaaactag gctctcagta aataaatacg tatatcgctt taaatcgaaa a
//
