LOCUS       NM_001012193            1647 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus retinol dehydrogenase 11 (Rdh11), mRNA.
ACCESSION   NM_001012193 XM_343084
VERSION     NM_001012193.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1647)
  AUTHORS   Belyaeva OV, Wu L, Shmarakov I, Nelson PS and Kedishvili NY.
  TITLE     Retinol dehydrogenase 11 is essential for the maintenance of
            retinol homeostasis in liver and testis in mice
  JOURNAL   J Biol Chem 293 (18), 6996-7007 (2018)
   PUBMED   29567832
REFERENCE   2  (bases 1 to 1647)
  AUTHORS   Kiser PD, Golczak M, Maeda A and Palczewski K.
  TITLE     Key enzymes of the retinoid (visual) cycle in vertebrate retina
  JOURNAL   Biochim Biophys Acta 1821 (1), 137-151 (2012)
   PUBMED   21447403
  REMARK    Review article
REFERENCE   3  (bases 1 to 1647)
  AUTHORS   Kasus-Jacobi A, Ou J, Birch DG, Locke KG, Shelton JM, Richardson
            JA, Murphy AJ, Valenzuela DM, Yancopoulos GD and Edwards AO.
  TITLE     Functional characterization of mouse RDH11 as a retinol
            dehydrogenase involved in dark adaptation in vivo
  JOURNAL   J Biol Chem 280 (21), 20413-20420 (2005)
   PUBMED   15790565
REFERENCE   4  (bases 1 to 1647)
  AUTHORS   Kasus-Jacobi A, Ou J, Bashmakov YK, Shelton JM, Richardson JA,
            Goldstein JL and Brown MS.
  TITLE     Characterization of mouse short-chain aldehyde reductase (SCALD),
            an enzyme regulated by sterol regulatory element-binding proteins
  JOURNAL   J Biol Chem 278 (34), 32380-32389 (2003)
   PUBMED   12807874
REFERENCE   5  (bases 1 to 1647)
  AUTHORS   Haeseleer F, Jang GF, Imanishi Y, Driessen CAGG, Matsumura M,
            Nelson PS and Palczewski K.
  TITLE     Dual-substrate specificity short chain retinol dehydrogenases from
            the vertebrate retina
  JOURNAL   J Biol Chem 277 (47), 45537-45546 (2002)
   PUBMED   12226107
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079276.1.
            
            On Feb 11, 2005 this sequence version replaced XM_343084.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1647
                     /gene="Rdh11"
                     /note="retinol dehydrogenase 11"
                     /db_xref="GeneID:362757"
                     /db_xref="RGD:1312001"
     exon            1..149
                     /gene="Rdh11"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1035
                     /gene="Rdh11"
                     /EC_number="1.1.1.300"
                     /note="retinol dehydrogenase 11 (all-trans/9-cis/11-cis)"
                     /codon_start=1
                     /product="retinol dehydrogenase 11 precursor"
                     /protein_id="NP_001012193.1"
                     /db_xref="GeneID:362757"
                     /db_xref="RGD:1312001"
                     /translation="MFWFPLLLSLPFILFLVTPKIRKMLSCGVCTSNVQLSGKVAIVT
                     GANTGIGKETAKDLARRGARVYLACRDMQKGELVASEIQATTGNSQVLVRKLDLADTK
                     SIRAFAEGFLAEEKYLHILINNAGVMMCPYSKTADGFEMHFGVNHLGHFLLTHLLLEK
                     LKESGPSRVVNVSSLAHHLGRIHFHNLHGEKFYSGGLAYCHSKLANILFTKELARRLK
                     GSRVTTYSVHPGTVHSELIRHSTALKWLWQLFFFFIKTPQQGAQTSLYCAVTEGIEGL
                     SGSHFSDCQLAWVSSQAGNETIARRLWDVSCDLLGLPMDW"
     exon            150..268
                     /gene="Rdh11"
                     /inference="alignment:Splign:2.1.0"
     exon            269..424
                     /gene="Rdh11"
                     /inference="alignment:Splign:2.1.0"
     exon            425..529
                     /gene="Rdh11"
                     /inference="alignment:Splign:2.1.0"
     exon            530..739
                     /gene="Rdh11"
                     /inference="alignment:Splign:2.1.0"
     exon            740..929
                     /gene="Rdh11"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1622
                     /gene="Rdh11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggggtgtg tctaggaatt aaaagccata gtccggctgt cctctttgga gcatcaactt
       61 tcactgcgct tcggtggtgc tgagatgttt tggtttccgc tcctgctctc tcttcccttc
      121 atcctgttct tggtcacgcc gaaaatcagg aaaatgctgt cctgtggggt gtgcacatct
      181 aacgtccagc tttccgggaa ggtagccata gtcaccggtg ctaacacagg cattgggaaa
      241 gagacagcca aagacctggc ccgaagagga gcccgtgtgt atttggcttg ccgggatatg
      301 cagaaggggg aactggtggc tagtgagatc caagccacca cagggaatag ccaggtcctc
      361 gtacggaaac tggacctagc tgacaccaag tctattcgag cctttgccga aggcttctta
      421 gctgaggaaa agtacctgca cattctaatc aacaatgcag gagtgatgat gtgcccctac
      481 tctaagactg cagatggctt tgagatgcac tttggagtca accacctggg tcacttcctc
      541 ttgacccatt tgctgctaga aaagctaaag gagtcaggcc catcaagggt agtcaatgtg
      601 tcttctctgg cacaccatct gggaaggatc catttccata acctgcatgg cgagaagttc
      661 tacagtggag gcctggctta ctgccacagc aaactagcca acattctctt cactaaggaa
      721 ctggccagga ggctgaaagg ctctagagtg acaacatatt ctgtccatcc cggcacagtc
      781 cactctgaac tgattcggca ctcgactgct ttgaaatggc tttggcagct tttcttcttt
      841 ttcatcaaga cccctcaaca gggagcccag acaagcctgt actgtgccgt gacagaaggt
      901 atcgagggcc taagtggaag tcatttcagt gactgccagt tggcatgggt ctctagccaa
      961 gctggcaatg agacaatagc cagacggcta tgggatgtca gctgtgacct gctgggcctc
     1021 cctatggatt ggtaagtagt ggcggtttgg ctcaaaagaa gattggaaga gctgatgatt
     1081 gtccttcaaa gtggccaaaa ccttgaagat gaagaaggca gaacttcaag cctcgcctgc
     1141 ttggcatcca gttaaatccc agtatactgc caggttcctc taaacccttt cagtttgtcc
     1201 tgacttattc tgttcctgct cctgccagcg tttctagtag tatcatggac tgagacagag
     1261 gaccttccta tgacccacac agatcccatt ttcctttgga agctactcct aaccaggagc
     1321 agaaagcgat ataaaggctg gtgtgtggca acgtggatta gatggagctc ttcccagcca
     1381 accatccttt ccttgtgctc cattggaacc tcaggtgaac ctcaggagtc cagtgacctg
     1441 gcccaagagc aggtctttgt ggtcccaaca tctggatact taacaaaagt tttcactaaa
     1501 tctggcagtt tgaagctttt gataccaaaa cacttttcta tacccagacc acagaagagc
     1561 ttccttctct aagaagtttg tgaaatttga agaacagaaa taaaaataaa gccaaactgt
     1621 caaaaaaaaa aaaaaaaaaa aaaaaaa
//
