LOCUS       NM_181478               1061 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus retinol dehydrogenase 10 (Rdh10), mRNA.
ACCESSION   NM_181478
VERSION     NM_181478.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Napoli,J.L.
  TITLE     Physiological insights into all-trans-retinoic acid biosynthesis
  JOURNAL   Biochim Biophys Acta 1821 (1), 152-167 (2012)
   PUBMED   21621639
  REMARK    Review article
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Kiser,P.D., Golczak,M., Maeda,A. and Palczewski,K.
  TITLE     Key enzymes of the retinoid (visual) cycle in vertebrate retina
  JOURNAL   Biochim Biophys Acta 1821 (1), 137-151 (2012)
   PUBMED   21447403
  REMARK    Review article
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Wang,C., Kane,M.A. and Napoli,J.L.
  TITLE     Multiple retinol and retinal dehydrogenases catalyze
            all-trans-retinoic acid biosynthesis in astrocytes
  JOURNAL   J Biol Chem 286 (8), 6542-6553 (2011)
   PUBMED   21138835
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Farjo,K.M., Moiseyev,G., Takahashi,Y., Crouch,R.K. and Ma,J.X.
  TITLE     The 11-cis-retinol dehydrogenase activity of RDH10 and its
            interaction with visual cycle proteins
  JOURNAL   Invest Ophthalmol Vis Sci 50 (11), 5089-5097 (2009)
   PUBMED   19458327
REFERENCE   5  (bases 1 to 1061)
  AUTHORS   Sandell,L.L., Sanderson,B.W., Moiseyev,G., Johnson,T.,
            Mushegian,A., Young,K., Rey,J.P., Ma,J.X., Staehling-Hampton,K. and
            Trainor,P.A.
  TITLE     RDH10 is essential for synthesis of embryonic retinoic acid and is
            required for limb, craniofacial, and organ development
  JOURNAL   Genes Dev 21 (9), 1113-1124 (2007)
   PUBMED   17473173
REFERENCE   6  (bases 1 to 1061)
  AUTHORS   Wu,B.X., Moiseyev,G., Chen,Y., Rohrer,B., Crouch,R.K. and Ma,J.X.
  TITLE     Identification of RDH10, an All-trans Retinol Dehydrogenase, in
            Retinal Muller Cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (11), 3857-3862 (2004)
   PUBMED   15505029
REFERENCE   7  (bases 1 to 1061)
  AUTHORS   Wu,B.X., Chen,Y., Chen,Y., Fan,J., Rohrer,B., Crouch,R.K. and
            Ma,J.X.
  TITLE     Cloning and characterization of a novel all-trans retinol
            short-chain dehydrogenase/reductase from the RPE
  JOURNAL   Invest Ophthalmol Vis Sci 43 (11), 3365-3372 (2002)
   PUBMED   12407145
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY178865.1.
            
            On Jun 3, 2003 this sequence version replaced NM_181478.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY178865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..1061
                     /gene="Rdh10"
                     /note="retinol dehydrogenase 10"
                     /db_xref="GeneID:353252"
                     /db_xref="RGD:727793"
     exon            1..303
                     /gene="Rdh10"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1040
                     /gene="Rdh10"
                     /EC_number="1.1.1.300"
                     /note="retinol dehydrogenase 10 (all-trans)"
                     /codon_start=1
                     /product="retinol dehydrogenase 10"
                     /protein_id="NP_852143.1"
                     /db_xref="GeneID:353252"
                     /db_xref="RGD:727793"
                     /translation="MNIVVEFFLVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGA
                     GSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEE
                     EILPPCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDE
                     LIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVV
                     GFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQA
                     MKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNN
                     NEAKNGI"
     exon            304..539
                     /gene="Rdh10"
                     /inference="alignment:Splign:2.1.0"
     exon            540..638
                     /gene="Rdh10"
                     /inference="alignment:Splign:2.1.0"
     exon            639..784
                     /gene="Rdh10"
                     /inference="alignment:Splign:2.1.0"
     exon            785..916
                     /gene="Rdh10"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1061
                     /gene="Rdh10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggggcgt cgcgatgaac atcgtggtgg agttcttcct ggtcactttc aaagtgctgt
       61 gggcgttcgt gctggccgcg gcgcgctggc tggtgcggcc caaggagaag agcgtggccg
      121 gccaggtgtg cctcatcacg ggcgcgggca gcggcctggg ccgcctcttc gctctggagt
      181 tcgctcgacg ccgggcactg ctggttctct gggacatcaa cacgcagagc aatgaggaga
      241 ccgcaggcat ggtgcgccac atctaccggg acctggaggc ggccgacgcc gctgctctgc
      301 aagctgggaa cggtgaggag gaaatcctgc ccccatgtaa cttacaggtt tttacctata
      361 cctgtgatgt ggggaagaga gagaatgtct acctgacagc tgaaagggtc cgcaaggagg
      421 ttggtgaggt ctcggtcctg gtcaataacg ctggtgtggt ttctggacat caccttctgg
      481 aatgtcctga tgagctcatt gagagaacca tgatggtcaa ctgccacgca cacttctgga
      541 ccactaaggc ctttcttcca acgatgctgg agattaatca tggccatatt gtgacggtgg
      601 cgagctccct gggactgttc agcactgctg gagttgagga ttactgtgcc agtaagtttg
      661 gagttgtggg ttttcatgaa tctctgagtc atgaactgaa ggctgctgaa aaggatggaa
      721 ttaaaacaac tttggtttgc ccttaccttg tagacacggg catgttcaga ggctgccgaa
      781 tcagaaaaga aatcgagccc tttttgcccc ctttgaagcc cgattactgt gtgaagcagg
      841 ccatgaaggc catcctcact gaccagccca tgatctgcac ccctcgtctc atgtacatcg
      901 tgacattcat gaagagcatc cttcccttcg aagcagtcgt gtgcatgtat cgatttctag
      961 gagcagacaa gtgtatgtac ccctttattg ctcagagaaa acaagccaca aacaataatg
     1021 aagcaaaaaa tggaatctaa agtgcttttg tacggagtgc c
//
