LOCUS       NM_199208               2797 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus retinol dehydrogenase 16 (Rdh16), mRNA.
ACCESSION   NM_199208 XM_216817
VERSION     NM_199208.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2797)
  AUTHORS   Wang,Y., Sun,J., Chen,L., Zhou,S., Lin,H., Wang,Y., Lin,N. and
            Ge,R.S.
  TITLE     Effects of resveratrol on rat neurosteroid synthetic enzymes
  JOURNAL   Fitoterapia 122, 61-66 (2017)
   PUBMED   28823883
REFERENCE   2  (bases 1 to 2797)
  AUTHORS   Guo,J., Li,L., Zhou,S., Su,Y., Li,X., Sun,J. and Ge,R.S.
  TITLE     Butylated hydroxyanisole alters rat 5alpha-reductase and
            3alpha-hydroxysteroid dehydrogenase: Implications for influences of
            neurosteroidogenesis
  JOURNAL   Neurosci Lett 653, 132-138 (2017)
   PUBMED   28552457
REFERENCE   3  (bases 1 to 2797)
  AUTHORS   Wang,C., Kane,M.A. and Napoli,J.L.
  TITLE     Multiple retinol and retinal dehydrogenases catalyze
            all-trans-retinoic acid biosynthesis in astrocytes
  JOURNAL   J Biol Chem 286 (8), 6542-6553 (2011)
   PUBMED   21138835
REFERENCE   4  (bases 1 to 2797)
  AUTHORS   Liden,M., Tryggvason,K. and Eriksson,U.
  TITLE     The C-terminal region of cis-retinol/androgen dehydrogenase 1
            (CRAD1) confers ER localization and in vivo enzymatic function
  JOURNAL   Exp Cell Res 311 (2), 205-217 (2005)
   PUBMED   16223484
REFERENCE   5  (bases 1 to 2797)
  AUTHORS   Hinojos,C.A., Boerwinkle,E., Fornage,M. and Doris,P.A.
  TITLE     Combined genealogical, mapping, and expression approaches to
            identify spontaneously hypertensive rat hypertension candidate
            genes
  JOURNAL   Hypertension 45 (4), 698-704 (2005)
   PUBMED   15710778
REFERENCE   6  (bases 1 to 2797)
  AUTHORS   Jurukovski,V., Markova,N.G., Karaman-Jurukovska,N., Randolph,R.K.,
            Su,J., Napoli,J.L. and Simon,M.
  TITLE     Cloning and characterization of retinol dehydrogenase transcripts
            expressed in human epidermal keratinocytes
  JOURNAL   Mol Genet Metab 67 (1), 62-73 (1999)
   PUBMED   10329026
REFERENCE   7  (bases 1 to 2797)
  AUTHORS   Gough,W.H., VanOoteghem,S., Sint,T. and Kedishvili,N.Y.
  TITLE     cDNA cloning and characterization of a new human microsomal
            NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and
            3alpha-hydroxysteroids
  JOURNAL   J Biol Chem 273 (31), 19778-19785 (1998)
   PUBMED   9677409
REFERENCE   8  (bases 1 to 2797)
  AUTHORS   Chai,X., Zhai,Y. and Napoli,J.L.
  TITLE     cDNA cloning and characterization of a
            cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase
  JOURNAL   J Biol Chem 272 (52), 33125-33131 (1997)
   PUBMED   9407098
REFERENCE   9  (bases 1 to 2797)
  AUTHORS   Chai,X., Zhai,Y., Popescu,G. and Napoli,J.L.
  TITLE     Cloning of a cDNA for a second retinol dehydrogenase type II.
            Expression of its mRNA relative to type I
  JOURNAL   J Biol Chem 270 (47), 28408-28412 (1995)
   PUBMED   7499345
REFERENCE   10 (bases 1 to 2797)
  AUTHORS   Ohishi,N., Imaoka,S., Suzuki,T. and Funae,Y.
