LOCUS       NM_001108037            1674 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus retinol dehydrogenase 12 (Rdh12), mRNA.
ACCESSION   NM_001108037 XM_001080897 XM_234334
VERSION     NM_001108037.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1674)
  AUTHORS   Daiger SP, Sullivan LS and Bowne SJ.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   2  (bases 1 to 1674)
  AUTHORS   Chen C, Thompson DA and Koutalos Y.
  TITLE     Reduction of all-trans-retinal in vertebrate rod photoreceptors
            requires the combined action of RDH8 and RDH12
  JOURNAL   J Biol Chem 287 (29), 24662-24670 (2012)
   PUBMED   22621924
REFERENCE   3  (bases 1 to 1674)
  AUTHORS   Kiser PD, Golczak M, Maeda A and Palczewski K.
  TITLE     Key enzymes of the retinoid (visual) cycle in vertebrate retina
  JOURNAL   Biochim Biophys Acta 1821 (1), 137-151 (2012)
   PUBMED   21447403
  REMARK    Review article
REFERENCE   4  (bases 1 to 1674)
  AUTHORS   Wright AF, Chakarova CF, Abd El-Aziz MM and Bhattacharya SS.
  TITLE     Photoreceptor degeneration: genetic and mechanistic dissection of a
            complex trait
  JOURNAL   Nat Rev Genet 11 (4), 273-284 (2010)
   PUBMED   20212494
  REMARK    Review article
REFERENCE   5  (bases 1 to 1674)
  AUTHORS   Marchette LD, Thompson DA, Kravtsova M, Ngansop TN, Mandal MN and
            Kasus-Jacobi A.
  TITLE     Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in
            photoreceptor cells
  JOURNAL   Free Radic Biol Med 48 (1), 16-25 (2010)
   PUBMED   19686838
REFERENCE   6  (bases 1 to 1674)
  AUTHORS   Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA,
            Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA and
            Palczewski K.
  TITLE     Retinol dehydrogenase (RDH12) protects photoreceptors from
            light-induced degeneration in mice
  JOURNAL   J Biol Chem 281 (49), 37697-37704 (2006)
   PUBMED   17032653
REFERENCE   7  (bases 1 to 1674)
  AUTHORS   Perrault I, Hanein S, Gerber S, Barbet F, Ducroq D, Dollfus H,
            Hamel C, Dufier JL, Munnich A, Kaplan J and Rozet JM.
  TITLE     Retinal dehydrogenase 12 (RDH12) mutations in leber congenital
            amaurosis
  JOURNAL   Am J Hum Genet 75 (4), 639-646 (2004)
   PUBMED   15322982
REFERENCE   8  (bases 1 to 1674)
  AUTHORS   Haeseleer F, Jang GF, Imanishi Y, Driessen CAGG, Matsumura M,
            Nelson PS and Palczewski K.
  TITLE     Dual-substrate specificity short chain retinol dehydrogenases from
            the vertebrate retina
  JOURNAL   J Biol Chem 277 (47), 45537-45546 (2002)
   PUBMED   12226107
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080897.1, XM_234334.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680422,
                              SAMN06680429 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1674
                     /gene="Rdh12"
                     /note="retinol dehydrogenase 12"
                     /db_xref="GeneID:314264"
                     /db_xref="RGD:1310462"
     exon            1..201
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1084
                     /gene="Rdh12"
                     /EC_number="1.1.1.300"
                     /note="retinol dehydrogenase 12 (all-trans/9-cis/11-cis)"
                     /codon_start=1
                     /product="retinol dehydrogenase 12 precursor"
                     /protein_id="NP_001101507.1"
                     /db_xref="GeneID:314264"
                     /db_xref="RGD:1310462"
                     /translation="MLVILVLLTSFFSILYLATPSIRKFFAGGVCTTKVQIPGKVVVI
                     TGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQVLVRKLDLSDT
                     KSIRTFAEGFLAEEKKLHILINNAGVMMCPYSKTVDGFETHFGVNHLGHFLLTYLLLG
                     RLKESAPARVINLSSVAHLGGKIRFHDLQSKKRYCSGFAYSHSKLANVLFTRELAKRL
                     QGTGVTAYVVHPGCVLSEITRHSFLMCLLWRLFSPFFKSPWQGAQTSLHCALEEGLEP
                     LSGKYFSDCKRTWVSPRARNKKTAERLWNVSCELLGIQWE"
     exon            202..320
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            321..476
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            477..581
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            582..791
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            792..981
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1674
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagttgctg agtgccccgg agagagagga gcctagagtc aacagaagct gccaggaatt
       61 ggagccagag aaggatcctc cggccaagtt gagagtggaa gctgcagaga cagcaactaa
      121 ggcggttgac aagatgctgg ttatcttggt actgctcacg tccttcttct cgatcttgta
      181 cctggcgact ccatccatca ggaagttctt tgctggtgga gtttgtacaa cgaaggtgca
      241 gatcccaggg aaggtagtgg tcatcacagg tgccaacaca ggcattggca aggagacagc
      301 cagagagctt gctcgaagag gagcacgagt atacattgcg tgtcgagatg tgctgaaggg
      361 agagtctgct gccagtgaaa tccgagcaga caccaagaac tcccaggtgc tagtgcggaa
      421 actggacctc tctgacacca aatccatccg aacctttgct gagggcttcc tagcagagga
      481 gaagaagctt catattttga tcaataatgc aggcgtgatg atgtgtccat attctaagac
      541 agtagatggc tttgaaaccc actttggagt caaccacctg ggccacttcc ttcttacata
      601 cctgcttttg gggaggctga aggagtctgc tcccgcacgg gtgataaacc tatcctcggt
      661 ggcccacctt ggtggcaaga tccgtttcca tgacctccaa agcaagaagc gatactgcag
      721 tggtttcgcc tatagtcaca gcaagctggc caacgtgctt ttcacccgag agctggccaa
      781 gcggctccaa gggaccggag tcacggccta tgtggttcac ccaggttgcg tcctgtctga
      841 gatcaccagg cactccttcc tgatgtgcct gttgtggcgc ctcttctcgc ccttcttcaa
      901 gtccccttgg cagggggctc agaccagcct gcactgcgcc ctggaggagg gcctggagcc
      961 cctgagcgga aagtacttca gtgactgcaa gaggacgtgg gtatccccaa gggcccggaa
     1021 caagaaaaca gctgagcgct tgtggaatgt cagctgtgag cttctaggaa tccagtggga
     1081 atagttggcc tgaagaccag ggccttttca ggcctaatcc atgccagaaa aaaaggggac
     1141 caaagagaag gctgactgga aaggattatc ctcctggctt ggtgctgctg taactcctgc
     1201 ctactaagaa ccttctggag ccctttatac acatgttttt gtgaagcagg attgtaggac
     1261 aggatgatac tcatacttct agatggttct caaaggatta gagaatccac agctcccttg
     1321 ggcaagaggc tgaacatggg ggtggaggag gatcctgaga agttggatcg gttccctctc
     1381 cagtaccact gatgtgagct tacatgctca taggagcaac cagcatcaca catttctata
     1441 ccctcaaact ctagcttggc ctctttttcc ttgaaatgaa atgctagtca caaccctgga
     1501 gtctggacca actcaggaag aaatagctca ttttggccaa acttcatttc ttcttttgag
     1561 catcccggag ccactcatga agctgggccc ttcccatttt tcatcatgta attttttttc
     1621 ctaaaccatt ctctttacct caatttttag agaaataaag atttgtgttt atct
//