  TITLE     Characterization of two P-450 isozymes placed in the rat CYP2D
            subfamily
  JOURNAL   Biochim Biophys Acta 1158 (3), 227-236 (1993)
   PUBMED   8251521
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 2, 2021 this sequence version replaced NM_199208.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079153.1, U33500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               JAXUCZ010000007.1  65501964-65502375
            413-671             JAXUCZ010000007.1  65505898-65506156
            672-835             JAXUCZ010000007.1  65507718-65507881
            836-2797            JAXUCZ010000007.1  65508343-65510304
FEATURES             Location/Qualifiers
     source          1..2797
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2797
                     /gene="Rdh16"
                     /gene_synonym="Rdh2; RoDHII"
                     /note="retinol dehydrogenase 16"
                     /db_xref="GeneID:299511"
                     /db_xref="RGD:735050"
     exon            1..412
                     /gene="Rdh16"
                     /gene_synonym="Rdh2; RoDHII"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1053
                     /gene="Rdh16"
                     /gene_synonym="Rdh2; RoDHII"
                     /EC_number="1.1.1.105"
                     /EC_number="1.1.1.315"
                     /EC_number="1.1.1.209"
                     /EC_number="1.1.1.53"
                     /note="retinol dehydrogenase type 2; 29 kDa protein;
                     retinol dehydrogenase type II (RODH II); retinol
                     dehydrogenase 2; retinol dehydrogenase 2-like; retinol
                     dehydrogenase 16 (all-trans); retinol dehydrogenase type
                     1"
                     /codon_start=1
                     /product="retinol dehydrogenase 16"
                     /protein_id="NP_954678.1"
                     /db_xref="GeneID:299511"
                     /db_xref="RGD:735050"
                     /translation="MWLYLLALVGLWNLLRLFRERKVVSHLQDKYVFITGCDSGFGNL
                     LARQLDRRGMRVLAACLTEKGAEQLRSKTSDRLETVILDVTKTESIVAATQWVKERVG
                     NTGLWGLVNNAGISGHLGPNEWMNKQNIASVLDVNLLGMIEVTLSTVPLVRKARGRVV
                     NVASIAGRLSFCGGGYCISKYGVEAFSDSLRRELSYFGVKVAIVEPGFFRTDVTNGVT
                     LSSNFQMLWDQTSSEVREVYGENYLASYLKMLNGLDQRCNKDLSLVTDCMEHALTSCH
                     PRTRYSAGWDAKFFYLPMSYLPTFLVDALFYWTSPKPEKAL"
     exon            413..671
                     /gene="Rdh16"
                     /gene_synonym="Rdh2; RoDHII"
                     /inference="alignment:Splign:2.1.0"
     exon            672..835
                     /gene="Rdh16"
                     /gene_synonym="Rdh2; RoDHII"
                     /inference="alignment:Splign:2.1.0"
     exon            836..2797
                     /gene="Rdh16"
                     /gene_synonym="Rdh2; RoDHII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaggctg gagtccctga agcttacacc atcctgtggg agccgatgcc cgtctcattt
       61 tgactcagag tctgtccctc tgcttgtctt ctacaaacca tgtggctgta cctgctggca
      121 ctggtgggcc tgtggaacct cctgcgcttg ttcagggaga ggaaggtggt aagccatctc
      181 caagacaaat atgtcttcat cacgggctgt gactcaggct ttgggaacct gctggccaga
      241 cagctggaca ggagaggcat gagggtgctg gctgcatgtc tgactgagaa gggagccgag
      301 cagctgagga gcaagacatc ggacaggctg gagacagtga tccttgatgt caccaagaca
      361 gagagtattg tggcagccac tcagtgggtg aaggagcgag ttgggaacac aggactctgg
      421 ggcctggtca acaatgctgg catctccggc cacctgggtc ccaatgagtg gatgaacaaa
      481 cagaacattg caagtgtgct ggatgtgaac ctgttgggca tgatcgaggt gactctgagc
      541 acggtgccct tagtgaggaa ggcgaggggc cgtgtggtca acgttgccag catcgcaggc
      601 cgactgtctt tttgtggtgg tggttactgc atctccaagt atggtgtaga ggccttctca
      661 gactccctca ggagagagct ctcctatttt ggggtcaagg tggctattgt agagcctggc
      721 ttcttcagga ctgatgtgac caatggtgtc acattatcat caaacttcca gatgctgtgg
      781 gaccagacca gctcagaagt cagggaagtc tatggcgaga actacctggc atcttatctg
      841 aaaatgctaa atggattgga ccagaggtgc aacaaagatc tgtctctggt gactgactgc
      901 atggagcacg ccctgacttc ctgtcaccct cgcacccggt actcagctgg ttgggatgcc
      961 aagttcttct acctccccat gagctatctg cccacctttc ttgtggatgc ccttttctac
     1021 tggacttctc caaagcctga gaaagctctc tgaagtcttt acctatgtac ataactgagg
     1081 agatgttggt acagtgttag ggaggggatc ctgaggagga ggtcggagtg ctgaggaggg
     1141 agggaggtca ttcctctggg gtttagtcca cactcttcat tttgctaatt ttcctgtgct
     1201 actactcaag gctgatgatg acccaagaaa tagccaaaga attctgcgaa gaagttcaaa
     1261 tacaaaagtg ctggcagttg cctaggctct gagcaccatg acctaccatg gcgatccaca
     1321 caaatgagga gtttgagacc agcttgtacc aaacactgcc ctgagtcccc ctgtgcagga
     1381 agtgcacatg ccctggctag tttgtaccct atgcagcata gaagtgtccc tgctctgaag
     1441 tcacctgtga ccctggtgtc aggtttgaga agaatcacta ataattctaa cactcatgct
     1501 tgaaggccag gtcgacagcc ctgggtggga gagtcggtta cttgtggtga gaatatagta
     1561 gaggatagag acattaattt tttttaaatt tactttgaag tcatggctct tcttttcttt
     1621 tttggagtct tttccttttt agagcatagc atgaggtgac ctcttgttcc ctgtgattta
     1681 aacaatggca ttgctggttg gtgaggttta gattgcaggg gtaaggggaa tgtcctgaga
     1741 agggtgtgca taggccagca ggaatttcct tgcccgtctc agcccttcta gccactgagg
     1801 tgggaataac tgctgtccat tcaaaactta acaacaaccc ctaaggcata agagcatgca
     1861 tgcaagtcca tgaacagaac ttacctgttg gcttcagctc caccactccc tccctgtgaa
     1921 ctcactaagt ggccacatct ttcctgcaga ctcaccaaag tgatcatccc tttcttacag
     1981 actcactaag tgaccatccc ttcctgcaga cccatgaaat gaccatccct ctgtagagac
     2041 cccctaggcg accaaccctt ccctcagact cactaagtga attttgcttg ctgaacctca
     2101 ctaagtgacc attcctttct gcacactcag aggtaagcat cccttcctgc agacacacta
     2161 agtgatcatc cctttctgca gactcattaa ttgaccatac ctatcctgca gaatcaggaa
     2221 gttaccatcc ctccttgcag atccagtaaa ttctcttcaa ttccctgtag atttactaag
     2281 tgaccaccca tttcctgccc tcactaagtg acaatacctt ccctgcagac ccactaatac
     2341 acgcttcctt catatcctac tcaggaagtg accatgtcaa ctgagccctt ctgactgact
     2401 gtccgactgt ccttgtcaat tgccactctc atgtcccctc cctctctcac tgccacactc
     2461 ctccatcagc atgtagagag tgtctttttc aactttggtc tttccttttg tggacaacat
     2521 ttctgcaaaa gagcaagggt ctggaacttg ccctggcctc tgacccctgg atgtgtgtgc
     2581 tgctaggtca atgaatctca agggtaggct gattagtgaa agcctctgtg gaagagacag
     2641 agaaccctgg gctcaggaca gactcacccc tgggacagac ttccatagaa gcctgactat
     2701 tcttctctca gtaaaatatg tgcaccgagt agccacagga gtaacttgaa tagacaataa
     2761 tttttagttt aatgaatata gattttcctc tactcta
//
